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1. Full Text Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
by Taccone, Fabio Silvio and Laterre, Pierre-François and Dugernier, Thierry and Spapen, Herbert and Delattre, Isabelle and Wittebole, Xavier and De Backer, Daniel and Layeux, Brice and Wallemacq, Pierre and Vincent, Jean-Louis and Jacobs, Frédérique
Critical Care, ISSN 1364-8535, 07/2010, Volume 14, Issue 4, pp. R126 - R126
Introduction: Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum beta-lactam concentrations when standard dosages are... 
BREAKPOINT DETERMINATIONS | GRAM-NEGATIVE INFECTIONS | STREPTOCOCCUS-PNEUMONIAE | MEROPENEM PHARMACOKINETICS | PIPERACILLIN-TAZOBACTAM | VENTILATOR-ASSOCIATED PNEUMONIA | INTENSIVE-CARE-UNIT | CONTINUOUS-INFUSION | CRITICALLY-ILL PATIENTS | BLOOD-STREAM INFECTIONS | CRITICAL CARE MEDICINE | beta-Lactams - pharmacokinetics | Anti-Bacterial Agents - blood | Ceftazidime - blood | Piperacillin - blood | Prospective Studies | Humans | Middle Aged | Male | Chromatography, High Pressure Liquid | Shock, Septic - metabolism | Cephalosporins - therapeutic use | Microbial Sensitivity Tests | Piperacillin - administration & dosage | beta-Lactams - blood | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Sepsis - metabolism | Thienamycins - blood | Cephalosporins - blood | Shock, Septic - drug therapy | Penicillanic Acid - therapeutic use | Female | Drug Therapy, Combination | Penicillanic Acid - analogs & derivatives | Penicillanic Acid - administration & dosage | Thienamycins - therapeutic use | Anti-Bacterial Agents - pharmacokinetics | beta-Lactams - therapeutic use | Ceftazidime - therapeutic use | Penicillanic Acid - blood | Piperacillin - therapeutic use | Research
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2. Full Text Subtherapeutic initial β-lactam concentrations in select critically Ill patients: Association between augmented renal clearance and low trough drug concentrations
by Udy, Andrew A and Varghese, Julie M and Altukroni, Mahdi and Briscoe, Scott and McWhinney, Brett C and Ungerer, Jacobus P and Lipman, Jeffrey and Roberts, Jason A
Chest, ISSN 0012-3692, 2012, Volume 142, Issue 1, pp. 30 - 39
Background: beta-Lactams are routinely used as empirical therapy in critical illness, with extended concentrations above the minimum inhibitory concentration... 
CEFTAZIDIME | CEFEPIME | RESPIRATORY SYSTEM | POPULATION PHARMACOKINETICS | PSEUDOMONAS-AERUGINOSA | ORGAN BLOOD-FLOW | PHARMACODYNAMICS | SEPTIC PATIENTS | CREATININE CLEARANCE | SEVERE SEPSIS | CEFPIROME | CRITICAL CARE MEDICINE | Multivariate Analysis | beta-Lactams - pharmacokinetics | Anti-Bacterial Agents - blood | Humans | Middle Aged | Male | Metabolic Clearance Rate | Kidney Function Tests | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | beta-Lactams - blood | Anti-Bacterial Agents - therapeutic use | Kidney - metabolism | Aged, 80 and over | Adult | Female | Retrospective Studies | Staphylococcal Infections - blood | Staphylococcal Infections - drug therapy | Treatment Outcome | Anti-Bacterial Agents - pharmacokinetics | Creatinine - blood | Critical Illness - therapy | ROC Curve | Aged | beta-Lactams - therapeutic use
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3. Full Text Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens
by Ana M. Sandri and Cornelia B. Landersdorfer and Jovan Jacob and Márcio M. Boniatti and Micheline G. Dalarosa and Diego R. Falci and Tainá F. Behle and Rosaura C. Bordinhão and Jiping Wang and Alan Forrest and Roger L. Nation and Jian Li and Alexandre P. Zavascki
Clinical Infectious Diseases, ISSN 1058-4838, 8/2013, Volume 57, Issue 4, pp. 524 - 531
Background. Polymyxin B is a last-line therapy for multidrug-resistant gram-negative bacteria. There is a dearth of pharmacokinetic data to guide dosing in... 
