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1. Full Text The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy
by Navari, Rudolph M and Nagy, Cindy K and Gray, Sarah E
Supportive Care in Cancer, ISSN 0941-4355, 6/2013, Volume 21, Issue 6, pp. 1655 - 1663
Olanzapine has been shown to be a safe and effective agent for the prevention of chemotherapy-induced nausea and vomiting (CINV). Olanzapine may also be an... 
Breakthrough nausea and emesis | Pain Medicine | Chemotherapy | Nursing | Rehabilitation Medicine | Olanzapine | Medicine & Public Health | Oncology | Metoclopramide | Nursing Management/Nursing Research | PREVENTION | APREPITANT | PROPHYLAXIS | ANTIEMETIC ACTIVITY | CANCER-PATIENTS | INDUCED EMESIS | CISPLATIN | ONCOLOGY | HEALTH CARE SCIENCES & SERVICES | DOUBLE-BLIND | REHABILITATION | PALONOSETRON | QUALITY-OF-LIFE | Cyclophosphamide - administration & dosage | Isoquinolines - adverse effects | Nausea - chemically induced | Humans | Middle Aged | Antiemetics - administration & dosage | Dexamethasone - adverse effects | Male | Antineoplastic Agents - administration & dosage | Cyclophosphamide - adverse effects | Quinuclidines - administration & dosage | Cisplatin - administration & dosage | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Antiemetics - adverse effects | Female | Nausea - drug therapy | Vomiting - prevention & control | Quinuclidines - adverse effects | Doxorubicin - administration & dosage | Dexamethasone - administration & dosage | Double-Blind Method | Morpholines - administration & dosage | Metoclopramide - administration & dosage | Vomiting - drug therapy | Neoplasms - drug therapy | Nausea - prevention & control | Vomiting - chemically induced | Metoclopramide - adverse effects | Cisplatin - adverse effects | Benzodiazepines - administration & dosage | Aged | Benzodiazepines - adverse effects | Isoquinolines - administration & dosage | Doxorubicin - adverse effects | Care and treatment | Cyclophosphamide | Anthracyclines | Dexamethasone | Nausea | Cancer | Side effects | Drug therapy | Vomiting | Index Medicus
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2. Full Text Intranasal delivery: Physicochemical and therapeutic aspects
by Costantino, Henry R and Illum, Lisbeth and Brandt, Gordon and Johnson, Paul H and Quay, Steven C
International Journal of Pharmaceutics, ISSN 0378-5173, 2007, Volume 337, Issue 1, pp. 1 - 24
Interest in intranasal (IN) administration as a non-invasive route for drug delivery continues to grow rapidly. The nasal mucosa offers numerous benefits as a... 
Intranasal drug delivery | Pharmacokinetics | Nasal mucosa | Physicochemical properties | IN-VIVO BIOAVAILABILITY | DEPENDENT DIABETIC-PATIENTS | DIMETHYL-BETA-CYCLODEXTRIN | DIFFERENT MOLECULAR-WEIGHTS | NORKETAMINE PLASMA-CONCENTRATIONS | intranasal drug delivery | physicochemical properties | pharmacokinetics | nasal mucosa | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | ACUTE CHILDHOOD SEIZURES | CSF FOLLOWING INTRANASAL | NASAL DRUG-DELIVERY | WATER-SOLUBLE COMPOUNDS | Cholinesterase Inhibitors - pharmacokinetics | Hypnotics and Sedatives - chemistry | Central Nervous System - metabolism | Molecular Weight | Humans | Vaccines - pharmacokinetics | Cholinesterase Inhibitors - chemistry | Hypnotics and Sedatives - administration & dosage | Antiemetics - administration & dosage | Analgesics - pharmacokinetics | Antiemetics - pharmacokinetics | Inflammation - metabolism | Vaccines - chemistry | Cardiovascular Agents - pharmacokinetics | Drug Compounding | Antiemetics - chemistry | Nasal Mucosa - metabolism | Cardiovascular Agents - administration & dosage | Drug Administration Schedule | Hypnotics and Sedatives - pharmacokinetics | Drug Stability | Solubility | Analgesics - administration & dosage | Administration, Intranasal | Chemistry, Pharmaceutical | Carrier Proteins - metabolism | Cholinesterase Inhibitors - administration & dosage | Analgesics - chemistry | Hydrophobic and Hydrophilic Interactions | Vaccines - administration & dosage | Cardiovascular Agents - chemistry
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3. Full Text Intravenous buspirone for the prevention of postoperative nausea and vomiting
by Kranke, Peter and Röhm, Kerstin D and Diemunsch, Pierre and Gan, Tong J and Apfel, Christian C and Eberhart, Leopold and Minkowitz, Harold S and Wallenborn, Jan and Chassard, Dominique and Lebuffe, Gilles and Fox, Gabriel M and Tramèr, Martin R
European Journal of Clinical Pharmacology, ISSN 0031-6970, 11/2012, Volume 68, Issue 11, pp. 1465 - 1472
Buspirone, a partial 5HT1A agonist and D2 and D3 antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy... 
