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1. Full Text Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria
by Boyle, Michelle J and Reiling, Linda and Feng, Gaoqian and Langer, Christine and Osier, Faith H and Aspeling-Jones, Harvey and Cheng, Yik Sheng and Stubbs, Janine and Tetteh, Kevin K.A and Conway, David J and McCarthy, James S and Muller, Ivo and Marsh, Kevin and Anders, Robin F and Beeson, James G
Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 580 - 590
Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine... 
IMMUNITY | RESPONSES | GROWTH-INHIBITION | PARASITEMIA | SPECIFICITY | VACCINE | FRAGMENT | IMMUNOLOGY | BLOOD-STAGE ANTIGENS | IMMUNOGLOBULIN-G | CHILDREN | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Prospective Studies | Protozoan Proteins - antagonists & inhibitors | Humans | Merozoite Surface Protein 1 - genetics | Child, Preschool | Complement Fixation Tests | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Complement C1q - metabolism | Immunoglobulin G - biosynthesis | Malaria Vaccines - immunology | Female | Antigens, Protozoan - genetics | Merozoite Surface Protein 1 - antagonists & inhibitors | Child | Complement Pathway, Classical | Erythrocytes - immunology | Merozoites - immunology | Gene Expression | Parasitemia - immunology | Antibodies, Protozoan - biosynthesis | Host-Pathogen Interactions | Malaria, Falciparum - parasitology | Animals | Malaria Vaccines - administration & dosage | Merozoite Surface Protein 1 - immunology | Adolescent | Malaria, Falciparum - immunology | Parasitemia - prevention & control | Parasitemia - parasitology | Erythrocytes - parasitology | Protozoan Proteins - immunology | Proteins | Viral antibodies | Antibodies | Plasmodium falciparum | Malaria | Survival analysis | Parasites | Microscopy | Blood banks
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2. Full Text Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies
by Triller, Gianna and Scally, Stephen W and Costa, Giulia and Pissarev, Maria and Kreschel, Cornelia and Bosch, Alexandre and Marois, Eric and Sack, Brandon K and Murugan, Rajagopal and Salman, Ahmed M and Janse, Chris J and Khan, Shahid M and Kappe, Stefan H.I and Adegnika, Ayola A and Mordmüller, Benjamin and Levashina, Elena A and Julien, Jean-Philippe and Wardemann, Hedda and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1197 - 1209.e10
Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of ( ) sporozoites, can protect from malaria in animal models... 
circumsporozoite protein | Plasmodium falciparum | natural infection | affinity maturation | protective antibodies | malaria | memory B cells | epitope specificity | human | X-ray structures | SYSTEM | RESPONSES | IMMUNITY | TRANSMISSION | MEMORY B-CELLS | HUMAN MALARIA | STAGE | PLASMODIUM-FALCIPARUM SPOROZOITES | CIRCUMSPOROZOITE PROTEIN | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | Plasmodium berghei - immunology | Immunoglobulin Heavy Chains - biosynthesis | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | B-Lymphocytes - parasitology | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sporozoites - immunology | Epitopes - immunology | Sporozoites - chemistry | Immunity, Humoral | Female | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Protein Interaction Domains and Motifs | Immunoglobulin Heavy Chains - immunology | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Antigens, Protozoan - chemistry | Antibodies, Protozoan - immunology | Malaria - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antibodies, Protozoan - chemistry | Antibodies, Protozoan - biosynthesis | Malaria - prevention & control | Malaria, Falciparum - parasitology | Animals | B-Lymphocytes - immunology | Protein Conformation, beta-Strand | Malaria - parasitology | Malaria, Falciparum - immunology | Protein Binding | Immunologic Memory | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Viral antibodies | Wildlife conservation | Malaria | Analysis | Children's hospitals | Malaria vaccine | Antibodies | Development and progression | B cells | Health aspects | Antigenic determinants | Vector-borne diseases | Animal models | Immunological memory | Immunoglobulins | Complementarity | Molecular structure | Vaccines | Epitopes | Parasites | Aquatic insects | Immunity | Disease transmission | Lymphocytes B | Coding | Sporozoites | Monoclonal antibodies | Affinity | Immunity (humoral) | Human behavior | Complementarity-determining region 3 | Binding sites | Circumsporozoite protein
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3. Full Text Protective CD8 + T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
by Ewer, Katie J and O'Hara, Geraldine A and Duncan, Christopher J. A and Collins, Katharine A and Sheehy, Susanne H and Reyes-Sandoval, Arturo and Goodman, Anna L and Edwards, Nick J and Elias, Sean C and Halstead, Fenella D and Longley, Rhea J and Rowland, Rosalind and Poulton, Ian D and Draper, Simon J and Blagborough, Andrew M and Berrie, Eleanor and Moyle, Sarah and Williams, Nicola and Siani, Loredana and Folgori, Antonella and Colloca, Stefano and Sinden, Robert E and Lawrie, Alison M and Cortese, Riccardo and Gilbert, Sarah C and Nicosia, Alfredo and Hill, Adrian V. S
Nature Communications, ISSN 2041-1723, 11/2013, Volume 4, Issue 1, p. 2836
Induction of antigen-specific CD8(+) T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8(+) T... 
