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Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1027 - 1031
The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal... 
NETWORK | INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE | POLYCYSTIC KIDNEY-DISEASE | BIOLOGY | GENETICS & HEREDITY | DISORDERS | PROTEINS | FIBROBLASTS | Humans | Fluorescent Dyes - metabolism | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Fibroblasts - ultrastructure | Obesity - genetics | Embryo, Mammalian - metabolism | Intellectual Disability - genetics | Indoles - metabolism | Tubulin - metabolism | Cell Nucleus - metabolism | Transfection | Mice, Mutant Strains | Cilia - ultrastructure | Bardet-Biedl Syndrome - genetics | Chromones - pharmacology | Microsatellite Repeats | Fibroblasts - metabolism | Genetic Linkage | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Cilia - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Fluorescent Antibody Technique, Direct | Retinal Degeneration - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Mice, Transgenic | Genetic Markers | Cilia - metabolism | Cilia - genetics | Pigment Epithelium of Eye - metabolism | Animals | Embryo, Mammalian - cytology | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Polymorphism, Single Nucleotide | Mutation | Pigment Epithelium of Eye - cytology | Penis - abnormalities | Gene mutations | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Brain diseases | Proteins | Tissue | Scanning electron microscopy | Transmission electron microscopy | Cysts | Rodents | Cell division | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | WHITE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | BROWN ADIPOSE-TISSUE | IDENTIFICATION | CELL BIOLOGY | OBESITY | GENE | INFLAMMATION | EXPRESSION | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | Index Medicus | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2012, Volume 32, Issue 39, pp. 13454 - 13469
Abnormal deposition and intercellular propagation of alpha-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and... 
IMMUNIZATION | PROTEIN | PLASMA | BIOMARKER | ALZHEIMERS-DISEASE | MOUSE MODEL | PATHOLOGY | FC-GAMMA-RIIA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PARKINSONS-DISEASE | Synaptic Transmission - physiology | Antibodies - metabolism | Lewy Body Disease - immunology | Humans | alpha-Synuclein - immunology | Extracellular Space - drug effects | Nerve Degeneration - genetics | Cell Communication - physiology | Culture Media, Conditioned - pharmacology | Phosphopyruvate Hydratase - metabolism | Amyloid - ultrastructure | Antigens, CD - metabolism | Neuroglia - drug effects | Brain - metabolism | Lewy Body Disease - genetics | Extracellular Space - metabolism | Amyloid - metabolism | Microfilament Proteins - metabolism | alpha-Synuclein - genetics | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cell Line | Microscopy, Electron, Transmission | Cytokines - metabolism | Mice, Transgenic | Nerve Degeneration - immunology | Cathepsin D - metabolism | Extracellular Space - immunology | Antibodies - pharmacology | Caveolin 1 - metabolism | Lewy Body Disease - metabolism | Platelet-Derived Growth Factor - metabolism | Animals | Analysis of Variance | Brain - pathology | Immunization, Passive | Neuroglia - metabolism | Mice | Chromatography, Gel | alpha-Synuclein - metabolism | Nerve Degeneration - drug therapy | Astrocytes - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e25178 - e25178
Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been... 
HIPPOCAMPAL SLICES | ADENOSINE KINASE | P2X RECEPTOR | HEMICHANNELS | BIOLOGY | ASTROCYTE PROGENITORS | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | CHANNELS | CELL-CELL COMMUNICATION | ATP RELEASE | Potassium - metabolism | Seizures - prevention & control | Connexins - physiology | Epilepsy - metabolism | Neurons - cytology | Seizures - metabolism | Seizures - chemically induced | Brain - metabolism | Adenosine Triphosphate - metabolism | Behavior, Animal - drug effects | Neurons - metabolism | Astrocytes - cytology | Epilepsy - prevention & control | Brain - cytology | Nerve Tissue Proteins - physiology | Kainic Acid - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Hippocampus - cytology | Blotting, Western | Hippocampus - metabolism | Animals | Epilepsy - chemically induced | Fluorescent Antibody Technique | Mice | Status Epilepticus - metabolism | Astrocytes - metabolism | Brain | Neurons | Epilepsy | GABA | Genetic engineering | Seizures (Medicine) | Glutamate | Neurosciences | Hyperactivity | Nervous system | Membrane channels | Channels | γ-Aminobutyric acid | Membrane conductance | Metabolites | Rodents | Cooperation | Physiology | Seizures | Seizing | Adenosine | Astrocytes | Transgenic mice | Pharmacology | Metabolism | Embryos | Resistance | Medicine | Signaling | Conductance | ATP | Kainic acid | Hippocampus | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12655 - 12660
The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac... 
