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Journal of the American Chemical Society, ISSN 0002-7863, 07/2012, Volume 134, Issue 29, pp. 12308 - 12318
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 9, pp. 2530 - 2540
The anti-CD20 mAb rituximab is central to the treatment of B-cell malignancies, but resistance remains a significant problem. We recently reported that... 
MUTATION STATUS | ADVANCED FOLLICULAR LYMPHOMA | ANTI-CD20 ANTIBODY | R-CHOP | CHRONIC LYMPHOCYTIC-LEUKEMIA | CD38 EXPRESSION | MONOCLONAL-ANTIBODY | ZAP-70 EXPRESSION | CALCIUM FLUX | HEMATOLOGY | ANTIGEN RECEPTOR | Phosphorylation | Humans | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Lymphoma, Mantle-Cell - pathology | Recombinant Fusion Proteins - metabolism | Receptors, IgG - metabolism | Antibodies, Neoplasm - metabolism | Receptors, IgG - genetics | Lysosomes - metabolism | Transfection | Lymphoma, B-Cell - immunology | Antigens, Neoplasm - metabolism | Antigen-Antibody Complex - metabolism | Cell Line, Tumor - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | B-Lymphocytes - metabolism | Macrophages - physiology | Antigens, CD20 - immunology | Antibodies, Neoplasm - immunology | Antibodies, Monoclonal, Murine-Derived - immunology | Antigens, Neoplasm - immunology | Antibodies, Monoclonal, Murine-Derived - metabolism | Lymphoma, Mantle-Cell - drug therapy | Rituximab | Treatment Outcome | Antibodies, Neoplasm - administration & dosage | Antigens, CD20 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Endocytosis - physiology | B-Lymphocytes - immunology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor - immunology | Lymphoma, B-Cell - pathology | Biomarkers | Protein Processing, Post-Translational | Drug Resistance, Neoplasm - physiology | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 473 - 488
Journal Article
Journal Article
mAbs, ISSN 1942-0862, 01/2013, Volume 5, Issue 1, pp. 22 - 33
Several novel anti-CD20 monoclonal antibodies are currently in development with the aim of improving the treatment of B cell malignancies. Mutagenesis and... 
leukemia | type II | ofatumumab | immunotherapy | Rituximab | non-Hodgkin lymphoma | type I | obinutuzumab | GA101 | structure | Non-Hodgkin lymphoma | Obinutuzumab | Immunotherapy | Leukemia | Type I | Type II | Ofatumumab | Structure | MEDICINE, RESEARCH & EXPERIMENTAL | MANTLE CELL LYMPHOMAS | FC-GAMMA-RIIIA | IBRITUMOMAB TIUXETAN RADIOIMMUNOTHERAPY | FOLLICULAR LYMPHOMA | RANDOMIZED CONTROLLED-TRIAL | REFRACTORY LOW-GRADE | NON-HODGKINS-LYMPHOMA | CHRONIC LYMPHOCYTIC-LEUKEMIA | TERM-FOLLOW-UP | ANTI-CD20 MAB | Epitope Mapping | Epitopes - metabolism | Humans | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Crystallography, X-Ray | Epitopes - immunology | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Antigens, CD20 - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Antibodies, Monoclonal, Murine-Derived - immunology | Antibodies, Monoclonal, Humanized - metabolism | Antibodies, Monoclonal, Murine-Derived - metabolism | Models, Molecular | Clinical Trials as Topic | Antigens, CD20 - metabolism | Antigens, CD20 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Animals | Lymphoma, Non-Hodgkin - therapy | Epitopes - chemistry | Mice | Antibodies, Monoclonal - metabolism | Antibodies, Monoclonal, Humanized - immunology | Antigens, CD20 - chemistry | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Index Medicus | Review
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 27, pp. 19760 - 19772
Glucose-dependent insulinotropic polypeptide (GIP) is an endogenous hormonal factor (incretin) that, upon binding to its receptor (GIPr; a class B... 
IN-VITRO | GLUCAGON RECEPTOR | AFFINITY MATURATION | HIGH-FAT DIET | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIBOSOME DISPLAY | PHAGE DISPLAY | EXTRACELLULAR DOMAIN | GASTRIC-INHIBITORY POLYPEPTIDE | PROTEIN-COUPLED-RECEPTOR | Receptors, Gastrointestinal Hormone - chemistry | Epitopes - metabolism | Humans | Antibodies, Monoclonal, Murine-Derived - chemistry | Crystallography, X-Ray | Male | Structure-Activity Relationship | Receptors, Gastrointestinal Hormone - metabolism | Immunoglobulin Fab Fragments - metabolism | HEK293 Cells | Protein Structure, Quaternary | Insulin - genetics | Insulin Secretion | Gastric Inhibitory Polypeptide | Immunoglobulin Fab Fragments - genetics | Protein Structure, Secondary | Antibodies, Monoclonal, Murine-Derived - metabolism | Rats | Epitopes - genetics | Rats, Sprague-Dawley | Immunoglobulin Fab Fragments - pharmacology | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Insulin - metabolism | Animals | Hydrogen Bonding | Immunoglobulin Fab Fragments - chemistry | Receptors, Gastrointestinal Hormone - genetics | Dogs | Protein Binding | Epitopes - chemistry | Mice | Antibodies, Monoclonal, Murine-Derived - genetics | Antibodies, Monoclonal, Murine-Derived - pharmacology | Index Medicus | Protein Structure and Folding | Crystal Structure | Incretin | Antibody Engineering | Glucose-dependent Insulinotropic Polypeptide (GIP) | G-Protein-coupled Receptors (GPCR) | Diabetes | Antagonist | Phage Display | GIP Receptor (GIPr)
Journal Article
Journal Article
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 12/2014, Volume 13, Issue 12, pp. 5471 - 5485
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2016, Volume 472, Issue 1, pp. 281 - 286
Polyreactive antibodies represent a considerable fraction of the immune repertoires. Some antibodies acquire polyreactivity post-translationally after... 
Thermodynamics | Immunoglobulins | Heme | Antibody polyreactivity | MECHANISM | SPECIFICITY | IGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REDOX-REACTIVE AUTOANTIBODIES | MAST-CELL SURVIVAL | BIOPHYSICS |