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Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 9, pp. 1685 - 1693
Fc gamma receptor (Fc gamma R) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | MELANOMA | ANTI-GITR MAB | REGULATORY T-CELLS | COSTIMULATION | IGG1 | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | BLOCKADE | BINDING | TUMOR-IMMUNITY | Brief Definitive Report
Journal Article
Journal Article
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 08/2014, Volume 2, Issue 1
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 10957 - 10975
The modulation of immune checkpoint receptors has been one of the most successful, exciting, and explored approaches for cancer immunotherapy. Currently,... 
CHEMISTRY, MEDICINAL | ANTI-GITR MAB | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | CO-STIMULATION | COMBINED NIVOLUMAB | HUMAN CTLA-4 | B7 FAMILY | CANCER-IMMUNOTHERAPY | MONOCLONAL-ANTIBODIES | T-CELLS
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 9/2010, Volume 59, Issue 9, pp. 1367 - 1377
In vitro, engagement of GITR on Treg cells by the agonistic anti-GITR mAb, DTA-1, appears to abrogate their suppressive function. The consequence of in vivo... 
Therapy | Immunology | Depletion | Medicine & Public Health | Anti-GITR | Oncology | Cancer Research | Tumour | Regulatory T cells | HY | ACTIVATION | DENDRITIC CELLS | INDUCED TNF RECEPTOR | IMMUNOLOGY | SUPPRESSION | IDENTIFICATION | TUMOR-IMMUNITY | CUTTING EDGE | FAMILY | MEMBER | ONCOLOGY | LIGAND | Forkhead Transcription Factors - immunology | Neoplasm Transplantation | T-Lymphocytes, Regulatory - metabolism | Receptors, Nerve Growth Factor - immunology | Antibodies, Monoclonal - therapeutic use | Male | Receptors, Nerve Growth Factor - metabolism | Adoptive Transfer | Lymphocyte Depletion | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Forkhead Transcription Factors - metabolism | Immunotherapy | Urinary Bladder Neoplasms - pathology | Mice, Inbred CBA | Antibodies, Monoclonal - immunology | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | Antigens, Neoplasm - immunology | Mice, Inbred C57BL | Glucocorticoid-Induced TNFR-Related Protein | Rats | Mice, Transgenic | Forkhead Transcription Factors - genetics | Receptors, Nerve Growth Factor - genetics | Gene Knock-In Techniques | Animals | Urinary Bladder Neoplasms - therapy | Urinary Bladder Neoplasms - immunology | Cell Line, Tumor | Mice | Receptors, Tumor Necrosis Factor - immunology | Cell research | Care and treatment | Analysis | Oncology, Experimental | Research | Drug therapy | T cells | Cancer
Journal Article
Oncology Letters, ISSN 1792-1074, 02/2019, Volume 17, Issue 2, pp. 2425 - 2430
Since the publication of a novel protocol in 1991, cytokine-induced killer (CIK) cells have shown promising results in the treatment against neoplastic... 
Anti-CD40 | Monoclonal antibody | Cytokine-induced killer cells | Immunotherapy | Anti-GITR | anti-CD40 | anti-GITR | STIMULATION | RECOGNITION | PROTEIN LIGAND | RECEPTOR | CANCER-IMMUNOTHERAPY | cytokine-induced killer cells | ONCOLOGY | immunotherapy | UPDATE | LEUKEMIA | monoclonal antibody | EXPRESSION | ANTIGEN
Journal Article
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 09/2018, Volume 22, Issue 9, pp. 783 - 797
Journal Article
Urologic Oncology: Seminars and Original Investigations, ISSN 1078-1439, 2016, Volume 34, Issue 12, pp. 566 - 576
Abstract Tremendous advances in our understanding of the tumor immunology and molecular biology of urothelial carcinoma (UC) have led to the recent approval of... 
Urology | Combination immune therapy | Immune biomarker | Urothelial carcinoma | Immunotherapy | Novel clinical trial design | BLADDER-CANCER | NATURAL-KILLER-CELLS | LONG-TERM SURVIVAL | INDOLEAMINE 2,3-DIOXYGENASE | CHRONIC VIRAL-INFECTION | IMMUNE-SYSTEM | ANTI-GITR MAB | ONCOLOGY | REGULATORY T-CELLS | UROLOGY & NEPHROLOGY | TUMOR-ASSOCIATED MACROPHAGES | INDEPENDENT PROGNOSTIC-FACTOR | Tumor Escape - drug effects | Humans | Antibodies, Monoclonal - adverse effects | Neoplasm Proteins - immunology | Antibodies, Monoclonal - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Carcinoma, Transitional Cell - therapy | Molecular Targeted Therapy | Biomarkers, Tumor | Costimulatory and Inhibitory T-Cell Receptors - antagonists & inhibitors | Costimulatory and Inhibitory T-Cell Receptors - immunology | Tumor Escape - immunology | Immunotherapy, Adoptive | Therapies, Investigational | Clinical Trials as Topic | Urinary Bladder Neoplasms - drug therapy | Immunity, Innate | B7-H1 Antigen - immunology | Forecasting | Tumor Microenvironment - immunology | Antineoplastic Agents, Immunological - adverse effects | B7-H1 Antigen - antagonists & inhibitors | Antineoplastic Agents, Immunological - therapeutic use | Carcinoma, Transitional Cell - immunology | Urinary Bladder Neoplasms - therapy | Carcinoma, Transitional Cell - drug therapy | Urinary Bladder Neoplasms - immunology | Programmed Cell Death 1 Receptor - immunology | Research Design | Care and treatment | Carcinoma | Drug therapy | Molecular biology | Cancer
Journal Article