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1. Full Text Bispecific antibodies
by Kontermann, Roland E and Brinkmann, Ulrich
Drug discovery today, ISSN 1359-6446, 07/2015, Volume 20, Issue 7, pp. 838 - 847
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Recombinant Proteins - therapeutic use | Antibody Specificity | Immunotherapy - methods | Antineoplastic Agents - immunology | Humans | Anti-Inflammatory Agents - immunology | Antineoplastic Agents - therapeutic use | Epitopes, T-Lymphocyte | Antibodies, Bispecific - immunology | Antibodies, Bispecific - therapeutic use | Animals | Signal Transduction - drug effects | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Anti-Inflammatory Agents - therapeutic use | T-Lymphocytes - immunology | Binding Sites, Antibody | Index Medicus
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2. Full Text Alternative molecular formats and therapeutic applications for bispecific antibodies
by Spiess, Christoph and Zhai, Qianting and Carter, Paul J
Molecular immunology, ISSN 0161-5890, 10/2015, Volume 67, Issue 2, pp. 95 - 106
Antibody therapeutics | Antibody engineering | Bispecific antibodies | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Immunotherapy - methods | Antigens, Neoplasm - immunology | Antineoplastic Agents - immunology | Humans | Antineoplastic Agents - therapeutic use | Cell Adhesion Molecules - immunology | Antibodies, Bispecific - immunology | CD3 Complex - metabolism | Cell Adhesion Molecules - metabolism | Epithelial Cell Adhesion Molecule | Antineoplastic Agents - metabolism | Antibodies, Bispecific - therapeutic use | Models, Immunological | Neoplasms - therapy | Antibodies, Bispecific - metabolism | Neoplasms - immunology | CD3 Complex - immunology | Antigens, Neoplasm - metabolism | Antigens, CD19 - metabolism | Antigens, CD19 - immunology | Viral antibodies | Antibodies | T cells | Health aspects | Antigenic determinants | Index Medicus
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3. Full Text Factor VIII–Mimetic Function of Humanized Bispecific Antibody in Hemophilia A
by Shima, Midori and Hanabusa, Hideji and Taki, Masashi and Matsushita, Tadashi and Sato, Tetsuji and Fukutake, Katsuyuki and Fukazawa, Naoki and Yoneyama, Koichiro and Yoshida, Hiroki and Nogami, Keiji
The New England journal of medicine, ISSN 0028-4793, 05/2016, Volume 374, Issue 21, pp. 2044 - 2053
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Antibodies, Monoclonal, Humanized - therapeutic use | Factor IX - analysis | Antibodies, Bispecific - pharmacology | Hemophilia A - immunology | Humans | Middle Aged | Male | Hemorrhage - prevention & control | Injections, Subcutaneous - adverse effects | Hemophilia A - complications | Dose-Response Relationship, Drug | Antibodies, Bispecific - therapeutic use | Factor X - analysis | Antibodies, Monoclonal, Humanized - blood | Antibodies, Monoclonal, Humanized - pharmacology | Hemorrhage - etiology | Adolescent | Factor VIII - antagonists & inhibitors | Adult | Antibodies, Bispecific - blood | Drug Therapy, Combination | Hemophilia A - drug therapy | Child | Factor VIII - therapeutic use | Immunoglobulins | Inhibitor drugs | Intravenous administration | Body weight | Hemorrhage | Patients | Bleeding | Clotting | Mimicry | Thromboplastin | Coagulation factors | Hemophilia | Alloantibodies | Children | Drug therapy | Bispecific antibodies | Index Medicus | Abridged Index Medicus
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4. Full Text Bispecific antibodies rise again
by Garber, Ken
Nature reviews. Drug discovery, ISSN 1474-1776, 11/2014, Volume 13, Issue 11, pp. 799 - 801
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Antibodies, Bispecific - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | United States | Humans | United States Food and Drug Administration | Index Medicus
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5. Full Text Bispecific antibodies and their applications
by Fan, Gaowei and Wang, Zujian and Hao, Mingju and Li, Jinming
