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Food and Chemical Toxicology, ISSN 0278-6915, 09/2015, Volume 83, pp. 111 - 124
The concept of using phytochemicals has ushered in a new revolution in pharmaceuticals. Naturally occurring polyphenols (like curcumin, morin, resveratrol,... 
Neurodegenerative disease | Curcumin | Inflammation | Diabetes | Antioxidant | Cancer | OXIDATIVE STRESS | WINGLESS SIGNALING PATHWAY | FOOD SCIENCE & TECHNOLOGY | DOWN-REGULATION | CELL-CYCLE ARREST | ENDOPLASMIC-RETICULUM STRESS | FORKHEAD TRANSCRIPTION FACTORS | ARJUNOLIC ACID | IN-VITRO | RETRACTED ARTICLE. SEE | TOXICOLOGY | NF-KAPPA-B | Neoplasms - metabolism | Neuroprotective Agents - therapeutic use | Arthritis - metabolism | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Cardiovascular Diseases - prevention & control | Humans | Neurodegenerative Diseases - prevention & control | Neoplasms - prevention & control | Curcumin - metabolism | Neuroprotective Agents - metabolism | Antineoplastic Agents, Phytogenic - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Dietary Supplements - adverse effects | Neuroprotective Agents - adverse effects | Antineoplastic Agents, Phytogenic - therapeutic use | Arthritis - prevention & control | Antineoplastic Agents, Phytogenic - adverse effects | Diabetes Complications - prevention & control | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - metabolism | Curcumin - therapeutic use | Diabetes Complications - metabolism | Curcumin - adverse effects | Neurodegenerative Diseases - metabolism | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antioxidants - adverse effects | Hypoglycemic Agents - adverse effects | Antioxidants | Polyphenols | Nervous system diseases | Arthritis | Resveratrol | Index Medicus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 06/2015, Volume 207, pp. 18 - 30
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 03/2016, Volume 23, Issue 8, pp. 774 - 791
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of... 
Natural drug | Polyphenol | Morin | Anti-oxidant | Anti-diabetic | Anti-inflammatory | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-oxidant | polyphenol | PSIDIUM-GUAJAVA | ANTIOXIDANT ACTIVITY RELATIONSHIPS | P-GLYCOPROTEIN | IN-VITRO | INDUCED DIABETIC-RATS | anti-inflammatory | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | flavonoid | anti-diabetic | NATURALLY-OCCURRING FLAVONOIDS | HUMAN MAST-CELLS | natural drug | QUANTITATIVE STRUCTURE | Antihypertensive Agents - pharmacology | Antioxidants - chemistry | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Antihypertensive Agents - metabolism | Neuroprotective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antineoplastic Agents - metabolism | Neuroprotective Agents - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neuroprotective Agents - chemistry | Anti-Bacterial Agents - metabolism | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Biological Products - chemistry | Animals | Flavonoids - metabolism | Biological Products - metabolism | Anti-Bacterial Agents - pharmacology | Flavonoids - chemistry
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2018, Volume 104, Issue 1, pp. 188 - 200
The accuracy of physiologically based pharmacokinetic (PBPK) model prediction in children, especially those younger than 2 years old, has not been... 
CLEARANCE | TISSUE DISTRIBUTION | IN-VIVO | VOLUME | ONTOGENY | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | SIMULATION | DESLORATADINE | EXPOSURE | Humans | Anti-Asthmatic Agents - metabolism | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Sufentanil - metabolism | Bronchodilator Agents - metabolism | Quinolines - pharmacokinetics | Theophylline - pharmacokinetics | Esomeprazole - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Ondansetron - metabolism | Child | Cytochrome P-450 CYP2C9 - metabolism | Histamine H1 Antagonists, Non-Sedating - pharmacokinetics | Infant, Newborn | Itraconazole - metabolism | Serotonin Antagonists - pharmacokinetics | Tramadol - pharmacokinetics | Theophylline - metabolism | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Proton Pump Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Serotonin Antagonists - metabolism | Analgesics, Opioid - metabolism | Diclofenac - metabolism | Lansoprazole - pharmacokinetics | Loratadine - pharmacokinetics | Sufentanil - pharmacokinetics | Infant | Anti-Asthmatic Agents - pharmacokinetics | Itraconazole - pharmacokinetics | Antifungal Agents - pharmacokinetics | Antifungal Agents - metabolism | Loratadine - metabolism | Cytochrome P-450 CYP2C8 - metabolism | Lansoprazole - metabolism | Acetates - metabolism | Esomeprazole - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Ondansetron - pharmacokinetics | Tramadol - metabolism | Diclofenac - pharmacokinetics | Quinolines - metabolism | Pharmaceutical Preparations - metabolism | Proton Pump Inhibitors - pharmacokinetics | Bronchodilator Agents - pharmacokinetics | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2C19 - metabolism | Loratadine - analogs & derivatives | Histamine H1 Antagonists, Non-Sedating - metabolism | Pharmacokinetics | Acetates - pharmacokinetics
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 6/2008, Volume 65, Issue 11, pp. 1631 - 1652
Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of... 
