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1. Full Text Seizure‐Promoting Effect of Blood–Brain Barrier Disruption
by Marchi, Nicola and Angelov, Lilyana and Masaryk, Thomas and Fazio, Vincent and Granata, Tiziana and Hernandez, Nadia and Hallene, Kerri and Diglaw, Tammy and Franic, Linda and Najm, Imad and Janigro, Damir
Epilepsia (Copenhagen), ISSN 0013-9580, 04/2007, Volume 48, Issue 4, pp. 732 - 742
Epileptogenesis | Tight junctions | Endothelial cells | Cerebrovascular disease | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Pharmacology. Drug treatments | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Neuroprotective agent | Medical sciences | Neuropharmacology | Nervous system (semeiology, syndromes) | Humans | Middle Aged | Blood-Brain Barrier - physiopathology | Male | Tomography, X-Ray Computed | Antineoplastic Agents - therapeutic use | Methotrexate - therapeutic use | Brain Neoplasms - complications | Electroencephalography - statistics & numerical data | Mannitol - pharmacology | Seizures - physiopathology | Lymphoma - drug therapy | Antineoplastic Agents - adverse effects | Swine | S100 Proteins - blood | Adult | Female | Disease Models, Animal | Cerebrovascular Disorders - physiopathology | Cerebrovascular Disorders - chemically induced | Brain - physiopathology | Seizures - diagnosis | Treatment Outcome | Biomarkers - blood | Functional Laterality | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Animals | Mannitol - administration & dosage | Seizures - etiology | Lymphoma - complications | Methotrexate - administration & dosage | Osmotic Pressure - drug effects | Infusions, Intra-Arterial | Epilepsy | Analysis | Index Medicus
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2. Full Text The Blood–Brain Barrier and Epilepsy
by Oby, Emily and Janigro, Damir
Epilepsia (Copenhagen), ISSN 0013-9580, 11/2006, Volume 47, Issue 11, pp. 1761 - 1774
Membrane transport proteins | Monosaccharide transport proteins | Epileptogenesis | Cerebral blood flow | Antiepileptic drugs | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Diseases of the nervous system | Pharmacology. Drug treatments | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Medical sciences | Neuropharmacology | Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) | Nervous system (semeiology, syndromes) | Anticonvulsants - pharmacokinetics | Cerebrovascular Circulation - physiology | Cerebrovascular Circulation - drug effects | Humans | Blood-Brain Barrier - physiopathology | Anticonvulsants - therapeutic use | Rats | Epilepsy - metabolism | Epilepsy - physiopathology | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Animals | Epilepsy - drug therapy | Drug Resistance, Multiple - physiology | Disease Models, Animal | Physiological aspects | Anticonvulsants | Epilepsy | Index Medicus
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3. Full Text Blood–brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches
by Marchi, Nicola and Granata, Tiziana and Ghosh, Chaitali and Janigro, Damir
Epilepsia (Copenhagen), ISSN 0013-9580, 11/2012, Volume 53, Issue 11, pp. 1877 - 1886
Glucocorticosteroids | Brain‐periphery axis | Inflammation | Brain homeostasis | Blood–brain barrier | Blood-brain barrier | Brain-periphery axis | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Pharmacology. Drug treatments | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Medical sciences | Neuropharmacology | Nervous system (semeiology, syndromes) | Animals | Humans | Blood-Brain Barrier - physiopathology | Anticonvulsants - metabolism | Anticonvulsants - therapeutic use | Epilepsy - drug therapy | Biological Transport - physiology | Epilepsy - physiopathology | Blood-Brain Barrier - metabolism | Epilepsy - blood | Neurosciences | Seizures (Medicine) | Neurons | Health aspects | Epilepsy | Index Medicus | Drugs | Neuroimaging | Blood cells | Discordance | Data processing | Nervous system | Antiepileptic agents | Angiogenesis | Reviews | Energy | Hemodynamics | Pharmacokinetics | Seizures
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4. Full Text Lamotrigine in pregnancy – therapeutic drug monitoring in maternal blood, amniotic fluid, and cord blood
by Paulzen, Michael and Lammertz, Sarah E and Veselinovic, Tanja and Goecke, Tamme W and Hiemke, Christoph and Gründer, Gerhard
International clinical psychopharmacology, ISSN 0268-1315, 09/2015, Volume 30, Issue 5, pp. 249 - 254
epilepsy | placental transfer | cord blood | lamotrigine | pregnancy | pharmacokinetics | mood stabilizer | therapeutic drug monitoring | amniotic fluid | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Young Adult | Anticonvulsants - pharmacokinetics | Amniotic Fluid - metabolism | Humans | Adult | Female | Drug Monitoring | Fetal Blood - metabolism | Pregnancy - blood | Infant, Newborn | Triazines - pharmacokinetics | Index Medicus
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5. Full Text The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy
by Brandt, Claudia and Hillmann, Petra and Noack, Andreas and Römermann, Kerstin and Öhler, Leon A and Rageot, Denise and Beaufils, Florent and Melone, Anna and Sele, Alexander M and Wymann, Matthias P and Fabbro, Doriano and Löscher, Wolfgang
