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Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5996, pp. 1168 - 1174
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of... 
Human sexual behavior | HIV infections | Antiinfectives | Gels | HIV | RESEARCH ARTICLES | Placebos | Experimentation | AIDS | Infections | Condoms | VAGINAL GEL | INDIVIDUALS | SOUTH-AFRICA | PROPHYLAXIS | IN-VITRO | TRANSMISSION | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | MALE CIRCUMCISION | RANDOMIZED CONTROLLED-TRIAL | CHALLENGES | HIV Infections - prevention & control | Anti-Infective Agents, Local - therapeutic use | Urban Population - statistics & numerical data | HIV Infections - epidemiology | Humans | Anti-Infective Agents, Local - adverse effects | Drug Resistance, Viral | Administration, Intravaginal | Viral Load | Incidence | Anti-HIV Agents - administration & dosage | Tenofovir | Young Adult | Adenine - adverse effects | HIV-1 - physiology | Adenine - therapeutic use | Adult | Anti-HIV Agents - therapeutic use | Female | Vaginal Creams, Foams, and Jellies | Rural Population - statistics & numerical data | Sexual Behavior | Adenine - analogs & derivatives | Double-Blind Method | Organophosphonates - therapeutic use | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | South Africa - epidemiology | Organophosphonates - adverse effects | Adenine - administration & dosage | Pregnancy | Organophosphonates - administration & dosage | Anti-Infective Agents, Local - administration & dosage | Adolescent | Patient Compliance | Pregnancy Outcome | Prevention | Anti-infective agents | Research | HIV infection | Index Medicus
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 08/2014, Volume 471, Issue 1-2, pp. 45 - 55
Journal Article
Journal of Dental Research, ISSN 0022-0345, 1/2016, Volume 95, Issue 1, pp. 50 - 57
Journal Article
Science, ISSN 0036-8075, 7/2008, Volume 321, Issue 5888, pp. 532 - 534
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2010, Volume 36, Issue 2, pp. 322 - 328
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2006, Volume 173, Issue 12, pp. 1348 - 1355
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 12/2012, Volume 186, Issue 12, pp. 1272 - 1278
Journal Article
Clinical Orthopaedics and Related Research, ISSN 0009-921X, 1/2015, Volume 473, Issue 1, pp. 337 - 347
Local delivery can achieve the high antimicrobial concentrations necessary to kill biofilm-related microbes. Degradation times for resorbable carriers are too... 
Surgical Orthopedics | Medicine & Public Health | Sports Medicine | Orthopedics | Surgery | Conservative Orthopedics | Medicine/Public Health, general | SURGERY | BONE CEMENTS | IN-VITRO | GRAFT COPOLYMER HYDROGELS | DRUG-DELIVERY | PSEUDOMONAS-AERUGINOSA | EXPERIMENTAL OSTEOMYELITIS | ANTIBIOTIC-RESISTANCE | STAPHYLOCOCCUS-AUREUS | COLLAGEN SPONGE | ORTHOPEDICS | BACTERIAL BIOFILMS | Radius - microbiology | Viscosity | Hydrogels | Blood Urea Nitrogen | Drug Implants | Gentamicins - administration & dosage | Gentamicins - toxicity | Prosthesis-Related Infections - drug therapy | Drug Carriers | Bone Wires - adverse effects | Kidney - metabolism | Prosthesis-Related Infections - microbiology | Time Factors | Anti-Bacterial Agents - chemistry | Anti-Infective Agents, Local - chemistry | Kidney Diseases - chemically induced | Radius - drug effects | Female | Kidney Diseases - blood | Prosthesis-Related Infections - diagnosis | Staphylococcal Infections - microbiology | Anti-Bacterial Agents - toxicity | Radius - surgery | Anti-Infective Agents, Local - toxicity | Disease Models, Animal | Gentamicins - chemistry | Rabbits | Staphylococcal Infections - drug therapy | Kidney - drug effects | Solubility | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Absorbable Implants | Debridement | Maximum Tolerated Dose | Staphylococcal Infections - diagnosis | Animals | Anti-Infective Agents, Local - administration & dosage | Creatinine - blood | Polymers - chemistry | Anti-Bacterial Agents - administration & dosage | Urea | Anti-infective agents | Index Medicus | Abridged Index Medicus | Basic Research
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0125363 - e0125363
Objectives The CHARM-01 study characterized the safety, acceptability, pharmacokinetics (PK), and pharmacodynamics (PD) of three tenofovir (TFV) gels for... 
TRIALS | AFRICAN WOMEN | ORAL TENOFOVIR | HIV-INFECTION | MICROBICIDE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | TISSUE | PREEXPOSURE PROPHYLAXIS | Anti-HIV Agents - pharmacology | T-Lymphocyte Subsets - immunology | Rectum - pathology | Humans | Middle Aged | Tenofovir - pharmacology | Anti-Infective Agents, Local - adverse effects | Male | Tenofovir - administration & dosage | Intestinal Mucosa - drug effects | Anti-HIV Agents - administration & dosage | Young Adult | HIV Infections - immunology | Microbiota | Intestinal Mucosa - immunology | T-Lymphocyte Subsets - drug effects | Adult | Female | Tenofovir - adverse effects | Gels | Anti-Infective Agents, Local - pharmacology | Anti-HIV Agents - adverse effects | HIV Infections - virology | Immunophenotyping | Treatment Outcome | Intestinal Mucosa - microbiology | Chemistry, Pharmaceutical | Medication Adherence | Phenotype | Anti-Infective Agents, Local - administration & dosage | T-Lymphocyte Subsets - metabolism | HIV Infections - drug therapy | Intestinal Mucosa - pathology | Tenofovir | Patient outcomes | Economic aspects | Dosage and administration | Research | Drug therapy | HIV infection | Formulations | Pharmacodynamics | Mucosa | Vagina | Infections | Pharmacology | Acceptability | Disease prevention | Medicine | Mens health | Randomization | Acquired immune deficiency syndrome--AIDS | Safety engineering | Human immunodeficiency virus--HIV | Rectum | Safety | Inhibition | Transgender persons | Pharmacokinetics | Drug dosages | Index Medicus | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
Journal Article