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Publication DateNutrition, Metabolism and Cardiovascular Diseases, ISSN 0939-4753, 2007, Volume 18, Issue 2, pp. 158 - 168
Abstract Appetite is regulated by a complex system of central and peripheral signals which interact in order to modulate the individual response to nutrient...
Cardiovascular | Energy balance | Adiposity signals | Neuropeptides | Satiety signals | Hypothalamus | Eating behavior | AMPHETAMINE-REGULATED TRANSCRIPT | CORTICOTROPIN-RELEASING HORMONE | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOCANNABINOID SYSTEM | neuropeptides | energy balance | eating behavior | adiposity signals | NEUROPEPTIDE-Y | BODY-WEIGHT | AGOUTI-RELATED PROTEIN | ANOREXIA-NERVOSA | NUTRITION & DIETETICS | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | satiety signals | CILIARY NEUROTROPHIC FACTOR | hypothalamus | CARDIOVASCULAR RISK-FACTORS | Cannabinoid Receptor Modulators - metabolism | Satiety Response | Obesity - drug therapy | Peptide YY - metabolism | Humans | Leptin - metabolism | Anti-Obesity Agents - therapeutic use | Cholecystokinin - metabolism | Adiposity | Neurosecretory Systems - metabolism | Glucagon-Like Peptide 1 - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Appetite Regulation - drug effects | Feeding Behavior | Neuropeptides - metabolism | Obesity - physiopathology | Pituitary Hormone-Releasing Hormones - metabolism | Obesity - metabolism | Ghrelin - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Neurosecretory Systems - drug effects | Biogenic Monoamines - metabolism | Anti-Obesity Agents - pharmacology | Hormones
Cardiovascular | Energy balance | Adiposity signals | Neuropeptides | Satiety signals | Hypothalamus | Eating behavior | AMPHETAMINE-REGULATED TRANSCRIPT | CORTICOTROPIN-RELEASING HORMONE | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOCANNABINOID SYSTEM | neuropeptides | energy balance | eating behavior | adiposity signals | NEUROPEPTIDE-Y | BODY-WEIGHT | AGOUTI-RELATED PROTEIN | ANOREXIA-NERVOSA | NUTRITION & DIETETICS | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | satiety signals | CILIARY NEUROTROPHIC FACTOR | hypothalamus | CARDIOVASCULAR RISK-FACTORS | Cannabinoid Receptor Modulators - metabolism | Satiety Response | Obesity - drug therapy | Peptide YY - metabolism | Humans | Leptin - metabolism | Anti-Obesity Agents - therapeutic use | Cholecystokinin - metabolism | Adiposity | Neurosecretory Systems - metabolism | Glucagon-Like Peptide 1 - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Appetite Regulation - drug effects | Feeding Behavior | Neuropeptides - metabolism | Obesity - physiopathology | Pituitary Hormone-Releasing Hormones - metabolism | Obesity - metabolism | Ghrelin - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Neurosecretory Systems - drug effects | Biogenic Monoamines - metabolism | Anti-Obesity Agents - pharmacology | Hormones
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Loading RightsJournal of Endocrinology, ISSN 0022-0795, 04/2017, Volume 233, Issue 1, pp. 15 - 24
The anorectic anxlanx mouse exhibits a mitochondrial complex I dysfunction that is related to aberrant expression of hypothalamic neuropeptides and...
