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PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179863
Protein alpha-helical coiled coil structures are known to induce antibodies able to block critical functions in different pathogens. In a previous study, a... 
VACCINE DEVELOPMENT | ANTIBODIES | FORCE | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | ANTIGENS | NEW-GUINEAN CHILDREN | DOMAINS | EPIDEMIOLOGY | Papua New Guinea | Immunoglobulin G - blood | Humans | Peptides - genetics | Child, Preschool | Plasmodium vivax - genetics | Infant | Protozoan Proteins - genetics | Antibodies, Protozoan - blood | Malaria Vaccines - immunology | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Malaria, Vivax - prevention & control | Plasmodium vivax - chemistry | Amino Acid Sequence | Protein Conformation, alpha-Helical | Antigens, Protozoan - chemistry | Peptides - chemistry | Malaria, Vivax - parasitology | Peptides - immunology | Risk Factors | Immunity, Innate | Plasmodium vivax - immunology | Animals | Malaria, Vivax - immunology | Longitudinal Studies | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Proteins | Antigens | Immune response | Malaria | Health aspects | Immunoglobulin G | Coils | Disease | Peptides | IgG antibody | Erythrocytes | Antibodies | Infections | Biology | Vaccines | Parasites | Immunity | Tropical diseases | Population | Children | Age | Immune system | Vector-borne diseases | Pathogens | Medical research | Immunoglobulins | Markers | Equilibrium | Correlation analysis | Protein structure | Hygiene | Plasmodium vivax | Malària | Resposta immunitària | Malaria, Vivax | Malaria Vaccines | Antibodies, Protozoan | Protozoan Proteins | Antigens, Protozoan | Life Sciences | Human health and pathology | Immunology | Infectious diseases
Journal Article
Journal of Nanobiotechnology, ISSN 1477-3155, 09/2017, Volume 15, Issue 1, pp. 62 - 10
Background: The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development... 
Protein nanoparticles | Self-assembly | Malaria | P27 | P27A | Vaccine | Blood stage | Tex1 | CIRCUMSPOROZOITE PROTEIN | T-CELL EPITOPES | NANOSCIENCE & NANOTECHNOLOGY | ANTIGENS | HUMAN INHIBITORY ANTIBODIES | HELPER EPITOPES | RESPONSES | INVASION | PEPTIDES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | MHC CLASS-II | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Nanoparticles - chemistry | Humans | Plasmodium falciparum - immunology | Protozoan Proteins - therapeutic use | Protozoan Proteins - genetics | Malaria Vaccines - chemistry | Proliferating Cell Nuclear Antigen - genetics | Nanoparticles - therapeutic use | Plasmodium falciparum - genetics | Antigens, Protozoan - therapeutic use | Malaria Vaccines - immunology | Protein Engineering | Protein Domains | Proliferating Cell Nuclear Antigen - immunology | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Malaria Vaccines - therapeutic use | Plasmodium falciparum - chemistry | Amino Acid Sequence | Immunization | Antigens, Protozoan - chemistry | Models, Molecular | Proliferating Cell Nuclear Antigen - chemistry | Animals | Malaria, Falciparum - immunology | Mice | Mice, Inbred BALB C | Proliferating Cell Nuclear Antigen - therapeutic use | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Proteins | Prevention | Plasmodium falciparum | Immune response | Parasitic diseases | Analysis | Research | Health aspects | Public health | Coils | Animal models | Candidates | Peptides | Delivery systems | Amino acids | Vaccines | Nanoparticles | Lymphocytes | Low cost | Cross-protection | Immune system | Vector-borne diseases | Antigens | Immunoglobulins | Particulates | Epitopes | Immunogenicity | Scaffolding | Protein expression | Scaffolds
Journal Article
Malaria Journal, ISSN 1475-2875, 2010, Volume 9, Issue 1, pp. 129 - 129
Accurate diagnosis is essential for prompt and appropriate treatment of malaria. While rapid diagnostic tests (RDTs) offer great potential to improve malaria... 
Malaria, Falciparum - genetics | Antigens, Protozoan - immunology | Immunoassay - standards | Humans | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sequence Analysis, DNA | Genetic Variation | Malaria, Falciparum - parasitology | Animals | Plasmodium falciparum - genetics | Plasmodium falciparum - isolation & purification | Reagent Kits, Diagnostic | Sensitivity and Specificity | Malaria, Falciparum - diagnosis | Polymerase Chain Reaction | Immunoassay - methods | DNA, Protozoan - genetics | Antigens, Protozoan - genetics | Protozoan Proteins - immunology | Plasmodium falciparum | Usage | Malaria | Genetic variation | Causes of | Medical tests | Genetic aspects | Diagnosis | Research | Health aspects | Peptides | Diagnostic tests | Erythrocytes | Biochemistry | Nucleotides | Drug resistance | pH effects | Immunity | Institutions | Blood | Proteins | Anions | Quality assurance | Defence mechanisms | Chromosomes | Deoxyribonucleic acid--DNA | Testing | Antigens | Mortality | Case management | Chromosome 7 | Amino acid sequence | Regression analysis | Epitopes | Gene expression | Membrane proteins | Disease transmission | Infectious diseases | Quality control | Monoclonal antibodies | Arrays | Binding sites | Drugs | Genes | Transmission | Science | Antibodies | Amino acids | Biology | Infections | Genomes | Parasites | Tests | Ethics | Actin | Quality | Evolution | Chromosome 13 | Aspartic acid | Vector-borne diseases | Alanine | Immune response | Nucleotide sequence | Product testing | Management | Investigations | Sensitivity | Microscopy | Molecular biology | Life cycles | Immunoassay | Malaria, Falciparum | Protozoan Proteins | DNA, Protozoan | Antigens, Protozoan | Life Sciences | Other
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 26, pp. 4308 - 4315
Journal Article
Vaccine, ISSN 0264-410X, 2007, Volume 25, Issue 21, pp. 4301 - 4311
Abstract To investigate the vaccine potential of both the Toxoplasma GRA2 and GRA6 antigens, the full length recombinant proteins were produced in Escherichia... 
