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1. Full Text Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
by Moessner, Ekkehard and Bruenker, Peter and Moser, Samuel and Puentener, Ursula and Schmidt, Carla and Herter, Sylvia and Grau, Roger and Gerdes, Christian and Nopora, Adam and van Puijenbroek, Erwin and Ferrara, Claudia and Sondermann, Peter and Jaeger, Christiane and Strein, Pamela and Fertig, Georg and Friess, Thomas and Schuell, Christine and Bauer, Sabine and Dal Porto, Joseph and Del Nagro, Christopher and Dabbagh, Karim and Dyer, Martin J. S and Poppema, Sibrand and Klein, Christian and Umana, Pablo
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 22, pp. 4393 - 4402
CD20 is an important target for the treatment of B-cell malignancies, including non-Hodgkin lymphoma as well as autoimmune disorders. B-cell depletion therapy... 
COMPLEMENT | RITUXIMAB | IN-VIVO | LIPID RAFTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | MONOCLONAL-ANTIBODY | FOLLICULAR LYMPHOMA | HEMATOLOGY | C-RECEPTOR POLYMORPHISMS | FULLY HUMAN | Lymphoma, Non-Hodgkin - immunology | Neoplasm Transplantation | Humans | Lymphoma, B-Cell - therapy | Macaca fascicularis | Transplantation, Heterologous | Antibodies, Monoclonal, Humanized | Lymphoma, B-Cell - immunology | Protein Engineering | Female | Antibodies, Monoclonal - immunology | Antigens, CD20 - immunology | Antibodies, Monoclonal, Murine-Derived | Antibody-Dependent Cell Cytotoxicity | Antibodies, Monoclonal - pharmacology | Rituximab | Receptors, IgG - immunology | Mice, SCID | Antibodies, Monoclonal - genetics | Animals | B-Lymphocytes - immunology | Lymphoma, Non-Hodgkin - therapy | Cell Line, Tumor | Immunoglobulin Variable Region - genetics | Mice | In Vitro Techniques | Immunity, Cellular | Immunoglobulin Fc Fragments - genetics | Lymphocyte Depletion - methods | Cytotoxicity, Immunologic | Immunobiology
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2. Full Text Antibody‐dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells
by Ochoa, Maria Carmen and Minute, Luna and Rodriguez, Inmaculada and Garasa, Saray and Perez‐Ruiz, Elisabeth and Inogés, Susana and Melero, Ignacio and Berraondo, Pedro
Immunology and Cell Biology, ISSN 0818-9641, 04/2017, Volume 95, Issue 4, pp. 347 - 355
Antibody‐dependent cellular cytotoxicity (ADCC) is a set of mechanisms that target cells coated with IgG antibodies of the proper subclasses (IgG1 in the... 
HUMAN-TUMOR-CELLS | NATURAL-KILLER-CELLS | PHASE-II TRIAL | IN-VITRO | ANTI-CD20 MONOCLONAL-ANTIBODY | TGF-BETA | FC-GAMMA-RIIIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | RECOMBINANT INTERLEUKIN-2 | IMMUNOLOGY | CELL BIOLOGY | Macrophages - physiology | Killer Cells, Natural - transplantation | Immunotherapy, Adoptive - methods | Antibody-Dependent Cell Cytotoxicity | Cytokines - metabolism | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Antigens, Neoplasm - immunology | Humans | Antibody Affinity | Molecular Targeted Therapy | Receptors, IgG - metabolism | Neoplasms - therapy | Animals | Neoplasms - immunology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Toll-Like Receptors - metabolism
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3. Full Text Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC
by Collins, Shauna M and Bakan, Courtney E and Swartzel, Gina D and Hofmeister, Craig C and Efebera, Yvonne A and Kwon, Hakju and Starling, Gary C and Ciarlariello, David and Bhaskar, Shakthi and Briercheck, Edward L and Hughes, Tiffany and Yu, Jianhua and Rice, Audie and Benson Jr, Don M
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 12/2013, Volume 62, Issue 12, pp. 1841 - 1849
Elotuzumab is a monoclonal antibody in development for multiple myeloma (MM) that targets CS1, a cell surface glycoprotein expressed on MM cells. In... 