NONHUMAN-PRIMATES | PRIME-BOOST IMMUNIZATION | MEDIATED PROTECTION | POLYMERASE-CHAIN-REACTION | VACCINIA VIRUS ANKARA | DNA VACCINES | RHESUS-MONKEYS | MULTIDISCIPLINARY SCIENCES | INFLUENZA-VIRUS | NAIVE ADULTS | PHASE 2A TRIAL | Adenoviruses, Simian - immunology | Malaria, Falciparum - prevention & control | Humans | Middle Aged | Male | Leukocytes, Mononuclear | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Vaccinia virus - genetics | Vaccinia virus - immunology | Adenoviruses, Simian - genetics | Young Adult | Immunization, Secondary | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Adult | Female | Immunization | Genetic Vectors - immunology | Antibodies, Protozoan - immunology | Genetic Vectors - genetics | Malaria, Falciparum - parasitology | Animals | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Adolescent | Malaria, Falciparum - immunology | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Malaria Vaccines - genetics
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4. Full Text Structural and immunological characterization of recombinant 6-cysteine domains of the plasmodium falciparum sexual stage protein Pfs230
by MacDonald, Nicholas J and Nguyen, Vu and Shimp, Richard and Reiter, Karine and Herrera, Raul and Burkhardt, Martin and Muratova, Olga and Kumar, Krishan and Aebig, Joan and Rausch, Kelly and Lambert, Lynn and Dawson, Nikiah and Sattabongkot, Jetsumon and Ambroggio, Xavier and Duffy, Patrick E and Wu, Yimin and Narum, David L
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 19913 - 19922
Development of a Plasmodium falciparum (Pf) transmission blocking vaccine (TBV) has the potential to significantly impact malaria control. Antibodies elicited... 
TARGET | IMMUNITY | Pfs230 | PFS48/45 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | recombinant protein expression | CANDIDATE | Pichia pastoris | malaria | SURFACE-ANTIGEN PFS230 | yeast | protein structure | vaccine | AERUGINOSA EXOPROTEIN-A | RTS,S/AS01 MALARIA VACCINE | TRANSMISSION-BLOCKING VACCINE | transmission blocking | ANTIBODY-RESPONSES | Malaria, Falciparum - genetics | Rabbits | Malaria, Falciparum - prevention & control | Antigens, Protozoan - chemistry | Antigens, Protozoan - immunology | Malaria Vaccines - pharmacology | Antibodies, Protozoan - immunology | Humans | Protozoan Proteins - pharmacology | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Malaria Vaccines - chemistry | Malaria, Falciparum - transmission | Animals | Antigens, Protozoan - pharmacology | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Protein Domains | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Plasmodium falciparum - chemistry | Immunology
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5. Full Text Serological signatures of declining exposure following intensification of integrated malaria control in two rural Senegalese communities
by Perraut, Ronald and Varela, Marie-Louise and Loucoubar, Cheikh and Niass, Oumy and Sidibe, Awa and Tall, Adama and Trape, Jean-François and Wotodjo, Amele Nyedzie and Mbengue, Babacar and Sokhna, Cheikh and Vigan-Womas, Inès and Toure, Aissatou and Richard, Vincent and Mercereau-Puijalon, Odile
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179146
Recent control scale-up has reduced malaria in many areas but new tools are needed to monitor further progress, including indicators of decreasing exposure to... 