Monte Carlo methods | Renal function | Body weight | Critical care | Population estimates | Drug design | ARTICLES AND COMMENTARIES | Dosage | Pharmacokinetics | Polymyxins | Blood plasma | Plasma protein binding | Urinary recovery | Dose selection | urinary recovery | INFECTIOUS DISEASES | MURINE THIGH | dose selection | MICROBIOLOGY | plasma protein binding | IMMUNOLOGY | NEGATIVE BACTERIAL-INFECTIONS | polymyxins | COLISTIN METHANESULFONATE | MODELS | PSEUDOMONAS-AERUGINOSA | pharmacokinetics | Polymyxin B - administration & dosage | Anti-Bacterial Agents - blood | Body Weight | Blood Chemical Analysis | Polymyxin B - blood | Humans | Middle Aged | Urine - chemistry | Critical Illness | Male | Anti-Bacterial Agents - urine | Polymyxin B - urine | Polymyxin B - pharmacokinetics | Young Adult | Tandem Mass Spectrometry | Administration, Intravenous | Anti-Bacterial Agents - pharmacokinetics | Aged, 80 and over | Chromatography, Liquid | Adult | Female | Aged | Anti-Bacterial Agents - administration & dosage | Care and treatment | Usage | Bacterial infections | Critically ill | Dosage and administration | Drug resistance | Drug therapy | Polymyxin B | Health aspects
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4. Full Text Ion suppression; A critical review on causes, evaluation, prevention and applications
by Furey, Ambrose and Moriarty, Merisa and Bane, Vaishali and Kinsella, Brian and Lehane, Mary
Talanta, ISSN 0039-9140, 10/2013, Volume 115, pp. 104 - 122
The consequences of matrix effects in mass spectrometry analysis are a major issue of concern to analytical chemists. The identification of any ion suppressing... 
Analytical chemistry | Matrix effects | Ion suppression | Clinical, environmental and food applications | Mass spectrometry | LC–MS | LC-MS | CHEMISTRY, ANALYTICAL | LC-ESI-MS | HUMAN PLASMA | SAMPLE PREPARATION | Clinical | environmental and food | TANDEM MASS-SPECTROMETRY | INTERNAL STANDARDS | SIGNAL SUPPRESSION | QUANTITATIVE-DETERMINATION | PERFORMANCE LIQUID-CHROMATOGRAPHY | applications | SOLID-PHASE EXTRACTION | ELECTROSPRAY-IONIZATION | Psychotropic Drugs - blood | Ions - chemistry | Liquid Phase Microextraction | Anti-Bacterial Agents - blood | Psychotropic Drugs - urine | Solid Phase Microextraction | Chromatography, Liquid - standards | United States | Humans | Anti-Bacterial Agents - urine | Calibration | Mollusca - chemistry | Spectrometry, Mass, Electrospray Ionization - standards | Reference Standards | Animals | Validation Studies as Topic | Antineoplastic Agents - urine | Antineoplastic Agents - blood | Plants - chemistry | United States Food and Drug Administration | Retarding | Solvents | Mathematical analysis | Chemists | Instrumentation | Foods | Blood | Optimization
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5. Full Text Simultaneous quantitation of azole antifungals, antibiotics, imatinib, and raltegravir in human plasma by two-dimensional high-performance liquid chromatography–tandem mass spectrometry
by Jourdil, Jean-François and Tonini, Julia and Stanke-Labesque, Françoise
Journal of Chromatography B, ISSN 1570-0232, 03/2013, Volume 919-920, pp. 1 - 9
► Fast and simultaneous quantitation of different classes of drugs in human plasma. ► Simple sample preparation step by protein precipitation. ► LC–MS/MS... 