Immunology | Medicine & Public Health | Immunotherapy | Multiple myeloma | Oncology | Cancer Research | Natural killer cells | Elotuzumab | MULTIPLE-MYELOMA | NTB-A | ACTIVATION | CRACC | NATURAL-KILLER-CELL | PROLIFERATION | IMMUNOLOGY | COMBINATION | ONCOLOGY | LENALIDOMIDE | MONOCLONAL-ANTIBODIES | EXPRESSION | Cell Proliferation | Immunoprecipitation | Lymphocyte Activation | Humans | RNA, Messenger - genetics | Antibody-Dependent Cell Cytotoxicity - immunology | Multiple Myeloma - immunology | Interferon-gamma - metabolism | Signaling Lymphocytic Activation Molecule Family | Transcription Factors - genetics | Multiple Myeloma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Transcription Factors - metabolism | Multiple Myeloma - drug therapy | Flow Cytometry | Antibodies, Monoclonal, Humanized - pharmacology | Killer Cells, Natural - immunology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Tumor Cells, Cultured | Receptors, Immunologic - genetics | Real-Time Polymerase Chain Reaction | Receptors, Immunologic - metabolism | Monoclonal antibodies | Killer cells | Analysis | Cells
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4. Full Text Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers
by Lambotte, Olivier and Ferrari, Guido and Moog, Christiane and Yates, Nicole L and Liao, Hua-Xin and Parks, Robert J and Hicks, Charles B and Owzar, Kouros and Tomaras, Georgia D and Montefiori, David C and Haynes, Barton F and Jean-François Delfraissy, Delfraissy
AIDS, ISSN 0269-9370, 05/2009, Volume 23, Issue 8, pp. 897 - 906
To determine the spectrum of antiviral antibodies in HIV-1-infected individuals in whom viral replication is spontaneously undetectable, termed HIV controllers... 
HIV controller | Neutralizing antibodies | FcγR | Antibody-dependent cell cytotoxicity | Humoral immunity | Autoantibodies - metabolism | env Gene Products, Human Immunodeficiency Virus - immunology | Antibody-Dependent Cell Cytotoxicity | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Antibodies, Neutralizing - metabolism | Neutralization Tests | RNA, Viral - blood | Epitopes | Case-Control Studies | CD8-Positive T-Lymphocytes | Young Adult | HIV-1 - physiology | Adult | Aged | France | Life Sciences | Immunology | neutralizing antibodies | humoral immunity | antibody-dependent cell cytotoxicity
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5. Full Text CD14+ monocyte‐derived galectin‐9 induces natural killer cell cytotoxicity in chronic hepatitis C
by Nishio, Akira and Tatsumi, Tomohide and Nawa, Takatoshi and Suda, Takahiro and Yoshioka, Teppei and Onishi, Yoshiki and Aono, Satoshi and Shigekawa, Minoru and Hikita, Hayato and Sakamori, Ryotaro and Okuzaki, Daisuke and Fukuhara, Takasuke and Matsuura, Yoshiharu and Hiramatsu, Naoki and Takehara, Tetsuo
Hepatology, ISSN 0270-9139, 01/2017, Volume 65, Issue 1, pp. 18 - 31
Natural killer (NK) cell activation is associated with both liver injury and persistent infection in chronic hepatitis C (CHC); however, the detailed mechanism... 
TIM-3 EXPRESSION | B-VIRUS | APOPTOSIS | IN-VITRO | VIRUS-INFECTION | GAMMA PRODUCTION | ROLES | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | Antibody-Dependent Cell Cytotoxicity | Lymphocyte Activation | Humans | Middle Aged | Male | Monocytes - immunology | Killer Cells, Natural - physiology | Lipopolysaccharide Receptors | Galectins - physiology | Hepatitis C, Chronic - immunology | Aged, 80 and over | Adult | Female | Aged | Alanine | Liver | Chronic infection | Cytotoxicity | Leukocytes (mononuclear) | Infections | T cell receptors | Lymphocytes T | Hepatoma | CD14 antigen | Galectin-9 | Hepatitis | Monocytes | Cell activation | Clonal deletion | Hepatocytes | Persistent infection | Alanine transaminase | Peripheral blood mononuclear cells | Natural killer cells | Hepatitis C | Phosphatidylserine | Apoptosis
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6. Full Text Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity
by Scaltriti, M and Verma, C and Guzman, M and Jimenez, J and Parra, J.L and Pedersen, K and Smith, D.J and Landolfi, S and Ramon Y Cajal, S and Arribas, J and Baselga, J
Oncogene, ISSN 0950-9232, 02/2009, Volume 28, Issue 6, pp. 803 - 814
Lapatinib is a human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitor (TKI) that has clinical activity in HER2-amplified breast cancer. In... 
