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PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167294 - e0167294
Mallotus philippensis L.(MP) commonly known as Kamala tree in Hindi, is a small to medium-sized monoecious tree. The objective of the study was to evaluate the... 
INDUCED PAW EDEMA | CARRAGEENAN | JAPONICUS | ASSAY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BIOLOGY | DISEASE | LIPID PEROXIDES | RATS | LEUKOTRIENES | Free Radical Scavengers - pharmacology | Inflammation - pathology | Plant Extracts - chemistry | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Catalase - antagonists & inhibitors | Glutathione Peroxidase - antagonists & inhibitors | Flavanones - chemistry | Inflammation - drug therapy | Lipid Peroxidation - drug effects | Carrageenan - adverse effects | Granuloma - etiology | Cytokines - blood | Glutathione Peroxidase - metabolism | Mallotus Plant - chemistry | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Flavanones - pharmacology | Rats | Edema - drug therapy | Inflammation - etiology | Catalase - metabolism | Edema - etiology | Granuloma - pathology | Animals | Anti-Inflammatory Agents - chemistry | Granuloma - drug therapy | Edema - pathology | Dimethyl | Granuloma | Hydrocarbons | Lipids | Acetylsalicylic acid | Cotton | Interleukin 6 | Antioxidants | Catalase | Methyl alcohol | Rodents | Interleukin 1 | Tumor necrosis factor-TNF | Peroxidase | Drug dosages | Glutathione | Methanol | Trees | Glutathione peroxidase | Edema | Antiinflammatory agents | Cytokines | Albinism | Scavenging | Pharmacology | Inflammation | Tumor necrosis factor-α | Malondialdehyde | Chromatography | Chemistry | Carrageenan | Index Medicus
Journal Article
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2017, Volume 12, Issue 13, pp. 1022 - 1032
Acute lung injury (ALI) has a high lethality rate, and interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) contribute most to tissue deterioration in... 
anti-inflammatory | cytokines | thiazolo[3,2 | pyrimidines | acute lung injury | interleukins | thiazolo[3,2-a]pyrimidines | MORTALITY | PYRIMIDINE-DERIVATIVES | CHEMISTRY, MEDICINAL | MACROPHAGES | SEPSIS | DISCOVERY | RESPIRATORY-DISTRESS-SYNDROME | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | AGENTS | INHIBITORS | INFLAMMATORY RESPONSE | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Pyrimidines - chemical synthesis | Tumor Necrosis Factor-alpha - genetics | Thiazoles - administration & dosage | Thiazoles - therapeutic use | RNA, Messenger - metabolism | Antigens, CD - metabolism | Sepsis - drug therapy | Sepsis - metabolism | Acute Lung Injury - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Interleukin-6 - metabolism | Macrophages, Peritoneal - drug effects | Quantitative Structure-Activity Relationship | Interleukin-6 - genetics | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Mice, Inbred ICR | Animals | Pneumonia - drug therapy | Thiazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Pyrimidines - therapeutic use | Antigens, Differentiation, Myelomonocytic - metabolism | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Lipopolysaccharides - pharmacology | Macrophages, Peritoneal - metabolism | Pneumonia - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Acute respiratory distress syndrome | Pyrimidines | Interleukins | Anti-inflammatory drugs | Mitogens | Analysis | Drugs | Ventilators | Antiinflammatory agents | Lung | Interleukin | Lethality | Inflammation | Derivatives | Macrophages | Drug development | Lipopolysaccharides | Interleukin 6 | Inhibitors | Synthesis | Tumor necrosis factor | Rodents | Attenuation | Tumor necrosis factor-TNF | Peritoneum | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2015, Volume 23, Issue 24, pp. 7543 - 7564
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2017, Volume 12, Issue 13, pp. 1013 - 1013
The front cover picture shows a series of newly discovered compounds with high inhibitory activities against lipopolysaccharide (LPS)‐induced cytokine... 
anti-inflammatory | cytokines | thiazolo[3,2 | pyrimidines | acute lung injury | interleukins | Ventilators | Antiinflammatory agents | Cytokines | Lung | Bronchus | Inflammation | Derivatives | Bioactive | Lipopolysaccharides | Bronchoalveolar lavage | Rodents | Sepsis | Mice | Pretreatment | Alveoli
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
A new series of 2-substituted mercapto-4(3 )-quinazolinone were synthesized and assessed for anti-inflammatory and analgesic activities and inhibition of... 
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | SELECTIVE-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ANALOGS | ANTITUMOR-ACTIVITY | DRUGS | BIOLOGICAL EVALUATION | DERIVATIVES | PROSTAGLANDIN SYNTHESIS | QUINAZOLINES | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
Journal Article
2013, ISBN 1845939107, xi, 398
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