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Nature Cell Biology, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 807 - 817
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2012, Volume 30, Issue 6, pp. 593 - 599
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7693, pp. 544 - 548
Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | BLADDER-CANCER | THERAPY | LANDSCAPE | SUBTYPES | UROTHELIAL CARCINOMA | MULTIDISCIPLINARY SCIENCES | GENES | ADAPTIVE IMMUNE RESISTANCE | MPDL3280A | CD8-Positive T-Lymphocytes - cytology | Humans | Antibodies, Monoclonal - therapeutic use | Urothelium - pathology | Urologic Neoplasms - pathology | Neoplasm Metastasis | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | Immunotherapy | Antibodies - immunology | Antigens, Neoplasm - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Antigens, Neoplasm - analysis | Disease Models, Animal | Fibroblasts - metabolism | Antibodies - therapeutic use | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | B7-H1 Antigen - immunology | Urologic Neoplasms - immunology | Antibodies - pharmacology | Tumor Microenvironment - immunology | Collagen - metabolism | Phenotype | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | CD8-Positive T-Lymphocytes - drug effects | Urothelium - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Urothelium - drug effects | Transforming Growth Factor beta - metabolism | Cohort Studies | Drug Resistance, Neoplasm - drug effects | PD-1 protein | CD8 antigen | Transforming growth factor-a | Antibodies | Parenchyma | Lymphocytes T | Metastasis | Immunity | Metastases | Genotype & phenotype | Signal transduction | Lymphocytes | Cell cycle | Fibroblasts | Growth factors | Urothelial cancer | Phenotypes | Cytokines | Melanoma | Blocking | Gene expression | Patients | Generalized linear models | Signaling | Stromal cells | Medical prognosis | Collagen | PD-L1 protein | Ligands | Determinants | Infiltration | Cancer | Tumors | Apoptosis | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
American Journal of Pathology, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 1647 - 1656
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream... 
ADJUVANT CHEMOTHERAPY | CELLS | INHIBITION | THERAPY | HUMAN-BREAST-CANCER | MUTATIONS | PATHOLOGY | RECEPTORS | TRASTUZUMAB RESISTANCE | EXPRESSION | CARCINOMA | Lung Neoplasms - drug therapy | Receptors, Estrogen - metabolism | Receptor, ErbB-2 - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Immunoenzyme Techniques | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Ductal, Breast - drug therapy | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Survival Rate | Lymphatic Metastasis | Brain Neoplasms - drug therapy | Mutation - genetics | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases | Carcinoma, Lobular - metabolism | Trastuzumab | Bone Neoplasms - mortality | Phosphorylation | Prognosis | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | In Situ Hybridization | Lung Neoplasms - secondary | Adult | Female | Bone Neoplasms - drug therapy | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - mortality | Aged | Carcinoma, Lobular - drug therapy | Index Medicus | Abridged Index Medicus | Regular
Journal Article
Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma,... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | HAIRY-CELL LEUKEMIA | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | VEMURAFENIB | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 31 - 44
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks... 