Breast cancer | ErbB receptor | Tyrosine kinase inhibitor | Antibody-dependent cell cytotoxicity (ADCC) | Trastuzumab | ADJUVANT CHEMOTHERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | breast cancer | OVARIAN-CANCER | ANTITUMOR-ACTIVITY | CELL BIOLOGY | trastuzumab | antibody-dependent cell cytotoxicity (ADCC) | BREAST-CANCER CELLS | FACTOR RECEPTOR EGFR | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | GENETICS & HEREDITY | MONOCLONAL-ANTIBODY CETUXIMAB | tyrosine kinase inhibitor | METASTATIC BREAST | Neoplasm Transplantation | Signal Transduction | Antibodies, Monoclonal - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Breast Neoplasms - drug therapy | Remission Induction | Breast Neoplasms - metabolism | Drug Synergism | Antibodies, Monoclonal, Humanized | Animals | Cell Line, Tumor | Cell Membrane - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Quinazolines - pharmacology | Physiological aspects | Cancer cells | Research | Oncology | Genetics | Inhibitor drugs | Kinases | Index Medicus
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7. Full Text Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity
by Grier, Jennifer T and Forbes, Lisa R and Monaco-Shawver, Linda and Oshinsky, Jennifer and Atkinson, T. Prescott and Moody, Curtis and Pandey, Rahul and Campbell, Kerry S and Orange, Jordan S
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3769 - 3780
The Fc receptor on NK cells, FcyRIIIA (CD 16), has been extensively studied for its role in mediating antibody-dependent cellular cytotoxicity (ADCC). A... 
GAMMA | MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | FC-RECEPTOR | ACTIVATION | LIGAND-BINDING | TYROSINE PHOSPHORYLATION | HUMAN CD2 | ADHESION MOLECULES | IMMUNOLOGICAL SYNAPSE | MONOCLONAL-ANTIBODIES | Herpesviridae Infections - etiology | Humans | Receptors, IgG - chemistry | Child, Preschool | Male | Mutation, Missense | Young Adult | Receptors, IgG - genetics | Cell Line - immunology | Epstein-Barr Virus Infections - etiology | Killer Cells, Natural - immunology | Female | Castleman Disease - virology | Papillomavirus Infections - etiology | Immunologic Deficiency Syndromes - immunology | CD2 Antigens - biosynthesis | Disease Susceptibility | GPI-Linked Proteins - immunology | Antibody-Dependent Cell Cytotoxicity | Models, Molecular | Castleman Disease - etiology | Genotype | Receptors, IgG - immunology | Immunological Synapses | GPI-Linked Proteins - chemistry | Melanoma - immunology | Adolescent | Cell Line, Tumor | Immunologic Deficiency Syndromes - genetics | Protein Conformation | CD2 Antigens - immunology | Cytotoxicity, Immunologic | GPI-Linked Proteins - genetics
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8. Full Text Antibody-dependent cell cytotoxicity synapses form in mice during tumor-specific antibody immunotherapy
by Hubert, Pascale and Heitzmann, Adèle and Viel, Sophie and Nicolas, André and Sastre-Garau, Xavier and Oppezzo, Pablo and Pritsch, Otto and Osinaga, Eduardo and Amigorena, Sebastian
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5134 - 5143
Antibody-dependent cell cytotoxicity (ADCC) plays a critical role in monoclonal antibody (mAb)-mediated cancer therapy. ADCC, however, has not been directly... 
B-CELL | ONCOLOGY | CYCLOPHOSPHAMIDE | METASTATIC BREAST-CANCER | IN-VIVO | LYMPHOMA | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | C-RECEPTOR POLYMORPHISMS | T-CELLS | ANTIGEN | Mammary Neoplasms, Experimental - immunology | Antibody Specificity | Antibodies, Neoplasm - therapeutic use | Breast Neoplasms - immunology | Humans | Ovarian Neoplasms - pathology | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents, Alkylating - pharmacology | Antigens, Tumor-Associated, Carbohydrate - immunology | Cystadenocarcinoma, Serous - pathology | Cyclophosphamide - therapeutic use | Antibodies, Monoclonal, Humanized | Female | Cystadenocarcinoma, Serous - immunology | Macrophages - immunology | Mammary Neoplasms, Experimental - drug therapy | Immunological Synapses - ultrastructure | Antibody-Dependent Cell Cytotoxicity | Antibodies, Monoclonal - pharmacology | Neutrophils - immunology | Combined Modality Therapy | Receptors, IgG - immunology | Mammary Neoplasms, Experimental - therapy | Antineoplastic Agents, Alkylating - therapeutic use | Tumor Microenvironment - immunology | Animals | Breast Neoplasms - pathology | Cell Line, Tumor - immunology | Cyclophosphamide - pharmacology | Immunological Synapses - immunology | Immunization, Passive | Mice | Mice, Inbred BALB C | Trastuzumab | Ovarian Neoplasms - immunology | Index Medicus | Tumor Microenvironment | Macrophages | Breast Neoplasms | Life Sciences | Antigens, Tumor-Associated, Carbohydrate | Cystadenocarcinoma, Serous | Ovarian Neoplasms | Antibodies, Neoplasm | Antineoplastic Agents, Alkylating | Biochemistry, Molecular Biology | Neutrophils | Antibodies, Monoclonal | Immunological Synapses | Receptors, IgG | Cyclophosphamide | Mammary Neoplasms, Experimental | Cell Line, Tumor | Cancer
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9. Full Text Down-Regulation of NKG2D and NKp80 Ligands by Kaposi's Sarcoma-Associated Herpesvirus K5 Protects against NK Cell Cytotoxicity
by Mair Thomas and Jessica M. Boname and Sarah Field and Sergey Nejentsev and Mariolina Salio and Vincenzo Cerundolo and Mark Wills and Paul J. Lehner
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 5, pp. 1656 - 1661
Natural killer (NK) cells are important early mediators of host immunity to viral infections. The NK activatory receptors NKG2D and NKp80, both C-type... 
