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Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2017, Volume 171, pp. 305 - 317
Targeting the sterol biosynthesis pathway has been explored for the development of new bioactive compounds. Among the enzymes of this pathway, oxidosqualene... 
Drug design | Enzyme inhibitors | Oxidosqualene cyclase | Steroid biosynthesis | Therapeutics | LANOSTEROL CYCLASE | TRYPANOSOMA-CRUZI | BIOCHEMISTRY & MOLECULAR BIOLOGY | UMBELLIFERONE AMINOALKYL DERIVATIVES | MAMMALIAN 2,3-OXIDOSQUALENE CYCLASE | SACCHAROMYCES-CEREVISIAE | CANDIDA-ALBICANS | FAST TOOL | RING FORMATION | ENDOCRINOLOGY & METABOLISM | PLANT STEROLS | CHOLESTEROL-BIOSYNTHESIS | Anti-Infective Agents - metabolism | Drug Evaluation, Preclinical - trends | Anti-Infective Agents - pharmacology | Humans | Molecular Conformation | Anticholesteremic Agents - chemistry | Antiparasitic Agents - metabolism | Antifungal Agents - chemistry | Antineoplastic Agents - metabolism | Anticholesteremic Agents - metabolism | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Antifungal Agents - metabolism | Drug Design | Antineoplastic Agents - pharmacology | Intramolecular Transferases - chemistry | Antifungal Agents - pharmacology | Catalytic Domain | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Molecular Docking Simulation - trends | Antineoplastic Agents - chemistry | Intramolecular Transferases - metabolism | Animals | Intramolecular Transferases - antagonists & inhibitors | Antiparasitic Agents - pharmacology | Protein Conformation | Anticholesteremic Agents - pharmacology | Antiparasitic Agents - chemistry | Anti-infective agents | Drug discovery | Steroids | Usage | Analysis | Low density lipoproteins | Anticholesteremic agents | Physiological aspects | Lead compounds
Journal Article
Molecules, ISSN 1420-3049, 01/2017, Volume 22, Issue 1, p. 1
Journal Article
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 12/2012, Volume 100, pp. 50 - 61
Journal Article
Journal Article
Journal Article
Chemosphere, ISSN 0045-6535, 04/2017, Volume 172, pp. 193 - 200
Pharmaceutically emerging micropollutants have become an environmental concern in recent years. In the present paper, the reactive species (RSs)-induced... 
Photolysis | Sunlight | Water Pollutants, Chemical - chemistry | Anticholesteremic Agents - chemistry | Hypolipidemic Agents - chemistry | Kinetics | Clofibric Acid - chemistry
Journal Article
Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5868, pp. 1391 - 1394
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The... 
Carotenoids | Virulence | Pigments | Squalene | Ligands | Reports | Biosynthesis | Infections | Diphosphates | Cholesterols | Staphylococcus aureus | TARGET | SQUALENE SYNTHASE INHIBITOR | MULTIDISCIPLINARY SCIENCES | Organothiophosphorus Compounds - therapeutic use | Virulence - drug effects | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Organothiophosphorus Compounds - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Anti-Bacterial Agents - therapeutic use | Anti-Bacterial Agents - chemistry | Staphylococcal Infections - microbiology | Organothiophosphorus Compounds - chemical synthesis | Staphylococcus aureus - metabolism | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Cell Line | Staphylococcal Infections - drug therapy | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Organothiophosphorus Compounds - metabolism | Protein Structure, Secondary | Farnesyl-Diphosphate Farnesyltransferase - isolation & purification | Enzyme Inhibitors - pharmacology | Polyisoprenyl Phosphates - metabolism | Staphylococcus aureus - pathogenicity | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Anti-Bacterial Agents - chemical synthesis | Animals | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Xanthophylls - biosynthesis | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Cholesterol - biosynthesis | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacterial Proteins - isolation & purification | Prevention | Physiological aspects | Staphylococcus aureus infections | Anticholesteremic agents | Enzymes | Inhibitor drugs | Rodents | Bacteria | Biochemistry | Drug resistance | Cholesterol
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 16, pp. 6511 - 6518
Cholesterol synthesis in animals is controlled by the regulated transport of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum... 
Hydroxyls | Sterols | Plasmids | Drug regulation | Amino acids | Cell membranes | Cholesterols | Room temperature | Steroids | P branes | COPII vesicles | Scap | Sterol regulatory element-binding protein pathway | Cholesterol homeostasis | cholesterol homeostasis | COENZYME-A REDUCTASE | LIPID-SYNTHESIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | CLEAVAGE-ACTIVATING PROTEIN | IN-VITRO | ER MEMBRANES | HAMSTER OVARY CELLS | SENSING DOMAIN | sterol regulatory element-binding protein pathway | Receptors, Steroid - metabolism | Cricetulus | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Anticholesteremic Agents - chemistry | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Sterol Regulatory Element Binding Proteins - chemistry | Endoplasmic Reticulum - chemistry | Anticholesteremic Agents - metabolism | Hydroxyl Radical - chemistry | Hydroxycholesterols - chemistry | Membrane Proteins - metabolism | Golgi Apparatus - chemistry | CHO Cells | Amino Acid Sequence | Cricetinae | Sterol Regulatory Element Binding Proteins - metabolism | Receptors, Steroid - chemistry | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Golgi Apparatus - metabolism | Hydroxycholesterols - metabolism | Protein Binding - physiology | Homeostasis | Research | Binding proteins | Endoplasmic reticulum | Biological Sciences
Journal Article