Antifungals | Imatinib | Antibiotics | LC–MS/MS | Raltegravir | LC-MS/MS | CHEMISTRY, ANALYTICAL | POSACONAZOLE | BIOLOGICAL-FLUIDS | BIOCHEMICAL RESEARCH METHODS | VALIDATION | 9 BASIC PHARMACEUTICALS | HPLC-MS/MS | BLOOD SPOTS | LC-MS/MS METHOD | ION SUPPRESSION | SIMULTANEOUS QUANTIFICATION | SOLID-PHASE EXTRACTION | Azoles - blood | Limit of Detection | Reproducibility of Results | Anti-Bacterial Agents - blood | Chromatography, High Pressure Liquid - methods | Pyrimidines - blood | Benzamides - blood | Drug Stability | Humans | Pyrrolidinones - blood | Imatinib Mesylate | Antineoplastic Agents - blood | Least-Squares Analysis | Piperazines - blood | Raltegravir Potassium | Tandem Mass Spectrometry - methods | Antifungal Agents - blood | Antimitotic agents | Antiviral agents | Analysis | Antifungal agents | Liquid chromatography | Antineoplastic agents | Mass spectrometry | Rain and rainfall | Index Medicus
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6. Full Text Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients
by S. M. Garonzik and J. Li and V. Thamlikitkul and D. L. Paterson and S. Shoham and J. Jacob and F. P. Silveira and A. Forrest and R. L. Nation
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2011, Volume 55, Issue 7, pp. 3284 - 3294
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | MULTIDRUG-RESISTANT | HUMAN PLASMA | MODELS | PSEUDOMONAS-AERUGINOSA | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | BACILLI | NEGATIVE BACTERIAL-INFECTIONS | NEPHROTOXICITY | Colistin - pharmacokinetics | Anti-Bacterial Agents - blood | Colistin - analogs & derivatives | Humans | Middle Aged | Critical Illness | Male | Young Adult | Colistin - blood | Anti-Bacterial Agents - pharmacokinetics | Aged, 80 and over | Adult | Female | Aged | Pharmacology
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7. Full Text Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria
by Gendrin, Mathilde and Rodgers, Faye H and Yerbanga, Rakiswendé S and Ouédraogo, Jean Bosco and Basáñez, María-Gloria and Cohuet, Anna and Christophides, George K
Nature Communications, ISSN 2041-1723, 01/2015, Volume 6, Issue 1, p. 5921
Malaria reduction is most efficiently achieved by vector control whereby human populations at high risk of contracting and transmitting the disease are... 
MULTIDISCIPLINARY SCIENCES | ANTIMICROBIALS | FEBRILE ILLNESS | PLASMODIUM | DOXYCYCLINE | ANOPHELES-GAMBIAE | DIVERSITY | INFECTION | AZITHROMYCIN | POPULATION-DYNAMICS | CHALLENGES | Anti-Bacterial Agents - blood | Anopheles - parasitology | Streptomycin - pharmacology | Anopheles - drug effects | Humans | Plasmodium | Animals | Gastrointestinal Microbiome - drug effects | Analysis of Variance | Polymerase Chain Reaction | Survival Analysis | Fertility - drug effects | Anopheles - microbiology | Anti-Bacterial Agents - pharmacology | Malaria - transmission | Penicillins - pharmacology
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8. Full Text Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to Human Serum Albumin
by Zhang, Shao-Lin and Chang, Juan-Juan and Damu, Guri L.V and Fang, Bo and Zhou, Cheng-He and Zhou, Xiang-Dong and Geng, Rong-Xia
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2013, Volume 23, Issue 4, pp. 1008 - 1012
A series of novel berberine triazoles were synthesized and characterized by IR, NMR, MS and HRMS spectra. All target compounds and their precursors were... 
1,2,4-Triazole | Berberine | Human Serum Albumin | Antifungal | Antibacterial | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IN-VITRO | BIOLOGICAL EVALUATION | AGENTS | INHIBITORS | RESEARCHES | DERIVATIVES | BINDING | Antifungal Agents - pharmacology | Berberine - chemistry | Binding, Competitive | Anti-Bacterial Agents - blood | Cations - chemistry | Triazoles - blood | Gram-Positive Bacteria - drug effects | Triazoles - chemistry | Humans | Berberine - chemical synthesis | Berberine - blood | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | Triazoles - pharmacology | Gram-Negative Bacteria - drug effects | Metals - chemistry | Anti-Bacterial Agents - chemistry | Triazoles - chemical synthesis | Anti-Bacterial Agents - pharmacology | Antifungal Agents - blood | Serum Albumin - metabolism | Albumin | Triazoles
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9. Full Text Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study
by Roberts, Darren M and Roberts, Jason A and Roberts, Michael S and Liu, Xin and Nair, Priya and Cole, Louise and Lipman, Jeffrey and Bellomo, Rinaldo and RENAL Replacement Therapy Study In and RENAL Replacement Therapy Study Investigators
Critical Care Medicine, ISSN 0090-3493, 05/2012, Volume 40, Issue 5, pp. 1523 - 1528
OBJECTIVES:In critically ill patients receiving continuous renal replacement therapy, we aimed to assess the variability of antibiotic trough concentrations,... 