Biomedicine | Buspirone | Pharmacology/Toxicology | Randomised clinical trial | Antiemetic | Postoperative nausea and vomiting | CATS | MANAGEMENT | 5-HT1A RECEPTORS | ONDANSETRON | AGONISTS | FLESINOXAN | PROPHYLAXIS | ANXIOLYTICS | PHARMACOLOGY & PHARMACY | 5-HT(1A) RECEPTOR | CISPLATIN-INDUCED EMESIS | Anti-Anxiety Agents - administration & dosage | Injections, Intravenous | Buspirone - blood | Dopamine Antagonists - pharmacokinetics | Humans | Middle Aged | Receptors, Dopamine D3 - metabolism | Antiemetics - administration & dosage | Male | Buspirone - pharmacokinetics | Receptors, Dopamine D2 - metabolism | Dopamine Antagonists - administration & dosage | Incidence | Dose-Response Relationship, Drug | Young Adult | Anti-Anxiety Agents - pharmacokinetics | Buspirone - administration & dosage | Antiemetics - pharmacokinetics | Antiemetics - therapeutic use | Aged, 80 and over | Adult | Anti-Anxiety Agents - adverse effects | Antiemetics - adverse effects | Female | Anti-Anxiety Agents - therapeutic use | Buspirone - adverse effects | Receptors, Dopamine D3 - antagonists & inhibitors | Buspirone - therapeutic use | Receptor, Serotonin, 5-HT1A - metabolism | Postoperative Nausea and Vomiting - epidemiology | Double-Blind Method | Dopamine Antagonists - therapeutic use | Serotonin 5-HT1 Receptor Agonists - therapeutic use | Serotonin 5-HT1 Receptor Agonists - adverse effects | Postoperative Nausea and Vomiting - prevention & control | Receptor, Serotonin, 5-HT1A - chemistry | Buspirone - analogs & derivatives | Dopamine Antagonists - adverse effects | Serotonin 5-HT1 Receptor Agonists - administration & dosage | Aged | Dopamine D2 Receptor Antagonists | Postoperative Nausea and Vomiting - blood | Prevention | Complications and side effects | Buspirone hydrochloride | Adults | Nausea | Analysis | Postoperative period | Vomiting | Clinical trials | Pharmacology | Drug therapy | Clinical outcomes
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4. Full Text Perioperative Dexamethasone Administration and Risk of Bleeding Following Tonsillectomy in Children: A Randomized Controlled Trial
by Gallagher, LCDR Thomas Q and Hill, Courtney and Ojha, Shilpa and Ference, Elisabeth and Keamy, Donald G and Williams, Michael and Hansen, Maynard and Maurer, Rie and Collins, Corey and Setlur, Jennifer and Capra, LCDR Gregory G and Brigger, CDR Matthew T and Hartnick, Christopher J
JAMA, ISSN 0098-7484, 09/2012, Volume 308, Issue 12, pp. 1221 - 1226
CONTEXT Corticosteroids are commonly given to children undergoing tonsillectomy to reduce postoperative nausea and vomiting; however, they might increase the... 
MEDICINE, GENERAL & INTERNAL | METAANALYSIS | MORBIDITY | HEMORRHAGE | ADENOIDECTOMY | COMPLICATIONS | ADENOTONSILLECTOMY | Perioperative Care | Severity of Illness Index | Prospective Studies | Double-Blind Method | Humans | Child, Preschool | Dexamethasone - adverse effects | Male | Postoperative Hemorrhage - chemically induced | Risk | Postoperative Nausea and Vomiting - prevention & control | Dexamethasone - therapeutic use | Tonsillectomy | Antiemetics - therapeutic use | Adolescent | Antiemetics - adverse effects | Female | Child | Complications and side effects | Dexamethasone | Complications | Surgery | Causes of | Hemorrhage | Risk factors | Clinical trials | Drug therapy | Throat surgery | Children & youth
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5. Full Text A comprehensive multimodal pain treatment reduces opioid consumption after multilevel spine surgery
by Mathiesen, Ole and Dahl, Benny and Thomsen, Berit A and Kitter, Birgitte and Sonne, Nan and Dahl, Jørgen B and Kehlet, Henrik
European Spine Journal, ISSN 0940-6719, 9/2013, Volume 22, Issue 9, pp. 2089 - 2096
Major spine surgery with multilevel instrumentation is followed by large amount of opioid consumption, significant pain and difficult mobilization in a... 
