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1. Full Text Glucosinolates and isothiocyanates in health and disease
by Dinkova-Kostova, Albena T and Kostov, Rumen V
Trends in Molecular Medicine, ISSN 1471-4914, 2012, Volume 18, Issue 6, pp. 337 - 347
Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following... 
Pathology | PHENETHYL ISOTHIOCYANATE | MEDICINE, RESEARCH & EXPERIMENTAL | MIGRATION INHIBITORY FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYL ISOTHIOCYANATE | CRUCIFEROUS VEGETABLES | SULFORAPHANE RESTORES | CELL BIOLOGY | TRANSCRIPTION FACTOR NRF2 | TRAUMATIC BRAIN-INJURY | INTRACEREBRAL HEMORRHAGE | SPINAL-CORD-INJURY | BROCCOLI SPROUT BEVERAGES | Cardiovascular Diseases - drug therapy | Humans | Isothiocyanates - administration & dosage | Diabetic Nephropathies - drug therapy | Glucosinolates - chemistry | Neuroprotective Agents - pharmacology | Anticarcinogenic Agents - administration & dosage | Isothiocyanates - chemistry | Anti-Bacterial Agents - chemistry | Helicobacter Infections - drug therapy | Models, Animal | Neuroprotective Agents - administration & dosage | Anticarcinogenic Agents - pharmacology | Isothiocyanates - pharmacology | Neuroprotective Agents - chemistry | Cardiotonic Agents - chemistry | Cardiotonic Agents - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Cardiotonic Agents - administration & dosage | Glucosinolates - pharmacology | Central Nervous System - drug effects | Anti-Bacterial Agents - pharmacology | Cell Transformation, Neoplastic - drug effects | Anti-Bacterial Agents - administration & dosage | Glucosinolates - administration & dosage | Skin - drug effects | Proteins | Analysis
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2. Full Text Anthocyanins: Natural colorants with health-promoting properties
by He, Jian and Monica Giusti, M
Annual Review of Food Science and Technology, ISSN 1941-1413, 04/2010, Volume 1, Issue 1, pp. 163 - 187
Anthocyanins are flavonoids in fruits and vegetables that render them vivid red to blue. To date, there have been more than 635 anthocyanins identified in... 
anti-carcinogenic | anti-inflammatory | metabolism | cardiovascular diseases | absorption | oxidative stress | LACTASE-PHLORHIZIN HYDROLASE | FOOD SCIENCE & TECHNOLOGY | DNA-DAMAGE | SMALL-INTESTINE | RICH EXTRACTS | PHASE-II ENZYMES | COLON-CANCER | IN-VITRO | DENSITY-LIPOPROTEIN OXIDATION | PLACEBO-CONTROLLED TRIALS | VACCINIUM-MYRTILLUS BILBERRY | Antioxidants - chemistry | Food Coloring Agents - administration & dosage | Fruit - chemistry | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Food Coloring Agents - chemistry | Anticarcinogenic Agents - metabolism | Anthocyanins - metabolism | Pigmentation | Anthocyanins - administration & dosage | Food Coloring Agents - metabolism | Anthocyanins - chemistry | Vegetables - chemistry | Animals | Anticarcinogenic Agents - chemistry | Health Promotion | Anticarcinogenic Agents - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Antioxidants - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anthocyanin | Food research | Properties | Identification and classification | Health aspects
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3. Full Text Dietary agents for prevention and treatment of lung cancer
by Khan, Naghma and Mukhtar, Hasan
Cancer Letters, ISSN 0304-3835, 2015, Volume 359, Issue 2, pp. 155 - 164
Highlights • Lung cancer has the highest cancer-related deaths in the United States. • Dietary modification could be an attractive approach for the prevention... 
