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Journal of inorganic biochemistry, ISSN 0162-0134, 2016, Volume 160, pp. 125 - 139
Cobalt(II) complexes with a series of non-steroidal anti-inflammatory drugs (diflunisal, flufenamic acid, mefenamic acid and niflumic acid... 
Cobalt(II) complexes | Interaction with calf-thymus DNA | Interaction with albumins | Antioxidant activity | Non-steroidal anti-inflammatory drugs | MEFENAMIC-ACID | TRANSITION-METAL-COMPLEXES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINUCLEAR COPPER(II) COMPLEX | DNA-BINDING PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | TOLFENAMIC ACID STRUCTURE | FLUFENAMIC ACID | BIOLOGICAL EVALUATION | SCHIFF-BASE COMPLEXES | Free Radical Scavengers - chemistry | 2,2'-Dipyridyl - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Mefenamic Acid - chemistry | Aminopyridines - chemistry | Biphenyl Compounds - antagonists & inhibitors | Phenanthrolines - chemistry | Picrates - chemistry | Free Radical Scavengers - chemical synthesis | Biphenyl Compounds - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Intercalating Agents - chemical synthesis | Methanol - chemistry | Serum Albumin - chemistry | Binding Sites | Niflumic Acid - chemistry | 2,2'-Dipyridyl - chemistry | Models, Molecular | Coordination Complexes - chemistry | Intercalating Agents - chemistry | DNA - chemistry | Diflunisal - chemistry | Picrates - antagonists & inhibitors | Cations, Divalent | Flufenamic Acid - chemistry | Coordination Complexes - chemical synthesis | Kinetics | Cobalt - chemistry
Journal Article
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2016, Volume 16, Issue 2, pp. 113 - 141
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted... 
Antimicrobial | Pharmacological properties | Anticonvulsant | Anticancer | Antioxidant | Anti-inflammatory | Coumarin | MAO inhibitory | ANTIOXIDANT ACTIVITY | antimicrobial | antioxidant | 3-ARYLCOUMARINS SYNTHESIS | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | anticonvulsant | coumarin | INHIBITORY-ACTIVITY | pharmacological properties | ANTICONVULSANT AGENTS | IN-VITRO | anti-inflammatory | BIOLOGICAL EVALUATION | DERIVATIVES | HYBRIDS | Anti-HIV Agents - pharmacology | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Anti-Infective Agents - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Monoamine Oxidase Inhibitors - chemical synthesis | Anti-HIV Agents - chemical synthesis | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Anti-Infective Agents - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Monoamine Oxidase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Anticonvulsants - chemical synthesis | Antitubercular Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Anti-Infective Agents - chemical synthesis | Coumarins - pharmacology | Anti-HIV Agents - chemistry | Animals | Anticonvulsants - chemistry | Coumarins - chemical synthesis | Monoamine Oxidase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - pharmacology
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 02/2012, Volume 19, Issue 4, pp. 569 - 612
There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory,... 
Antimicrobial | Antimalarial | Anti-trypnosomal | Hydrazide | Antioxidant | Antiarthritis | Diuretic | Analgesic | Biological activities | Synthesis | Antiviral | Hydrazone | Anticancer | Anti-inflammatory | Antimycobacterial | ANTIOXIDANT ACTIVITY | ANTIMYCOBACTERIAL ACTIVITY | DESIGN | IN-VITRO | ANTICONVULSANT ACTIVITY | PHARMACOLOGY & PHARMACY | HYDRAZONES | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACYLHYDRAZONE DERIVATIVES | ANTIMALARIAL ACTIVITY | PHARMACOLOGICAL EVALUATION | ANTIMICROBIAL ACTIVITY | Hydrazines - pharmacology | Antioxidants - chemistry | Anticonvulsants - chemical synthesis | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Anticonvulsants - pharmacology | Anti-Infective Agents - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hydrazines - chemistry | Hydrazines - chemical synthesis | Animals | Organometallic Compounds - chemical synthesis | Anti-Infective Agents - chemistry | Anticonvulsants - chemistry | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Organometallic Compounds - pharmacology
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 07/2007, Volume 14, Issue 17, pp. 1829 - 1852
Journal Article
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2012, Volume 60, Issue 4, pp. 465 - 481
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 06/2016, Volume 22, Issue 21, pp. 3265 - 3301
Background: The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives... 
