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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2011, Volume 34, Issue 10, pp. 1613 - 1618
Accumulation of visceral fat induces various symptoms of metabolic syndrome such as insulin resistance and abnormal glucose/lipid metabolism and eventually... 
HepG2 | fatty liver | geniposide | metabolic disease | genipin | Metabolic disease | Geniposide | Fatty liver | Genipin | GARDENIA-JASMINOIDES | TSOD MOUSE | SIGNALING PATHWAY | INSULIN-RESISTANCE | FRUCTUS | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | EXPRESSION | Glucose Intolerance - metabolism | Gardenia | Hypoglycemic Agents - metabolism | Humans | Body Weight - drug effects | Male | Metabolic Syndrome - metabolism | Iridoids - metabolism | Diabetes Mellitus, Type 2 - metabolism | Metabolic Syndrome - drug therapy | Anti-Obesity Agents - therapeutic use | Adipose Tissue - metabolism | Fatty Acids, Nonesterified - metabolism | Plant Preparations - metabolism | Plant Preparations - pharmacology | Plant Preparations - therapeutic use | Phytotherapy | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Anti-Obesity Agents - metabolism | Hyperinsulinism - metabolism | Hypoglycemic Agents - therapeutic use | Fatty Liver - metabolism | Hyperinsulinism - complications | Obesity - complications | Liver - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Glucose Intolerance - complications | Metabolic Syndrome - complications | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Animals | Metabolic Diseases - metabolism | Iridoids - pharmacology | Lipid Metabolism - drug effects | Mice, Obese | Iridoids - therapeutic use | Metabolic Diseases - prevention & control | Mice | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue - drug effects | Anti-Obesity Agents - pharmacology | Metabolic Diseases - complications | Fatty Liver - etiology
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 283 - 17
The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and energy metabolism, and a validated target for therapeutic intervention... 
SIGNAL-TRANSDUCTION | CHELERYTHRINE | OBESITY | HEPATIC STELLATE CELLS | MULTIDISCIPLINARY SCIENCES | REVERSIBLE OXIDATION | IN-VIVO | KINASE-C | TYPE-2 DIABETES-MELLITUS | PROTEIN-TYROSINE-PHOSPHATASE | Levamisole - chemistry | Hypoglycemic Agents - metabolism | Humans | Leptin - metabolism | Crystallography, X-Ray | Small Molecule Libraries - metabolism | Isoquinolines - chemistry | Single-Chain Antibodies - metabolism | Levamisole - metabolism | Single-Chain Antibodies - genetics | Benzophenanthridines - chemistry | Enzyme Inhibitors - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Binding Sites | Anti-Obesity Agents - metabolism | Isoquinolines - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Leptin - chemistry | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Protein Structure, Secondary | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Recombinant Proteins - chemistry | Hypoglycemic Agents - chemistry | Recombinant Proteins - genetics | Small Molecule Libraries - chemistry | Anti-Obesity Agents - chemistry | Insulin - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Escherichia coli - genetics | Insulin - chemistry | Protein Binding | Molecular Docking Simulation | Benzophenanthridines - metabolism | Single-Chain Antibodies - chemistry | Tyrosine | Intervention | Obesity | Energy metabolism | Diabetes mellitus | Homeostasis | Metabolism | Insulin | Glucose metabolism | Signaling | Inhibitors | Leptin | Oxidation | Diabetes | Protein-tyrosine-phosphatase | Recombinant
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25565
Apart from its role during labor and lactation, oxytocin is involved in several other functions. Interestingly, oxytocin-and oxytocin receptor-deficient mice... 
BODY-WEIGHT | PPAR-ALPHA | TARGETED DISRUPTION | ADIPOCYTES | PLASMA | BIOLOGY | FAT | RECEPTOR GENE-EXPRESSION | DEFICIENT MICE | OLEOYLETHANOLAMIDE | MAMMARY-GLAND | Anti-Obesity Agents - blood | Oxytocin - pharmacology | Obesity - drug therapy | Diet - adverse effects | Body Weight - drug effects | Male | Dose-Response Relationship, Drug | Oleic Acids - metabolism | Adipose Tissue - metabolism | Oleic Acids - biosynthesis | Obesity - etiology | Endocannabinoids | Anti-Obesity Agents - metabolism | Anti-Obesity Agents - administration & dosage | Oxytocin - blood | Insulin Resistance | Rats | Obesity - physiopathology | PPAR alpha - genetics | Oxytocin - biosynthesis | Gene Knockout Techniques | Obesity - metabolism | Oxytocin - administration & dosage | PPAR alpha - deficiency | Animals | Mice | PPAR alpha - metabolism | Adipose Tissue - drug effects | Anti-Obesity Agents - pharmacology | Type 2 diabetes | Obesity | Enzymes | Monounsaturated fatty acids | Diet | Body weight | Physiological aspects | Insulin resistance | Adipose tissue | Lactation | Homeostasis | Body weight loss | Phospholipids | Adipocytes | Desaturase | High fat diet | Animal lactation | Infusion | Oxidation resistance | Oleic acid | Rodents | Coenzyme A | Physiology | Oxidation | Lipid metabolism | Drug dosages | Phosphatidylethanolamine | Oxytocin | Internal medicine | Diabetes mellitus | Weight loss | Triglycerides | Metabolism | Gene expression | Insulin | Body weight gain | Fatty acids | Lipolysis | Medicine | Glucose tolerance | Nutrition research | Intolerance | Weight control | Food intake | Peroxisome proliferator-activated receptors | Diabetes | Binding sites | Endocrinology
Journal Article
British Journal of Nutrition, ISSN 0007-1145, 09/2015, Volume 114, Issue 11, pp. 1774 - 1783
Obesity is one of the major health problems throughout the world. The present study investigated the preventive effect of epilactose - a rare non-digestible... 