Hematology, Oncology and Palliative Medicine | Prevention | Dietary agents | Treatment | Lung cancer | PHENETHYL ISOTHIOCYANATE | CARCINOMA CELLS | FACTOR-KAPPA-B | CELL-GROWTH | BENZYL ISOTHIOCYANATE | ONCOLOGY | SIGNALING PATHWAY | NUTRIENT MIXTURE | A/J MICE | TUMOR-GROWTH | GREEN TEA POLYPHENOL | Lung Neoplasms - drug therapy | Administration, Oral | Humans | Isothiocyanates - administration & dosage | Catechin - administration & dosage | Curcumin - administration & dosage | Adenocarcinoma - drug therapy | Indoles - administration & dosage | Plant Extracts - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Adenocarcinoma - prevention & control | Animals | Lung Neoplasms - prevention & control | Anticarcinogenic Agents - administration & dosage | Flavonoids - administration & dosage | Catechin - analogs & derivatives | Polyphenols - administration & dosage | Respiratory agents | Care and treatment | Cancer | Tea | Kinases | Rodents | Tumors | lung cancer | treatment | prevention
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4. Full Text Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
by Heather A. Hirsch and Dimitrios Iliopoulos and Kevin Struhl
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 3, pp. 972 - 977
Metformin, the first-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer stem cells in breast cancer cell lines. In... 
T lymphocytes | Cell growth | Phosphorylation | Stem cells | Cell lines | Breast cancer | Diabetes | Heterologous transplantation | Tumors | Cancer | Cancer treatment | Cancer prevention | Inflammation | cancer treatment | RESPIRATORY-CHAIN | METABOLIC SYNDROME | ACTIVATION | cancer prevention | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | CYCLE ARREST | DECREASES | CHEMOTHERAPY | BREAST-CANCER | DIABETIC-PATIENTS | inflammation | AMPK | Inflammation - pathology | Neoplastic Stem Cells - drug effects | Humans | NF-kappa B - metabolism | Breast Neoplasms - metabolism | Inflammation - metabolism | Hypoglycemic Agents - administration & dosage | Neoplastic Stem Cells - metabolism | Anticarcinogenic Agents - administration & dosage | Neoplastic Stem Cells - pathology | Female | Stress, Physiological - drug effects | Metformin - administration & dosage | Anticarcinogenic Agents - pharmacology | STAT3 Transcription Factor - metabolism | Doxorubicin - administration & dosage | Cell Line | Metformin - pharmacology | Breast Neoplasms - drug therapy | Cell Transformation, Neoplastic - metabolism | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Feedback, Physiological - drug effects | Inflammation - prevention & control | Mice | Cell Transformation, Neoplastic - drug effects | Cell Transformation, Neoplastic - pathology | Prevention | Cancer cells | Physiological aspects | Dosage and administration | Hypoglycemic agents | Metformin | Research | Cell transformation | Health aspects | Signal transduction | Metabolism | Biological Sciences
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5. Plants vs. cancer: A review on natural phytochemicals in preventing and treating cancers and their druggability
by Wang, Hu and Khor, Tin Oo and Shu, Limin and Su, Zheng-Yuan and Fuentes, Francisco and Lee, Jong-Hun and Kong, Ah-Ng Tony
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2012, Volume 12, Issue 10, pp. 1281 - 1305
Cancer remains to be one of the leading causes of death in the United States and around the world. The advent of modern drug-targeted therapies has undeniably... 
