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Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19512 - 19526
The incidence of multidrug-resistant Enterococcus faecium hospital infections has been steadily increasing. With the goal of discovering new vaccine antigens,... 
CAPSULAR POLYSACCHARIDE | NOSOCOMIAL PATHOGEN | VANCOMYCIN-RESISTANT | LEGIONAMINIC ACID | PNEUMOCOCCAL CONJUGATE | CELL-WALL | LIPOTEICHOIC ACID | GENE-CLUSTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAPHYLOCOCCUS-AUREUS | GENOME ANALYSIS | Fructans - chemistry | Gram-Positive Bacterial Infections - immunology | Enterococcus faecium - immunology | Immune Sera - chemistry | Bacterial Vaccines - genetics | Humans | Antigens, Bacterial - immunology | Bacterial Proteins - chemistry | Molecular Sequence Data | Teichoic Acids - chemistry | Lipopolysaccharides - immunology | Sialic Acids - chemistry | Bacterial Load - drug effects | Anti-Bacterial Agents - therapeutic use | Antibodies, Bacterial - biosynthesis | Drug Resistance, Multiple, Bacterial | Gram-Positive Bacterial Infections - microbiology | Opsonin Proteins - chemistry | Female | Vaccines, Conjugate | Bacterial Proteins - immunology | Bacterial Vaccines - biosynthesis | Sialic Acids - immunology | Antibodies, Bacterial - blood | Disease Models, Animal | Carbohydrate Sequence | Uronic Acids - immunology | Rabbits | Antigens, Bacterial - chemistry | Opsonin Proteins - immunology | Teichoic Acids - immunology | Enterococcus faecium - chemistry | Fructans - immunology | Gram-Positive Bacterial Infections - blood | Uronic Acids - chemistry | Animals | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Lipopolysaccharides - chemistry | Mice | Gram-Positive Bacterial Infections - prevention & control | Enterococcus | vaccine | carbohydrate structure | antigen | Microbiology | teichoic acid
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 24, pp. E2209 - E2218
...)-linked poly-N-acetyl-D-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphylococcus aureus or polyglucosamine in selected Gram-negative bacterial pathogens... 
Carbohydrates | Animal models | Infectious diseases | Malaria | Immunotherapy | carbohydrates | UNITED-STATES | animal models | PNEUMOCOCCAL DISEASE | ACTINOMYCETEMCOMITANS | MULTIDISCIPLINARY SCIENCES | infectious diseases | malaria | DISPERSIN-B | CONJUGATE VACCINES | immunotherapy | RESISTANCE | STAPHYLOCOCCUS-AUREUS | HUMAN MONOCLONAL-ANTIBODIES | MOLECULAR-BASIS | POLYSACCHARIDE | Plasmodium berghei - immunology | Gram-Positive Bacteria - physiology | Acetylglucosamine - immunology | Plasmodium berghei - physiology | Bacterial Capsules - metabolism | Humans | Antibodies, Bacterial - pharmacology | Mycoses - microbiology | Host-Pathogen Interactions - drug effects | Gram-Negative Bacteria - immunology | Host-Pathogen Interactions - immunology | Fungi - immunology | Time Factors | Bacterial Infections - immunology | Immunoglobulin G - immunology | Fungi - physiology | Immunoglobulin G - pharmacology | Gram-Positive Bacteria - immunology | Gram-Negative Bacteria - physiology | Antibodies, Monoclonal - immunology | Bacterial Infections - microbiology | Staphylococcus aureus - metabolism | Mycoses - prevention & control | Opsonin Proteins - immunology | Antibodies, Monoclonal - pharmacology | Malaria - immunology | Mice, Inbred C57BL | Protein Binding - immunology | Malaria - prevention & control | Bacterial Infections - prevention & control | Animals | Malaria - parasitology | Survival Analysis | Antibodies, Bacterial - immunology | Staphylococcus aureus - immunology | Mice | Mycoses - immunology | Bacterial Capsules - immunology | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 44, pp. 19002 - 19007
.... anthracis vesicles formed at the outer layer of the bacterial cell had double-membrane spheres and ranged from 50 to 150 nm in diameter... 
