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Drug metabolism and disposition, ISSN 1521-009X, 2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism
Journal Article
Journal Article
Clinical pharmacology and therapeutics, ISSN 1532-6535, 2007, Volume 82, Issue 1, pp. 21 - 32
The low productivity and escalating costs of drug development have been well documented over the past several years. Less than 10% of new compounds that enter... 
TRIPTANS SEROTONIN | METAANALYSIS | DOSE-RESPONSE | INTEGRATION | 5-HT1B/1D AGONISTS | PHARMACOLOGY & PHARMACY | SIMULATION | MIGRAINE | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2011, Volume 378, Issue 9786, pp. 182 - 197
Summary The increasing prevalence, variable pathogenesis, progressive natural history, and complications of type 2 diabetes emphasise the urgent need for new... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | GLUCAGON-LIKE PEPTIDE-1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | ALPHA-CELL DYSFUNCTION | SMALL-MOLECULE | INSULIN-RESISTANCE | DOUBLE-BLIND | BARIATRIC SURGERY | BETA-CELL | INADEQUATE GLYCEMIC CONTROL | Glucokinase - physiology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Allylamine - therapeutic use | Liver - physiopathology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Peptides - administration & dosage | Hypoglycemic Agents - administration & dosage | Liver - drug effects | Insulin Resistance - physiology | Allylamine - pharmacology | Receptors, Dopamine D2 - drug effects | Glucagon-Like Peptide 1 - analysis | Venoms - administration & dosage | Indoles - pharmacology | Hyperglycemia - physiopathology | Colesevelam Hydrochloride | Bariatric Surgery | Hypoglycemic Agents - therapeutic use | Insulin-Secreting Cells - physiology | Obesity - surgery | Insulin - pharmacology | Comorbidity | Receptors, Dopamine D2 - agonists | Allylamine - analogs & derivatives | Treatment Outcome | Cardiovascular System - drug effects | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors | Bile Acids and Salts | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Randomized Controlled Trials as Topic | Anticholesteremic Agents - therapeutic use | Diabetes Mellitus, Type 2 - physiopathology | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | Obesity - epidemiology | Indoles - therapeutic use | Signal Transduction - physiology | Diabetes Mellitus, Type 2 - drug therapy | Anticholesteremic Agents - pharmacology | Type 2 diabetes | Technology application | Care and treatment | Therapeutics | Diagnosis | Research | Homeopathy | Materia medica and therapeutics | Obesity | Medical research | Insulin resistance | Diabetes | Insulin
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2003, Volume 9, Issue 1, pp. 10 - 19
Journal Article
Clinical therapeutics, ISSN 0149-2918, 2013, Volume 35, Issue 8, pp. 1082 - 1098
...). Hence, novel LDL-C-lowering agents that act via mechanisms distinct from HMG-CoA reductase inhibition are under investigation... 
Internal Medicine | Medical Education | unstable angina | dyslipidemia | monoclonal antibody | antisense oligonucleotide | hypercholesterolemia | myocardial infarction | Myocardial infarction | Hypercholesterolemia | Monoclonal antibody | Antisense oligonucleotide | Unstable angina | Dyslipidemia | TRIGLYCERIDE TRANSFER PROTEIN | B SYNTHESIS INHIBITION | LOW-DENSITY-LIPOPROTEIN | SUBTILISIN/KEXIN TYPE 9 | MONOCLONAL-ANTIBODY | RANDOMIZED CONTROLLED-TRIAL | PLASMA PCSK9 LEVELS | APOLIPOPROTEIN-B | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | PHARMACOLOGY & PHARMACY | ANTISENSE OLIGONUCLEOTIDES | Proprotein Convertases - antagonists & inhibitors | Apolipoproteins B - metabolism | Humans | Antibodies, Monoclonal - therapeutic use | Hypercholesterolemia - drug therapy | Proprotein Convertases - genetics | Oligonucleotides, Antisense - therapeutic use | Serine Endopeptidases - genetics | Cholesterol, LDL - blood | Apolipoproteins B - antagonists & inhibitors | Oligonucleotides, Antisense - pharmacology | Antibodies, Monoclonal - pharmacology | Proprotein Convertases - metabolism | Carrier Proteins - antagonists & inhibitors | Apolipoproteins B - genetics | Clinical Trials as Topic | Oligonucleotides, Antisense - adverse effects | Anticholesteremic Agents - adverse effects | Animals | Anticholesteremic Agents - therapeutic use | Carrier Proteins - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Serine Endopeptidases - metabolism | Anticholesteremic Agents - pharmacology | Acute Coronary Syndrome - prevention & control | Proprotein Convertase 9 | Prevention | Blood cholesterol | Low density lipoproteins | Clinical trials | Pharmacology | Coronary heart disease | Statins | Cardiovascular agents | Cardiovascular disease | Lipids | Heart attacks | Acute coronary syndromes | Cholesterol
Journal Article