AMPK | Glucose uptake | Phosphocreatine | Lactate | ATP | ACTIVATED PROTEIN-KINASE | K-ATP CHANNELS | FOOD-INTAKE | ALZHEIMERS-DISEASE | GLUCOSE-UTILIZATION | ARCUATE NUCLEUS | HUMAN SKELETAL-MUSCLE | NEUROPEPTIDE-Y | glucose uptake | phosphocreatine | ENDOCRINOLOGY & METABOLISM | MITOCHONDRIAL DYSFUNCTION | lactate | ENERGY-METABOLISM | Carbohydrate Metabolism - physiology | Animals | Hypothalamus - metabolism | Adenosine Monophosphate - metabolism | Adenosine Triphosphate - metabolism | Lactic Acid - metabolism | Brain Ischemia - metabolism | Glucose - metabolism | Anorexia - metabolism | Mice | Phosphocreatine - metabolism | NADH-ubiquinone oxidoreductase | Anorexia | Energy metabolism | Neurotransmitter release | AMP | Neuropeptides | Carbohydrate metabolism | Inosine monophosphate | Hypothalamus | Glucose | Metabolism | Electron transport chain | Energy balance | Glucose metabolism | Mitochondria | Ischemia | Food intake | Rodents | Glycolysis | Lactic acid
AMPK | Glucose uptake | Phosphocreatine | Lactate | ATP | ACTIVATED PROTEIN-KINASE | K-ATP CHANNELS | FOOD-INTAKE | ALZHEIMERS-DISEASE | GLUCOSE-UTILIZATION | ARCUATE NUCLEUS | HUMAN SKELETAL-MUSCLE | NEUROPEPTIDE-Y | glucose uptake | phosphocreatine | ENDOCRINOLOGY & METABOLISM | MITOCHONDRIAL DYSFUNCTION | lactate | ENERGY-METABOLISM | Carbohydrate Metabolism - physiology | Animals | Hypothalamus - metabolism | Adenosine Monophosphate - metabolism | Adenosine Triphosphate - metabolism | Lactic Acid - metabolism | Brain Ischemia - metabolism | Glucose - metabolism | Anorexia - metabolism | Mice | Phosphocreatine - metabolism | NADH-ubiquinone oxidoreductase | Anorexia | Energy metabolism | Neurotransmitter release | AMP | Neuropeptides | Carbohydrate metabolism | Inosine monophosphate | Hypothalamus | Glucose | Metabolism | Electron transport chain | Energy balance | Glucose metabolism | Mitochondria | Ischemia | Food intake | Rodents | Glycolysis | Lactic acid
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Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Journal of Clinical Investigation, ISSN 0021-9738, 09/2007, Volume 117, Issue 9, pp. 2621 - 2637
Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related to ectopic lipid deposition in nonadipose tissue....
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | ANOREXIA-NERVOSA | HEPATIC INSULIN-RESISTANCE | TRANSGENIC MOUSE | I SR-BI | OB/OB MICE | PLASMA-LIPOPROTEIN | GENE-EXPRESSION | SECRETORY PROTEIN ADIPONECTIN | DEFICIENT MICE | Immunohistochemistry | Leptin - metabolism | Fats - pharmacology | Macrophages | PPAR gamma - metabolism | Adipose Tissue - metabolism | Diglycerides - metabolism | Insulin Resistance - physiology | Islets of Langerhans - metabolism | Adiponectin - genetics | Islets of Langerhans - cytology | Lipoproteins - metabolism | Adiponectin - metabolism | Adipose Tissue - anatomy & histology | Obesity - chemically induced | Liver - metabolism | Gene Expression Regulation | Organ Size | Mice, Transgenic | Obesity - metabolism | Obesity - pathology | Triglycerides - metabolism | Insulin - metabolism | Phenotype | Animals | PPAR gamma - agonists | Mice | Adipose Tissue - drug effects | Animal Feed | Physiological aspects | Obesity | Insulin resistance | Research
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | ANOREXIA-NERVOSA | HEPATIC INSULIN-RESISTANCE | TRANSGENIC MOUSE | I SR-BI | OB/OB MICE | PLASMA-LIPOPROTEIN | GENE-EXPRESSION | SECRETORY PROTEIN ADIPONECTIN | DEFICIENT MICE | Immunohistochemistry | Leptin - metabolism | Fats - pharmacology | Macrophages | PPAR gamma - metabolism | Adipose Tissue - metabolism | Diglycerides - metabolism | Insulin Resistance - physiology | Islets of Langerhans - metabolism | Adiponectin - genetics | Islets of Langerhans - cytology | Lipoproteins - metabolism | Adiponectin - metabolism | Adipose Tissue - anatomy & histology | Obesity - chemically induced | Liver - metabolism | Gene Expression Regulation | Organ Size | Mice, Transgenic | Obesity - metabolism | Obesity - pathology | Triglycerides - metabolism | Insulin - metabolism | Phenotype | Animals | PPAR gamma - agonists | Mice | Adipose Tissue - drug effects | Animal Feed | Physiological aspects | Obesity | Insulin resistance | Research
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Loading RightsLife Sciences, ISSN 0024-3205, 02/2017, Volume 170, pp. 56 - 63
Cancer cachexia characterized by a chronic wasting syndrome, involves skeletal muscle loss and adipose tissue loss and resistance to conventional nutritional...