dialysis | pharmacokinetics | critically ill patient | Antibiotic | pharmacodynamics | therapeutic drug monitoring | antibiotic | CLEARANCE | VANCOMYCIN PHARMACOKINETICS | CONTINUOUS VENOVENOUS HEMOFILTRATION | ELIMINATION | PNEUMONIA | FAILURE | MEROPENEM | CIPROFLOXACIN | HEMODIAFILTRATION | CRITICAL CARE MEDICINE | Anti-Bacterial Agents - blood | Piperacillin - blood | Humans | Middle Aged | Thienamycins - pharmacokinetics | Critical Illness | Piperacillin - pharmacokinetics | Male | Piperacillin - administration & dosage | Thienamycins - blood | Female | Penicillanic Acid - analogs & derivatives | Penicillanic Acid - administration & dosage | Vancomycin - administration & dosage | Thienamycins - administration & dosage | Ciprofloxacin - blood | Ciprofloxacin - pharmacokinetics | Vancomycin - blood | Vancomycin - pharmacokinetics | Ciprofloxacin - administration & dosage | Anti-Bacterial Agents - pharmacokinetics | Penicillanic Acid - pharmacokinetics | Acute Kidney Injury - therapy | Aged | Hemofiltration - methods | Anti-Bacterial Agents - administration & dosage | Penicillanic Acid - blood
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10. Full Text Exopolymers from Tolypothrix tenuis and three Anabaena sp. (Cyanobacteriaceae) as novel blood clotting agents for wound management
by Bhatnagar, Monica and Bhatnagar, Ashish and Parwani, Laxmi and Sharma, Vinay and Ganguly, Jhuma
Carbohydrate Polymers, ISSN 0144-8617, 01/2014, Volume 99, pp. 692 - 699
Rapid initiation of clotting is critical to trauma patients. In the present study exopolymers (EPs) from four desert cyanobacteria including and three species... 
Biodegradable | Wound healing | Cyanobacteria | Cytotoxicity | Thrombogenic | Antibacterial | Exopolymers | POLYMER SCIENCE | MOLECULAR-WEIGHT | ACID | CHITOSAN | INJURY | CHEMISTRY, ORGANIC | PLATELET-ADHESION | CHEMISTRY, APPLIED | POLYSACCHARIDE | Biocompatible Materials - isolation & purification | Gas Chromatography-Mass Spectrometry | Biocompatible Materials - chemistry | Cyanobacteria - chemistry | Escherichia coli - drug effects | Humans | Prothrombin Time | Hemostatics - pharmacology | Spectroscopy, Fourier Transform Infrared | Anti-Bacterial Agents - chemistry | Escherichia coli - growth & development | Bacillus - growth & development | Hemostatics - chemistry | Polymers - isolation & purification | Biocompatible Materials - pharmacology | Hemostatics - isolation & purification | Anabaena - chemistry | Anti-Bacterial Agents - isolation & purification | Blood Coagulation - drug effects | Partial Thromboplastin Time | Polymers - pharmacology | Polymers - chemistry | Anti-Bacterial Agents - pharmacology | Bacillus - drug effects | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Biomass energy | Polysaccharides
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11. Full Text Simultaneous quantification of antimicrobial agents for multidrug-resistant bacterial infections in human plasma by ultra-high-pressure liquid chromatography–tandem mass spectrometry
by Tsai, I-Lin and Sun, Hsin-Yun and Chen, Guan-Yuan and Lin, Shu-Wen and Kuo, Ching-Hua
Talanta, ISSN 0039-9140, 11/2013, Volume 116, pp. 593 - 603
Antibiotic-resistant bacterial infection is one of the most serious clinical problems worldwide. Vancomycin, teicoplanin, daptomycin, and colistin are... 
