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Mini reviews in medicinal chemistry, ISSN 1389-5575, 2016, Volume 16, Issue 2, pp. 113 - 141
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted... 
Antimicrobial | Pharmacological properties | Anticonvulsant | Anticancer | Antioxidant | Anti-inflammatory | Coumarin | MAO inhibitory | ANTIOXIDANT ACTIVITY | antimicrobial | antioxidant | 3-ARYLCOUMARINS SYNTHESIS | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | anticonvulsant | coumarin | INHIBITORY-ACTIVITY | pharmacological properties | ANTICONVULSANT AGENTS | IN-VITRO | anti-inflammatory | BIOLOGICAL EVALUATION | DERIVATIVES | HYBRIDS | Anti-HIV Agents - pharmacology | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Anti-Infective Agents - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Monoamine Oxidase Inhibitors - chemical synthesis | Anti-HIV Agents - chemical synthesis | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Anti-Infective Agents - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Monoamine Oxidase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Anticonvulsants - chemical synthesis | Antitubercular Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Anti-Infective Agents - chemical synthesis | Coumarins - pharmacology | Anti-HIV Agents - chemistry | Animals | Anticonvulsants - chemistry | Coumarins - chemical synthesis | Monoamine Oxidase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - pharmacology
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 08/2015, Volume 22, Issue 24, pp. 2819 - 2857
Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory,... 
Antichagasic agents | Heterocyclic N-oxides | Bioisosteres | Factor xa inhibitors | Antimalarials | Hypoxia | Nitric oxide mimics | Coagulation cascade direct thrombin inhibitors | hypoxia | TRANSITION-METAL CATALYSIS | BETA-AMINOESTER CLASS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | antichagasic agents | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | antimalarials | HUMAN-LEUKOCYTE ELASTASE | coagulation cascade direct thrombin inhibitors | CARBON BOND FORMATION | 1,3-DIOXIDE CORE SCAFFOLDS | HIV-1 ENTRY INHIBITORS | PHARMACOLOGY & PHARMACY | bioisosteres | factor Xa inhibitors | LONG-TERM POTENTIATION | FACTOR XA INHIBITOR | nitric oxide mimics | Anti-HIV Agents - pharmacology | Neuroprotective Agents - therapeutic use | Antihypertensive Agents - pharmacology | Humans | Antineoplastic Agents - therapeutic use | Herbicides - pharmacology | Antihypertensive Agents - therapeutic use | Anti-Bacterial Agents - therapeutic use | Fibrinolytic Agents - pharmacology | Cyclic N-Oxides - therapeutic use | Animals | Neuroprotective Agents - pharmacology | Cyclic N-Oxides - pharmacology | Protein Kinase Inhibitors - therapeutic use | Fibrinolytic Agents - therapeutic use | Anti-HIV Agents - therapeutic use | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2005, Volume 12, Issue 6, pp. 657 - 666
Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human... 
Antimalarial | Anticancer mechanism | Anti-HIV derivatives | Biotransformation | Anti-HIV mechanism | Anticancer derivates | Antiinflammatory | Betulinic acid | ANTI-AIDS AGENTS | anti-HIV mechanism | ACTIVATION | CHEMISTRY, MEDICINAL | HIV ACTIVITY | TRITERPENOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEM BARK | ENVELOPE GLYCOPROTEIN | anti-HIV derivatives | betulinic acid | antimalarial | HUMAN-IMMUNODEFICIENCY-VIRUS | anticancer mechanism | biotransformation | TYPE-1 ENVELOPE | anticancer derivatives | PHARMACOLOGY & PHARMACY | antiinflammatory | INHIBITORS | CONSTITUENTS | Anti-HIV Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Triterpenes - pharmacology | Anti-Inflammatory Agents - pharmacology | Humans | Molecular Conformation | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Anti-HIV Agents - chemistry | Triterpenes - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Triterpenes - chemical synthesis | Anti-Bacterial Agents - chemistry | Antimalarials - chemistry | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Antineoplastic Agents, Phytogenic - pharmacology | Antimalarials - chemical synthesis
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 09/2011, Volume 18, Issue 25, pp. 3825 - 3852
The chemistry of chromones is very well known. This system is widely used in organic chemistry as an intermediate compound for the synthesis of numerous... 