Bacillus anthracis | Antigens | Anthrax | Toxicity | Gram positive bacteria | Antibodies | Toxins | Macrophages | Fatty acids | Gram negative bacteria | Passive immunity | Immunizations | Monoclonal antibody | OUTER-MEMBRANE | passive immunity | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC CELLS | MONOCLONAL-ANTIBODY | SHIGELLA-FLEXNERI | GRAM-NEGATIVE BACTERIA | immunizations | PSEUDOMONAS-AERUGINOSA | CRYPTOCOCCUS-NEOFORMANS | STAPHYLOCOCCUS-AUREUS | POSITIVE BACTERIA | monoclonal antibody | ADENYLATE-CYCLASE | Membrane Glycoproteins - metabolism | Antigens, Bacterial - immunology | Antibodies, Bacterial - pharmacology | Cell Membrane Structures - immunology | Immunoglobulin M - immunology | Immunoglobulin M - metabolism | Bacillus anthracis - ultrastructure | Anthrax - prevention & control | Cell Membrane Structures - metabolism | Bacterial Proteins - immunology | Membrane Glycoproteins - immunology | Bacillus anthracis - genetics | Anthrax - pathology | Bacillus anthracis - metabolism | Antibodies, Monoclonal - immunology | Macrophages - immunology | Macrophages - microbiology | Cell Membrane Structures - genetics | Anthrax - immunology | Anthrax - epidemiology | Antibodies, Monoclonal - pharmacology | Bacterial Toxins - immunology | Bacterial Proteins - genetics | Anthrax - metabolism | Membrane Glycoproteins - genetics | Particle Size | Bacterial Toxins - metabolism | Cell Membrane Structures - ultrastructure | Macrophages - metabolism | Animals | Bacillus anthracis - immunology | Antibodies, Bacterial - immunology | Bacterial Proteins - metabolism | Mice | Mice, Inbred BALB C | Antigens, Bacterial - metabolism | Bacterial toxins | Monoclonal antibodies | Cellular immunity | Research | Properties | Health aspects | Biological Sciences
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2007, Volume 178, Issue 4, pp. 2171 - 2181
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 30, Issue 34, pp. 5099 - 5109
Highlights ► Vaccination against Staphylococcus aureus is achieved with toxoids. ► Toxoids are >107 inactivated and stimulate immunity to S. aureus . ►... 
Allergy and Immunology | Superantigen | Vaccine | Rabbit Model | Cytolysin | Staphylococcus aureus | ENTEROTOXIN-F | MEDICINE, RESEARCH & EXPERIMENTAL | BETA-TOXIN | STREPTOCOCCAL PYROGENIC EXOTOXIN | ALPHA-TOXIN | IMMUNOLOGY | VIRULENCE | METHICILLIN-RESISTANT | MEDICAL PROGRESS | PANTON-VALENTINE LEUKOCIDIN | TOXIC-SHOCK-SYNDROME | INFECTIVE ENDOCARDITIS | Hemolysin Proteins - immunology | Adjuvants, Immunologic - administration & dosage | Superantigens - administration & dosage | Humans | Vaccination | Cytotoxins - administration & dosage | Male | Neutralization Tests | Pneumonia, Staphylococcal - microbiology | Shock, Septic - immunology | Shock, Septic - therapy | Hemolysin Proteins - administration & dosage | Endocarditis, Bacterial - microbiology | Female | Bacterial Proteins - immunology | Staphylococcal Infections - microbiology | Staphylococcal Toxoid - immunology | Staphylococcal Vaccines - immunology | Antibodies, Bacterial - blood | Pneumonia, Staphylococcal - immunology | Cell Line | Rabbits - immunology | Staphylococcal Infections - immunology | Bacterial Toxins - immunology | Exotoxins - immunology | Pneumonia, Staphylococcal - therapy | Endocarditis, Bacterial - immunology | Superantigens - immunology | Staphylococcus aureus - pathogenicity | Shock, Septic - microbiology | Staphylococcal Infections - therapy | Animals | Staphylococcal Toxoid - administration & dosage | Antibody Formation | Antibodies, Bacterial - immunology | Bacterial Toxins - administration & dosage | Staphylococcus aureus - immunology | Rabbits - microbiology | Cytotoxins - immunology | CD40 Antigens - immunology | Endocarditis, Bacterial - therapy | Rabbits | Medical colleges | Biological products | Staphylococcus aureus infections | Antibodies | Septic shock | Sulfates | T cells | Viral antibodies | Surface active agents | Immunotherapy | Mitogens | Index Medicus
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 44, pp. 6030 - 6040
... anthracis is an obligate pathogen in that bacterial reproductive cycles occur only in a suitable host; in nature, it exists in the form of spores that are metabolically... 
