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Current medicinal chemistry, ISSN 0929-8673, 03/2016, Volume 23, Issue 8, pp. 774 - 791
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of... 
Natural drug | Polyphenol | Morin | Anti-oxidant | Anti-diabetic | Anti-inflammatory | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-oxidant | polyphenol | PSIDIUM-GUAJAVA | ANTIOXIDANT ACTIVITY RELATIONSHIPS | P-GLYCOPROTEIN | IN-VITRO | INDUCED DIABETIC-RATS | anti-inflammatory | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | flavonoid | anti-diabetic | NATURALLY-OCCURRING FLAVONOIDS | HUMAN MAST-CELLS | natural drug | QUANTITATIVE STRUCTURE | Antihypertensive Agents - pharmacology | Antioxidants - chemistry | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Antihypertensive Agents - metabolism | Neuroprotective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antineoplastic Agents - metabolism | Neuroprotective Agents - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neuroprotective Agents - chemistry | Anti-Bacterial Agents - metabolism | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Biological Products - chemistry | Animals | Flavonoids - metabolism | Biological Products - metabolism | Anti-Bacterial Agents - pharmacology | Flavonoids - chemistry
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 466, Issue 7309, pp. 935 - 940
.... Here we report the 2.1 angstrom crystal structure of a potent, new class, broad-spectrum antibacterial agent in complex with Staphylococcus aureus DNA gyrase and DNA, showing a new mode of inhibition that circumvents... 
BREAKAGE-REUNION DOMAIN | BAD BUGS | MECHANISM | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DRUGS | DNA GYRASE | FUSION PROTEIN | INFECTIOUS-DISEASES-SOCIETY | CLEAVAGE | Staphylococcus aureus - enzymology | Crystallography, X-Ray | Structure-Activity Relationship | Quinolines - pharmacology | Quinolones - chemistry | Anti-Bacterial Agents - chemistry | Topoisomerase II Inhibitors | Apoenzymes - metabolism | DNA, Superhelical - chemistry | Drug Design | Binding Sites | Ciprofloxacin - metabolism | Drug Resistance | Catalytic Domain | Escherichia coli - enzymology | DNA Gyrase - chemistry | Quinolines - chemistry | Quinolones - metabolism | Models, Molecular | Anti-Bacterial Agents - metabolism | DNA - metabolism | Quinolines - metabolism | DNA Gyrase - metabolism | DNA - chemistry | Manganese - metabolism | Apoenzymes - chemistry | Ciprofloxacin - chemistry | Aspartic Acid - metabolism | Protein Conformation | Anti-Bacterial Agents - pharmacology | DNA, Superhelical - metabolism | Arginine - metabolism | DNA Cleavage | Antimitotic agents | Enzymes | Drug resistance in microorganisms | Topoisomerases | DNA | Genes | Research | Properties | Antineoplastic agents | Antibacterial agents | Staphylococcus aureus | Bacteria | Mutation | E coli | Deoxyribonucleic acid--DNA | Streptococcus infections
Journal Article
Marine drugs, ISSN 1660-3397, 09/2018, Volume 16, Issue 9, p. 319
The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical... 
Endophytes | Mangrove microorganisms | Bioactive natural products | Drug leads | CHEMISTRY, MEDICINAL | NATURAL-PRODUCT DISCOVERY | drug leads | CELL-CYCLE ARREST | endophytes | INDOLE-DITERPENES | ENDOPHYTIC FUNGUS | IN-VITRO | bioactive natural products | mangrove microorganisms | BACTERIAL DIVERSITY | A-C | MCF-7 CELLS | HETEROLOGOUS EXPRESSION | PENICILLIUM-BROCAE MA-231 | Glycoside Hydrolase Inhibitors - metabolism | Glycoside Hydrolase Inhibitors - isolation & purification | Plants - microbiology | Antiviral Agents - metabolism | Biodiversity | Fungi - metabolism | Endophytes - metabolism | Wetlands | Antineoplastic Agents - metabolism | Antineoplastic Agents - isolation & purification | Antifungal Agents - metabolism | Antineoplastic Agents - pharmacology | Biological Factors - metabolism | Biological Factors - isolation & purification | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - antagonists & inhibitors | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Bacteria - metabolism | Soil Microbiology | Anti-Bacterial Agents - metabolism | Anti-Bacterial Agents - isolation & purification | Glycoside Hydrolase Inhibitors - pharmacology | Drug Discovery | Antifungal Agents - isolation & purification | Anti-Bacterial Agents - pharmacology | Antiviral Agents - isolation & purification | Biological Factors - pharmacology | Fungicides | Ecosystems | Cytotoxicity | Genomes | Biology | Phosphatase | Ecosystem biology | Fungi | Proteins | Microorganisms | Secondary metabolites | Metabolites | Bioactive compounds | Bacteria | Physiology | Ecological distribution | Tyrosine | Antiviral agents | Plants (botany) | Mangrove swamps | Mangroves | Glucosidase | Lead compounds | Biological activity | Salinity | Studies | Organic chemistry | Soils | Chemistry | Soil microorganisms | Ecological niches | Natural products | Morphology | Niches | Protein-tyrosine-phosphatase | Cancer
Journal Article