Skeletal muscle wasting | Cancer cachexia | Acute phase response | Metabolic abnormalities | Tumor necrosis factor- alpha (TNF-α) | MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | PANCREATIC-CANCER | MESSENGER-RNA LEVELS | ACUTE-PHASE RESPONSE | RESTING ENERGY-EXPENDITURE | SKELETAL-MUSCLE MYOTUBES | TUMOR-NECROSIS-FACTOR | Tumor necrosis factor- alpha (TNF-alpha) | PHARMACOLOGY & PHARMACY | INSULIN-RECEPTOR SUBSTRATE-1 | UBIQUITIN-PROTEASOME PATHWAY | ADIPOSE-TISSUE | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Uncoupling Protein 3 - metabolism | Muscular Atrophy - metabolism | Uncoupling Protein 2 - metabolism | Humans | Insulin Resistance | Ubiquitin - chemistry | Anorexia - metabolism | Muscle, Skeletal - metabolism | Inflammation | Metabolism | Adipose Tissue - metabolism | Lipids - chemistry | Animals | Carbohydrates - chemistry | Weight Loss | Proteasome Endopeptidase Complex - metabolism | Cachexia - metabolism | Interleukin-6 - metabolism | Gluconeogenesis
Skeletal muscle wasting | Cancer cachexia | Acute phase response | Metabolic abnormalities | Tumor necrosis factor- alpha (TNF-α) | MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | PANCREATIC-CANCER | MESSENGER-RNA LEVELS | ACUTE-PHASE RESPONSE | RESTING ENERGY-EXPENDITURE | SKELETAL-MUSCLE MYOTUBES | TUMOR-NECROSIS-FACTOR | Tumor necrosis factor- alpha (TNF-alpha) | PHARMACOLOGY & PHARMACY | INSULIN-RECEPTOR SUBSTRATE-1 | UBIQUITIN-PROTEASOME PATHWAY | ADIPOSE-TISSUE | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Uncoupling Protein 3 - metabolism | Muscular Atrophy - metabolism | Uncoupling Protein 2 - metabolism | Humans | Insulin Resistance | Ubiquitin - chemistry | Anorexia - metabolism | Muscle, Skeletal - metabolism | Inflammation | Metabolism | Adipose Tissue - metabolism | Lipids - chemistry | Animals | Carbohydrates - chemistry | Weight Loss | Proteasome Endopeptidase Complex - metabolism | Cachexia - metabolism | Interleukin-6 - metabolism | Gluconeogenesis
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Loading RightsClinical Chemistry, ISSN 0009-9147, 09/2004, Volume 50, Issue 9, pp. 1511 - 1525
Background: Recent studies point to the adipose tissue as a highly active endocrine organ secreting a range of hormones. Leptin, ghrelin, adiponectin, and...
BODY-WEIGHT | GASTRIC BYPASS-SURGERY | TUMOR-NECROSIS-FACTOR | ANOREXIA-NERVOSA | GROWTH-HORMONE | INSULIN-RESISTANCE | LIVER FIBROSIS | ANTIINFLAMMATORY PROTEIN | MEDICAL LABORATORY TECHNOLOGY | TYPE-2 DIABETES-MELLITUS | ADIPOSE-TISSUE | Humans | Leptin - metabolism | Peptide Hormones - blood | Hormones, Ectopic - metabolism | Muscle, Skeletal - metabolism | Gastric Mucosa - metabolism | Hormones, Ectopic - blood | Adiponectin | Leptin - physiology | Peptide Hormones - metabolism | Adipose Tissue - metabolism | Leptin - blood | Ghrelin | Peptide Hormones - chemistry | Receptors, Cell Surface - chemistry | Energy Metabolism - physiology | Peptide Hormones - physiology | Resistin | Receptors, Leptin | Proteins - physiology | Leptin - chemistry | Intercellular Signaling Peptides and Proteins | Liver - metabolism | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - blood | Hormones, Ectopic - physiology | Obesity - metabolism | Hormones, Ectopic - chemistry | Animals | Proteins - metabolism | Proteins - chemistry | Adipose tissues | Liver diseases | Eating disorders | Glucose | Peptide hormones | Insulin | Dextrose | Glucose metabolism | Leptin | Atherosclerosis | Physiological aspects | Insulin resistance | Diabetes