EVALUATING HUMAN EXPOSURE | WESTERN KENYAN HIGHLANDS | MEROZOITE SURFACE PROTEIN-1 | HOLOENDEMIC AREA | PLASMODIUM-FALCIPARUM INFECTION | CLINICAL MALARIA | MULTIDISCIPLINARY SCIENCES | TRANSMISSION INTENSITY | GSG6-P1 SALIVARY PEPTIDE | ANOPHELES-GAMBIAE | ANTIBODY-RESPONSES | Salivary Glands - immunology | Antigens, Protozoan - immunology | Prevalence | Immunoglobulin G - blood | Humans | Male | Plasmodium falciparum - immunology | Young Adult | Antibodies, Protozoan - blood | Rural Health - statistics & numerical data | Health Surveys - methods | Immunoglobulin G - immunology | Malaria, Falciparum - epidemiology | Adult | Antigens, Protozoan - blood | Female | Plasmodium falciparum - physiology | Child | Senegal - epidemiology | Rural Population - statistics & numerical data | Anopheles - parasitology | Cross-Sectional Studies | Enzyme-Linked Immunosorbent Assay | Antibodies, Protozoan - immunology | Host-Parasite Interactions - immunology | Malaria, Falciparum - parasitology | Animals | Adolescent | Malaria, Falciparum - immunology | Anopheles - immunology | Health Surveys - statistics & numerical data | Cohort Studies | Control | Disease transmission | Malaria | Analysis | Risk factors | Peptides | Immunoglobulin G | Rural communities | Infections | Serology | Vaccines | Parasites | Blood | Proteins | Inoculation | Historical account | Villages | Children | Signatures | Indicators | Cross sections | Monitoring | Age | Vector-borne diseases | Antigens | Parasitology | Rural areas | Markers | Tools | Salivary gland | Data processing | Exposure | Conversion | Catalytic converters | Studies | Surveys | Amplification | Adults | Recording | Age groups | Malaria, Falciparum | Innate immunity | Cellular Biology | Adaptive immunology | Antigens, Protozoan | Life Sciences | Plasmodium falciparum | Immunology | Anopheles gambiae | Rural Population | Host-Parasite Interactions | Cell Behavior | Salivary Glands | Biochemistry, Molecular Biology | Antibodies, Protozoan | Rural Health | Microbiology and Parasitology | Human health and pathology | Infectious diseases | Health Surveys | Senegal | Santé publique et épidémiologie | Molecular biology
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6. Full Text Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display
by Singh, Susheel K and Thrane, Susan and Janitzek, Christoph M and Nielsen, Morten A and Theander, Thor G and Theisen, Michael and Salanti, Ali and Sander, Adam F
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 30, pp. 3726 - 3732
Graphical abstract 
Allergy and Immunology | Transmission-blocking | Plasmodium falciparum | Pfs48/45 | SMFA | Acinetobacter phage AP205, virus-like-particles | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | PARTICLES | CIRCUMSPOROZOITE PROTEIN | IMMUNOLOGY | Immunogenicity, Vaccine | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Peptides - genetics | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Vaccines, Virus-Like Particle - chemistry | Epitopes - immunology | Malaria, Falciparum - transmission | Antibodies, Protozoan - blood | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Female | Antigens, Protozoan - genetics | Protozoan Proteins - administration & dosage | Antigens, Protozoan - chemistry | Peptides - chemistry | Adjuvants, Immunologic | Antibodies, Protozoan - immunology | Peptides - immunology | Epitopes - genetics | Vaccines, Virus-Like Particle - administration & dosage | Animals | Recombinant Proteins - immunology | Vaccines, Virus-Like Particle - immunology | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Antigens | Disease transmission | Vaccines | Malaria | Medical research | Tuberculosis vaccines | Tuberculosis | Monoclonal antibodies | Medicine, Experimental | Recombinant proteins | Antigenic determinants | Vector-borne diseases | Proteins | Immunoglobulins | Peptides | Plasmids | Cloning | Viruses | Parasites
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7. Full Text Plasmodium falciparum protein microarray antibody profiles correlate with protection from symptomatic malaria in Kenya
by Dent, Arlene E and Nakajima, Rie and Liang, Li and Baum, Elisabeth and Moormann, Ann M and Sumba, Peter Odada and Vulule, John and Babineau, Denise and Randall, Arlo and Davies, D. Huw and Felgner, Philip L and Kazura, James W
Journal of Infectious Diseases, ISSN 0022-1899, 11/2015, Volume 212, Issue 9, pp. 1429 - 1438
Background. Immunoglobulin G antibodies (Abs) to Plasmodium falciparum antigens have been associated with naturally acquired immunity to symptomatic malaria.... 
