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1994, Handbook of experimental pharmacology, ISBN 9783540571230, Volume 113., xxi, 406
Book
The New England Journal of Medicine, ISSN 0028-4793, 08/2009, Volume 361, Issue 8, pp. 745 - 755
Men receiving androgen-deprivation therapy for nonmetastatic prostate cancer are at high risk for bone loss and fractures. This placebo-controlled study... 
ZOLEDRONIC ACID | MEDICINE, GENERAL & INTERNAL | PLACEBO | BONE-MINERAL DENSITY | FRACTURES | RISK | COMPLICATIONS | RANDOMIZED CONTROLLED-TRIAL | POSTMENOPAUSAL WOMEN | OSTEOPOROSIS | ALENDRONATE | Lumbar Vertebrae - injuries | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Fractures, Bone - epidemiology | Antibodies, Monoclonal - therapeutic use | Male | Osteoporosis - drug therapy | Prostatic Neoplasms - physiopathology | Bone Remodeling - drug effects | Incidence | Antibodies, Monoclonal, Humanized | Spinal Fractures - prevention & control | RANK Ligand - pharmacology | Injections, Subcutaneous | Aged, 80 and over | RANK Ligand - therapeutic use | Gonadotropin-Releasing Hormone - agonists | Lumbar Vertebrae - physiology | Prostatic Neoplasms - drug therapy | RANK Ligand - adverse effects | Osteoporosis - chemically induced | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Prostatic Neoplasms - surgery | Antibodies, Monoclonal - pharmacology | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Lumbar Vertebrae - drug effects | Denosumab | Bone Density Conservation Agents - pharmacology | Orchiectomy | Bone Density - drug effects | Androgen Antagonists - therapeutic use | Aged | Androgen Antagonists - adverse effects | Fractures, Bone - prevention & control | Osteoporosis | Bone density | Prostate cancer | Older people | Men | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2013, Volume 110, Issue 32, pp. E2987 - E2996
Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated in the malignant process of multiple cancers, making disruption of... 
MetMAb | HGFR | OA5D5 | Scatter factor | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | PHARMACOKINETIC PK | DOSE-ESCALATION | SINGLE-AGENT | scatter factor | C-MET | BINDING-SITE | RECEPTOR MET | MONOCLONAL-ANTIBODIES | Proto-Oncogene Proteins c-met - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Hepatocyte Growth Factor - pharmacology | Antibodies, Monoclonal, Humanized - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Protein Binding - drug effects | Drug Design | Antineoplastic Agents - pharmacology | Hepatocyte Growth Factor - chemistry | Antibodies, Monoclonal - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Immunoglobulin Fab Fragments - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Models, Molecular | Mice, Transgenic | Antineoplastic Agents - chemistry | Mice, SCID | Immunoglobulin Fab Fragments - pharmacology | Mice, Inbred C3H | Hepatocyte Growth Factor - metabolism | Neoplasms - drug therapy | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Antibodies, Monoclonal - genetics | Animals | Mice, Nude | Immunoglobulin Fab Fragments - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Proto-Oncogene Proteins c-met - chemistry | Neoplasms - pathology | Antibodies, Monoclonal, Humanized - chemistry | Prescription drugs | Antigens | Phosphorylation | Monoclonal antibodies | Biochemistry | Binding sites | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3270 - 3275
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e90353 - e90353
Background: In advanced cancers, transforming growth factor-beta (TGFb) promotes tumor growth and metastases and suppresses host antitumor immunity. GC1008 is... 
