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PloS one, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131177
Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal antibodies (mAbs... 
RECOMBINANT IMMUNOTOXIN | IMMUNOGENICITY | MULTIDISCIPLINARY SCIENCES | PURIFICATION | SURFACE-PROTEINS | STAPHYLOCOCCUS-AUREUS | ANTITUMOR-ACTIVITY | MONOCLONAL-ANTIBODIES | FRAGMENTATION | CANCER-THERAPY | PROTEIN LIGATION | Cysteine Endopeptidases - chemistry | Staphylococcus aureus - enzymology | Aminoacyltransferases - immunology | Receptor, ErbB-2 - genetics | Humans | Bacterial Proteins - chemistry | Ovarian Neoplasms - pathology | Ki-1 Antigen - immunology | Maytansine - pharmacology | Immunoconjugates - immunology | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Protein Engineering | Maytansine - chemistry | Female | Antineoplastic Agents - pharmacology | Bacterial Proteins - immunology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Oligopeptides - chemistry | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Aminoacyltransferases - chemistry | Antineoplastic Agents - immunology | Maytansine - analogs & derivatives | Antibodies, Monoclonal - pharmacology | Oligopeptides - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Staphylococcus aureus - chemistry | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Ki-1 Antigen - antagonists & inhibitors | Mice | Antibodies, Monoclonal, Humanized - immunology | Cysteine Endopeptidases - immunology | Maytansine - immunology | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Ki-1 Antigen - genetics | Ovarian Neoplasms - immunology | Monoclonal antibodies | Enzymes | Cysteine | Peptides | Biopharmaceutics | Drugs | Conjugates | Addition polymerization | Ovarian carcinoma | Clinical trials | Pentaglycine | Cancer therapies | Molecular weight | Ovarian cancer | Proteins | Tubulin | CD30 antigen | Xenografts | Medical research | Immunoglobulins | Polypeptides | Cloning | Polymerization | Breast cancer | ErbB-2 protein | Substrates | Chemotherapy | Lysine | Heavy chains | Toxins | Conjugation | Sortase | Tumors
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2008, Volume 3, Issue 12, p. e3942
... that provide heterosubtypic protection. METHODS AND FINDINGS: Here we describe a panel of 13 monoclonal antibodies (mAbs... 
BIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Humans | Molecular Sequence Data | Neutralization Tests | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Peptide Library | Immunoglobulin M - immunology | Antibody Specificity - immunology | B-Lymphocytes - virology | Influenza, Human - virology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Immunologic Memory - immunology | Protein Structure, Tertiary | Amino Acid Sequence | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Antibodies, Monoclonal - isolation & purification | Antibodies, Viral - isolation & purification | Cross Reactions | Animals | B-Lymphocytes - immunology | Influenza A Virus, H5N1 Subtype - immunology | Antibodies, Viral - chemistry | Dogs | Hydrophobic and Hydrophilic Interactions | Antibodies, Viral - immunology | Mice | Tissue Donors | Binding Sites, Antibody | Influenza, Human - prevention & control | Influenza, Human - immunology | Immunoglobulin M | Pandemics | Laboratories | Prophylaxis | H alpha line | Viruses | Infections | Vaccines | Hydrophobicity | Avian flu | Proteins | Hemagglutinins | Antigens | Immunological memory | Memory cells | Immunoglobulins | Therapeutic applications | Mortality | Glycoproteins | Antigenic variants | Immune response (humoral) | Lymphocytes B | Neutralizing | Influenza | Monoclonal antibodies | Ligands | Combinatorial analysis
Journal Article
Human antibodies, ISSN 1093-2607, 1997
Journal
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 32, pp. E2987 - E2996
.... To address this limitation, we have developed onartuzumab, an Escherichia coli-derived, humanized, and affinity-matured monovalent monoclonal antibody against MET, generated using the knob-into-hole... 
MetMAb | HGFR | OA5D5 | Scatter factor | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | PHARMACOKINETIC PK | DOSE-ESCALATION | SINGLE-AGENT | scatter factor | C-MET | BINDING-SITE | RECEPTOR MET | MONOCLONAL-ANTIBODIES | Proto-Oncogene Proteins c-met - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Hepatocyte Growth Factor - pharmacology | Antibodies, Monoclonal, Humanized - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Protein Binding - drug effects | Drug Design | Antineoplastic Agents - pharmacology | Hepatocyte Growth Factor - chemistry | Antibodies, Monoclonal - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Immunoglobulin Fab Fragments - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Models, Molecular | Mice, Transgenic | Antineoplastic Agents - chemistry | Mice, SCID | Immunoglobulin Fab Fragments - pharmacology | Mice, Inbred C3H | Hepatocyte Growth Factor - metabolism | Neoplasms - drug therapy | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Antibodies, Monoclonal - genetics | Animals | Mice, Nude | Immunoglobulin Fab Fragments - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Proto-Oncogene Proteins c-met - chemistry | Neoplasms - pathology | Antibodies, Monoclonal, Humanized - chemistry | Biological Sciences | PNAS Plus
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 1580 - 9
Journal Article