Vancomycin | Colistin | LC–MS/MS | Teicoplanin | Daptomycin | LC-MS/MS | CHEMISTRY, ANALYTICAL | FLUORESCENCE POLARIZATION IMMUNOASSAY | POLYMYXINS | DAPTOMYCIN PHARMACOKINETICS | SERUM | DERIVATIZATION | URINE | HPLC DETERMINATION | Anti-Bacterial Agents - blood | Chromatography, High Pressure Liquid - methods | Formates - chemistry | Humans | Teicoplanin - therapeutic use | Gram-Negative Bacterial Infections - microbiology | Anti-Bacterial Agents - therapeutic use | Colistin - blood | Drug Resistance, Multiple, Bacterial | Gram-Positive Bacterial Infections - microbiology | Protein Denaturation | Acetonitriles - chemistry | Colistin - therapeutic use | Daptomycin - blood | Tandem Mass Spectrometry - methods | Daptomycin - therapeutic use | Limit of Detection | Reproducibility of Results | Gram-Negative Bacterial Infections - drug therapy | Calibration | Gram-Positive Bacterial Infections - blood | Vancomycin - blood | Teicoplanin - blood | Vancomycin - therapeutic use | Gram-Negative Bacterial Infections - blood | Drug Monitoring | Gram-Positive Bacterial Infections - drug therapy | Drug resistance in microorganisms | Bacterial infections | Liquid chromatography | Drug therapy | Mass spectrometry | Health aspects | Antibacterial agents
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12. Full Text Protein Binding of β-Lactam Antibiotics in Critically Ill Patients: Can We Successfully Predict Unbound Concentrations?
by Gloria Wong and Scott Briscoe and Syamhanin Adnan and Brett McWhinney and Jacobus Ungerer and Jeffrey Lipman and Jason A. Roberts
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2013, Volume 57, Issue 12, pp. 6165 - 6170
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CEFTAZIDIME | CLEARANCE | THERAPY | CEFEPIME | PHARMACOKINETICS | INTENSIVE-CARE-UNIT | CEFTRIAXONE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | FLUCLOXACILLIN | HYPOALBUMINEMIA | beta-Lactams - pharmacokinetics | Anti-Bacterial Agents - blood | Humans | Middle Aged | Critical Illness | Male | Metabolic Clearance Rate | Blood Proteins - metabolism | beta-Lactams - blood | Drug Dosage Calculations | Anti-Bacterial Agents - pharmacokinetics | Creatinine - blood | Protein Binding | Adult | Female | Aged | Drug Monitoring | Pharmacology
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13. Full Text Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco)
by Fomani, Marie and Ngeufa Happi, Emmanuel and Nouga Bisoue, Achille and Ndom, Jean Claude and Kamdem Waffo, Alain François and Sewald, Norbert and Wansi, Jean Duplex
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2016, Volume 26, Issue 2, pp. 306 - 309
Two novel acridone–quinoline alkaloids, acriquinoline A ( ) and acriquinoline B ( ), together with twenty-two known compounds were isolated from the methanol... 
Antibacterial activity | Cytotoxicity | Acridone–quinoline alkaloids | Oxidative burst inhibition | Citrus reticulata | Rutaceae | Acridone-quinoline alkaloids | CHEMISTRY, MEDICINAL | FRUIT | CHEMISTRY, ORGANIC | ACRIDONE ALKALOIDS | Oomycetes - drug effects | Anti-Bacterial Agents - blood | Acridones - blood | Escherichia coli - drug effects | Humans | Antifungal Agents - chemistry | Zymosan - pharmacology | Respiratory Burst - drug effects | Acridones - chemistry | Candida albicans - drug effects | Antineoplastic Agents - isolation & purification | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Acridones - isolation & purification | Antifungal Agents - pharmacology | Anti-Bacterial Agents - isolation & purification | Antineoplastic Agents - chemistry | Antifungal Agents - isolation & purification | Citrus | Antineoplastic Agents - blood | Cell Line, Tumor | Acridones - pharmacology | Anti-Bacterial Agents - pharmacology | Staphylococcus aureus - drug effects | Antifungal Agents - blood | Bacillus subtilis - drug effects | Mucor - drug effects | Citrus fruits | Antibacterial agents
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