T lymphocytes | Pathology | RNA | HEK293 cells | Genes | Cell lines | Antibodies | Small nuclear RNA | Gene expression regulation | HIV 1 | 7SK SNRNA | TRANSCRIPTION FACTOR BCL11B | ELONGATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | POLYMERASE | HIV-1 TAT | MICROGLIAL CELLS | T-CELL LINEAGE | BROMODOMAIN PROTEIN BRD4 | RNA-Binding Proteins - genetics | Humans | Myosin Heavy Chains - genetics | Cardiomegaly - pathology | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Myosin Heavy Chains - metabolism | RNA, Small Nuclear - genetics | Tumor Suppressor Proteins - genetics | HEK293 Cells | Cardiac Myosins - metabolism | Repressor Proteins - metabolism | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Cyclin-Dependent Kinase 9 - genetics | Cardiac Myosins - genetics | Repressor Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Cyclin-Dependent Kinase 9 - metabolism | Mice | RNA, Small Nuclear - metabolism | Cardiomegaly - genetics | RNA-Binding Proteins - metabolism | Cardiomegaly - metabolism | Physiological aspects | Transcription factors | Genetic aspects | Heart enlargement | Health aspects | Myosin | Proteins | Heart | Acquired immune deficiency syndrome--AIDS | Ribonucleic acid--RNA | Cancer | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
Diabetologia, ISSN 0012-186X, 7/2010, Volume 53, Issue 7, pp. 1395 - 1405
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2006, Volume 116, Issue 4, pp. 916 - 928
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 2, pp. 215 - 229
Accumulation of Na channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the... 
MYELINATED AXONS | PROTEIN | INITIAL SEGMENTS | PERIPHERAL NERVOUS-SYSTEM | BETA-IV-SPECTRIN | ADHESION MOLECULES | ANKYRIN-BINDING | IDENTIFICATION | NEUROSCIENCES | SODIUM-CHANNEL DISTRIBUTION | K+ CHANNELS | Cytoskeletal Proteins | Age Factors | Humans | Myelin-Associated Glycoprotein - metabolism | Cercopithecus aethiops | Sciatic Nerve - growth & development | Cell Adhesion Molecules - immunology | Phosphoproteins - metabolism | Ranvier's Nodes - metabolism | Ranvier's Nodes - ultrastructure | Cell Compartmentation | Sciatic Nerve - metabolism | Transfection - methods | Gene Expression Regulation, Developmental | Cloning, Molecular - methods | Sodium Channels - metabolism | Macromolecular Substances - immunology | Cell Adhesion Molecules, Neuronal - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Spectrin - metabolism | Microscopy, Immunoelectron - methods | Protein Structure, Tertiary | Amino Acid Sequence | Blotting, Western - methods | Myelin Basic Protein - metabolism | Fluorescent Antibody Technique - methods | Cells, Cultured | Axons - metabolism | Rats | S100 Proteins - metabolism | Schwann Cells - metabolism | Cell Adhesion Molecules - metabolism | Claudins | Animals | Schwann Cells - ultrastructure | Ankyrins - metabolism | Blotting, Northern - methods | Neurofilament Proteins - metabolism | Macromolecular Substances - metabolism | Ganglia, Spinal - metabolism | Protein Binding - physiology | Receptors, Peptide - metabolism | Immunoglobulins | Proteins | Microscopy | Plasmids | Rodents | Ligands | Experiments | Binding sites | Index Medicus
Journal Article
Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6001, pp. 239 - 243
For proper partitioning of chromosomes in mitosis, the chromosomal passenger complex (CPC) including Aurora B and survivin must be localized at the center of... 