Receptors | Human herpesvirus 8 | Cell lines | Alleles | HeLa cells | Cytotoxicity | Ligands | Natural killer cells | Down regulation | Mica | Ubiquitin | E3 ligase | Immune evasion | NATURAL-KILLER-CELLS | MEDIATED CYTOTOXICITY | MULTIDISCIPLINARY SCIENCES | HUMAN CYTOMEGALOVIRUS | VIRAL PROTEIN | ubiquitin | MHC CLASS-I | immune evasion | ACTIVE ANTIRETROVIRAL THERAPY | GENE-EXPRESSION | COSTIMULATION | GLYCOPROTEIN | T-CELLS | Membrane Glycoproteins - metabolism | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Receptors, Immunologic - antagonists & inhibitors | Herpesvirus 8, Human - immunology | Histocompatibility Antigens Class I - metabolism | Immediate-Early Proteins - metabolism | Lectins, C-Type - metabolism | Lysosomes - metabolism | Receptors, Natural Killer Cell | Genes, Viral | Killer Cells, Natural - immunology | Lysine - metabolism | Amino Acid Sequence | Cell Line | NK Cell Lectin-Like Receptor Subfamily K | Killer Cells, Natural - virology | Down-Regulation | Herpesvirus 8, Human - genetics | Histocompatibility Antigens Class I - genetics | Lysine - genetics | Immediate-Early Proteins - genetics | Cytotoxicity, Immunologic | Killer cells | Chemical properties | Herpesviruses | Research | Health aspects | Antibody-dependent cell cytotoxicity | Biological Sciences
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10. Full Text Monoclonal Antibody 2C6 Targets a Cross-Clade Conformational Epitope in gp41 with Highly Active Antibody-Dependent Cell Cytotoxicity
by Sojar, H and Baron, S and Sullivan, JT and Garrett, M and van Haaren, MM and Hoffman, J and Overbaugh, J and Doranz, BJ and Hicar, MD
JOURNAL OF VIROLOGY, ISSN 0022-538X, 09/2019, Volume 93, Issue 17
Previous studies in our laboratory characterized a panel of highly mutated HIV-specific conformational epitope-targeting antibodies (Abs) from a panel of... 
ENVELOPE GLYCOPROTEIN TRIMERS | antibody | PROTECTION | conformational epitope | NATIVE HIV | antibody-dependent cell cytotoxicity | VAGINAL SHIV CHALLENGE | IMMUNOGENICITY | VIROLOGY | HIV ENVELOPE | BROADLY NEUTRALIZING ANTIBODIES | IMMUNE-RESPONSES | IMMUNODEFICIENCY-VIRUS TYPE-1 | PARTICLES BEARING
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11. Full Text Ibrutinib antagonizes rituximab-dependent NK cell-mediated cytotoxicity
by Kohrt, Holbrook E and Sagiv-Barfi, Idit and Rafiq, Sarwish and Herman, Sarah E. M and Butchar, Jonathon P and Cheney, Carolyn and Zhang, Xiaoli and Buggy, Joseph J and Muthusamy, Natarajan and Levy, Ronald and Johnson, Amy J and Byrd, John C
Blood, ISSN 0006-4971, 03/2014, Volume 123, Issue 12, pp. 1957 - 1960
BTK | HEMATOLOGY | ITK | Cell Line | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Pyrimidines - administration & dosage | Humans | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Rituximab | Pyrazoles - administration & dosage | Animals | Drug Interactions | Lymphoma, B-Cell - immunology | Pyrimidines - adverse effects | Cell Line, Tumor | Killer Cells, Natural - immunology | Killer Cells, Natural - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Killer Cells, Natural - metabolism | Antibody-Dependent Cell Cytotoxicity - drug effects | Lymphoma, B-Cell - drug therapy | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyrazoles - adverse effects | Correspondence
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