Natural compounds | Chemoprevention | Pathway | Druggability | Anti-cancer | Mechanism | Phytochemical | BETA-PHENYLETHYL ISOTHIOCYANATE | CHEMISTRY, MEDICINAL | POTENTIAL MOLECULAR TARGETS | GENE-EXPRESSION PROFILES | VITAMIN-D-RECEPTOR | CELL-CYCLE ARREST | FACTOR-KAPPA-B | HUMAN PROSTATE-CANCER | ONCOLOGY | ACIDS DOCOSAHEXAENOIC ACID | MOUSE PERITONEAL-MACROPHAGES | LPS-INDUCED INFLAMMATION | Humans | Neoplasms - prevention & control | Biological Products - pharmacology | Plant Preparations - administration & dosage | Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Anticarcinogenic Agents - administration & dosage | Plant Preparations - pharmacology | Plant Preparations - therapeutic use | Biological Products - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Anticarcinogenic Agents - pharmacology | Anticarcinogenic Agents - therapeutic use | Biological Products - therapeutic use
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6. Full Text Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: A pooled analysis in the ovarian cancer association consortium
by Trabert, Britton and Ness, Roberta B and Lo-Ciganic, Wei-Hsuan and Murphy, Megan A and Goode, Ellen L and Poole, Elizabeth M and Brinton, Louise A and Webb, Penelope M and Nagle, Christina M and Jordan, Susan J and Risch, Harvey A and Rossing, Mary Anne and Doherty, Jennifer A and Goodman, Marc T and Lurie, Galina and Kjær, Susanne K and Hogdall, Estrid and Jensen, Allan and Cramer, Daniel W and Terry, Kathryn L and Vitonis, Allison and Bandera, Elisa V and Olson, Sara and King, Melony G and Chandran, Urmila and Anton-Culver, Hoda and Ziogas, Argyrios and Menon, Usha and Gayther, Simon A and Ramus, Susan J and Gentry-Maharaj, Aleksandra and Wu, Anna H and Pearce, Celeste Leigh and Pike, Malcolm C and Berchuck, Andrew and Schildkraut, Joellen M and Wentzensen, Nicolas and Australian Ovarian Canc Study Grp and Ovarian Canc Assoc Consortium and Ovarian Cancer Association Consortium and Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer) and on behalf of the Ovarian Cancer Association Consortium and Australian Ovarian Cancer Study Group, the Australian Cancer Study (Ovarian Cancer)
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 2, pp. djt431 - djt431
Background Regular aspirin use is associated with reduced risk of several malignancies. Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal... 
PROSTATE | ANALGESIC DRUGS | LUNG | HORMONE-THERAPY | METAANALYSIS | SCREENING TRIAL | ONCOLOGY | INFLAMMATION | PRIMARY PREVENTION | INCESSANT OVULATION | ENDOMETRIAL CANCER | United States - epidemiology | Drug Administration Schedule | Ovarian Neoplasms - prevention & control | Humans | Neoplasms, Glandular and Epithelial - epidemiology | Acetaminophen - administration & dosage | Logistic Models | Risk | Data Collection | Neoplasms, Glandular and Epithelial - prevention & control | Australia - epidemiology | Case-Control Studies | Aspirin - administration & dosage | Incidence | Ovarian Neoplasms - epidemiology | Anticarcinogenic Agents - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Carcinoma, Ovarian Epithelial | Denmark - epidemiology | Female | Protective Agents - administration & dosage | Odds Ratio | United Kingdom - epidemiology | Prevention | Pharmacology, Experimental | Acetaminophen | Dosage and administration | Disease susceptibility | Nonsteroidal anti-inflammatory drugs | Research | Ovarian cancer
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7. Full Text Bovine milk-derived exosomes for drug delivery
by Munagala, Radha and Aqil, Farrukh and Jeyabalan, Jeyaprakash and Gupta, Ramesh C
Cancer Letters, ISSN 0304-3835, 2015, Volume 371, Issue 1, pp. 48 - 61
Highlights • Bovine milk is a biocompatible and scalable source of exosomes. • Milk exosomes can serve as a vehicle to deliver both hydrophilic and lipophilic... 