Allergy and Immunology | Anthrax toxins | Bacillus anthracis | HtrA | Anthrax | Live attenuated vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | VIRULENCE DETERMINANT | TOXIN | EDEMA FACTOR | GUINEA-PIGS | IMMUNOLOGY | LETHAL FACTOR | ANIMAL-MODELS | CANDIDATES | PROTEOMIC ANALYSIS | PROTECTIVE ANTIGEN | Genes, Bacterial - genetics | Humans | Antigens, Bacterial - immunology | Antigens, Bacterial - genetics | Mutation - immunology | Anthrax Vaccines - immunology | Anthrax - prevention & control | Genes, Bacterial - immunology | Vaccination - methods | Virulence - genetics | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Bacterial Toxins - genetics | Female | Bacterial Proteins - immunology | Bacillus anthracis - genetics | Anthrax Vaccines - genetics | Rabbits | Guinea Pigs | Anthrax - immunology | Bacterial Toxins - immunology | Bacterial Proteins - genetics | Mutation - genetics | Mice, Inbred ICR | Vaccines, Attenuated - immunology | Animals | Spores, Bacterial - genetics | Virulence - immunology | Bacillus anthracis - immunology | Antibodies, Bacterial - immunology | Spores, Bacterial - immunology | Mice | Vaccines, Attenuated - genetics | Anthrax vaccine | Genes | Genetic aspects | Antigens | Molecular genetics | Analysis | Vaccination | Genetic research | Temperature requirements | Animal models | Pathogenesis | Virulence | Infections | Immune status | Vaccines | High temperature | Lethal factor | Veterinary medicine | Immunity | Proteins | Bacteria | Attenuation | Public health | Immune system | Edema | Immunization | Immune response | LEF protein | Protective antigen | Guinea pigs | Mutation | Respiration
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 474, Issue 7351, pp. 385 - 389
Live vaccines have long been known to trigger far more vigorous immune responses than their killed counterparts(1-6). This has been attributed to the ability... 
TRANSCRIPTION FACTORS | PHAGOSOME | PROTECTIVE IMMUNITY | ACTIVATION | T-CELL RESPONSES | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INFLAMMASOME | TOLL-LIKE RECEPTORS | INNATE | REGULATORS | Phagosomes - microbiology | RNA, Messenger - immunology | Inflammasomes - metabolism | Interferon-beta - immunology | Bacterial Vaccines - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Adaptor Proteins, Vesicular Transport - deficiency | Microbial Viability - immunology | Bacteria - immunology | Phagosomes - immunology | Interferon-beta - genetics | RNA, Bacterial - genetics | Macrophages - immunology | Macrophages - microbiology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Microbial Viability - genetics | Adaptor Proteins, Vesicular Transport - immunology | Macrophages - cytology | Bacteria - genetics | Virulence Factors | Immunity, Innate - immunology | Vaccines, Attenuated - immunology | Vaccines, Inactivated - immunology | Animals | Carrier Proteins - metabolism | Bacterial Vaccines - immunology | Inflammasomes - immunology | Dendritic Cells - microbiology | RNA, Bacterial - immunology | Antibodies, Bacterial - immunology | Bacteria - pathogenicity | Dendritic Cells - cytology | Mice | Phagocytosis | Vaccines, Attenuated - genetics | Proteins | Bacteria | Microbiology | Kinases | Immune system | toll-like receptors | transcription factors | inflammasome | innate | recognition | phagosome | t-cell responses | activation | regulators | protective immunity
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0145945
Salmonella enterica serovar Typhi expresses a capsule of Vi polysaccharide, while most Salmonella serovars, including S. Enteritidis and S. Typhimurium, do... 
SERUM RESISTANCE | CELLS | COMPLEMENT | MUTANTS | PROTECTION | MULTIDISCIPLINARY SCIENCES | INVASIVE NONTYPHOIDAL SALMONELLA | POLYSACCHARIDE | Immune Sera - chemistry | Species Specificity | Humans | Antigens, Bacterial - immunology | Salmonella Infections - immunology | Antibodies, Bacterial - pharmacology | Complement Membrane Attack Complex - chemistry | Lipopolysaccharides - antagonists & inhibitors | Lipopolysaccharides - immunology | Polysaccharides, Bacterial - antagonists & inhibitors | Lipopolysaccharides - blood | Typhoid-Paratyphoid Vaccines - antagonists & inhibitors | Antibodies, Bacterial - biosynthesis | Complement C3 - chemistry | Immunity, Humoral | Typhoid-Paratyphoid Vaccines - administration & dosage | Complement Membrane Attack Complex - pharmacology | Immunization | Phagocytosis - drug effects | Salmonella typhimurium - immunology | Phagocytes - drug effects | Phagocytosis - immunology | Polysaccharides, Bacterial - immunology | Salmonella typhi - immunology | Phagocytes - immunology | Salmonella Infections - prevention & control | Bacterial Capsules - chemistry | Typhoid Fever - microbiology | Phagocytes - microbiology | Typhoid-Paratyphoid Vaccines - blood | Polysaccharides, Bacterial - blood | Salmonella Infections - microbiology | Typhoid Fever - prevention & control | Primary Cell Culture | Typhoid Fever - immunology | Complement C3 - pharmacology | Bacterial Capsules - immunology | Typhoid-Paratyphoid Vaccines - immunology | Care and treatment | Typhoid fever | Salmonella typhosa | Dosage and administration | Research | Risk factors | Lipopolysaccharides | Killing | Water-borne diseases | Salmonella | Antigens | Immunoglobulins | Disease | Antibodies | Infections | Complement | Genomes | Vaccines | Typhoid | College campuses | Blood | Fever | Medicine | Complement component C3 | Cross-protection | Public health
Journal Article