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science & technology (21) 21
life sciences & biomedicine (17) 17
animals (13) 13
trypanosoma cruzi - drug effects (12) 12
humans (10) 10
physical sciences (10) 10
antichagasic (9) 9
chemistry (9) 9
pharmacology & pharmacy (9) 9
chemistry, medicinal (8) 8
antichagasic activity (7) 7
antiparasitic agents (7) 7
biochemistry & molecular biology (7) 7
chagas disease - drug therapy (7) 7
analysis (6) 6
antibiotics. antiinfectious agents. antiparasitic agents (6) 6
biological and medical sciences (6) 6
medical sciences (6) 6
pharmacology. drug treatments (6) 6
trypanocidal agents - pharmacology (6) 6
antiprotozoal agents - chemistry (5) 5
parasitology (5) 5
structure-activity relationship (5) 5
trypanocidal agents - chemistry (5) 5
antichagasic drugs (4) 4
chemistry, multidisciplinary (4) 4
doença de chagas (4) 4
molecular structure (4) 4
trypanosoma cruzi (4) 4
trypanosoma cruzi - enzymology (4) 4
antichagasic agents (3) 3
antichagásicos potenciais (3) 3
antiparasitic agents - pharmacology (3) 3
antiprotozoal agents - pharmacology (3) 3
benznidazole (3) 3
chagas disease (3) 3
chagas' disease (3) 3
drugs (3) 3
mice (3) 3
models, molecular (3) 3
nitroimidazoles - pharmacology (3) 3
parasitic diseases (3) 3
parasitic sensitivity tests (3) 3
trypanocidal agents - therapeutic use (3) 3
amastigotes (2) 2
antineoplastic agents - pharmacology (2) 2
antiparasitic agents - chemical synthesis (2) 2
antiparasitic agents - chemistry (2) 2
antiparasitários (2) 2
antiprotozoal agents - chemical synthesis (2) 2
antiprotozoal agents - therapeutic use (2) 2
bioisosters (2) 2
bioisósteros (2) 2
cell line (2) 2
cercopithecus aethiops (2) 2
chagas disease - parasitology (2) 2
chemistry, analytical (2) 2
chemistry, organic (2) 2
crystallography, x-ray (2) 2
cyclic n-oxides - pharmacology (2) 2
cyclic n-oxides - therapeutic use (2) 2
dispersive liquid-liquid microextraction (2) 2
dispersive liquid–liquid microextraction (2) 2
dose-response relationship, drug (2) 2
drug discovery (2) 2
electrochemistry (2) 2
female (2) 2
hidrazonas (2) 2
homoallylamines (2) 2
human (2) 2
ionic liquids (2) 2
ionic liquids - chemistry (2) 2
latenciação (2) 2
leishmania (2) 2
liberadores de óxido nítrico (2) 2
life sciences (2) 2
liquid chromatography (2) 2
macrophages (2) 2
methods (2) 2
microbiology (2) 2
molecular conformation (2) 2
molecular docking (2) 2
nadh, nadph oxidoreductases - antagonists & inhibitors (2) 2
nifurtimox (2) 2
nifurtimox - chemistry (2) 2
nifurtimox - pharmacology (2) 2
nifurtimox - toxicity (2) 2
nitric oxide (2) 2
organic chemistry (2) 2
parasites (2) 2
potential antichagasic agents (2) 2
prodrug design (2) 2
protozoa (2) 2
quantitative structure-activity relationship (2) 2
solvents (2) 2
stereoisomerism (2) 2
thiadiazines - pharmacology (2) 2
toxicity (2) 2
trichomonacidal (2) 2
tropical diseases (2) 2
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1. Heterocyclic N-Oxides - An emerging class of therapeutic agents
by Mfuh, A.M and Larionov, O.V
Current medicinal chemistry, ISSN 0929-8673, 08/2015, Volume 22, Issue 24, pp. 2819 - 2857
Antichagasic agents | Heterocyclic N-oxides | Bioisosteres | Factor xa inhibitors | Antimalarials | Hypoxia | Nitric oxide mimics | Coagulation cascade direct thrombin inhibitors | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Anti-HIV Agents - pharmacology | Neuroprotective Agents - therapeutic use | Antihypertensive Agents - pharmacology | Humans | Antineoplastic Agents - therapeutic use | Herbicides - pharmacology | Antihypertensive Agents - therapeutic use | Anti-Bacterial Agents - therapeutic use | Fibrinolytic Agents - pharmacology | Cyclic N-Oxides - therapeutic use | Animals | Neuroprotective Agents - pharmacology | Cyclic N-Oxides - pharmacology | Protein Kinase Inhibitors - therapeutic use | Fibrinolytic Agents - therapeutic use | Anti-HIV Agents - therapeutic use | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology
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2. Full Text Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies
by Gerpe, Alejandra and Aguirre, Gabriela and Boiani, Lucía and Cerecetto, Hugo and González, Mercedes and Olea-Azar, Claudio and Rigol, Carolina and Maya, Juan D and Morello, Antonio and Piro, Oscar E and Arán, Vicente J and Azqueta, Amaia and de Ceráin, Adela López and Monge, Antonio and Rojas, María Antonieta and Yaluff, Gloria
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 10, pp. 3467 - 3480
Indazole N-oxide | Leishmanocidal activity | Antichagasic activity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | General aspects | Pharmacology. Drug treatments | Biological and medical sciences | Antiparasitic agents | Medical sciences | Antineoplastic agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Indazoles - chemistry | Parasitic Sensitivity Tests | Indazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Cells, Cultured | Models, Molecular | Crystallography, X-Ray | Antiprotozoal Agents - chemistry | Antineoplastic Agents - chemistry | Antiprotozoal Agents - pharmacology | Indazoles - pharmacology | Animals | Cell Line, Tumor | Electrochemistry | Leishmania - drug effects | Trypanosoma cruzi - drug effects | Antiprotozoal Agents - chemical synthesis | Antineoplastic Agents - pharmacology | Quantitative Structure-Activity Relationship | Index Medicus
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3. Full Text N-Mannich bases of benzimidazole as a potent antitubercular and antiprotozoal agents: Their synthesis and computational studies
by Patel, Vatsal M and Patel, Navin B and Chan-Bacab, Manuel J and Rivera, Gildardo
Synthetic communications, ISSN 0039-7911, 03/2020, Volume 50, Issue 6, pp. 858 - 878
antichagasic | leishmanicidal | MD simulation | benzimidazole | molecular docking | antitubercular | Molecular dynamics | Synthesis | Tuberculosis | Computer simulation | Toxicity | Dynamic stability
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4. Macrocycles as potential therapeutic agents in neglected diseases
by Penã, Stella and Scarone, Laura and Serra, Gloria
Future medicinal chemistry, ISSN 1756-8919, 03/2015, Volume 7, Issue 3, pp. 355 - 382
antichagasic | antitrypanosomal | antilesihmania | macrocyles | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Macrocyclic Compounds - chemistry | Humans | Molecular Conformation | Neglected Diseases - drug therapy | Trypanocidal Agents - chemistry | Trypanocidal Agents - therapeutic use | Antiprotozoal Agents - chemistry | Antiprotozoal Agents - therapeutic use | Drug Discovery | Macrocyclic Compounds - therapeutic use
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5. Full Text 5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: Preliminary in vivo studies
by Cabrera, Eliana and Murguiondo, Mariana González and Arias, Marelina González and Arredondo, Carolina and Pintos, Cristina and Aguirre, Gabriela and Fernández, Marcelo and Basmadjián, Yester and Rosa, Raquel and Pacheco, José Pedro and Raymondo, Stella and Di Maio, Rossanna and González, Mercedes and Cerecetto, Hugo
European journal of medicinal chemistry, ISSN 0223-5234, 2009, Volume 44, Issue 10, pp. 3909 - 3914