Hematology, Oncology and Palliative Medicine | Chemopreventive agents | Drug delivery | Tumor-targeting | Chemotherapeutic drugs | Milk-derived exosomes | SYSTEM | CELLS | RNA | IMMUNE-RELATED MICRORNAS | MICROVESICLES | CANCER-THERAPY | BREAST-MILK | EXTRACELLULAR VESICLES | ONCOLOGY | IN-VIVO | NANOTECHNOLOGY | Exosomes - metabolism | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Antineoplastic Agents - administration & dosage | Milk - toxicity | Anticarcinogenic Agents - pharmacokinetics | Drug Carriers | Nanoparticles | Tissue Distribution | Anticarcinogenic Agents - administration & dosage | Cattle | Exosomes - immunology | Female | Antineoplastic Agents - pharmacokinetics | Milk - immunology | Administration, Oral | Solubility | Immune Tolerance | Chemistry, Pharmaceutical | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Milk - metabolism | Cell Line, Tumor | Folic Acid - metabolism | Cell Proliferation - drug effects | Drugs | Drug delivery systems | Vehicles | Milk | Proteins | Automation | Statistical analysis | Hematology | Rodents | Ligands | Software | Brownian movements | Index Medicus | chemopreventive agents | drug delivery | chemotherapeutic drugs | tumor-targeting
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8. Full Text Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy
by Estrela, José M and Mena, Salvador and Obrador, Elena and Benlloch, María and Castellano, Gloria and Salvador, Rosario and Dellinger, Ryan W
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2017, Volume 60, Issue 23, pp. 9413 - 9436
Natural polyphenols are organic chemicals which contain phenol units in their structures. They show antitumor properties. However, a key problem is their short... 
BREAST-CANCER | HUMAN PROSTATE-CANCER | CHEMISTRY, MEDICINAL | IN-VIVO TOXICITY | CELL-CYCLE ARREST | FACTOR-KAPPA-B | INHIBITS PHORBOL ESTER | HUMAN HEPATOCELLULAR-CARCINOMA | DRUG-DELIVERY SYSTEMS | ABERRANT CRYPT FOCI | GREEN TEA POLYPHENOL | Neoplasms - metabolism | Phytochemicals - administration & dosage | Phytochemicals - therapeutic use | Humans | Polyphenols - pharmacology | Biological Availability | Anticarcinogenic Agents - pharmacokinetics | Drug Delivery Systems | Neoplasms - drug therapy | Phytochemicals - pharmacokinetics | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Polyphenols - pharmacokinetics | Anticarcinogenic Agents - administration & dosage | Polyphenols - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Anticarcinogenic Agents - pharmacology | Antineoplastic Agents, Phytogenic - pharmacokinetics | Phytochemicals - pharmacology | Polyphenols - administration & dosage | Anticarcinogenic Agents - therapeutic use | Index Medicus
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9. Full Text Aspirin for the primary prevention of cardiovascular disease and colorectal cancer: A decision analysis for the U.S. preventive services task force
by Dehmer, Steven P and Maciosek, Michael V and Flottemesch, Thomas J and LaFrance, Amy B and Whitlock, Evelyn P
Annals of Internal Medicine, ISSN 0003-4819, 06/2016, Volume 164, Issue 12, pp. 777 - 786
Background: Evidence indicates that aspirin is effective for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC) but also... 
UNITED-STATES | MORTALITY | POPULATION | MEDICINE, GENERAL & INTERNAL | EVENTS | LOW-DOSE ASPIRIN | ALTERNATE-DAY | SCORES | RISK | RANDOMIZED CONTROLLED-TRIAL | HEALTH OUTCOMES | Quality-Adjusted Life Years | Primary Prevention | Risk Assessment | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Decision Support Techniques | Colorectal Neoplasms - prevention & control | Male | Aspirin - administration & dosage | Fibrinolytic Agents - adverse effects | Gastrointestinal Hemorrhage - chemically induced | Stroke - chemically induced | Anticarcinogenic Agents - administration & dosage | Aspirin - adverse effects | Fibrinolytic Agents - therapeutic use | Adult | Female | Aged | Anticarcinogenic Agents - adverse effects | Aspirin - therapeutic use | Fibrinolytic Agents - administration & dosage | Anticarcinogenic Agents - therapeutic use | Prevention | Aspirin | Dosage and administration | Cardiovascular diseases | Colorectal cancer | Cardiovascular system | Adults
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10. Full Text Aspirin for the Chemoprevention of Colorectal Adenomas: Meta-analysis of the Randomized Trials
by Cole, Bernard F and Logan, Richard F and Halabi, Susan and Benamouzig, Robert and Sandler, Robert S and Grainge, Matthew J and Chaussade, Stanislas and Baron, John A
Journal of the National Cancer Institute, ISSN 0027-8874, 2/2009, Volume 101, Issue 4, pp. 256 - 266
Background Multiple lines of evidence indicate that aspirin has an antineoplastic effect in the large bowel. Randomized clinical trials have been conducted to... 
ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | CLINICAL-TRIALS | MEN | DOUBLE-BLIND | RISK | SULINDAC | CANCER | CYCLOOXYGENASE-2 INHIBITOR | PRIMARY PREVENTION | RECTAL POLYPS | Confidence Intervals | Double-Blind Method | Neoplasm Recurrence, Local - prevention & control | Humans | Middle Aged | Adenoma - prevention & control | Colorectal Neoplasms - prevention & control | Male | Aspirin - administration & dosage | Randomized Controlled Trials as Topic | Dose-Response Relationship, Drug | Medication Adherence | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anticarcinogenic Agents - administration & dosage | Aspirin - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Female | Aged | Anticarcinogenic Agents - adverse effects | Odds Ratio | Research Design | Prevention | Aspirin | Dosage and administration | Research | Colorectal cancer | Cancer | Clinical trials | Preventive medicine | Meta-analysis | Index Medicus
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11. Full Text The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol
by Teskač, K and Kristl, J
International Journal of Pharmaceutics, ISSN 0378-5173, 2010, Volume 390, Issue 1, pp. 61 - 69
The potential for colloidal carriers to increase drug bioavailability has spurred a renewed interest in their uptake mechanisms and movement within cells.... 
Nanoparticles | Cell uptake | Cell membrane | Resveratrol | Cell cycle | Nanomedicine | Controlled release | APOPTOSIS | PROTECTION | NLC | DRUG-DELIVERY | EPR | DELIVERY-SYSTEMS | INDUCTION | CANCER | SLN | PHARMACOLOGY & PHARMACY | LEUKEMIA | Stilbenes - administration & dosage | Nanoparticles - chemistry | Humans | Biological Availability | Delayed-Action Preparations - chemistry | Stilbenes - metabolism | Anticarcinogenic Agents - metabolism | Stilbenes - pharmacology | Drug Carriers - chemistry | Anticarcinogenic Agents - pharmacokinetics | Lipids - chemistry | Lecithins - chemistry | Anticarcinogenic Agents - administration & dosage | Delayed-Action Preparations - pharmacology | Metabolism - drug effects | Anticarcinogenic Agents - pharmacology | Poloxamer - chemistry | Drug Carriers - metabolism | Cell Size - drug effects | Keratinocytes - cytology | Static Electricity | Drug Carriers - pharmacology | Necrosis - chemically induced | Cell Shape - drug effects | Particle Size | Delayed-Action Preparations - metabolism | Keratinocytes - drug effects | Keratinocytes - metabolism | Intracellular Space - metabolism | Hydrophobic and Hydrophilic Interactions | Stilbenes - pharmacokinetics | Cell Proliferation - drug effects | Cell Cycle - drug effects | Cell Nucleus - drug effects | Cell Line, Transformed | Microscopy, Fluorescence
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12. Full Text Resveratrol: review on therapeutic potential and recent advances in drug delivery
by Pangeni, Rudra and Sahni, Jasjeet K and Ali, Javed and Sharma, Shrestha and Baboota, Sanjula
Expert Opinion on Drug Delivery, ISSN 1742-5247, 08/2014, Volume 11, Issue 8, pp. 1285 - 1298
Introduction: Natural products have seen a wide range of acceptability for the prevention and treatment of diseases throughout history. Resveratrol, a member... 
stilbene | antioxidant | bioavailability | resveratrol | Bioavailability | Antioxidant | Resveratrol | Stilbene | ANTIOXIDANT ACTIVITY | PHENOLIC-COMPOUNDS | POLYGONUM-CUSPIDATUM | PROTECTS DOPAMINERGIC-NEURONS | IN-VITRO | NITRIC-OXIDE | TRANS-RESVERATROL | PHARMACOLOGY & PHARMACY | RED WINE | HEALTHY-VOLUNTEERS |