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Nature, ISSN 0028-0836, 08/2014, Volume 514, Issue 7524, pp. 642 - 645
To protect against human immunodeficiency virus (HIV-1) infection, broadly neutralizing antibodies (bnAbs) must be active at the portals of viral entry in the... 
HALF-LIFE | CHALLENGE | IMMUNITY | TRANSPORT | NEUTRALIZING ANTIBODIES | HUMAN IGG1 | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MONOCLONAL-ANTIBODIES | HIV-1 VACCINE | HIV Antibodies - blood | Antibodies, Neutralizing - analysis | HIV Infections - prevention & control | Immunity, Mucosal - immunology | Antibody-Dependent Cell Cytotoxicity - immunology | Half-Life | Administration, Rectal | Antibody Affinity - immunology | Male | HIV - immunology | Macaca mulatta | Antibodies, Viral - blood | Receptors, IgG - metabolism | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV Envelope Protein gp160 - chemistry | Antibodies, Viral - analysis | HIV - chemistry | Intestinal Mucosa - immunology | Female | Transcytosis | Simian Immunodeficiency Virus - immunology | HIV Antibodies - analysis | Mutagenesis, Site-Directed | Histocompatibility Antigens Class I - immunology | Antibody Affinity - genetics | Antibodies, Neutralizing - genetics | Binding Sites - genetics | Receptors, IgG - immunology | Rectum - immunology | Simian Acquired Immunodeficiency Syndrome - prevention & control | Animals | Receptors, Fc - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Immunization, Passive | Antibodies, Viral - immunology | HIV Envelope Protein gp160 - immunology | Mice | HIV Antibodies - genetics | Antibodies, Neutralizing - blood | Antibodies, Viral - genetics | CD4 Antigens - metabolism | Viral antibodies | Infection | Prevention | Fc receptors | Protein research | Antibodies | Primates | Research | Simian immunodeficiency virus | Health aspects | T cell receptors | Physiology | Mutation | Human immunodeficiency virus--HIV | Viral infections | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 515, Issue 7525, pp. 138 - 142
The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in... 
B-CELLS | SPECIFICITIES | MULTIDISCIPLINARY SCIENCES | SERA | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENV TRIMERS | VULNERABILITY | GP120 | HUMAN MONOCLONAL-ANTIBODIES | CLEAVAGE | DEPENDENT EPITOPE | Immunoglobulin Fab Fragments - ultrastructure | Antibody Specificity | Epitope Mapping | HIV Envelope Protein gp41 - immunology | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Leukocytes, Mononuclear | HIV Envelope Protein gp41 - chemistry | Virus Internalization - drug effects | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Receptors, CCR5 - metabolism | HIV Antibodies - immunology | Conserved Sequence | Inhibitory Concentration 50 | HIV Envelope Protein gp120 - chemistry | HIV Antibodies - pharmacology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Cell Line | Immunoglobulin Fab Fragments - genetics | HIV-1 - drug effects | Antibodies, Monoclonal - pharmacology | Models, Molecular | Antibodies, Neutralizing - pharmacology | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Antibodies, Monoclonal - genetics | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | Cell Membrane - virology | Epitopes - chemistry | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | CD4 Antigens - metabolism | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Genetic aspects | Research | HIV infection | Antigenic determinants | Amino acids | Mutation | Vaccines | Human immunodeficiency virus--HIV | Binding sites | Index Medicus
Journal Article
eJournal
Nature (London), ISSN 1476-4687, 2016, Volume 533, Issue 7601, pp. 105 - 109
Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency virus type 1 (HIV-1) infection, little progress has been made in... 
SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS | POTENT | TRANSMISSION | HIV-1/SIV CHIMERIC VIRUS | BROADLY NEUTRALIZING ANTIBODY | MULTIDISCIPLINARY SCIENCES | IMPROVES PROTECTION | PASSIVE TRANSFER | MACAQUES | INFECTION | MONOCLONAL-ANTIBODIES | HIV Antibodies - blood | Antibodies, Neutralizing - administration & dosage | HIV Infections - prevention & control | AIDS Vaccines - immunology | Macaca mulatta - immunology | Half-Life | Male | Antibodies, Monoclonal - blood | HIV Infections - immunology | Macaca mulatta - virology | Antibodies, Neutralizing - immunology | Immunoglobulin Fc Fragments - immunology | HIV Antibodies - immunology | Time Factors | Female | HIV Infections - transmission | Antibodies, Monoclonal - immunology | Simian Immunodeficiency Virus - immunology | Protein Structure, Tertiary | SAIDS Vaccines - administration & dosage | Immunoglobulin Fc Fragments - chemistry | Antibodies, Neutralizing - genetics | Mutation - genetics | Simian Acquired Immunodeficiency Syndrome - blood | HIV Antibodies - administration & dosage | Simian Acquired Immunodeficiency Syndrome - prevention & control | Antibodies, Monoclonal - genetics | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Antibodies, Monoclonal - administration & dosage | HIV Antibodies - genetics | AIDS Vaccines - administration & dosage | Immunoglobulin Fc Fragments - genetics | Antibodies, Neutralizing - blood | Prevention | Viral antibodies | Antibodies | Dosage and administration | HIV infection | Patient outcomes | Monoclonal antibodies | Immunoglobulins | Immunization | Vaccines | Human immunodeficiency virus--HIV | Viral infections
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 03/2017, Volume 525, Issue 4, pp. 955 - 975
ABSTRACT P11 (S100a10), a member of the S100 family of proteins, has widespread distribution in the vertebrate body, including in the brain, where it has a key... 