SURVIVAL | EPITHELIAL-MESENCHYMAL TRANSDIFFERENTIATION | INHIBITION | SOLID TUMORS | EFFICACY | VIVO | MULTIDISCIPLINARY SCIENCES | METASTATIC BREAST-CANCER | KERATOACANTHOMAS | T-CELLS | PROGRESSION | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Positron-Emission Tomography | Kidney Neoplasms - diagnosis | Aged, 80 and over | Transforming Growth Factor beta - antagonists & inhibitors | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Renal Cell - drug therapy | Carcinoma, Renal Cell - pathology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | Melanoma - pathology | Transforming Growth Factor beta - blood | Carcinoma, Renal Cell - diagnosis | Melanoma - drug therapy | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Neoplasm Staging | Oncology, Experimental | Melanoma | Clinical trials | Monoclonal antibodies | Bone morphogenetic proteins | Research | Carcinoma, Renal cell | Metastasis | Transforming growth factors | Cancer | Intravenous administration | Toxicity | Transforming growth factor-b | Medical treatment | Transforming growth factor-a | Pharmacology | Patients | Immunity | Constraining | Metastases | Anticancer properties | Isoforms | Biomarkers | Antitumor activity | Bioindicators | Safety | Clear cell-type renal cell carcinoma | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2014, Volume 370, Issue 5, pp. 412 - 420
Journal Article
Circulation, ISSN 0009-7322, 09/2012, Volume 126, Issue 10, pp. 1256 - 1266
Background-CD4+CD25+Foxp3+ regulatory T cells (Tregs) attenuate atherosclerosis, but their therapeutic application by adoptive transfer is limited by the need... 
atherosclerosis | inflammation | cytokines | CARDIAC & CARDIOVASCULAR SYSTEMS | DENDRITIC CELLS | SUBSETS | E KNOCKOUT MICE | LESIONS | AGGRAVATES ATHEROSCLEROSIS | SMOOTH-MUSCLE | INTERFERON-GAMMA | MEDIATED SUPPRESSION | PERIPHERAL VASCULAR DISEASE | IN-VIVO EXPANSION | HEMATOLOGY | E-DEFICIENT MICE | T-Lymphocytes, Regulatory - metabolism | Dose-Response Relationship, Immunologic | Antigen-Antibody Complex - pharmacology | Male | T-Lymphocytes, Regulatory - immunology | Antibodies, Neutralizing - immunology | Interleukin-2 - immunology | Cell Division - immunology | Dietary Fats - pharmacology | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Antibodies, Monoclonal - immunology | Disease Models, Animal | Biomarkers - metabolism | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Antibodies, Monoclonal - pharmacology | Antibodies, Neutralizing - pharmacology | Cell Division - drug effects | Disease Progression | T-Lymphocytes, Regulatory - drug effects | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Apolipoproteins E - genetics | Interleukin-2 - pharmacology | Mice | Antigen-Antibody Complex - immunology | CD4 Antigens - metabolism | Development and progression | Interleukin-2 | Research | T cells | Analysis | Atherosclerosis | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 515, Issue 7525, pp. 138 - 142
The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in... 
B-CELLS | SPECIFICITIES | MULTIDISCIPLINARY SCIENCES | SERA | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENV TRIMERS | VULNERABILITY | GP120 | HUMAN MONOCLONAL-ANTIBODIES | CLEAVAGE | DEPENDENT EPITOPE | Immunoglobulin Fab Fragments - ultrastructure | Antibody Specificity | Epitope Mapping | HIV Envelope Protein gp41 - immunology | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Leukocytes, Mononuclear | HIV Envelope Protein gp41 - chemistry | Virus Internalization - drug effects | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Receptors, CCR5 - metabolism | HIV Antibodies - immunology | Conserved Sequence | Inhibitory Concentration 50 | HIV Envelope Protein gp120 - chemistry | HIV Antibodies - pharmacology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Cell Line | Immunoglobulin Fab Fragments - genetics | HIV-1 - drug effects | Antibodies, Monoclonal - pharmacology | Models, Molecular | Antibodies, Neutralizing - pharmacology | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Antibodies, Monoclonal - genetics | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | Cell Membrane - virology | Epitopes - chemistry | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | CD4 Antigens - metabolism | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Genetic aspects | Research | HIV infection | Antigenic determinants | Amino acids |