X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2098) 2098
Publication (178) 178
Book Review (45) 45
Book / eBook (41) 41
Book Chapter (9) 9
Conference Proceeding (3) 3
Magazine Article (2) 2
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (1530) 1530
index medicus (1049) 1049
antidepressive agents - pharmacology (1037) 1037
male (981) 981
humans (841) 841
mice (781) 781
rats (696) 696
antidepressants (673) 673
pharmacology & pharmacy (661) 661
neurosciences (564) 564
depression (538) 538
antidepressive agents - therapeutic use (498) 498
antidepressive agents - chemical synthesis (457) 457
female (330) 330
psychiatry (329) 329
depression - drug therapy (327) 327
depression, mental (320) 320
antidepressant (317) 317
motor activity - drug effects (309) 309
behavior, animal - drug effects (306) 306
structure-activity relationship (304) 304
chemistry, medicinal (297) 297
antidepressive agents - chemistry (285) 285
analysis (259) 259
serotonin (259) 259
disease models, animal (241) 241
dose-response relationship, drug (236) 236
major depression (217) 217
fluoxetine (204) 204
forced swimming test (204) 204
brain (199) 199
brain - metabolism (194) 194
brain - drug effects (192) 192
rats, sprague-dawley (188) 188
serotonin - metabolism (177) 177
rats, wistar (176) 176
swimming (165) 165
antidepressive agents, tricyclic - pharmacology (163) 163
biochemistry & molecular biology (161) 161
depressive disorder - drug therapy (160) 160
clinical neurology (151) 151
drugs (141) 141
molecular structure (140) 140
major depressive disorder (134) 134
antidepressive agents - administration & dosage (130) 130
pharmacology (128) 128
chemistry, organic (126) 126
fluoxetine - pharmacology (125) 125
hippocampus - drug effects (123) 123
tail suspension test (121) 121
stress (117) 117
hippocampus - metabolism (115) 115
serotonin uptake inhibitors - pharmacology (115) 115
adult (114) 114
neurology (114) 114
rat-brain (111) 111
depression - metabolism (110) 110
antidepressive agents (108) 108
research (108) 108
norepinephrine - metabolism (105) 105
in vitro techniques (102) 102
time factors (101) 101
hippocampus (98) 98
drug therapy (97) 97
stereoisomerism (97) 97
dopamine (95) 95
biomedicine (94) 94
chemistry (94) 94
antidepressive agents - adverse effects (93) 93
article (93) 93
mental depression (92) 92
anti-anxiety agents - pharmacology (91) 91
anxiety (91) 91
middle aged (91) 91
receptors (91) 91
antidepressive agents - metabolism (89) 89
drug design (88) 88
imipramine - pharmacology (88) 88
piperazines - pharmacology (88) 88
mice, inbred c57bl (87) 87
antidepressive agents, second-generation - pharmacology (85) 85
dopamine - metabolism (85) 85
imipramine (85) 85
chemical phenomena (84) 84
drug interactions (84) 84
behavioral sciences (83) 83
double-blind (83) 83
pharmacology/toxicology (82) 82
forced swim test (77) 77
serotonin reuptake inhibitors (77) 77
chemistry, multidisciplinary (76) 76
oxidative stress (76) 76
antidepressants, tricyclic (75) 75
depressive disorder, major - drug therapy (75) 75
behavior (74) 74
physiological aspects (74) 74
desipramine - pharmacology (73) 73
ligands (73) 73
rat (73) 73
rodents (73) 73
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (35) 35
Collection Dvlpm't (Acquisitions) - Closed Orders (5) 5
Collection Dvlpm't (Acquisitions) - Vendor file (2) 2
UTL at Downsview - May be requested (2) 2
UofT at Mississauga - Stacks (2) 2
UofT at Scarborough - Stacks (2) 2
Engineering & Comp. Sci. - Stacks (1) 1
Gerstein Science - Circulation Desk (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2090) 2090
German (17) 17
French (11) 11
Italian (10) 10
Chinese (7) 7
Russian (6) 6
Polish (4) 4
Japanese (2) 2
Portuguese (1) 1
Romanian (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 9, pp. 3206 - 3221
The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin... 
FREELY MOVING RATS | ARYL BROMIDES | SEROTONIN REUPTAKE INHIBITORS | IN-VIVO MICRODIALYSIS | CHEMISTRY, MEDICINAL | PALLADIUM-CATALYZED SYNTHESIS | 5-HT1A RECEPTORS | MOOD DISORDERS | DRUG DISCOVERY | FRONTAL-CORTEX | ANTIDEPRESSANT-LIKE BEHAVIOR | Xenopus | Humans | Microsomes, Liver - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Sulfides - chemistry | Serotonin 5-HT1 Receptor Agonists - pharmacology | Sulfides - chemical synthesis | Piperazines - chemistry | Structure-Activity Relationship | Hippocampus - drug effects | Serotonin Uptake Inhibitors - chemical synthesis | Receptors, Serotonin, 5-HT1 - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Antidepressive Agents - chemistry | Oocytes - drug effects | Antidepressive Agents - pharmacology | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Sulfides - pharmacology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Drug Partial Agonism | Drug Stability | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Recombinant Proteins - agonists | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT3 Receptor Antagonists - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - metabolism | Hippocampus - metabolism | Animals | Oocytes - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Serotonin Uptake Inhibitors - pharmacology
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2014, Volume 57, Issue 11, pp. 4543 - 4557
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2016, Volume 108, pp. 334 - 346
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, pp. 142 - 154
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3436 - 3447
A series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-HT , 5-HT , 5-HT and dopamine D... 
D2/5-HT2A antagonist | Imidazolidine-2,4-dione spirohydantoins | Antidepressant activity | Antipsychotic activity | 5-HT1A partial agonist | partial agonist | 5-HT | antagonist | CHEMISTRY, MEDICINAL | PROTEIN | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | SCHIZOPHRENIA | PSYCHOLOGICAL SYMPTOMS | IDENTIFICATION | AGONISTS | D-2/5-HT2A antagonist | 5-HT1A RECEPTOR | DOPAMINE D-3 | RECEPTOR LIGANDS | 5-HTA partial agonist | ARIPIPRAZOLE | Depression - physiopathology | Imidazolidines - pharmacology | Male | Anxiety - drug therapy | Hyperkinesis - physiopathology | Structure-Activity Relationship | Receptors, Dopamine D2 - metabolism | Receptor, Serotonin, 5-HT2A - chemistry | Antipsychotic Agents - chemical synthesis | Hyperkinesis - drug therapy | Depression - drug therapy | Anti-Anxiety Agents - chemical synthesis | Receptors, Dopamine D2 - chemistry | Antidepressive Agents - pharmacology | Hyperkinesis - chemically induced | Swimming | Receptor, Serotonin, 5-HT1A - metabolism | Hydantoins - chemical synthesis | Hydantoins - pharmacology | Imidazolidines - chemical synthesis | Anti-Anxiety Agents - pharmacology | Anxiety - physiopathology | Dextroamphetamine | Receptors, Serotonin - chemistry | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Animals | Receptor, Serotonin, 5-HT1A - chemistry | Aripiprazole - pharmacology | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Mice | Antipsychotic Agents - pharmacology | Receptor, Serotonin, 5-HT2A - metabolism | Antidepressants | Schizophrenia | Medical colleges | Analysis | Depression, Mental
Journal Article