antibody | antigen | malaria | protein microarray | protective immunity | INFECTIOUS DISEASES | HUMORAL IMMUNE-RESPONSES | STAGE | VACCINE | EXPORT | MICROBIOLOGY | ANTIGENS | IMMUNOLOGY | IDENTIFICATION | CHALLENGES | DENSITY | PTEX | INFECTION | Antigens, Protozoan - immunology | Immunoglobulin G - blood | Humans | Middle Aged | Child, Preschool | Infant | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Young Adult | Antibodies, Protozoan - blood | Plasmodium falciparum - isolation & purification | Adult | Antigens, Protozoan - blood | Female | Child | Merozoites - immunology | Protozoan Proteins - blood | Antibodies, Protozoan - immunology | Malaria - immunology | Proportional Hazards Models | Membrane Proteins - immunology | Antimalarials - therapeutic use | Immunity, Innate | Kenya | Animals | Adolescent | Protein Array Analysis | Aged | Mice | Malaria - drug therapy | Malaria - blood | Protozoan Proteins - immunology | Plasmodium falciparum | Care and treatment | Malaria | Immunoglobulin G | Dosage and administration | Research | Children | Health aspects | Major and Brief Reports
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8. Full Text Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope
by Imkeller, Katharina and Scally, Stephen W and Bosch, Alexandre and Marti, Gemma Pidelaserra and Costa, Giulia and Triller, Gianna and Murugan, Rajagopal and Renna, Valerio and Jumaa, Hassan and Kremsner, Peter G and Kim Lee Sim, B and Hoffman, Stephen L and Mordmüller, Benjamin and Levashina, Elena A and Julien, Jean-Philippe and Wardemann, Hedda and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Science, ISSN 0036-8075, 06/2018, Volume 360, Issue 6395, pp. 1358 - 1362
Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading... 
SPOROZOITE | REPERTOIRE | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | VACCINE | SEQUENCE | MALARIA PARASITE | SURFACE-ANTIGEN | INFECTION | MONOCLONAL-ANTIBODIES | Repetitive Sequences, Nucleic Acid - genetics | Antibody Formation - immunology | Antigens, Protozoan - chemistry | Antigens, Protozoan - immunology | Antibodies, Protozoan - immunology | Lymphocyte Activation | Antibodies, Protozoan - genetics | Humans | Repetitive Sequences, Nucleic Acid - immunology | Selection, Genetic | Antibody Affinity - genetics | Antibody Affinity - immunology | Epitopes, B-Lymphocyte - immunology | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Antibodies, Protozoan - chemistry | B-Lymphocytes - immunology | Antigens, Protozoan - genetics | Mutation | Antibody Formation - genetics | Protozoan Proteins - immunology | Physiological aspects | B cells | Antigenic determinants | Binding | Vector-borne diseases | Antigens | Immunoglobulins | Malaria | Maturation | Erythrocytes | Activation | T cell receptors | Parasites | Clustering | Molecular chains | Proteins | Cell activation | Lymphocytes B | Monoclonal antibodies | Clonal selection | Affinity | Human behavior | Circumsporozoite protein | Immunology
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9. Full Text Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide
by Michelle L. Tonkin and Magali Roques and Mauld H. Lamarque and Martine Pugnière and Dominique Douguet and Joanna Crawford and Maryse Lebrun and Martin J. Boulanger
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6041, pp. 463 - 467
Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the... 