Yeasts | Phosphorylation | Heterochromatin | Kinetochores | REPORTS | Centromeres | HeLa cells | Histones | Antibodies | Chromosomes | Genetic mutation | SISTER-CHROMATID COHESION | LOCALIZATION | ATTACHMENT | MITOTIC CHROMOSOME | KINETOCHORE | MULTIDISCIPLINARY SCIENCES | MEIOSIS | SPINDLE | CHECKPOINT | SHUGOSHIN | AURORA-B | Chromatin - metabolism | Chromosomes, Human - physiology | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Centromere - metabolism | Threonine - metabolism | Schizosaccharomyces - genetics | Aurora Kinase B | Heterochromatin - metabolism | Schizosaccharomyces pombe Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromosomes, Fungal - physiology | Amino Acid Sequence | Chromosome Segregation | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Inhibitor of Apoptosis Proteins | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nucleosomes - metabolism | Aurora Kinases | Serine - metabolism | Schizosaccharomyces - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Histones - metabolism | Mutation | Proteins | Cell division | Biochemistry | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 249 - 258
Psoriasis is a type I interferon-driven T cell-mediated disease characterized by the recruitment of plasmacytoid dendritic cells (pDC) into the skin. The... 
PATHOGENESIS | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | DERMATITIS | INFLAMMATION | LYMPH-NODES | IN-VIVO | CYTOKINE | IMMUNOLOGY | PRECURSORS | T-CELLS | PROTEASES | CD8-Positive T-Lymphocytes - cytology | Neutrophils - cytology | Membrane Glycoproteins - metabolism | Skin - metabolism | Humans - metabolism | Antigens, CD - metabolism | Chemotaxis, Leukocyte - physiology | Lectins, C-Type - metabolism | Chemotaxis, Leukocyte - drug effects | Psoriasis - pathology | Psoriasis - metabolism | CD8-Positive T-Lymphocytes - metabolism | Receptors, Chemokine - genetics | Neutrophils - metabolism | Antibodies, Monoclonal - immunology | Fibroblasts - metabolism | Tretinoin - pharmacology | Antibodies, Monoclonal - pharmacology | Neutrophils - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Chemokines - genetics | Blotting, Western | Intercellular Adhesion Molecule-1 - metabolism | Calcitriol - pharmacology | Fibroblasts - drug effects | Chemokines - metabolism | Fibroblasts - cytology | Receptors, Immunologic - genetics | Chemokine CXCL10 - metabolism | Dermatitis, Atopic - genetics | Gene Expression - drug effects | Culture Media, Conditioned - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Lectins, C-Type - genetics | Psoriasis - genetics | Adult | Dendritic Cells - metabolism | Skin - pathology | Intercellular Signaling Peptides and Proteins | Receptors, Chemokine - metabolism | Cells, Cultured | Dermatitis, Atopic - pathology | Receptors, Chemokine - immunology | Membrane Glycoproteins - genetics | Chemokine CXCL10 - genetics | CD8-Positive T-Lymphocytes - drug effects | Dendritic Cells - cytology | Dermatitis, Atopic - metabolism | Receptors, Immunologic - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0161803 - e0161803
We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for... 
OVEREXPRESSION | STEM-CELLS | ACTIVATION | MULTIPARAMETRIC OPTIMIZATION | MULTIDISCIPLINARY SCIENCES | NMR SPECTROSCOPIC ANALYSIS | MULTIDRUG-RESISTANCE | ENERGY-METABOLISM | HYPOXIA | CANCER | P-31 | Melanoma - metabolism | Magnetic Resonance Spectroscopy | Humans | Gene Expression Regulation, Neoplastic | Alanine - metabolism | Melanoma - pathology | Metabolomics - methods | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Amino Acids - metabolism | Pilot Projects | Lactates - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Melanoma - genetics | Glycerylphosphorylcholine - metabolism | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Glucose - metabolism | Biomarkers, Tumor - genetics | Cell Membrane - metabolism | Phosphatidylethanolamines - metabolism | Phospholipids - metabolism | Cell metabolism | Physiological aspects | Genetic aspects | Research | Binding proteins | Melanoma | Energy metabolism | Nuclear magnetic resonance--NMR | Lung cancer | Amino acids | Lipids | Phospholipids | Glucose | Drug resistance | Cell surface | Magnetic resonance spectroscopy | Metabolites | Energy | Spectrum analysis | Interleukin 1 | Inhibition | Lipid metabolism | Water chemistry | Alanine | Degradation products | Statistical analysis | Cold | Phosphorus | Breast cancer | Metabolism | Gene expression | Acids | Stem cells | Glycolysis | Monoclonal antibodies | Hypoxia | Lactic acid | NMR spectroscopy | Surface markers | Tumors | Index Medicus | Life Sciences | Cellular Biology | Nuclear magnetic resonance | NMR
Journal Article