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Journal Article
Nature, ISSN 0028-0836, 2011, Volume 474, Issue 7351, pp. 385 - 389
Live vaccines have long been known to trigger far more vigorous immune responses than their killed counterparts(1-6). This has been attributed to the ability... 
TRANSCRIPTION FACTORS | PHAGOSOME | PROTECTIVE IMMUNITY | ACTIVATION | T-CELL RESPONSES | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INFLAMMASOME | TOLL-LIKE RECEPTORS | INNATE | REGULATORS | Phagosomes - microbiology | RNA, Messenger - immunology | Inflammasomes - metabolism | Interferon-beta - immunology | Bacterial Vaccines - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Adaptor Proteins, Vesicular Transport - deficiency | Microbial Viability - immunology | Bacteria - immunology | Phagosomes - immunology | Interferon-beta - genetics | RNA, Bacterial - genetics | Macrophages - immunology | Macrophages - microbiology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Microbial Viability - genetics | Adaptor Proteins, Vesicular Transport - immunology | Macrophages - cytology | Bacteria - genetics | Virulence Factors | Immunity, Innate - immunology | Vaccines, Attenuated - immunology | Vaccines, Inactivated - immunology | Animals | Carrier Proteins - metabolism | Bacterial Vaccines - immunology | Inflammasomes - immunology | Dendritic Cells - microbiology | RNA, Bacterial - immunology | Antibodies, Bacterial - immunology | Bacteria - pathogenicity | Dendritic Cells - cytology | Mice | Phagocytosis | Vaccines, Attenuated - genetics | Proteins | Bacteria | Microbiology | Kinases | Immune system | Index Medicus | toll-like receptors | transcription factors | inflammasome | innate | recognition | phagosome | t-cell responses | activation | regulators | protective immunity
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2013, Volume 110, Issue 24, pp. E2209 - E2218
Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple... 
Carbohydrates | Animal models | Infectious diseases | Malaria | Immunotherapy | carbohydrates | UNITED-STATES | animal models | PNEUMOCOCCAL DISEASE | ACTINOMYCETEMCOMITANS | MULTIDISCIPLINARY SCIENCES | infectious diseases | malaria | DISPERSIN-B | CONJUGATE VACCINES | immunotherapy | RESISTANCE | STAPHYLOCOCCUS-AUREUS | HUMAN MONOCLONAL-ANTIBODIES | MOLECULAR-BASIS | POLYSACCHARIDE | Plasmodium berghei - immunology | Gram-Positive Bacteria - physiology | Acetylglucosamine - immunology | Plasmodium berghei - physiology | Bacterial Capsules - metabolism | Humans | Antibodies, Bacterial - pharmacology | Mycoses - microbiology | Host-Pathogen Interactions - drug effects | Gram-Negative Bacteria - immunology | Host-Pathogen Interactions - immunology | Fungi - immunology | Time Factors | Bacterial Infections - immunology | Immunoglobulin G - immunology | Fungi - physiology | Immunoglobulin G - pharmacology | Gram-Positive Bacteria - immunology | Gram-Negative Bacteria - physiology | Antibodies, Monoclonal - immunology | Bacterial Infections - microbiology | Staphylococcus aureus - metabolism | Mycoses - prevention & control | Opsonin Proteins - immunology | Antibodies, Monoclonal - pharmacology | Malaria - immunology | Mice, Inbred C57BL | Protein Binding - immunology | Malaria - prevention & control | Bacterial Infections - prevention & control | Animals | Malaria - parasitology | Survival Analysis | Antibodies, Bacterial - immunology | Staphylococcus aureus - immunology | Mice | Mycoses - immunology | Bacterial Capsules - immunology | Proteins | Pathogens | Eukaryotes | Microbiology | Prokaryotes | Staphylococcus infections | Cell adhesion & migration | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 44, pp. 19002 - 19007
Extracellular vesicle production is a ubiquitous process in Gram-negative bacteria, but little is known about such process in Gram-positive bacteria. We report... 