Life Sciences | Biochemistry, general | anti-tumor | antioxidant | Life Sciences, general | inflammation | angiogenesis | Curcumin | Biomedicine general | anticancer | Cell Biology | Angiogenesis | Inflammation | Anti-tumor | Anticancer | Antioxidant | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMOPREVENTIVE AGENT CURCUMIN | BREAST-CARCINOMA CELLS | SMOOTH-MUSCLE-CELL | CELL-CYCLE PROGRESSION | MULTIPLE-MYELOMA CELLS | CELL BIOLOGY | ARYL-HYDROCARBON RECEPTOR | EPIDERMAL-GROWTH-FACTOR | PROSTATE CANCER AGENTS | RAT PERITONEAL-MACROPHAGES | NF-KAPPA-B | curcumin | NF-kappa B - antagonists & inhibitors | Antioxidants - chemistry | Curcumin - therapeutic use | Free Radical Scavengers - metabolism | Oxidation-Reduction | Free Radical Scavengers - chemistry | Antioxidants - metabolism | Curcumin - chemistry | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Curcumin - metabolism | Antineoplastic Agents - chemistry | Iron - metabolism | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Antioxidants - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Signal Transduction - physiology | Free Radical Scavengers - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neoplasms - pathology | Curcuma - chemistry | Clinical trials | Herbal medicine | Antioxidants | Oncology | Free radicals | Bioavailability | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2014, Volume 84, pp. 206 - 239
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 40 - 55
Many chronic human diseases, including multiple neurodegenerative diseases, are associated with deleterious protein aggregates, also called protein amyloids.... 
Covalent mechanisms | Non-covalent mechanisms | Amyloid inhibitor | Natural products | Inhibition mechanisms | CLINICAL-TRIAL | PROTEIN AGGREGATION | ALZHEIMERS-DISEASE | SOLID DISPERSION | TEA POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE | ALPHA-SYNUCLEIN AGGREGATION | BETA-PEPTIDE AGGREGATION | A-BETA | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | AROMATIC-INHIBITOR | Amyloidosis - prevention & control | Drugs, Investigational - pharmacology | Antioxidants - chemistry | Nootropic Agents - metabolism | Antioxidants - metabolism | Healthy Diet | Humans | Polyphenols - pharmacology | Drugs, Investigational - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Flavonoids - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Polyphenols - metabolism | Amyloidogenic Proteins - antagonists & inhibitors | Drugs, Investigational - chemistry | Protein Aggregation, Pathological - prevention & control | Amyloidosis - diet therapy | Drug Design | Flavonoids - pharmacology | Protein Aggregation, Pathological - diet therapy | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Chelating Agents - therapeutic use | Biological Products - therapeutic use | Chelating Agents - chemistry | Nootropic Agents - therapeutic use | Amyloidosis - drug therapy | Antioxidants - pharmacology | Chelating Agents - pharmacology | Nootropic Agents - chemistry | Drug Discovery | Protein Aggregation, Pathological - drug therapy | Amyloidogenic Proteins - metabolism | Antioxidants - therapeutic use | Biological Products - chemistry | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Flavonoids - metabolism | Polyphenols - chemistry | Biological Products - metabolism | Polyphenols - therapeutic use | Chelating Agents - metabolism | Dietary Supplements | Flavonoids - chemistry | Amyloidosis - metabolism | Nootropic Agents - pharmacology | Medicine, Experimental | Medical research | Nervous system diseases | Glycoproteins | Drug discovery | Index Medicus
Journal Article