BODY-WEIGHT | GASTRIC BYPASS-SURGERY | TUMOR-NECROSIS-FACTOR | ANOREXIA-NERVOSA | GROWTH-HORMONE | INSULIN-RESISTANCE | LIVER FIBROSIS | ANTIINFLAMMATORY PROTEIN | MEDICAL LABORATORY TECHNOLOGY | TYPE-2 DIABETES-MELLITUS | ADIPOSE-TISSUE | Humans | Leptin - metabolism | Peptide Hormones - blood | Hormones, Ectopic - metabolism | Muscle, Skeletal - metabolism | Gastric Mucosa - metabolism | Hormones, Ectopic - blood | Adiponectin | Leptin - physiology | Peptide Hormones - metabolism | Adipose Tissue - metabolism | Leptin - blood | Ghrelin | Peptide Hormones - chemistry | Receptors, Cell Surface - chemistry | Energy Metabolism - physiology | Peptide Hormones - physiology | Resistin | Receptors, Leptin | Proteins - physiology | Leptin - chemistry | Intercellular Signaling Peptides and Proteins | Liver - metabolism | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - blood | Hormones, Ectopic - physiology | Obesity - metabolism | Hormones, Ectopic - chemistry | Animals | Proteins - metabolism | Proteins - chemistry | Adipose tissues | Liver diseases | Eating disorders | Glucose | Peptide hormones | Insulin | Dextrose | Glucose metabolism | Leptin | Atherosclerosis | Physiological aspects | Insulin resistance | Diabetes
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Loading RightsJournal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 12/2011, Volume 31, Issue 12, pp. 2324 - 2333
Manganese (Mn2+)-enhanced magnetic resonance imaging studies of the neuronal pathways of the hypothalamus showed that information about the regulation of food...
GABA | animal models | astrocytes | calcium channels | MR spectroscopy | NMR-SPECTROSCOPIC ANALYSIS | RESONANCE-IMAGING MEMRI | ANTERIOR-PITUITARY-CELLS | NEURONAL ACTIVATION | NEUROSCIENCES | BRAIN ENERGY-METABOLISM | PERIPHERAL INJECTION | N-ACETYLASPARTATE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MAGNETIC-RESONANCE | HEMATOLOGY | DEHYDRATION-INDUCED ANOREXIA | Magnetic Resonance Spectroscopy | Rats, Wistar | Chlorides - pharmacology | Hippocampus - chemistry | gamma-Aminobutyric Acid - metabolism | Homeostasis | Rats | Anorexia - metabolism | Hippocampus - drug effects | Amino Acids - metabolism | Hippocampus - metabolism | Magnetic Resonance Imaging | Animals | Hypothalamus - metabolism | Image Processing, Computer-Assisted | Female | Hypothalamus - drug effects | Manganese Compounds - pharmacology | Dehydration - metabolism | Hypothalamus - chemistry | Energy Metabolism - drug effects | Manganese Poisoning - metabolism | Original
GABA | animal models | astrocytes | calcium channels | MR spectroscopy | NMR-SPECTROSCOPIC ANALYSIS | RESONANCE-IMAGING MEMRI | ANTERIOR-PITUITARY-CELLS | NEURONAL ACTIVATION | NEUROSCIENCES | BRAIN ENERGY-METABOLISM | PERIPHERAL INJECTION | N-ACETYLASPARTATE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MAGNETIC-RESONANCE | HEMATOLOGY | DEHYDRATION-INDUCED ANOREXIA | Magnetic Resonance Spectroscopy | Rats, Wistar | Chlorides - pharmacology | Hippocampus - chemistry | gamma-Aminobutyric Acid - metabolism | Homeostasis | Rats | Anorexia - metabolism | Hippocampus - drug effects | Amino Acids - metabolism | Hippocampus - metabolism | Magnetic Resonance Imaging | Animals | Hypothalamus - metabolism | Image Processing, Computer-Assisted | Female | Hypothalamus - drug effects | Manganese Compounds - pharmacology | Dehydration - metabolism | Hypothalamus - chemistry | Energy Metabolism - drug effects | Manganese Poisoning - metabolism | Original
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Loading RightsFEBS Letters, ISSN 0014-5793, 2008, Volume 582, Issue 10, pp. 1471 - 1476
Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the...
