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Immunopharmacology and immunotoxicology, ISSN 0892-3973, 1987
Journal
Clinical pharmacology and therapeutics, ISSN 1532-6535, 2008, Volume 84, Issue 5, pp. 548 - 558
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 04/2019, Volume 10, p. 363
.... The demonstrated pivotal role of calcitonin gene-related peptide (CGRP) has fostered the development of CGRP antagonists, unfortunately endowed with liver toxicity, and monoclonal... 
treatment | migraine | anti-CGRP | monoclonal antibodies anti-CGRP | RECEPTOR | ERENUMAB | TRIAL | PHARMACOKINETICS | DRUGS | PHARMACOLOGY & PHARMACY | CHANNELS | CGRP | pharmacology of migraine | Monoclonal antibodies | Peptides | Drug therapy | Migraine | Calcitonin | Genes
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 361, Issue 8, pp. 745 - 755
.... This placebo-controlled study investigated the effects of denosumab, a fully human monoclonal antibody against the receptor activator of nuclear factor-κ... 
ZOLEDRONIC ACID | FRACTURE | MEDICINE, GENERAL & INTERNAL | PLACEBO | BONE-MINERAL DENSITY | RISK | COMPLICATIONS | RANDOMIZED CONTROLLED-TRIAL | POSTMENOPAUSAL WOMEN | OSTEOPOROSIS | ALENDRONATE | Lumbar Vertebrae - injuries | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Fractures, Bone - epidemiology | Antibodies, Monoclonal - therapeutic use | Male | Osteoporosis - drug therapy | Prostatic Neoplasms - physiopathology | Bone Remodeling - drug effects | Incidence | Antibodies, Monoclonal, Humanized | Spinal Fractures - prevention & control | RANK Ligand - pharmacology | Injections, Subcutaneous | Aged, 80 and over | RANK Ligand - therapeutic use | Gonadotropin-Releasing Hormone - agonists | Lumbar Vertebrae - physiology | Prostatic Neoplasms - drug therapy | RANK Ligand - adverse effects | Osteoporosis - chemically induced | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Prostatic Neoplasms - surgery | Antibodies, Monoclonal - pharmacology | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Lumbar Vertebrae - drug effects | Denosumab | Bone Density Conservation Agents - pharmacology | Orchiectomy | Bone Density - drug effects | Androgen Antagonists - therapeutic use | Aged | Androgen Antagonists - adverse effects | Fractures, Bone - prevention & control | Osteoporosis | Bone density | Prostate cancer | Older people | Men | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 32, pp. E2987 - E2996
.... To address this limitation, we have developed onartuzumab, an Escherichia coli-derived, humanized, and affinity-matured monovalent monoclonal antibody against MET, generated using the knob-into-hole... 
MetMAb | HGFR | OA5D5 | Scatter factor | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | PHARMACOKINETIC PK | DOSE-ESCALATION | SINGLE-AGENT | scatter factor | C-MET | BINDING-SITE | RECEPTOR MET | MONOCLONAL-ANTIBODIES | Proto-Oncogene Proteins c-met - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Hepatocyte Growth Factor - pharmacology | Antibodies, Monoclonal, Humanized - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Protein Binding - drug effects | Drug Design | Antineoplastic Agents - pharmacology | Hepatocyte Growth Factor - chemistry | Antibodies, Monoclonal - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Immunoglobulin Fab Fragments - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Models, Molecular | Mice, Transgenic | Antineoplastic Agents - chemistry | Mice, SCID | Immunoglobulin Fab Fragments - pharmacology | Mice, Inbred C3H | Hepatocyte Growth Factor - metabolism | Neoplasms - drug therapy | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Antibodies, Monoclonal - genetics | Animals | Mice, Nude | Immunoglobulin Fab Fragments - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Proto-Oncogene Proteins c-met - chemistry | Neoplasms - pathology | Antibodies, Monoclonal, Humanized - chemistry | Biological Sciences | PNAS Plus
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e90353
.... GC1008 is a human anti-TGFb monoclonal antibody that neutralizes all isoforms of TGFb. Here, the safety and activity of GC1008 was evaluated in patients with advanced malignant melanoma and renal cell carcinoma. Methods... 
SURVIVAL | EPITHELIAL-MESENCHYMAL TRANSDIFFERENTIATION | INHIBITION | SOLID TUMORS | EFFICACY | VIVO | MULTIDISCIPLINARY SCIENCES | METASTATIC BREAST-CANCER | KERATOACANTHOMAS | T-CELLS | PROGRESSION | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Positron-Emission Tomography | Kidney Neoplasms - diagnosis | Aged, 80 and over | Transforming Growth Factor beta - antagonists & inhibitors | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Renal Cell - drug therapy | Carcinoma, Renal Cell - pathology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | Melanoma - pathology | Transforming Growth Factor beta - blood | Carcinoma, Renal Cell - diagnosis | Melanoma - drug therapy | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Neoplasm Staging | Oncology, Experimental | Melanoma | Clinical trials | Monoclonal antibodies | Bone morphogenetic proteins | Research | Carcinoma, Renal cell | Metastasis | Transforming growth factors | Cancer | Intravenous administration | Toxicity | Transforming growth factor-b | Medical treatment | Transforming growth factor-a | Pharmacology | Patients | Immunity | Constraining | Metastases | Anticancer properties | Isoforms | Biomarkers | Antitumor activity | Safety | Clear cell-type renal cell carcinoma
Journal Article
PloS one, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0131177
Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal antibodies (mAbs... 
RECOMBINANT IMMUNOTOXIN | IMMUNOGENICITY | MULTIDISCIPLINARY SCIENCES | PURIFICATION | SURFACE-PROTEINS | STAPHYLOCOCCUS-AUREUS | ANTITUMOR-ACTIVITY | MONOCLONAL-ANTIBODIES | FRAGMENTATION | CANCER-THERAPY | PROTEIN LIGATION | Cysteine Endopeptidases - chemistry | Staphylococcus aureus - enzymology | Aminoacyltransferases - immunology | Receptor, ErbB-2 - genetics | Humans | Bacterial Proteins - chemistry | Ovarian Neoplasms - pathology | Ki-1 Antigen - immunology | Maytansine - pharmacology | Immunoconjugates - immunology | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Protein Engineering | Maytansine - chemistry | Female | Antineoplastic Agents - pharmacology | Bacterial Proteins - immunology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Oligopeptides - chemistry | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Aminoacyltransferases - chemistry | Antineoplastic Agents - immunology | Maytansine - analogs & derivatives | Antibodies, Monoclonal - pharmacology | Oligopeptides - immunology | Antineoplastic Agents - chemistry | Immunoconjugates - chemistry | Staphylococcus aureus - chemistry | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Ki-1 Antigen - antagonists & inhibitors | Mice | Antibodies, Monoclonal, Humanized - immunology | Cysteine Endopeptidases - immunology | Maytansine - immunology | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Ki-1 Antigen - genetics | Ovarian Neoplasms - immunology | Monoclonal antibodies | Enzymes | Cysteine | Peptides | Biopharmaceutics | Drugs | Conjugates | Addition polymerization | Ovarian carcinoma | Clinical trials | Pentaglycine | Cancer therapies | Molecular weight | Ovarian cancer | Proteins | Tubulin | CD30 antigen | Xenografts | Medical research | Immunoglobulins | Polypeptides | Cloning | Polymerization | Breast cancer | ErbB-2 protein | Substrates | Chemotherapy | Lysine | Heavy chains | Toxins | Conjugation | Sortase | Tumors
Journal Article