Anti- Trypanosoma cruzi agents | 5-Nitrofuranes | Antichagasic in vivo activity | Anti-Trypanosoma cruzi agents | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Antiparasitic agents | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Chagas Disease - pathology | Nifurtimox - toxicity | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Animals | Nitrofurans - toxicity | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Female | Trypanocidal Agents - therapeutic use | Mice | Nifurtimox - therapeutic use | Nifurtimox - chemistry | Nitrofurans - chemistry | Nitrofurans - therapeutic use | Nitro compounds | Analysis | Index Medicus
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6. Full Text Determination and characterization of new benzimidazoles with activity against Trypanosoma cruzi by UV spectroscopy and HPLC
by Brain-Isasi, Stephanie and Quezada, Cristián and Pessoa, Hernán and Morello, Antonio and Kogan, Marcelo J and Álvarez-Lueje, Alejandro
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 16, pp. 7622 - 7630
log P | Determination | p Ka | Nitrophenylbenzimidazole | Antichagasic | HPLC | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Antiparasitic agents | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Animals | Trypanocidal Agents - pharmacology | Benzimidazoles - chemical synthesis | Electrochemistry | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Benzimidazoles - pharmacology | Trypanocidal Agents - chemistry | Kinetics | Benzimidazoles - chemistry | Spectrophotometry, Ultraviolet | Index Medicus
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7. Full Text Dipeptidyl nitrile derivatives suppress the Trypanosoma cruzi in vitro infection
by Quilles, José C and Shamim, Anwar and Tezuka, Daiane Y and Batista, Pedro H.J and Lopes, Carla D and de Albuquerque, Sérgio and Montanari, Carlos A and Leitão, Andrei
Experimental parasitology, ISSN 0014-4894, 12/2020, Volume 219, pp. 108032 - 108032
Chagas disease | Cysteine protease inhibition | Antichagasic compounds | Cell-based assays | Viability | Parasite forms | Life Sciences & Biomedicine | Parasitology | Science & Technology | Cell Line | Nitriles - pharmacology | Area Under Curve | Cell Survival | Cysteine Proteinase Inhibitors - toxicity | Stereoisomerism | Trypanosoma cruzi - metabolism | Kidney - cytology | Trypanosoma cruzi - enzymology | Haplorhini | Tetrazolium Salts | Animals | Trypanosoma cruzi - growth & development | Analysis of Variance | Proteolysis | Cysteine Proteinase Inhibitors - pharmacology | Antiparasitic Agents - pharmacology | Nitriles - chemistry | Thiazoles | Trypanosoma cruzi - drug effects | Cysteine Proteinase Inhibitors - chemistry | Antiparasitic Agents - chemistry | Index Medicus
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8. The chemotherapy of Chagas' disease: An overview
by Paulino, Margot and Iribarne, F and Dubin, M and Aguilera-Morales, S and Tapia, O and Stoppani, A.O.M
Mini reviews in medicinal chemistry, ISSN 1389-5575, 05/2005, Volume 5, Issue 5, pp. 499 - 519
Antichagasic agents | Trypanothione metabolism | Trypanosomiasis | Chemotherapy targets | Trypanothione reductase inhibitors | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Animals | Trypanocidal Agents - pharmacology | Humans | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Trypanocidal Agents - chemistry | Trypanocidal Agents - therapeutic use | NADH, NADPH Oxidoreductases - antagonists & inhibitors | NADH, NADPH Oxidoreductases - metabolism | Trypanosoma cruzi - enzymology | Trypanosomatina - drug effects | Trypanosomatina - enzymology
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9. Full Text Pyrazinoates as antiparasitic agents against Trypanosoma cruzi