Clodronic Acid - pharmacology | Gene Expression - genetics | Dendritic Cells - immunology | Humans | Pregnancy Proteins - genetics | Microvessels - pathology | Pregnancy Proteins - metabolism | Chemotactic Factors - metabolism | Neoplasm Metastasis - immunology | Antibodies - immunology | Neovascularization, Pathologic - immunology | Macrophages, Peritoneal - drug effects | Macrophages - pathology | Neoplasms - blood supply | Down-Regulation - genetics | Mice, Knockout | Macrophages - metabolism | Neoplasms - immunology | Cell Line, Tumor | Placenta Growth Factor | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Macrophages, Peritoneal - metabolism | Neoplasms - metabolism | CD8-Positive T-Lymphocytes - pathology | Gene Expression - drug effects | Regional Blood Flow - genetics | Dendritic Cells - pathology | Culture Media, Conditioned - pharmacology | Lung Neoplasms - pathology | Hypoxia - metabolism | Neovascularization, Pathologic - pathology | Regional Blood Flow - drug effects | Transfection | Lung Neoplasms - secondary | Neoplasms - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Lung Neoplasms - genetics | Microvessels - ultrastructure | Cytokines - metabolism | Mice, Inbred C57BL | Microvessels - drug effects | Pregnancy Proteins - immunology | Antibodies - pharmacology | Proteins - genetics | Neoplasm Metastasis - genetics | Hypoxia - genetics | Lung Neoplasms - immunology | Animals | Proteins - metabolism | Endothelial Cells - cytology | Neoplasm Metastasis - pathology | Macrophages - drug effects | Neovascularization, Pathologic - genetics | Cell Proliferation - drug effects | Proteins - pharmacology | Neoplasms - pathology | Endothelial Cells - drug effects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7635, pp. 41 - 45
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | METABOLISM | MULTIDISCIPLINARY SCIENCES | STEM-CELL | CHEMORESISTANCE | BRAIN-METASTASIS | STROMAL CELLS | TUMOR-GROWTH | CARCINOMA | PROGRESSION | Palmitic Acid - metabolism | Palmitic Acid - pharmacology | CD36 Antigens - genetics | Cell Proliferation | Mouth Neoplasms - drug therapy | Prognosis | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Diet, High-Fat - adverse effects | Male | Mouth Neoplasms - metabolism | Antibodies, Neutralizing - immunology | Mouth Neoplasms - diagnosis | CD36 Antigens - metabolism | Neoplasm Metastasis - drug therapy | Neoplastic Stem Cells - metabolism | Neoplasm Metastasis - prevention & control | Antibodies, Neutralizing - therapeutic use | Lymphatic Metastasis - pathology | Hyaluronan Receptors - metabolism | Neoplastic Stem Cells - pathology | Female | Lipid Metabolism - genetics | Disease Models, Animal | Palmitic Acid - administration & dosage | CD36 Antigens - immunology | Antibodies, Neutralizing - pharmacology | Penetrance | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | Neoplasm Metastasis - pathology | CD36 Antigens - antagonists & inhibitors | Lymphatic Metastasis - genetics | Mouth Neoplasms - pathology | Mice | Cancer cells | Genetic aspects | Metastasis | Lipid metabolism | Gene expression | Health aspects | Fatty acids | Oral cancer | Lipids | Metabolism | Cells | Tumors | Index Medicus
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 09/2009, Volume 33, Issue 9, pp. 1401 - 1408
Gastrointestinal stromal tumors (GISTs), KIT or platelet derived growth factor receptor alpha (PDGFRA) signaling driven mesenchymal tumors of the... 
PDGFRA | Chloride channel protein | Sarcoma | DOG1 | KIT | Mutation | Gastrointestinal stromal tumor | PDGFRA MUTATIONS | GASTRIC TUMORS | SURGERY | sarcoma | MARKER | KINASE-C-THETA | MONOCLONAL-ANTIBODY | PATHOLOGY | mutation | chloride channel protein | gastrointestinal stromal tumor | TERM-FOLLOW-UP | EXPRESSION | PKC-THETA | MORPHOLOGY | Immunohistochemistry | Myenteric Plexus - pathology | Predictive Value of Tests | Anoctamin-1 | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Stomach Neoplasms - metabolism | Leiomyoma - metabolism | Myenteric Plexus - metabolism | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Esophageal Neoplasms - pathology | Leiomyoma - pathology | Chloride Channels | Gastrointestinal Stromal Tumors - diagnosis | Esophageal Neoplasms - metabolism | Mesenchymoma - diagnosis | Biomarkers, Tumor - metabolism | Membrane Proteins - metabolism | Intestinal Neoplasms - diagnosis | Colorectal Neoplasms - metabolism | Peritoneal Neoplasms - pathology | Mesenchymoma - metabolism | Diagnosis, Differential | Stomach Neoplasms - diagnosis | Intestinal Neoplasms - metabolism | Sarcoma, Synovial - metabolism | Peritoneal Neoplasms - metabolism | Gastrointestinal Stromal Tumors - metabolism | Mesenchymoma - secondary | Colorectal Neoplasms - pathology | Sarcoma, Synovial - pathology | Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 6, pp. 717 - 726
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2014, Volume 20, Issue 19, pp. 5064 - 5074
Journal Article
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 02/2014, Volume 138, Issue 2, pp. 241 - 256
Journal Article