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Neurobiology of disease, ISSN 0969-9961, 2015, Volume 79, pp. 81 - 99
.... We describe here the generation and characterization of six novel conformation-specific monoclonal antibodies that recognize specifically α... 
Neurology | α-Synuclein | Conformation-specific monoclonal antibodies | Parkinson’s disease | Dementia with Lewy bodies | Parkinson's disease | NEURODEGENERATIVE DISORDERS | ALZHEIMERS-DISEASE | VESICLE DOCKING | BRAIN PATHOLOGY | NEUROSCIENCES | MULTIPLE SYSTEM ATROPHY | MEMBRANE-BINDING | ELEVATED LEVELS | SOLUBLE OLIGOMERS | alpha-Synuclein | LEWY BODIES | PARKINSONS-DISEASE | gamma-Synuclein - immunology | Membrane Glycoproteins - metabolism | Escherichia coli | Protein Multimerization | alpha-Synuclein - immunology | Neoplasm Proteins - immunology | tau Proteins - metabolism | Neoplasm Proteins - metabolism | Brain - metabolism | gamma-Synuclein - metabolism | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | beta-Synuclein - immunology | Antibodies, Monoclonal - immunology | Recombinant Proteins - metabolism | Parkinson Disease - pathology | Peptide Fragments - metabolism | Lewy Body Disease - pathology | Islet Amyloid Polypeptide - metabolism | Recombinant Proteins - chemistry | Antibodies, Monoclonal - isolation & purification | alpha-Synuclein - chemistry | Lewy Body Disease - metabolism | Animals | Recombinant Proteins - immunology | Alzheimer Disease - metabolism | Brain - pathology | Protein Conformation | Mice | Antibodies, Monoclonal - metabolism | beta-Synuclein - metabolism | alpha-Synuclein - metabolism | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 1532-6535, 2008, Volume 84, Issue 5, pp. 548 - 558
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 12, pp. 1108 - 1118
A monoclonal antibody to PCSK9 was studied in two single-dose trials in healthy volunteers and one multiple-dose trial in patients with familial or nonfamilial hypercholesterolemia... 
POPULATION | MEDICINE, GENERAL & INTERNAL | STATIN | MICE | MUTATIONS | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol
Journal Article
Journal of pharmacokinetics and pharmacodynamics, ISSN 1573-8744, 2011, Volume 39, Issue 1, pp. 67 - 86
...) model capable of characterizing the plasma and tissue pharmacokinetics (PK) of nonspecific or antigen specific monoclonal antibodies (mAbs... 
Biochemistry, general | Biomedical Engineering | Biomedicine | Physiologically based pharmacokinetic | Pharmacy | Tissue disposition | FcRn | Veterinary Medicine | Interspecies scaling | Monoclonal antibody | Pharmacology/Toxicology | PHARMACOKINETIC MODEL | SERUM HALF-LIVES | IGG ANTIBODIES | NEONATAL FC-RECEPTOR | EPITHELIAL-CELLS | I-RELATED RECEPTOR | DRUG DEVELOPMENT | PHARMACOLOGY & PHARMACY | RETROSPECTIVE ANALYSIS | IMMUNOGLOBULIN-G | DOSE ESTIMATION | Neoplasms - metabolism | Tissue Distribution - physiology | Area Under Curve | Humans | Receptors, Fc - metabolism | Immunoglobulins, Intravenous - administration & dosage | Male | Blood - metabolism | Endosomes - metabolism | Antibodies, Monoclonal - blood | Histocompatibility Antigens Class I - metabolism | Immunoglobulins, Intravenous - metabolism | Extracellular Space - metabolism | Antibodies, Monoclonal, Humanized - pharmacokinetics | Lymph - metabolism | Antibodies, Monoclonal, Humanized - blood | Antibodies, Monoclonal - immunology | Drug Evaluation, Preclinical - methods | Tissue Distribution - drug effects | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacokinetics | Rats | Histocompatibility Antigens Class I - genetics | Immunoglobulins, Intravenous - pharmacology | Haplorhini | Mice, Knockout | Xenograft Model Antitumor Assays | Algorithms | Animals | Pinocytosis - physiology | Models, Biological | Neoplasms - immunology | Receptors, Fc - genetics | Mice | Antibodies, Monoclonal - metabolism | Adalimumab | Animal Structures - metabolism | Physiological aspects | Monoclonal antibodies | Immunoglobulins | Immunity | Tumors | Endothelium
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 10/2018, Volume 84, Issue 10, pp. 2292 - 2302
... through changes in systemic inflammation, which alters CYP metabolism, have been well documented... 
disease–drug interaction | interleukin‐23 | tildrakizumab | high‐affinity humanized IgG1k antibody | cytochrome P450 | psoriasis | high-affinity humanized IgG1k antibody | interleukin-23 | TRANSPORTERS | disease-drug interaction | MECHANISMS | COMBINED PHENOTYPIC ASSESSMENT | INTERLEUKIN-6 | PROTEIN-DRUG INTERACTIONS | ENZYMES | INFLAMMATION | N-ACETYLTRANSFERASE-2 | PHARMACOLOGY & PHARMACY | EXPRESSION | XANTHINE-OXIDASE ACTIVITIES | Interleukin-23 Subunit p19 - antagonists & inhibitors | Caffeine - administration & dosage | Humans | Middle Aged | Psoriasis - diagnosis | Cytochrome P-450 Enzyme System - metabolism | Midazolam - administration & dosage | Antibodies, Monoclonal - therapeutic use | Male | Warfarin - administration & dosage | Caffeine - pharmacokinetics | Young Adult | Antibodies, Monoclonal, Humanized | Drug Interactions | Injections, Subcutaneous | Psoriasis - metabolism | Adult | Female | Dextromethorphan - pharmacokinetics | Psoriasis - immunology | Severity of Illness Index | Psoriasis - drug therapy | Administration, Oral | Omeprazole - administration & dosage | Antibodies, Monoclonal - pharmacokinetics | Omeprazole - pharmacokinetics | Treatment Outcome | Midazolam - pharmacokinetics | Warfarin - pharmacokinetics | Antibodies, Monoclonal - administration & dosage | Interleukin-23 Subunit p19 - immunology | Dextromethorphan - administration & dosage | Medical research | C-reactive protein | Biological products | Psoriasis | Dermatology | Cytochrome P-450 | Dermatologic agents | Anticoagulants (Medicine) | Rheumatoid factor | Metabolites | Interleukins | Formulae, receipts, prescriptions | Physiological aspects | Monoclonal antibodies | Medicine, Experimental | Caffeine | Original
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2014, Volume 383, Issue 1-2, pp. 111 - 117
Journal Article
Gut, ISSN 0017-5749, 12/2012, Volume 61, Issue 12, pp. 1693 - 1700
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 12, p. e0143520
...: activating or inhibitory. In this study, we systematically analyze effector functions of monoclonal IgG1 and its eight enzymatically engineered glycosylation variants... 
THERMAL-STABILITY |