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International Journal of Pharmaceutics, ISSN 0378-5173, 12/2011, Volume 421, Issue 2, pp. 388 - 396
pH-responsive polymer shell chitosan/poly (methacrylic acid) (CS-PMAA) was coated on mesoporous silica nanoparticles (MSN) through the facile polymerization... 
Mesoporous silica nanoparticle | pH sensitive | Drug delivery | Composite microsphere | SURFACE FUNCTIONALIZATION | PARTICLES | VESICLES | SPHERES | CHITOSAN | RELEASE | POLYELECTROLYTE | ACRYLIC-ACID | PHARMACOLOGY & PHARMACY | POLY(METHACRYLIC ACID) | HOLLOW NANOSPHERES | Antibiotics, Antineoplastic - toxicity | Nanoparticles - chemistry | Humans | Drug Carriers - toxicity | Doxorubicin - chemistry | Spectroscopy, Fourier Transform Infrared | Drug Carriers - chemistry | Microspheres | Polymethacrylic Acids - toxicity | Antibiotics, Antineoplastic - chemistry | X-Ray Diffraction | Doxorubicin - metabolism | Cell Survival - drug effects | Microscopy, Electron, Transmission | Silicon Dioxide - chemistry | Nanoparticles - ultrastructure | Thermogravimetry | Polymethacrylic Acids - chemistry | Chitosan - toxicity | Nanoparticles - toxicity | Doxorubicin - toxicity | Chitosan - chemistry | Silicon Dioxide - toxicity | Absorption - drug effects | HeLa Cells | Antibiotics, Antineoplastic - metabolism | Powder Diffraction | Hydrogen-Ion Concentration | Drugs | Drug delivery systems | Hydrogen-ion concentration | Silica | Vehicles | chitosan | microspheres | Polymerization | Shells | Confocal microscopy | Cytotoxicity | Hydrodynamics | Methacrylic acid | Sodium chloride | pH effects | Doxorubicin | Feeding | nanoparticles | Cancer | Index Medicus
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 02/2011, Volume 22, Issue 2, pp. 136 - 147
Galactosyl-terminated drug carriers are known to enhance drug accumulation in the liver, while possible accompanying hepatic toxicity is usually not clarified.... 
α,β-poly[(2-hydroxyethyl)-L-aspartamide] | doxorubicin | galactosyl | hepatotoxicity | hepatocellular carcinoma | POLYMER-BOUND DOXORUBICIN | PERFORMANCE | CARDIOTOXICITY | SYSTEMIC THERAPY | LACTOSAMINATED HUMAN ALBUMIN | alpha, beta-poly[(2-hydroxyethyl)-L-aspartamide] | PHARMACOKINETICS | ONCOLOGY | N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS | ADRIAMYCIN | CONJUGATE | PHARMACOLOGY & PHARMACY | PHASE-I | Antibiotics, Antineoplastic - toxicity | Humans | Peptides - pharmacokinetics | Drug Carriers - administration & dosage | Drug Carriers - toxicity | Peptides - administration & dosage | Galactose - analogs & derivatives | Liver Neoplasms, Experimental - metabolism | Peptides - toxicity | Doxorubicin - analogs & derivatives | Female | Antibiotics, Antineoplastic - pharmacokinetics | Heart Diseases - chemically induced | Chemical and Drug Induced Liver Injury - etiology | Doxorubicin - administration & dosage | Galactose - pharmacokinetics | Doxorubicin - pharmacokinetics | Doxorubicin - toxicity | Mice, Inbred ICR | Antibiotics, Antineoplastic - administration & dosage | Animals | Liver Neoplasms, Experimental - drug therapy | Cell Line, Tumor | Galactose - toxicity | Drug Carriers - pharmacokinetics | Mice | HeLa Cells | Galactose - administration & dosage | Toxicity Tests | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2009, Volume 26, Issue 3, pp. 492 - 501
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European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 08/2015, Volume 76, pp. 95 - 101
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 02/2016, Volume 223, pp. 1 - 10
Polymer drug carriers that are based on -(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been widely used in the development and synthesis of... 
Anti-tumour activity | Structure | Toxicity | HPMA | Doxorubicin | HYDRAZONE BOND | DRUG-DELIVERY | BIODISTRIBUTION | VASCULAR-PERMEABILITY | CHEMISTRY, MULTIDISCIPLINARY | N-(2-HYDROXYPROPYL) METHACRYLAMIDE COPOLYMERS | ENHANCED PERMEABILITY | IN-VITRO | PHARMACOLOGY & PHARMACY | MICE | MULTIDRUG-RESISTANCE | Neoplasms - metabolism | Doxorubicin - therapeutic use | Liver - pathology | Antibiotics, Antineoplastic - toxicity | Molecular Weight | Drug Carriers - therapeutic use | Dendrimers - therapeutic use | Drug Carriers - toxicity | Doxorubicin - chemistry | Intestines - metabolism | Spleen - drug effects | Structure-Activity Relationship | Acrylamides - pharmacokinetics | Drug Carriers - chemistry | Neoplasms - blood | Antibiotics, Antineoplastic - chemistry | Liver - drug effects | Female | Antibiotics, Antineoplastic - pharmacokinetics | Spleen - pathology | Dendrimers - toxicity | Bone Marrow - drug effects | Dendrimers - pharmacokinetics | Mice, Inbred C57BL | Acrylamides - toxicity | Doxorubicin - pharmacokinetics | Doxorubicin - toxicity | Acrylamides - chemistry | Neoplasms - drug therapy | Maximum Tolerated Dose | Animals | Antibiotics, Antineoplastic - therapeutic use | Bone Marrow - pathology | Cell Line, Tumor | Dendrimers - chemistry | Acrylamides - therapeutic use | Drug Carriers - pharmacokinetics | Mice | Mice, Inbred BALB C | Dextran | Anthracyclines | Analysis | Leukemia | Lymphomas | Permeability | T cells | Drugs | Drug delivery systems | Non-Hodgkin's lymphomas | Vehicles | Index Medicus
Journal Article