ependymal cells | anti‐GFP antibody RRID: AB_10073917 | endothelial cells | anti‐NeuN antibody RRID: AB_2298772 | anti‐p11 antibody RRID: AB_2183469 | anti‐Olig2 antibody RRID: AB_10861310 | anti‐GFP antibody RRID: AB_303395 | region‐specificity | neurons | glia | anti‐GFAP antibody RRID: AB_305808 | p11 | anti‐Aldh1L1 antibody RRID: AB_10712968 | anti‐CNPase antibody RRID: AB_10122287 | anti‐NG2 antibody RRID: AB_177646 | anti‐GFP antibody RRID: AB_10000240 | anti‐Iba1 antibody RRID: AB_839504 | expression mapping | depression | anti‐GFP antibody RRID: AB_300798 | meninges | anti-CNPase antibody RRID: AB_10122287 | anti-NeuN antibody RRID: AB_2298772 | region-specificity | anti-GFP antibody RRID: AB_300798 | anti-Aldh1L1 antibody RRID: AB_10712968 | anti-GFAP antibody RRID: AB_305808 | anti-GFP antibody RRID: AB_10073917 | anti-GFP antibody RRID: AB_303395 | anti-Olig2 antibody RRID: AB_10861310 | anti-Iba1 antibody RRID: AB_839504 | anti-p11 antibody RRID: AB_2183469 | anti-GFP antibody RRID: AB_10000240 | anti-NG2 antibody RRID: AB_177646 | ZOOLOGY | SEROTONIN | NERVOUS-SYSTEM | FOREBRAIN | WHITE-MATTER | NEUROSCIENCES | PREFRONTAL CORTEX | CHANNEL | TRANSLATIONAL PROFILING APPROACH | BLOOD-VESSELS | GROWTH-FACTOR | Immunohistochemistry | Mice, Inbred C57BL | Male | Annexin A2 - biosynthesis | Mice, Knockout | Brain - metabolism | Depression - metabolism | Animals | In Situ Hybridization | Image Processing, Computer-Assisted | Female | Mice | S100 Proteins - biosynthesis | Proteins | Viral antibodies | Brain | Neurons | Antidepressants | Depression, Mental | Antibodies
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 561, Issue 7724, pp. 479 - 484
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a... 
SHIV INFECTION | PRIMARY HIV-INFECTION | RESERVOIR | DURABLE CONTROL | BROADLY NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | PASSIVE TRANSFER | IN-VIVO | TREATMENT INTERRUPTION | T-CELLS | HUMANIZED MICE | Antibodies, Neutralizing - administration & dosage | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Drug Resistance, Viral | Antibodies, Monoclonal - therapeutic use | Male | Phylogeny | Anti-HIV Agents - administration & dosage | Young Adult | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - adverse effects | HIV Antibodies - immunology | HIV-1 - isolation & purification | Antibodies, Neutralizing - therapeutic use | Adult | Anti-HIV Agents - therapeutic use | Antibodies, Neutralizing - adverse effects | Female | HIV Antibodies - therapeutic use | Historically Controlled Study | Antibodies, Monoclonal - immunology | Carrier State - immunology | HIV Infections - virology | Viremia - drug therapy | HIV Antibodies - administration & dosage | Carrier State - virology | HIV-1 - immunology | Viremia - virology | Antibodies, Monoclonal - administration & dosage | Viremia - prevention & control | Adolescent | Carrier State - drug therapy | HIV Infections - drug therapy | Viremia - immunology | Aged | HIV Envelope Protein gp160 - immunology | Infusions, Intravenous | Binding Sites, Antibody | Virus Activation - immunology | Virus Latency - immunology | Anti-HIV Agents - immunology | Drug Combinations | Physiological aspects | HIV patients | Care and treatment | Drug therapy, Combination | HIV antibodies | Antiretroviral drugs | Therapy | Antiviral agents | Interruption | Immunoglobulins | Viremia | Clinical trials | Viruses | Infections | Genomes | Antiretroviral therapy | Antiretroviral agents | Lymphocytes | Human immunodeficiency virus--HIV | Monoclonal antibodies | Drug therapy | Bioinformatics | Binding sites
Journal Article
Nature immunology, ISSN 1529-2916, 2016, Volume 17, Issue 9, pp. 1102 - 1108