Receptors | Obligate parasites | REPORTS | Cell membranes | Parasitism | Parasites | Parasite hosts | APICAL MEMBRANE ANTIGEN-1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | MOVING JUNCTION | TOXOPLASMA-GONDII | INHIBITORY ANTIBODY | ERYTHROCYTE | Antigens, Protozoan - immunology | Molecular Sequence Data | Toxoplasma - ultrastructure | Antigens, Protozoan - metabolism | Protozoan Proteins - metabolism | Toxoplasma - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Host-Parasite Interactions | Toxoplasma - metabolism | Antibodies, Monoclonal - immunology | Plasmodium falciparum - chemistry | Amino Acid Sequence | Peptide Fragments - metabolism | Antigens, Protozoan - chemistry | Protein Structure, Secondary | Antibodies, Protozoan - immunology | Models, Molecular | Membrane Proteins - immunology | Toxoplasma - pathogenicity | Peptide Fragments - chemistry | Membrane Proteins - chemistry | Mutagenesis | Hydrophobic and Hydrophilic Interactions | Plasmodium falciparum - pathogenicity | Protein Binding | Protein Conformation | Protozoan Proteins - immunology | Amino Acid Substitution | Physiological aspects | Cell receptors | Research | Peptides | Medicinal Chemistry | Life Sciences | Cheminformatics | Computer Science | Bioinformatics | Chemical Sciences | Pharmaceutical sciences
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10. Full Text A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with montanide® ISA 720
by McCarthy, James S and Marjason, Joanne and Elliott, Suzanne and Fahey, Paul and Bang, Gilles and Malkin, Elissa and Tierney, Eveline and Aked-Hurditch, Hayley and Adda, Christopher and Cross, Nadia and Richards, Jack S and Fowkes, Freya J.I and Boyle, Michelle J and Long, Carole and Druilhe, Pierre and Beeson, James G and Anders, Robin F
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24413
Background: In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2),... 
MEROZOITE SURFACE PROTEIN-2 | IMMUNOGENICITY | HUMORAL RESPONSE | CLINICAL MALARIA | MULTIDISCIPLINARY SCIENCES | ANCHORED MEMBRANE-PROTEINS | IN-VITRO GROWTH | INHIBITORY ANTIBODIES | ENDEMIC AREA | PLASMODIUM-FALCIPARUM MALARIA | PAPUA-NEW-GUINEA | Protozoan Proteins - adverse effects | Antigens, Protozoan - immunology | Dose-Response Relationship, Immunologic | Immunity, Humoral - immunology | Humans | Plasmodium falciparum - immunology | Life Cycle Stages - immunology | Malaria Vaccines - chemistry | Young Adult | Protein Isoforms - chemistry | Malaria Vaccines - adverse effects | Malaria Vaccines - immunology | Antibodies - immunology | Adult | Protozoan Proteins - chemistry | Antigens, Protozoan - adverse effects | Antigens, Protozoan - chemistry | Protein Isoforms - adverse effects | Chemistry, Pharmaceutical | Mannitol - analogs & derivatives | Immunity, Cellular - immunology | Animals | Adolescent | Mannitol - chemistry | Plasmodium falciparum - growth & development | Protein Isoforms - immunology | Oleic Acids - chemistry | Protozoan Proteins - immunology | Cohort Studies | Malaria | Malaria vaccine | Immunoglobulin G | Vaccination | Clinical trials | Product development | Vaccines | Enzyme-linked immunosorbent assay | Erythrocytes | Antibodies | Infections | Biochemistry | Parasites | Merozoite surface protein 2 | Western blotting | Proteins | Technology transfer | Children | Recombinant | Vector-borne diseases | Medical research | Antigens | Immunization | Immunoglobulins | Polypeptides | Melanoma | Microscopy | Collaboration | Isoforms | Adults | Immunofluorescence
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