Obesity | Diabetes | Hypothalamus | Insulin | Leptin | ACTIVATED PROTEIN-KINASE | insulin | PHOSPHORYLATION | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | leptin | CELL BIOLOGY | BIOPHYSICS | FATTY-ACID OXIDATION | RESISTANCE | RECEPTORS | diabetes | obesity | hypothalamus | Hypothalamic Area, Lateral - metabolism | Insulin - physiology | Rats, Wistar | Receptors, Adiponectin - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Adiponectin - physiology | Phosphoproteins - metabolism | Leptin - physiology | Forkhead Transcription Factors - metabolism | Arcuate Nucleus of Hypothalamus - drug effects | Janus Kinase 2 - metabolism | Insulin Receptor Substrate Proteins | Leptin - pharmacology | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - metabolism | Insulin - pharmacology | Adiponectin - pharmacology | Arcuate Nucleus of Hypothalamus - metabolism | Rats | Anorexia - metabolism | Nerve Tissue Proteins - metabolism | Eating - drug effects | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Hypothalamic Area, Lateral - drug effects | Anorexia - chemically induced | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Adiponectin - genetics | RNA, Antisense - genetics
Obesity | Diabetes | Hypothalamus | Insulin | Leptin | ACTIVATED PROTEIN-KINASE | insulin | PHOSPHORYLATION | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | leptin | CELL BIOLOGY | BIOPHYSICS | FATTY-ACID OXIDATION | RESISTANCE | RECEPTORS | diabetes | obesity | hypothalamus | Hypothalamic Area, Lateral - metabolism | Insulin - physiology | Rats, Wistar | Receptors, Adiponectin - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Adiponectin - physiology | Phosphoproteins - metabolism | Leptin - physiology | Forkhead Transcription Factors - metabolism | Arcuate Nucleus of Hypothalamus - drug effects | Janus Kinase 2 - metabolism | Insulin Receptor Substrate Proteins | Leptin - pharmacology | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - metabolism | Insulin - pharmacology | Adiponectin - pharmacology | Arcuate Nucleus of Hypothalamus - metabolism | Rats | Anorexia - metabolism | Nerve Tissue Proteins - metabolism | Eating - drug effects | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Hypothalamic Area, Lateral - drug effects | Anorexia - chemically induced | Adaptor Proteins, Signal Transducing - metabolism | Receptors, Adiponectin - genetics | RNA, Antisense - genetics
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Loading RightsPLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0174894
Dexmedetomidine is generally used for sedaton in critically ill, it could shorten duration of mechanical ventilation, ICU stay and lower basic metabolism....
TRIAL | SKELETAL-MUSCLE | MULTIDISCIPLINARY SCIENCES | SEDATION | SIGNALS | PATIENT | SEPSIS | WEIGHT | CRITICALLY-ILL PATIENTS | INTENSIVE-CARE | PROPOFOL | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - metabolism | Dexmedetomidine - therapeutic use | Muscular Atrophy - metabolism | Endotoxemia - drug therapy | Rats | Male | Muscle, Skeletal - metabolism | Neuropeptides - metabolism | Muscular Atrophy - drug therapy | Agouti-Related Protein - metabolism | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Neuropeptide Y - metabolism | Pro-Opiomelanocortin - metabolism | Inflammation - metabolism | Animals | Hypothalamus - metabolism | Inflammation - drug therapy | Methylhistidines - metabolism | Muscle, Skeletal - drug effects | Hypothalamus - drug effects | Muscle, Skeletal - pathology | Endotoxemia - metabolism | Usage | Septicemia | Dexmedetomidine | Physiological aspects | Hypothalamic hormones | Inflammation | Models | Drug therapy | Atrophy, Muscular | Delirium | Coma | Drinking water | Anorexia | Peptides | Central nervous system | Nervous system | Neuropeptides | Bone surgery | Nuclei | Proteins | Alterations | Temperature effects | Surgery | Bone marrow | Anesthesia | Physiology | Anxiety | Starvation | Cytokines | Mortality | Metabolism | Gene expression | Insulin | Immunosuppression | Hospitals | Agouti-related protein | Binding energy | Ventilation | Sepsis | Adults | Mice | Environmental monitoring | Endocrinology | Kidney transplantation | Drugs | Adolescence | Animal models | Intensive care | Mental disorders | Arcuate nucleus | Medical services | Homeostasis | Antibodies | Risk | Stimulation | Infections | Medical schools | Atrophy | Pain | Metabolites | E coli | Lighting | Rodents | Attenuation | Adolescents | Malnutrition | Buffers | Hypertension | Appetite | Pain perception | Nutrition | Neurons | Complications | Medical instruments | Oxygen consumption | Parenteral nutrition | Medicine | Analgesia | Musculoskeletal system | Lungs | Steroids