Bacillus anthracis | Antigens | Anthrax | Toxicity | Gram positive bacteria | Antibodies | Toxins | Macrophages | Fatty acids | Gram negative bacteria | Passive immunity | Immunizations | Monoclonal antibody | OUTER-MEMBRANE | passive immunity | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC CELLS | MONOCLONAL-ANTIBODY | SHIGELLA-FLEXNERI | GRAM-NEGATIVE BACTERIA | immunizations | PSEUDOMONAS-AERUGINOSA | CRYPTOCOCCUS-NEOFORMANS | STAPHYLOCOCCUS-AUREUS | POSITIVE BACTERIA | monoclonal antibody | ADENYLATE-CYCLASE | Membrane Glycoproteins - metabolism | Antigens, Bacterial - immunology | Antibodies, Bacterial - pharmacology | Cell Membrane Structures - immunology | Immunoglobulin M - immunology | Immunoglobulin M - metabolism | Bacillus anthracis - ultrastructure | Anthrax - prevention & control | Cell Membrane Structures - metabolism | Bacterial Proteins - immunology | Membrane Glycoproteins - immunology | Bacillus anthracis - genetics | Anthrax - pathology | Bacillus anthracis - metabolism | Antibodies, Monoclonal - immunology | Macrophages - immunology | Macrophages - microbiology | Cell Membrane Structures - genetics | Anthrax - immunology | Anthrax - epidemiology | Antibodies, Monoclonal - pharmacology | Bacterial Toxins - immunology | Bacterial Proteins - genetics | Anthrax - metabolism | Membrane Glycoproteins - genetics | Particle Size | Bacterial Toxins - metabolism | Cell Membrane Structures - ultrastructure | Macrophages - metabolism | Animals | Bacillus anthracis - immunology | Antibodies, Bacterial - immunology | Bacterial Proteins - metabolism | Mice | Mice, Inbred BALB C | Antigens, Bacterial - metabolism | Bacterial toxins | Monoclonal antibodies | Cellular immunity | Research | Properties | Health aspects | Gram-positive bacteria | Membranes | Bacteriology | Cells | Immune system | Index Medicus | Biological Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2015, Volume 194, Issue 4, pp. 1763 - 1775
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 11/2010, Volume 51, Issue 10, pp. 1127 - 1137
Background. In the absence of an efficacious broadly protective vaccine, serogroup B Neisseria meningitidis (MenB) is the leading cause of bacterial meningitis... 
Antigens | Immune response | Vaccination | Vaccine components | Antibodies | Experimentation | Neisseria meningitidis | ARTICLES AND COMMENTARIES | Dosage | Epidemiology | Blood | UNITED-STATES | INFECTIOUS DISEASES | NEW-ZEALAND | PROTECTION | NEISSERIA-MENINGITIDIS | COMPONENTS | ANTIBODY | MICROBIOLOGY | IMMUNOLOGY | MENINGITIDIS GROUP-B | IMMUNOGENICITY | BACTERICIDAL ACTIVITY | NADA | Adhesins, Bacterial - genetics | Humans | Antigens, Bacterial - immunology | Neisseria meningitidis, Serogroup B - immunology | Infant | Male | Neisseria meningitidis, Serogroup B - genetics | Vaccines, Synthetic - immunology | Meningococcal Vaccines - adverse effects | Meningitis, Meningococcal - immunology | Neisseria meningitidis, Serogroup B - chemistry | Vaccines, Synthetic - adverse effects | Drug-Related Side Effects and Adverse Reactions | Female | Immunization Schedule | Antibodies, Bacterial - blood | Bacterial Outer Membrane Proteins - genetics | Serum Bactericidal Antibody Assay | Bacterial Outer Membrane Proteins - immunology | United Kingdom | Meningitis, Meningococcal - prevention & control | Cell Membrane - immunology | Meningococcal Vaccines - immunology | Vaccines, Synthetic - administration & dosage | Adhesins, Bacterial - immunology | Meningococcal Vaccines - administration & dosage | Prevention | Infants (Newborn) | Bacterial meningitis | Research | Demographic aspects | Diseases | Disease prevention | Proteins | Membranes | Immunization | Infectious diseases | Clinical trials | Meningitis | Vaccines | Gram-negative bacteria | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2007, Volume 178, Issue 4, pp. 2171 - 2181
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2014, Volume 289, Issue 26, pp. 18008 - 18021
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2006, Volume 177, Issue 1, pp. 501 - 510
Neisseria meningitidis binds factor H (M), a key regulator of the alternative complement pathway. A similar to 29 kD fH-binding protein expressed in the... 
