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Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2011, Volume 55, Issue 12, pp. 5485 - 5492
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 10, p. e0138976
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e56980
1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high in vitro efficacy against M. tuberculosis. To improve the physical... 
MYCOBACTERIUM-TUBERCULOSIS | ANTIMYCOBACTERIAL | ASSAY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | ANTIFUNGAL ACTIVITIES | PYRROLE DERIVATIVE BM212 | IDENTIFICATION | STREPTOMYCIN | Bacterial Proteins - antagonists & inhibitors | Cell Line | Microsomes - metabolism | Humans | Bacterial Proteins - genetics | Piperazines - toxicity | Piperazines - chemistry | Antibiotics, Antitubercular - pharmacology | Antibiotics, Antitubercular - toxicity | Mycobacterium tuberculosis - drug effects | Piperazines - pharmacology | Microbial Sensitivity Tests | Pyrroles - pharmacology | Animals | Antibiotics, Antitubercular - chemistry | Pyrroles - toxicity | Tuberculosis - drug therapy | Pyrroles - chemistry | Bacterial Proteins - metabolism | Female | Mice | Mycobacterium tuberculosis - metabolism | Tuberculosis - metabolism | Mycobacterium tuberculosis - genetics | Tuberculosis | Drug discovery | Chemical properties | Gene mutations | Health aspects | Drugs | Animal models | Oxygen | Research & development--R&D | Pyrroles | Thiomorpholine | Infections | Mutants | Gene sequencing | Morpholine | Discovery tools | Mutation | Sulfur | Lipophilicity | Piperazines | Microsomes | Bacterial Proteins | Life Sciences | Mycobacterium tuberculosis | Antibiotics, Antitubercular | Pharmaceutical sciences | Research & development | R&D
Journal Article
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2012, Volume 56, Issue 8, pp. 4331 - 4340
Journal Article
Journal Article
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2014, Volume 62, Issue 12, pp. 1214 - 1224
Journal Article
Archives of toxicology, ISSN 1432-0738, 2016, Volume 90, Issue 7, pp. 1585 - 1604
Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to... 
Mycobacterium | Antibiotic | Biomedicine | Environmental Health | Tuberculosis | Occupational Medicine/Industrial Medicine | Bactericidal | Pharmacology/Toxicology | Drug resistance | Biomedicine general | Mechanism | PARA-AMINOSALICYLIC ACID | INTRINSIC MACROLIDE RESISTANCE | PROTEIN-KINASE-G | CRYSTAL-STRUCTURE | DRUG-RESISTANCE | IN-VITRO | CELL-WALL | BETA-LACTAM ANTIBIOTICS | TOXICOLOGY | MULTIDRUG-RESISTANCE | MOLECULAR-BASIS | Antitubercular Agents - chemistry | Humans | Mycobacterium tuberculosis - drug effects | Oxazoles - chemistry | Pyrazinamide - therapeutic use | Aminosalicylic Acid - therapeutic use | Pyrazinamide - chemistry | Antibiotics, Antitubercular - chemistry | Oxazoles - administration & dosage | Antibiotics, Antitubercular - therapeutic use | Aminosalicylic Acid - chemistry | Antitubercular Agents - administration & dosage | Folic Acid - metabolism | Aminosalicylic Acid - administration & dosage | Molecular Structure | Drug Resistance, Multiple, Bacterial - genetics | Drug Therapy, Combination | Antibiotics, Antitubercular - administration & dosage | Drug Resistance, Multiple, Bacterial - drug effects | Oxazoles - therapeutic use | Antitubercular Agents - therapeutic use | Mycobacterium tuberculosis - genetics | Pyrazinamide - administration & dosage | Tuberculosis, Multidrug-Resistant - drug therapy | Drug resistance in microorganisms | Antibiotics | Index Medicus
Journal Article
PLoS computational biology, ISSN 1553-7358, 2017, Volume 13, Issue 8, p. e1005650
Granulomas are complex lung lesions that are the hallmark of tuberculosis (TB). Understanding antibiotic dynamics within lung granulomas will be vital to... 
MYCOBACTERIUM-TUBERCULOSIS | ANTITUBERCULOSIS DRUGS | MURINE TUBERCULOSIS | EARLY BACTERICIDAL ACTIVITY | MULTIDRUG-RESISTANT TUBERCULOSIS | SENSITIVITY-ANALYSIS | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | PULMONARY TUBERCULOSIS | CYNOMOLGUS MACAQUES | CONTAINING REGIMENS | WEEKLY RIFAPENTINE | Granuloma - microbiology | Rabbits | Computational Biology - methods | Humans | Antitubercular Agents - pharmacology | Fluoroquinolones - therapeutic use | Tuberculosis - microbiology | Fluoroquinolones - pharmacokinetics | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Mycobacterium tuberculosis - pathogenicity | Animals | Antitubercular Agents - pharmacokinetics | Computer Simulation | Fluoroquinolones - pharmacology | Tuberculosis - drug therapy | Antitubercular Agents - administration & dosage | Female | Granuloma - drug therapy | Antitubercular Agents - therapeutic use | Fluoroquinolones - administration & dosage | Tuberculosis | Patient outcomes | Drug interactions | Quinolone antibacterial agents | Dosage and administration | Comparative analysis | Drug therapy | Quinolones | Fluoroquinolones | Drugs | Levofloxacin | Granuloma | Funding | Chemical engineering | Infections | Moxifloxacin | Drug resistance | Medical schools | Replicating | Immunology | Sterilization | Bacteria | Mathematical models | Lesions | Drug dosages | Public health | Supervision | Medical research | Pharmacodynamics | Interruption | Effectiveness | Computer simulation | Multidrug resistance | Pharmacology | Bactericidal activity | Studies | Antibiotics | Lungs | Gatifloxacin | Computation | Computer applications | Pharmacokinetics | In vitro methods and tests | Methods | Biochemistry & Molecular Biology | MATHEMATICS AND COMPUTING | BASIC BIOLOGICAL SCIENCES | Mathematical & Computational Biology
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