TRIAL | SKELETAL-MUSCLE | MULTIDISCIPLINARY SCIENCES | SEDATION | SIGNALS | PATIENT | SEPSIS | WEIGHT | CRITICALLY-ILL PATIENTS | INTENSIVE-CARE | PROPOFOL | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - metabolism | Dexmedetomidine - therapeutic use | Muscular Atrophy - metabolism | Endotoxemia - drug therapy | Rats | Male | Muscle, Skeletal - metabolism | Neuropeptides - metabolism | Muscular Atrophy - drug therapy | Agouti-Related Protein - metabolism | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Neuropeptide Y - metabolism | Pro-Opiomelanocortin - metabolism | Inflammation - metabolism | Animals | Hypothalamus - metabolism | Inflammation - drug therapy | Methylhistidines - metabolism | Muscle, Skeletal - drug effects | Hypothalamus - drug effects | Muscle, Skeletal - pathology | Endotoxemia - metabolism | Usage | Septicemia | Dexmedetomidine | Physiological aspects | Hypothalamic hormones | Inflammation | Models | Drug therapy | Atrophy, Muscular | Delirium | Coma | Drinking water | Anorexia | Peptides | Central nervous system | Nervous system | Neuropeptides | Bone surgery | Nuclei | Proteins | Alterations | Temperature effects | Surgery | Bone marrow | Anesthesia | Physiology | Anxiety | Starvation | Cytokines | Mortality | Metabolism | Gene expression | Insulin | Immunosuppression | Hospitals | Agouti-related protein | Binding energy | Ventilation | Sepsis | Adults | Mice | Environmental monitoring | Endocrinology | Kidney transplantation | Drugs | Adolescence | Animal models | Intensive care | Mental disorders | Arcuate nucleus | Medical services | Homeostasis | Antibodies | Risk | Stimulation | Infections | Medical schools | Atrophy | Pain | Metabolites | E coli | Lighting | Rodents | Attenuation | Adolescents | Malnutrition | Buffers | Hypertension | Appetite | Pain perception | Nutrition | Neurons | Complications | Medical instruments | Oxygen consumption | Parenteral nutrition | Medicine | Analgesia | Musculoskeletal system | Lungs | Steroids
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Loading RightsCell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 703 - 712
Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone...
BODY-WEIGHT | GLUCOSE-HOMEOSTASIS | BETA-CELLS | PROOPIOMELANOCORTIN NEURONS | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC ARCUATE NUCLEUS | CENTRAL-NERVOUS-SYSTEM | INDUCED ANOREXIA | INSULIN-RECEPTOR SUBSTRATE-2 | IGF-1 RECEPTOR | NUTRIENT HOMEOSTASIS | CELL BIOLOGY | Glucose Intolerance - metabolism | Receptors, Leptin - genetics | Cytoskeletal Proteins - genetics | Leptin - metabolism | Homeostasis | Male | Insulin Receptor Substrate Proteins - metabolism | Obesity - genetics | Brain - metabolism | Forkhead Transcription Factors - metabolism | Cytoskeletal Proteins - metabolism | Female | Neurons - metabolism | Insulin - genetics | Insulin Receptor Substrate Proteins - genetics | Forkhead Transcription Factors - deficiency | Gene Expression | Glucose Intolerance - genetics | Signal Transduction | Glucose - genetics | Mice, Transgenic | Leptin - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Insulin - metabolism | Animals | Energy Metabolism | Insulin Resistance - genetics | Glucose - metabolism | Forkhead Box Protein O1 | Mice | Receptors, Leptin - metabolism | Neurons | Leptin | Insulin resistance | Diabetes | Glucose | Gene expression | Dextrose