Neuropharmacology, ISSN 0028-3908, 09/2018, Volume 140, pp. 107 - 120
Rapamycin | Tolerability | Pharmacokinetics | Everolimus | Epilepsy | Levetiracetam | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Azabicyclo Compounds - pharmacology | Phenobarbital - pharmacology | Phosphoinositide-3 Kinase Inhibitors | Seizures - prevention & control | Triazines - therapeutic use | Pyridines - pharmacokinetics | Hippocampus - drug effects | Morpholines - blood | Seizures - complications | Anticonvulsants - pharmacology | Ribosomal Proteins - metabolism | Everolimus - pharmacokinetics | Azabicyclo Compounds - therapeutic use | Female | Azabicyclo Compounds - pharmacokinetics | Phosphorylation - drug effects | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Morpholines - therapeutic use | Pyridines - therapeutic use | Anticonvulsants - blood | Anticonvulsants - pharmacokinetics | Triazines - pharmacology | Everolimus - pharmacology | Enzyme Inhibitors - pharmacology | Anticonvulsants - therapeutic use | Morpholines - pharmacology | Everolimus - blood | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Sirolimus - pharmacokinetics | Triazines - blood | Sirolimus - blood | Blood-Brain Barrier - drug effects | Sirolimus - pharmacology | Blood-Brain Barrier - metabolism | Epilepsy - complications | Catalysis - drug effects | Hippocampus - metabolism | Pyridines - blood | Animals | Levetiracetam - pharmacology | Azabicyclo Compounds - blood | Epilepsy - drug therapy | Mice | Pyridines - pharmacology | Morpholines - pharmacokinetics | Electroshock | Triazines - pharmacokinetics | Anticonvulsants | Seizures (Medicine) | Analysis | Index Medicus
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6. Full Text Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation
by van Vliet, Erwin A and Forte, Grazia and Holtman, Linda and den Burger, Jeroen C. G and Sinjewel, Arno and de Vries, Helga E and Aronica, Eleonora and Gorter, Jan A
Epilepsia (Copenhagen), ISSN 0013-9580, 2012, Volume 53, Issue 7, pp. 1254 - 1263
Temporal lobe epilepsy | Inflammation | Gliosis | Status epilepticus | Blood–brain barrier | Blood-brain barrier | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Pharmacology. Drug treatments | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Medical sciences | Neuropharmacology | Nervous system (semeiology, syndromes) | Microglia - metabolism | Electric Stimulation - adverse effects | TOR Serine-Threonine Kinases - metabolism | Vimentin - metabolism | Immunosuppressive Agents - therapeutic use | Seizures - drug therapy | Status Epilepticus - drug therapy | Male | Monocytes - metabolism | Phosphopyruvate Hydratase - metabolism | Electroencephalography | Statistics as Topic | Antigens, CD - metabolism | Time Factors | Statistics, Nonparametric | Cytokines - blood | Disease Models, Animal | Status Epilepticus - blood | Sirolimus - therapeutic use | Drug Administration Schedule | Microglia - drug effects | Status Epilepticus - etiology | Status Epilepticus - pathology | Rats | Sirolimus - blood | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Monocytes - drug effects | Animals | Signal Transduction - drug effects | Antigens, Differentiation, Myelomonocytic - metabolism | Seizures - etiology | CD11b Antigen - metabolism | Index Medicus
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7. Full Text Α Simple Method for the Determination of Lacosamide in Blood by GC‐MS
by Mouskeftara, Thomai and Alexandridou, Anastasia and Krokos, Adamantios and Gika, Helen and Mastrogianni, Orthodoxia and Orfanidis, Amvrosios and Raikos, Nikolaos
Journal of forensic sciences, ISSN 0022-1198, 01/2020, Volume 65, Issue 1, pp. 288 - 294
lacosamide | gas chromatography–mass spectrometry | forensic science | liquid–liquid extraction | clinical toxicology | therapeutic drug monitoring | fatal overdose concentration | Life Sciences & Biomedicine | Medicine, Legal | Legal Medicine | Science & Technology | Poisoning - diagnosis | Anticonvulsants - blood | Limit of Detection | Gas Chromatography-Mass Spectrometry | Lacosamide - blood | Lacosamide - poisoning | Anticonvulsants - poisoning | Humans | Linear Models | Forensic Toxicology | Liquid-Liquid Extraction | Drug Monitoring | Ethyl acetate | Linearity | Blood | Seizures | Index Medicus
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8. Full Text Simultaneous Analysis of 22 Antiepileptic Drugs in Postmortem Blood, Serum and Plasma Using LC–MS-MS with a Focus on Their Role in Forensic Cases
by Deeb, Shaza and McKeown, Denise A and Torrance, Hazel J and Wylie, Fiona M and Logan, Barry K and Scott, Karen S
Journal of analytical toxicology, ISSN 0146-4760, 10/2014, Volume 38, Issue 8, pp. 485 - 494
Physical Sciences | Toxicology | Chemistry | Chemistry, Analytical | Life Sciences & Biomedicine | Science & Technology | Anticonvulsants - blood | Limit of Detection | Reproducibility of Results | Carbamazepine - analogs & derivatives | Amines - blood | Humans | Triazines - blood | Pregabalin | Nipecotic Acids - blood | Piracetam - blood