Journal of hematology and oncology, ISSN 1756-8722, 12/2015, Volume 8, Issue 1, pp. 130 - 130
Catumaxomab | Diagnosis | Formats | Bispecific antibody | BiTE | Cancer | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Antibodies, Bispecific - therapeutic use | Neoplasms - therapy | Animals | Lymphocyte Activation - drug effects | Neoplasms - immunology | Neovascularization, Pathologic - drug therapy | T-Lymphocytes - drug effects | Humans | Neoplasms - blood supply | T-Lymphocytes - immunology | Antineoplastic Agents - therapeutic use | Drug Delivery Systems | Index Medicus
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6. Blinatumomab, a Bispecific T-cell Engager (BiTE®) for CD-19 Targeted Cancer Immunotherapy: Clinical Pharmacology and Its Implications
by Zhu, Min and Wu, Benjamin and Brandl, Christian and Johnson, Jessica and Wolf, Andreas and Chow, Andrew and Doshi, Sameer
Clinical pharmacokinetics, ISSN 0312-5963, 10/2016, Volume 55, Issue 10, pp. 1271 - 1288
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Body Weight | Age Factors | Drug Administration Schedule | Humans | Half-Life | Antibodies, Bispecific - pharmacokinetics | Male | Metabolic Clearance Rate | Antineoplastic Agents - therapeutic use | Renal Insufficiency - metabolism | Dose-Response Relationship, Drug | Antibodies, Bispecific - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | B-Lymphocytes - immunology | Cytokines - drug effects | Female | T-Lymphocytes - immunology | Antineoplastic Agents - pharmacokinetics | Lymphoma, Non-Hodgkin - drug therapy
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7. Full Text Bispecific T‐cell engagers for cancer immunotherapy
by Huehls, Amelia M and Coupet, Tiffany A and Sentman, Charles L
Immunology and cell biology, ISSN 0818-9641, 03/2015, Volume 93, Issue 3, pp. 290 - 296
Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Immunotherapy - methods | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Humans | Clinical Trials as Topic | T-Cell Antigen Receptor Specificity - genetics | Cancer Vaccines - therapeutic use | Neoplasms - therapy | Single-Chain Antibodies - metabolism | Animals | Single-Chain Antibodies - genetics | Neoplasms - immunology | Antigens, Neoplasm - metabolism | Protein Binding | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | Cytotoxicity, Immunologic | Index Medicus | blinatumomab | bispecific antibodies | BiTE | T cell re-targeting
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8. Full Text Bispecific antibodies for cancer therapy: A review
by Krishnamurthy, Anuradha and Jimeno, Antonio
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 05/2018, Volume 185, pp. 122 - 134
TrAbs | BiTEs | Catumaxomab | BsAbs | Blinatumomab | Bispecific antibodies | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antibodies, Bispecific - therapeutic use | Antineoplastic Agents - therapeutic use | Animals | Humans | Neoplasms - drug therapy | Drugs | Medical colleges | Care and treatment | Phosphatases | Leukemia | Colorectal cancer | T cells | Lung cancer, Non-small cell | Drug approval | Killer cells | Analysis | Monoclonal antibodies | Lymphomas | Health aspects | Cancer | Index Medicus
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9. Full Text Bispecific antibodies: a mechanistic review of the pipeline
by Labrijn, Aran F and Janmaat, Maarten L and Reichert, Janice M and Parren, Paul W. H. I
Nature reviews. Drug discovery, ISSN 1474-1776, 08/2019, Volume 18, Issue 8, pp. 585 - 608
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Antibodies, Bispecific - therapeutic use | Animals | Neoplasms - immunology | Humans | Drug Design | Antibodies, Bispecific - chemistry | Clinical Trials as Topic | Binding Sites, Antibody | Drug Evaluation, Preclinical | Molecular Targeted Therapy | Antibodies, Bispecific - immunology | Neoplasms - drug therapy | Viral antibodies | Pharmaceutical research | Antibodies | Drug targeting | Research | Health aspects | Identification and classification | Antigens | Pipelines | Index Medicus
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