BODY-WEIGHT | GLUCOSE-HOMEOSTASIS | BETA-CELLS | PROOPIOMELANOCORTIN NEURONS | ENDOCRINOLOGY & METABOLISM | HYPOTHALAMIC ARCUATE NUCLEUS | CENTRAL-NERVOUS-SYSTEM | INDUCED ANOREXIA | INSULIN-RECEPTOR SUBSTRATE-2 | IGF-1 RECEPTOR | NUTRIENT HOMEOSTASIS | CELL BIOLOGY | Glucose Intolerance - metabolism | Receptors, Leptin - genetics | Cytoskeletal Proteins - genetics | Leptin - metabolism | Homeostasis | Male | Insulin Receptor Substrate Proteins - metabolism | Obesity - genetics | Brain - metabolism | Forkhead Transcription Factors - metabolism | Cytoskeletal Proteins - metabolism | Female | Neurons - metabolism | Insulin - genetics | Insulin Receptor Substrate Proteins - genetics | Forkhead Transcription Factors - deficiency | Gene Expression | Glucose Intolerance - genetics | Signal Transduction | Glucose - genetics | Mice, Transgenic | Leptin - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Insulin - metabolism | Animals | Energy Metabolism | Insulin Resistance - genetics | Glucose - metabolism | Forkhead Box Protein O1 | Mice | Receptors, Leptin - metabolism | Neurons | Leptin | Insulin resistance | Diabetes | Glucose | Gene expression | Dextrose
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Loading RightsNature, ISSN 0028-0836, 10/2006, Volume 443, Issue 7112, pp. 709 - 712
The brain hypothalamus contains certain secreted molecules that are important in regulating feeding behaviour. Here we show that nesfatin, corresponding to...
SYSTEM | OBESITY | NUCLEOBINDIN | PATHWAY | CLONING | FOOD-INTAKE | NEFA | MULTIDISCIPLINARY SCIENCES | LEPTIN RECEPTOR | BINDING PROTEIN | MELANOCORTIN-4 RECEPTOR | Rats, Wistar | Leptin - metabolism | Injections, Intraventricular | Body Weight - drug effects | Male | Gene Expression Profiling | alpha-MSH - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Satiety Response - physiology | Receptors, Melanocortin - metabolism | Nerve Tissue Proteins - pharmacology | DNA-Binding Proteins - administration & dosage | Leptin - pharmacology | Nerve Tissue Proteins - administration & dosage | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Receptors, Leptin | Satiety Response - drug effects | DNA-Binding Proteins - pharmacology | Nerve Tissue Proteins - cerebrospinal fluid | Appetite Regulation - drug effects | Rats | Receptors, Cell Surface - metabolism | Anorexia - metabolism | DNA-Binding Proteins - chemistry | Feeding Behavior - physiology | Calcium-Binding Proteins - administration & dosage | Feeding Behavior - drug effects | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Rats, Zucker | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Anorexia - prevention & control | Anorexia - chemically induced | Mice | Appetite Regulation - physiology | Calcium-Binding Proteins - pharmacology | Receptors, Cell Surface - genetics | Proteins | Brain | Signal transduction | Hormones | Gene expression | Rodents
SYSTEM | OBESITY | NUCLEOBINDIN | PATHWAY | CLONING | FOOD-INTAKE | NEFA | MULTIDISCIPLINARY SCIENCES | LEPTIN RECEPTOR | BINDING PROTEIN | MELANOCORTIN-4 RECEPTOR | Rats, Wistar | Leptin - metabolism | Injections, Intraventricular | Body Weight - drug effects | Male | Gene Expression Profiling | alpha-MSH - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Satiety Response - physiology | Receptors, Melanocortin - metabolism | Nerve Tissue Proteins - pharmacology | DNA-Binding Proteins - administration & dosage | Leptin - pharmacology | Nerve Tissue Proteins - administration & dosage | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Receptors, Leptin | Satiety Response - drug effects | DNA-Binding Proteins - pharmacology | Nerve Tissue Proteins - cerebrospinal fluid | Appetite Regulation - drug effects | Rats | Receptors, Cell Surface - metabolism | Anorexia - metabolism | DNA-Binding Proteins - chemistry | Feeding Behavior - physiology | Calcium-Binding Proteins - administration & dosage | Feeding Behavior - drug effects | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Rats, Zucker | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Anorexia - prevention & control | Anorexia - chemically induced | Mice | Appetite Regulation - physiology | Calcium-Binding Proteins - pharmacology | Receptors, Cell Surface - genetics | Proteins | Brain | Signal transduction | Hormones | Gene expression | Rodents
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