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Science Translational Medicine, ISSN 1946-6234, 04/2014, Volume 6, Issue 230, pp. 230ra45 - 230ra45
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 05/2018, Volume 20, Issue 5, pp. 1302 - 1305
The aim of the current study (Clinical trial reg. no. NCT02715193, clinicaltrials.gov ) was to study the efficacy and safety of REMD‐477, a glucagon receptor... 
glucose homeostasis | glycaemic control, insulin | diabetes | HYPERGLUCAGONEMIA | insulin | ALPHA CELL HYPERPLASIA | GLUCOSE | ENDOCRINOLOGY & METABOLISM | HYPOGLYCEMIA | glycaemic control | Receptors, Glucagon - antagonists & inhibitors | Drugs, Investigational - adverse effects | Humans | Antibodies, Monoclonal - adverse effects | Diabetes Mellitus, Type 1 - metabolism | Drugs, Investigational - therapeutic use | Antibodies, Monoclonal - therapeutic use | Male | Antibodies, Blocking - administration & dosage | Hypoglycemia - prevention & control | Hypoglycemic Agents - administration & dosage | Injections, Subcutaneous | Adult | Female | Drug Therapy, Combination | Hypoglycemia - chemically induced | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Blood Glucose - analysis | Double-Blind Method | Drug Administration Schedule | Receptors, Glucagon - metabolism | Insulin - administration & dosage | Proof of Concept Study | Diabetes Mellitus, Type 1 - drug therapy | Monitoring, Ambulatory | Antibodies, Blocking - adverse effects | Antibodies, Monoclonal - administration & dosage | Diabetes Mellitus, Type 1 - blood | Antibodies, Blocking - therapeutic use | Hypoglycemic Agents - adverse effects | Insulin - therapeutic use | Viral antibodies | Medical research | Blood sugar monitoring | Glucagon | Type 1 diabetes | Clinical trials | Medicine, Experimental | Antibodies | Glucose | Dextrose | Diabetes therapy | Diabetes mellitus | Diabetes mellitus (insulin dependent) | Diabetes | Insulin | Patients | Index Medicus | glycemic control diabetes
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2009, Volume 15, Issue 19, pp. 6267 - 6276
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2005, Volume 23, Issue 35, pp. 8968 - 8977
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 01/2018, Volume 20, Issue 1, pp. 94 - 102
AimTo test the hypothesis that an improving body composition in insulin-resistant individuals could enhance insulin sensitivity. MethodsA total of 16 people... 
body composition | bimagrumab | HbA1c | insulin resistance | obesity | activin receptor | activin receptor II | RECEPTOR | GLUCOSE-TRANSPORT | FATTY-ACIDS | MUSCLE MASS | BROWN ADIPOSE-TISSUE | EXERCISE | LIRAGLUTIDE | OVERWEIGHT | ENDOCRINOLOGY & METABOLISM | WEIGHT | Glucose Intolerance - metabolism | Glycated Hemoglobin A - analysis | Follow-Up Studies | Obesity - drug therapy | Humans | Antibodies, Monoclonal - adverse effects | Anti-Obesity Agents - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Anti-Obesity Agents - therapeutic use | Glucose Intolerance - blood | Antibodies, Blocking - administration & dosage | Glucose Intolerance - drug therapy | Anti-Obesity Agents - pharmacokinetics | Hypoglycemic Agents - administration & dosage | Female | Obesity - diagnostic imaging | Body Mass Index | Hypoglycemic Agents - therapeutic use | Glucose Tolerance Test | Hypoglycemic Agents - pharmacokinetics | Adiposity - drug effects | Anti-Obesity Agents - administration & dosage | Double-Blind Method | Obesity - complications | Insulin Resistance | Antibodies, Monoclonal - pharmacokinetics | Absorptiometry, Photon | Glucose Intolerance - complications | Obesity - metabolism | Positron Emission Tomography Computed Tomography | Pilot Projects | Antibodies, Blocking - adverse effects | Antibodies, Monoclonal - administration & dosage | Adipose Tissue, Brown - diagnostic imaging | Antibodies, Blocking - therapeutic use | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Glucose Clamp Technique | Infusions, Intravenous | Thermogenesis - drug effects | Hypoglycemic Agents - adverse effects | Exercise | Blood sugar monitoring | Body weight | Physiological aspects | Glycosylated hemoglobin | Insulin resistance | Glucose tolerance tests | Insulin | Glucose tolerance | Dual energy X-ray absorptiometry | Body mass index | Intravenous administration | Body fat | Hemoglobin | Glucose | Positron emission tomography | Body composition | Index Medicus
Journal Article
International Immunopharmacology, ISSN 1567-5769, 03/2015, Volume 25, Issue 1, pp. 74 - 82
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 02/2018, Volume 20, Issue 2, pp. 283 - 291
AimsGlucagon receptor (GCGR) blockers are being investigated as potential therapeutics for type 1 and type 2 diabetes. Here we report the safety, tolerability,... 
phase 1 | glucagon stimulation | REGN | 1193 | GCGR | REGN1193 | ALPHA-CELLS | BLOOD-GLUCOSE | PANCREAS | HYPERPLASIA | ANTAGONIST LY2409021 | ISLET-CELL TUMOR | INSULIN | ENDOCRINOLOGY & METABOLISM | MICE | SECRETION | TYPE-2 DIABETES-MELLITUS | Receptors, Glucagon - antagonists & inhibitors | Follow-Up Studies | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Half-Life | Male | Metabolic Clearance Rate | Antibodies, Blocking - pharmacology | Patient Dropouts | Antibodies, Blocking - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Hypoglycemic Agents - administration & dosage | Adult | Female | Antibodies, Blocking - blood | Hypoglycemic Agents - pharmacokinetics | Lost to Follow-Up | Blood Glucose - analysis | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Receptors, Glucagon - metabolism | Biomarkers - blood | Hypoglycemic Agents - pharmacology | Antibodies, Blocking - adverse effects | Antibodies, Monoclonal - administration & dosage | Infusions, Intravenous | Hypoglycemic Agents - adverse effects | Cohort Studies | Type 2 diabetes | Hyperglycemia | Safety and security measures | Glucagon | Analysis | Therapeutics | Monoclonal antibodies | Glucose | Dextrose | Homeopathy | Materia medica and therapeutics | Food | Lipoproteins (low density) | Pharmacodynamics | Diabetes mellitus | Liver | Diabetes mellitus (insulin dependent) | Hypoglycemia | Plasma levels | Safety | Pharmacokinetics | Diabetes mellitus (non-insulin dependent) | Nonlinear systems | Index Medicus | Original
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 02/2017, Volume 57, Issue 2, pp. 161 - 172
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 6, pp. 1375 - 1387
Journal Article