Obesity | Uncoupling protein | Epilactose | Propionic acid | Skeletal muscle | LIPID-METABOLISM | OLIGOSACCHARIDES | RATS | BROWN ADIPOSE-TISSUE | GUT MICROBIOTA | IDENTIFICATION | NUTRITION & DIETETICS | INSULIN-RESISTANCE | ENERGY-METABOLISM | TRANSGENIC MICE | Propionates - metabolism | Up-Regulation | Adipose Tissue, White - immunology | Disaccharides - metabolism | Obesity - immunology | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Ion Channels - genetics | Male | Muscle, Skeletal - metabolism | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Obesity - microbiology | Anti-Obesity Agents - therapeutic use | Muscle, Skeletal - immunology | Mitochondrial Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Disaccharides - therapeutic use | Adipose Tissue, Brown - immunology | Anti-Obesity Agents - metabolism | Adipose Tissue, White - pathology | Cell Line | Mice, Inbred C57BL | Gastrointestinal Microbiome | Random Allocation | Fermentation | Adipose Tissue, Brown - pathology | Macrophage Activation | Obesity - metabolism | Prebiotics | Animals | Energy Metabolism | Ion Channels - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Obesity - prevention & control | Ion Channels - agonists | Adipose Tissue, Brown - metabolism | Uncoupling Protein 1 | Proteins | Nutrition research | Rodents | Metabolic disorders | Dietary supplements
Journal Article
Journal Article
Critical Reviews in Food Science and Nutrition, ISSN 1040-8398, 01/2016, Volume 56, Issue 1, pp. 92 - 112
Bioactive peptides are food derived components, usually consisting of 3-20 amino acids, which are inactive when incorporated within their parent protein. Once... 
Angiotensin-converting enzyme | bio-functional peptides | bioavailability | anti-obesity peptides | angiotensin II | renin-angiotensin system | METABOLIC SYNDROME | BIOACTIVE PEPTIDES | PROCESSING BY-PRODUCTS | SPONTANEOUSLY HYPERTENSIVE-RATS | I-CONVERTING-ENZYME | FOOD SCIENCE & TECHNOLOGY | HUMAN ADIPOSE-TISSUE | NUTRITION & DIETETICS | ACE-INHIBITORY PEPTIDE | CACO-2 CELL MONOLAYERS | FRAME PROTEIN HYDROLYSATE | Anti-Obesity Agents - economics | Obesity - diet therapy | Oligopeptides - economics | Obesity - drug therapy | Humans | Hypertension - drug therapy | Antihypertensive Agents - metabolism | Fish Proteins - isolation & purification | Anti-Obesity Agents - therapeutic use | Oligopeptides - therapeutic use | Dietary Proteins - metabolism | Antihypertensive Agents - isolation & purification | Proteolysis | Fish Proteins - therapeutic use | Aquatic Organisms - chemistry | Hypertension - diet therapy | Anti-Obesity Agents - metabolism | Antihypertensive Agents - economics | Dietary Proteins - isolation & purification | Peptide Fragments - economics | Peptide Fragments - metabolism | Fish Proteins - chemistry | Peptide Fragments - isolation & purification | Drug Discovery - trends | Fish Proteins - metabolism | Oligopeptides - metabolism | Antihypertensive Agents - therapeutic use | Anti-Obesity Agents - isolation & purification | Industrial Waste - analysis | Dietary Proteins - chemistry | Industrial Waste - economics | Dietary Supplements - economics | Oligopeptides - isolation & purification | Animals | Peptide Fragments - therapeutic use | Dietary Proteins - therapeutic use | Food-Processing Industry - economics
Journal Article
Endocrinology, ISSN 0013-7227, 05/2017, Volume 158, Issue 5, pp. 1314 - 1327
Journal Article
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 07/2017, Volume 23, Issue 25, pp. 3677 - 3688
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 04/2015, Volume 63, Issue 12, pp. 3168 - 3176
Journal Article