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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2013, Volume 344, Issue 1, pp. 23 - 32
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 04/2008, Volume 14, Issue 10, pp. 1001 - 1047
Amidoximes are compounds bearing both a hydroxyimino and an amino group at the same carbon atom which makes them versatile building blocks for the synthesis of... 
Amidines | Biological activities | Prodrugs | Amidoximes | NO donors | amidines | DIRECT THROMBIN INHIBITOR | SOLID-PHASE SYNTHESIS | NITRIC-OXIDE SYNTHASE | HUMAN LIVER-MICROSOMES | prodrugs | CYTOCHROME B REDUCTASE | METABOLIC N-HYDROXYLATION | biological activities | amidoximes | FIBRINOGEN RECEPTOR ANTAGONISTS | PHARMACOLOGY & PHARMACY | PNEUMOCYSTIS-CARINII PNEUMONIA | HYDROXY-L-ARGININE | FACTOR XA INHIBITOR | Antihypertensive Agents - pharmacology | Nitric Oxide Donors - chemistry | Antioxidants - chemistry | Anti-Arrhythmia Agents - pharmacology | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Prodrugs - chemistry | Anti-Allergic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Platelet Aggregation Inhibitors - chemical synthesis | Anti-Allergic Agents - chemical synthesis | Anti-Infective Agents - chemistry | Anti-Allergic Agents - chemistry | Platelet Aggregation Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Nitric Oxide Donors - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Central Nervous System Agents - chemistry | Pesticides - chemical synthesis | Anti-Arrhythmia Agents - chemistry | Antihypertensive Agents - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Oximes - chemical synthesis | Antineoplastic Agents - chemistry | Anti-Infective Agents - chemical synthesis | Oximes - chemistry | Antihypertensive Agents - chemistry | Anti-Arrhythmia Agents - chemical synthesis | Central Nervous System Agents - pharmacology | Platelet Aggregation Inhibitors - chemistry | Oximes - pharmacology | Pesticides - chemistry | Prodrugs - chemical synthesis | Nitric Oxide Donors - chemical synthesis | Central Nervous System Agents - chemical synthesis | Prodrugs - pharmacology | Pesticides - pharmacology
Journal Article
Journal Article
Molecular Diagnosis & Therapy, ISSN 1177-1062, 6/2013, Volume 17, Issue 3, pp. 165 - 184
Interindividual variability in drug response is a major clinical problem. Polymedication and genetic polymorphisms modulating drug-metabolising enzyme... 
Human Genetics | Pharmacotherapy | Cancer Research | Molecular Medicine | Biomedicine | Laboratory Medicine | IMPLEMENTATION CONSORTIUM GUIDELINES | CYP2D6 GENE DUPLICATION | ALLELIC VARIANT | GENETICS & HEREDITY | RESPONSIVE BREAST-CANCER | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | COMBINED PHENOTYPIC ASSESSMENT | HUMAN CYTOCHROME-P450 ENZYMES | ADVERSE DRUG-REACTIONS | DOSE REQUIREMENTS | ACTIVE METABOLITE | Cytochrome P-450 CYP2C9 | Cytochrome P-450 CYP2D6 - genetics | Pharmacogenetics | Psychotropic Drugs - pharmacokinetics | Anti-Arrhythmia Agents - pharmacology | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Estrogen Antagonists - pharmacology | Treatment Outcome | Anti-Arrhythmia Agents - metabolism | Anti-Arrhythmia Agents - pharmacokinetics | Antidepressive Agents - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Estrogen Antagonists - metabolism | Cytochrome P-450 CYP2C19 | Psychotropic Drugs - pharmacology | Estrogen Antagonists - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Antidepressive Agents - pharmacology | Inactivation, Metabolic - genetics | Psychotropic Drugs - metabolism | Antidepressive Agents - pharmacokinetics | Measurement | Physiological aspects | Genetic aspects | Drug therapy | Cytochrome P-450 | Psychotropic drugs | Enzymes | Genotype & phenotype | Metabolites | Antidepressants | Clinical medicine | Metabolism | Drug dosages | Patients | Polymorphism | Index Medicus | Review
Journal Article
Journal Article
Journal Article
Journal Article
SHOCK, ISSN 1073-2322, 03/2009, Volume 31, Issue 3, pp. 267 - 274
Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system,... 
SURGERY | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | POTASSIUM CHANNELS | K-ATP CHANNELS | GASTROINTESTINAL-TRACT | ISCHEMIA-REPERFUSION INJURY | infarct size | hydrogen sulfide | DECREASES CARDIOMYOCYTE APOPTOSIS | inflammation and regional myocardial infarction | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | Apoptosis | CRITICAL CARE MEDICINE | Hydroxy Acids - pharmacology | Phosphorylation | Sulfides - antagonists & inhibitors | Rats, Wistar | Apoptosis - drug effects | Anti-Arrhythmia Agents - pharmacology | Male | Tyrosine - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Myocardial Reperfusion Injury - pathology | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Cell Nucleus - metabolism | Cell Nucleus - pathology | Muscle Proteins - metabolism | Neutrophils - metabolism | Disease Models, Animal | Neutrophils - pathology | Sulfides - pharmacology | Cardiotonic Agents - antagonists & inhibitors | Malondialdehyde - metabolism | Decanoic Acids - pharmacology | Rats | Hydroxy Acids - antagonists & inhibitors | Cardiotonic Agents - pharmacology | Myocardial Reperfusion Injury - metabolism | Tyrosine - metabolism | Animals | Drug Antagonism | Anti-Arrhythmia Agents - antagonists & inhibitors | Active Transport, Cell Nucleus - drug effects | Decanoic Acids - antagonists & inhibitors | Myocardial Reperfusion Injury - prevention & control | Index Medicus
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2011, Volume 57, Issue 22, pp. 2244 - 2254
Journal Article