Mast cell stabilizers | Benzopyran-4-ones | Occurrence | Biological activity | Chromones | STELLERA-CHAMAEJASME L | CHEMISTRY, MEDICINAL | biological activity | mast cell stabilizers | BIOCHEMISTRY & MOLECULAR BIOLOGY | benzopyran-4-ones | DNA-BINDING PROPERTIES | occurrence | CONCENTRATING HORMONE-RECEPTOR-1 ANTAGONISTS | ANTI-HIV AGENTS | BENZOYL HYDRAZONE | ALDOSE REDUCTASE INHIBITORS | CHEMICAL-CONSTITUENTS | ANTIBACTERIAL ACTIVITY | LN(III) COMPLEXES | PHARMACOLOGY & PHARMACY | POTENTIAL ANTIINFLAMMATORY AGENTS | Plant Extracts - chemistry | Anti-Infective Agents - isolation & purification | Antioxidants - chemistry | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - isolation & purification | Plants - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Chromones - pharmacology | Chromones - therapeutic use | Anti-Inflammatory Agents - pharmacology | Enzyme Inhibitors - pharmacology | Anti-Infective Agents - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Enzyme Inhibitors - therapeutic use | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Chromones - chemistry | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Chromones - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Plant Extracts - therapeutic use | Antineoplastic Agents, Phytogenic - isolation & purification
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2012, Volume 20, Issue 11, pp. 3378 - 3395
.... Successful introduction of ralitoline as a potent anti-convulsant, etozoline as a antihypertensive, pioglitazone as a hypoglycemic agent and thiazolidomycin activity against streptomyces species... 
4-Thiazolidinone | Antitubercular | Antibacterial | DESIGN | 4-THIAZOLIDINONES | CHEMISTRY, MEDICINAL | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTI-HIV | ANTITUMOR-ACTIVITY | MOLECULAR DOCKING | ANTICANCER ACTIVITY | ANTICONVULSANT ACTIVITY | INHIBITORS | ANTIMICROBIAL ACTIVITY | Analgesics - pharmacology | Antihypertensive Agents - pharmacology | Antitubercular Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Thiazolidinediones - chemistry | Anticonvulsants - pharmacology | Receptor, Muscarinic M1 - agonists | Anti-Bacterial Agents - chemistry | Antidepressive Agents - chemistry | Antidepressive Agents - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Thiazolidinediones - pharmacology | Antifungal Agents - pharmacology | Antitubercular Agents - pharmacology | Hypoglycemic Agents - chemistry | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Thiazolidinediones - chemical synthesis | Analgesics - chemistry | Anticonvulsants - chemistry | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Streptomyces - drug effects | Data processing | pioglitazone | Hypoglycemic agents | Reviews | scaffolds | Antihypertensives
Journal Article
Nature medicine, ISSN 1546-170X, 2014, Volume 20, Issue 4, pp. 425 - 429
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 08/2016, Volume 22, Issue 28, pp. 4443 - 4450
Background: Ciclopirox (CPX) has been used as an antifungal agent in various formulations to treat superficial fungal infection for decades... 
Diabetes | HIV | Fungicide | Iron chelator | Ciclopirox | Cancer | ANTIFUNGAL AGENT | NAIL LACQUER | DEOXYHYPUSINE HYDROXYLASE | HYPUSINE MODIFICATION | SACCHAROMYCES-CEREVISIAE | iron chelator | DRUG-RESISTANCE MECHANISMS | CANDIDA-ALBICANS | PHARMACOLOGY & PHARMACY | cancer | CELL-CYCLE | fungicide | diabetes | WNT/BETA-CATENIN PATHWAY | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2009, Volume 4, Issue 6, pp. e6093 - e6093
The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected... 
TRANSCRIPTIONAL ACTIVATION | LONG TERMINAL REPEAT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | VALPROIC ACID | HUMAN-IMMUNODEFICIENCY-VIRUS | NF-KAPPA-B | BROMODOMAIN PROTEIN BRD4 | HISTONE DEACETYLASE | T-CELLS | P-TEFB | Anti-HIV Agents - pharmacology | HIV-1 - metabolism | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Humans | Middle Aged | Enzyme Inhibitors - pharmacology | Nucleosomes - metabolism | Cytoplasm - metabolism | I-kappa B Proteins - metabolism | Virus Latency - drug effects | Drug Synergism | Monocytes - virology | Cell Nucleus - metabolism | CD8-Positive T-Lymphocytes - metabolism | Phorbol Esters - pharmacology | Adult | HIV Infections - drug therapy | HIV-1 - enzymology | Aged | Highly active antiretroviral therapy | Antiviral agents | Control | Physiological aspects | Genetic research | Genetic transcription | T cells | HIV (Viruses) | Health aspects | Therapy | Oxidative stress | Histone deacetylase | Transcription | Laboratories | CD8 antigen | Leukocytes (mononuclear) | Viruses | Lymphocytes T | Infections | Activation | Remodeling | DNA-directed RNA polymerase | Synergism | Recruitment | Long terminal repeat | Cell growth | Transfection | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Elongation | Deoxyribonucleic acid--DNA | NF-κB protein | Latent infection | Gene expression | Ribonucleic acid--RNA | Patients | Virology | CD4 antigen | Monocytes | Inhibitors | Replication | Reservoirs | Combined treatment | RNA polymerase II | Index Medicus | HIV Infections | HIV-1 | Enzyme Inhibitors | Virus Latency | I-kappa B Proteins | Anti-HIV Agents | CD8-Positive T-Lymphocytes | Life Sciences | Microbiology and Parasitology | NF-kappa B | Nucleosomes | Phorbol Esters | Cell Nucleus | Cytoplasm | RNA | Acquired immune deficiency syndrome | Deoxyribonucleic acid | Ribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 1, p. 134
Journal Article