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1997, WHO expert series on neuroscience, ISBN 0889370885, Volume 3, xi, 132
Book
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6342, pp. 1084 - 1087
A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death of one volunteer and produced mild-to-severe... 
MOLECULAR CHARACTERIZATION | ENZYME | PAIN | ACID AMIDE HYDROLASE-1 | CLINICAL-TRIAL | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | RECEPTOR | BLOCKADE | ESTERASE | PF-04457845 | Anti-Anxiety Agents - metabolism | Analgesics - pharmacology | Pyridines - chemistry | Humans | Analgesics - metabolism | Pyridazines - pharmacology | Protein Interaction Maps | Pyridines - adverse effects | Cyclic N-Oxides - adverse effects | Cyclic N-Oxides - pharmacology | Urea - analogs & derivatives | Cyclic N-Oxides - metabolism | Anti-Anxiety Agents - adverse effects | Anti-Anxiety Agents - chemistry | Neurons - metabolism | Neurons - drug effects | Pyridazines - therapeutic use | Analgesics - adverse effects | Anti-Anxiety Agents - pharmacology | Amidohydrolases - antagonists & inhibitors | Cross Reactions | Cyclic N-Oxides - chemistry | Urea - therapeutic use | Pyridines - metabolism | Analgesics - chemistry | Cell Line, Tumor | Pyridines - pharmacology | Clinical Trials, Phase I as Topic | Urea - pharmacology | Amino acid sequence | Methods | Fatty-acid amide hydrolase | Brain | Profiling | Hydrolase | Neurons | Therapeutic applications | Cortex | Nervous system | Tissue analysis | Metabolism | Lipase | Tissues | Fatty acids | Proteins | Neurotoxicity | Pain | Inhibitors | Brain damage | Anxiety | Lipid metabolism | Brain injury | Index Medicus | Drugs | Networks | Proteomics | Amides
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 04/2015, Volume 353, Issue 1, pp. 213 - 233
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 11/2018, Volume 121, pp. 82 - 94
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 11/2010, Volume 35, Issue 12, pp. 2378 - 2391
Journal Article
Brain Research, ISSN 0006-8993, 2008, Volume 1211, pp. 37 - 43
Journal Article
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 153 - 163
Small molecule phosphodiesterase (PDE) 4 inhibitors have long been known to show therapeutic benefit in various preclinical models of psychiatric and... 
ALLOSTERIC MODULATORS | MESSENGER-RNA | MEMORY | PDE4 | DISEASE | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | RANDOMIZED CLINICAL-TRIALS | IDENTIFICATION | ROFLUMILAST | ROLIPRAM | Inflammation - chemically induced | Macaca fascicularis | Male | Thiazoles - therapeutic use | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Anti-Anxiety Agents - pharmacokinetics | Inflammation - drug therapy | Oxadiazoles - pharmacology | Phosphodiesterase 4 Inhibitors - adverse effects | Anti-Anxiety Agents - adverse effects | Behavior, Animal - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - drug effects | Benzamides - pharmacology | Pica - drug therapy | Anti-Anxiety Agents - therapeutic use | Cerebral Cortex - drug effects | Drug Evaluation, Preclinical | Oxadiazoles - pharmacokinetics | Rolipram - pharmacology | Cyclopropanes - pharmacology | Cerebral Cortex - enzymology | Phosphodiesterase 4 Inhibitors - pharmacokinetics | Callithrix | Nootropic Agents - pharmacokinetics | Anti-Anxiety Agents - pharmacology | Nootropic Agents - therapeutic use | Rats | Ferrets | Nootropic Agents - adverse effects | Phosphodiesterase 4 Inhibitors - pharmacology | Oxadiazoles - therapeutic use | Oxadiazoles - adverse effects | Animals | Aminopyridines - pharmacology | Thiazoles - pharmacology | Isoenzymes - antagonists & inhibitors | Nootropic Agents - pharmacology
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 12/2010, Volume 78, Issue 6, pp. 1105 - 1123
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7579, pp. 477 - 483
At least 120 non-olfactory G-protein-coupled receptors in the human genome are 'orphans' for which endogenous ligands are unknown, and many have no selective... 
EXTRACELLULAR ACIDIFICATION | ACTIVATION | COMPLEX | OGR1 | PROTEIN-COUPLED RECEPTOR | MULTIDISCIPLINARY SCIENCES | CAMP ACCUMULATION | SMOOTH-MUSCLE-CELLS | EXPRESSION | CANCER | Anti-Anxiety Agents - metabolism | Lorazepam - pharmacology | Memory - drug effects | Receptors, G-Protein-Coupled - metabolism | Humans | Anti-Anxiety Agents - analysis | Male | Receptors, G-Protein-Coupled - agonists | Lorazepam - analysis | Benzyl Alcohols - pharmacology | HEK293 Cells | Anti-Anxiety Agents - chemistry | Female | Triazines - chemistry | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Triazines - metabolism | Triazines - pharmacology | Lorazepam - metabolism | Anti-Anxiety Agents - pharmacology | Models, Molecular | Drug Discovery | Mice, Knockout | Triazines - analysis | Fear | Animals | Receptors, G-Protein-Coupled - deficiency | Signal Transduction - drug effects | Benzyl Alcohols - analysis | Allosteric Site | Lorazepam - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Conditioning, Classical | Benzyl Alcohols - metabolism | Ligands | Mice | Receptors, G-Protein-Coupled - chemistry | Physiological aspects | Cell receptors | Identification and classification | Ligands (Biochemistry) | Proteins | Yeast | Rodents | Physiology | Genomes | Kinases | proton-sensing | virtual screening | GPR68 | GPR65 | positive allosteric modulator (PAM) | functional selectivity | allosteric modulator
Journal Article