MOLECULAR-MECHANISM | OUTER-MEMBRANE PROTEINS | GENETIC-ANALYSIS | AMPLIFICATION CONVERTASE | SEROGROUP-B | DEFICIENCY STATES | SIALIC-ACID | IMMUNOLOGY | BACTERICIDAL ANTIBODIES | MONOCLONAL-ANTIBODIES | B NEISSERIA-MENINGITIDIS | Complement Factor H - antagonists & inhibitors | Vaccines, DNA - genetics | Neisseria meningitidis - metabolism | Humans | Antigens, Bacterial - immunology | Porins - metabolism | Vaccines, DNA - immunology | Molecular Sequence Data | Antigens, Bacterial - genetics | Blood Bactericidal Activity - genetics | Genetic Variation | Neisseria meningitidis - immunology | Gene Deletion | Adjuvants, Immunologic - metabolism | Adjuvants, Immunologic - genetics | Adult | Neisseria meningitidis - genetics | Bacterial Proteins - immunology | Complement Pathway, Alternative - genetics | Binding, Competitive - immunology | Amino Acid Sequence | Complement Factor H - immunology | Meningococcal Vaccines - genetics | Bacterial Adhesion - immunology | Meningococcal Vaccines - metabolism | Bacterial Proteins - genetics | Blood Bactericidal Activity - immunology | Complement Factor H - metabolism | Bacterial Outer Membrane Proteins - metabolism | Complement Pathway, Alternative - immunology | Bacterial Proteins - metabolism | Ligands | Antibodies, Monoclonal - metabolism | Meningococcal Vaccines - immunology | Binding Sites, Antibody | Vaccines, DNA - metabolism | Antigens, Bacterial - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 44, pp. 6030 - 6040
Highlights • A novel safe and efficacious anthrax live vaccine based on the Sterne strain was generated. • This vaccine exhibits disruption of htrA and cya... 
Allergy and Immunology | Anthrax toxins | Bacillus anthracis | HtrA | Anthrax | Live attenuated vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | VIRULENCE DETERMINANT | TOXIN | EDEMA FACTOR | GUINEA-PIGS | IMMUNOLOGY | LETHAL FACTOR | ANIMAL-MODELS | CANDIDATES | PROTEOMIC ANALYSIS | PROTECTIVE ANTIGEN | Genes, Bacterial - genetics | Humans | Antigens, Bacterial - immunology | Antigens, Bacterial - genetics | Mutation - immunology | Anthrax Vaccines - immunology | Anthrax - prevention & control | Genes, Bacterial - immunology | Vaccination - methods | Virulence - genetics | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Bacterial Toxins - genetics | Female | Bacterial Proteins - immunology | Bacillus anthracis - genetics | Anthrax Vaccines - genetics | Rabbits | Guinea Pigs | Anthrax - immunology | Bacterial Toxins - immunology | Bacterial Proteins - genetics | Mutation - genetics | Mice, Inbred ICR | Vaccines, Attenuated - immunology | Animals | Spores, Bacterial - genetics | Virulence - immunology | Bacillus anthracis - immunology | Antibodies, Bacterial - immunology | Spores, Bacterial - immunology | Mice | Vaccines, Attenuated - genetics | Anthrax vaccine | Genes | Genetic aspects | Antigens | Molecular genetics | Analysis | Vaccination | Genetic research | Temperature requirements | Animal models | Pathogenesis | Virulence | Infections | Immune status | Vaccines | High temperature | Lethal factor | Veterinary medicine | Immunity | Proteins | Bacteria | Attenuation | Public health | Edema | Immunization | Immune response | Immune systems | LEF protein | Protective antigen | Guinea pigs | Mutation | Respiration | Index Medicus
Journal Article