Allergy and Immunology | Protozoa | GRA6 | Toxoplasma gondii | Dense granule | GRA2 | Vaccination | MEDICINE, RESEARCH & EXPERIMENTAL | PARASITOPHOROUS VACUOLE | ESCHERICHIA-COLI | IMMUNOGLOBULIN-G ANTIBODIES | IMMUNOLOGY | CONGENITAL TOXOPLASMOSIS | EXCRETED-SECRETED ANTIGENS | protozoa | GONDII INFECTION | dense granule | INTERFERON-GAMMA | PREGNANT-WOMEN | VETERINARY SCIENCES | CIRCULATING ANTIGEN | DNA VACCINATION | vaccination | Toxoplasma - immunology | Antigens, Protozoan - immunology | Vaccines, Subunit - isolation & purification | Vaccines, Subunit - genetics | Humans | Lipid A - analogs & derivatives | Vaccines, Synthetic - immunology | Protozoan Proteins - genetics | Th1 Cells - immunology | Toxoplasmosis, Animal - prevention & control | Vaccines, Synthetic - isolation & purification | Antibodies, Protozoan - blood | Lipid A - immunology | Mice, Inbred CBA | Antigens, Protozoan - isolation & purification | Antigens, Protozoan - genetics | Brain - parasitology | Cytokines - immunology | Disease Models, Animal | Protozoan Vaccines - immunology | Adjuvants, Immunologic | Vaccines, Synthetic - genetics | Vaccines, Subunit - immunology | Animals | Escherichia coli - genetics | Protozoan Proteins - isolation & purification | Toxoplasmosis, Animal - immunology | Mice | Protozoan Proteins - immunology | Antigens | Analysis | Immunoglobulin G | Lipids | Health aspects | Recombinant proteins | Medical research | Parasites | Vaccines | Immune system | Toxoplasmosis, Animal | Brain | Vaccines, Subunit | Cytokines | Escherichia coli | Biochemistry, Molecular Biology | Antibodies, Protozoan | Protozoan Proteins | Lipid A | Toxoplasma | Antigens, Protozoan | Life Sciences | Th1 Cells | Protozoan Vaccines | Vaccines, Synthetic
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 19913 - 19922
Journal Article
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1197 - 1209.e10
Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of ( ) sporozoites, can protect from malaria in animal models... 
circumsporozoite protein | Plasmodium falciparum | natural infection | affinity maturation | protective antibodies | malaria | memory B cells | epitope specificity | human | X-ray structures | SYSTEM | RESPONSES | IMMUNITY | TRANSMISSION | MEMORY B-CELLS | HUMAN MALARIA | STAGE | PLASMODIUM-FALCIPARUM SPOROZOITES | CIRCUMSPOROZOITE PROTEIN | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | Plasmodium berghei - immunology | Immunoglobulin Heavy Chains - biosynthesis | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | B-Lymphocytes - parasitology | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sporozoites - immunology | Epitopes - immunology | Sporozoites - chemistry | Immunity, Humoral | Female | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Protein Interaction Domains and Motifs | Immunoglobulin Heavy Chains - immunology | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Antigens, Protozoan - chemistry | Antibodies, Protozoan - immunology | Malaria - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antibodies, Protozoan - chemistry | Antibodies, Protozoan - biosynthesis | Malaria - prevention & control | Malaria, Falciparum - parasitology | Animals | B-Lymphocytes - immunology | Protein Conformation, beta-Strand | Malaria - parasitology | Malaria, Falciparum - immunology | Protein Binding | Immunologic Memory | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Viral antibodies | Wildlife conservation | Malaria | Analysis | Children's hospitals | Malaria vaccine | Antibodies | Development and progression | B cells | Health aspects | Antigenic determinants | Vector-borne diseases | Animal models | Immunological memory | Immunoglobulins | Complementarity | Molecular structure | Vaccines | Epitopes | Parasites | Aquatic insects | Immunity | Disease transmission | Lymphocytes B | Coding | Sporozoites | Monoclonal antibodies | Affinity | Immunity (humoral) | Human behavior | Complementarity-determining region 3 | Binding sites | Circumsporozoite protein
Journal Article