by Vasconcelos, Camilla I and Varela, Marina T and Torrecilhas, Ana C and Fernandes, João P. S
Archiv der Pharmazie (Weinheim), ISSN 0365-6233, 11/2018, Volume 351, Issue 11, pp. e1800190 - n/a
antichagasic | antitrypanosoma agents | pyrazinoates | drug repositioning | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Cell Line | Cell Survival - drug effects | Parasitic Sensitivity Tests | Pyrazinamide - analogs & derivatives | Humans | THP-1 Cells | Structure-Activity Relationship | Pyrazinamide - chemistry | Antiparasitic Agents - chemical synthesis | Dose-Response Relationship, Drug | Pyrazinamide - pharmacology | Pyrazinamide - chemical synthesis | Antiparasitic Agents - pharmacology | Trypanosoma cruzi - drug effects | Molecular Structure | HeLa Cells | Antiparasitic Agents - chemistry | Antiparasitic agents | Analysis | Cells | Protozoa | Parasites | Index Medicus
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10. Full Text Insights into Chagas treatment based on the potential of bacteriocin AS-48
by Martín-Escolano, Rubén and Cebrián, Rubén and Martín-Escolano, Javier and Rosales, Maria J and Maqueda, Mercedes and Sánchez-Moreno, Manuel and Marín, Clotilde
International journal for parasitology -- drugs and drug resistance, ISSN 2211-3207, 08/2019, Volume 10, pp. 1 - 8
Drug discovery | Antichagasic agent | AS-48 | Bacteriocin | Trypanosoma cruzi | Pharmacology & Pharmacy | Parasitology | Life Sciences & Biomedicine | Science & Technology | Trypanocidal Agents - metabolism | Chagas Disease - parasitology | Nitroimidazoles - pharmacology | Reactive Oxygen Species - metabolism | Trypanosoma cruzi - metabolism | Enterococcus faecalis - chemistry | Mitochondria - metabolism | Mitochondria - drug effects | Animals | Enterococcus faecalis - metabolism | Trypanosoma cruzi - growth & development | Trypanocidal Agents - pharmacology | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Bacteriocins - pharmacology | Bacteriocins - metabolism | Index Medicus
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11. Full Text Structural relationships in the solid state of the anti-chagas agent (E)-phenylethenylbenzofuroxan
by Martins, Felipe Terra and Martins, Felipe Terra and Ayala, Alejandro Pedro and Ayala, Alejandro Pedro and Porcal, Williams and Porcal, Williams and Cerecetto, Hugo and Cerecetto, Hugo and González, Mercedes and González, Mercedes and Ellena, Javier and Ellena, Javier
Molecular diversity, ISSN 1381-1991, 11/2010, Volume 14, Issue 4, pp. 643 - 652
Life Sciences | Polymer Sciences | Biochemistry, general | FT-Raman | Antichagasic drug | Pharmacy | Geometry optimization | Mesomeric effect | Benzofuroxan derivative | Organic Chemistry | Crystal structure | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Stereoisomerism | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Phase Transition | Cyclic N-Oxides - therapeutic use | Cyclic N-Oxides - pharmacology | Oxadiazoles - pharmacology | X-Ray Diffraction | Antiprotozoal Agents - chemical synthesis | Spectrum Analysis, Raman | Molecular Structure | Oxadiazoles - chemistry | Oxadiazoles - chemical synthesis | Benzoxazoles - therapeutic use | Models, Molecular | Antiprotozoal Agents - chemistry | Cyclic N-Oxides - chemical synthesis | Benzoxazoles - chemical synthesis | Oxadiazoles - therapeutic use | Cyclic N-Oxides - chemistry | Benzoxazoles - chemistry | Models, Biological | Chagas Disease - drug therapy | Antiprotozoal Agents - therapeutic use | Raman spectroscopy | Structure | Mathematical optimization | Analysis | Crystals | Pharmacology | Molecular biology | Comparative analysis | Theory | Index Medicus
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