Antimicrobial | Imidazoles | Synthesis | Click chemistry | Anticancer | synthesis | antimicrobial | H-3 RECEPTOR ANTAGONISTS | ONE-POT SYNTHESIS | click chemistry | ZOSTER-VIRUS VZV | anticancer | PLASMODIUM-VIVAX MALARIA | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | VITRO ANTITUMOR-ACTIVITY | MICROWAVE-ASSISTED SYNTHESIS | POSSIBLE ANTICANDIDA AGENTS | ANTIMICROBIAL ACTIVITY | STRUCTURE-BASED DESIGN | Analgesics - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Infection - virology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Infection - drug therapy | Imidazoles - pharmacology | Infection - microbiology | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Analgesics - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Infection - parasitology
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 10, p. 2425
Non-steroidal anti-inflammatory drugs (NSAIDs) are an important pharmacological class of drugs used for the treatment of inflammatory diseases... 
Antinociceptive activity | Anti-inflammatory activity | Imidazo[2,1-b][1,3,4]thiadiazole derivatives | Molecular docking | SELECTIVE-INHIBITION | imidazo[2,1-b][1,3,4]thiadiazole derivatives | CARRAGEENAN | CYCLOOXYGENASE-2 | RAT | SEARCH | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANALGESIC ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | anti-inflammatory activity | molecular docking | PATHWAY | EDEMA | INFLAMMATION | antinociceptive activity | Analgesics - pharmacology | Molecular Conformation | Imidazoles - chemistry | Imidazoles - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Cyclooxygenase 1 - chemistry | Carrageenan - adverse effects | Female | Membrane Proteins - metabolism | Molecular Structure | Imidazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Thiadiazoles - pharmacology | Diclofenac - therapeutic use | Cyclooxygenase 2 - chemistry | Analgesics - administration & dosage | Rats | Edema - drug therapy | Imidazoles - pharmacology | Animals | Thiadiazoles - chemical synthesis | Membrane Proteins - chemistry | Analgesics - chemistry | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Diclofenac - administration & dosage | Edema - chemically induced | Thiadiazoles - administration & dosage
Journal Article
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 2015, Volume 89, pp. 743 - 816
The biological activity of Mannich bases, a structurally heterogeneous class of chemical compounds that are generated from various substrates through the introduction of an aminomethyl function... 
Aminomethylation | Drug design | Mannich bases | Structure–activity relationships | Biological activity | Structure-activity relationships | Structureeactivity relationships | CHEMISTRY, MEDICINAL | ANTIMICROBIAL ACTIVITY EVALUATION | ONE-POT SYNTHESIS | STATE ANALOG INHIBITORS | B VIRUS ACTIVITIES | ANTIMYCOBACTERIAL AGENTS ANALOGS | DOXORUBICIN-FORMALDEHYDE CONJUGATE | CORRESPONDING AZINE DERIVATIVES | REGIOSELECTIVE REACTION SYNTHESIS | MYCOBACTERIUM-TUBERCULOSIS ISOCITRATE | CYTOTOXIC ACTIVITY EVALUATION | Analgesics - pharmacology | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mannich Bases - chemical synthesis | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Drug Design | Mannich Bases - pharmacology | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Anticonvulsants - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Chemistry, Pharmaceutical | Mannich Bases - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Animals | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Antioxidants | Antiviral agents | Enzymes | Mental illness | Bases (Chemistry)
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2013, Volume 56, Issue 20, pp. 7804 - 7820
Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without... 
BREAST-CANCER | CHEMISTRY, MEDICINAL | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | CARDIOVASCULAR-SYSTEM | THERAPEUTIC TARGETS | TUMOR ANGIOGENESIS | CANCER PREVENTION | UP-REGULATION | ANGELIS SALT | AQUEOUS-SOLUTION | Models, Chemical | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Lung Neoplasms - pathology | Male | Prodrugs - chemistry | Enzyme Inhibitors - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Azo Compounds - chemistry | Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) - metabolism | Enzyme Inhibitors - chemistry | Molecular Structure | Aspirin - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Myocytes, Cardiac - cytology | Nitric Oxide - chemistry | Sarcomeres - drug effects | Sarcomeres - metabolism | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Nitrogen Oxides - chemistry | Animals | Myocytes, Cardiac - drug effects | Cyclooxygenase 2 - metabolism | Aspirin - chemical synthesis | Aspirin - chemistry | Cell Line, Tumor | Myocytes, Cardiac - metabolism | Prodrugs - chemical synthesis | Mice | Prodrugs - pharmacology | Index Medicus | DEA | nitric oxide | COX-2 | NSAID | cardioprotective | nitroxyl | diazeniumdiolate | anticancer | NONOate | anti-inflammatory | aspirin | IPA | GAPDH
Journal Article