Mobilization | Surgical Orthopedics | Medicine & Public Health | Opioid consumption | Multimodal pain treatment | Major spine surgery | Neurosurgery | MORPHINE | FUSION SURGERY | METHYLPREDNISOLONE | TRENDS | CLINICAL NEUROLOGY | ISSUES | RECOVERY | TOTAL DISC REPLACEMENT | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PLACEBO-CONTROLLED TRIAL | ORTHOPEDICS | Acetaminophen - adverse effects | Postoperative Nausea and Vomiting - chemically induced | Pain, Postoperative - drug therapy | Humans | Middle Aged | Acetaminophen - administration & dosage | Antiemetics - administration & dosage | Dexamethasone - adverse effects | Male | gamma-Aminobutyric Acid - administration & dosage | Spinal Fusion - adverse effects | Case-Control Studies | Young Adult | Analgesics, Opioid - adverse effects | Analgesics, Non-Narcotic - adverse effects | Aged, 80 and over | Amines - administration & dosage | Adult | Antiemetics - adverse effects | Female | Amines - adverse effects | Drug Therapy, Combination | gamma-Aminobutyric Acid - adverse effects | Spinal Diseases - surgery | Dexamethasone - administration & dosage | Cyclohexanecarboxylic Acids - adverse effects | Cyclohexanecarboxylic Acids - administration & dosage | Analgesics, Non-Narcotic - administration & dosage | Postoperative Nausea and Vomiting - drug therapy | Analgesics, Opioid - administration & dosage | Adolescent | Aged | Care and treatment | Pain | Corticosteroids | Anesthesia | Morphine | Nausea | Chronic pain | Original
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6. Full Text Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update
by Ethan Basch and Ann Alexis Prestrud and Paul J. Hesketh and Mark G. Kris and Petra C. Feyer and Mark R. Somerfield and Maurice Chesney and Rebecca Anne Clark-Snow and Anne Marie Flaherty and Barbara Freundlich and Gary Morrow and Kamakshi V. Rao and Rowena N. Schwartz and Gary H. Lyman and American Society of Clinical Oncology
Journal of Clinical Oncology, ISSN 0732-183X, 11/2011, Volume 29, Issue 31, pp. 4189 - 4198
Purpose To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology. Methods A systematic review of the medical literature... 
INDUCED EMESIS | CHEMOTHERAPY-INDUCED NAUSEA | PLUS DEXAMETHASONE | EFFICACY | ONCOLOGY | MODERATELY EMETOGENIC CHEMOTHERAPY | DOUBLE-BLIND | PREVENTION | APREPITANT | RANDOMIZED-TRIAL | PALONOSETRON | Serotonin Antagonists - administration & dosage | Dexamethasone - administration & dosage | Drug Administration Schedule | Nausea - chemically induced | Humans | Morpholines - administration & dosage | Radiotherapy - adverse effects | Vomiting - drug therapy | Quinuclidines - administration & dosage | Vomiting - chemically induced | Nausea - etiology | Antineoplastic Agents - adverse effects | Antiemetics - therapeutic use | Vomiting - etiology | Surveys and Questionnaires | Infusions, Intravenous | Nausea - drug therapy | Isoquinolines - administration & dosage | Vomiting - prevention & control | Neurokinin-1 Receptor Antagonists | ASCO Special | Gdln1 | Cmpl4 | Cmpl3
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7. Full Text Continuous administration of ramosetron with patient-controlled analgesia after laparoscopic distal gastrectomy does not delay postoperative bowel function recovery: A prospective, randomized, double-blinded study
by Jung, Hong Soo and Huh, Jaewon and Kim, Youngchan and Hong, Sang Hyun and Lee, Jaemin
Medicine, ISSN 0025-7974, 08/2018, Volume 97, Issue 31, p. e11503
Background: Currently, 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are indicated to slow gastrointestinal motility in the diarrhea-predominant... 
ANTAGONIST | MANAGEMENT | DIARRHEA | irritable bowel syndrome | PREVENTION | ILEUS | 5-hydroxytryptamine type 3 | postoperative nausea and vomiting | MEDICINE, GENERAL & INTERNAL | GASTRIC-CANCER | postoperative bowel function recovery | opioid-induced nausea and vomiting | NAUSEA | GASTROINTESTINAL MOTILITY | SEROTONIN | CHOLECYSTECTOMY | Prospective Studies | Analgesia, Patient-Controlled - methods | Double-Blind Method | Defecation - drug effects | Humans | Middle Aged | Antiemetics - administration & dosage | Male | Postoperative Nausea and Vomiting - prevention & control | Recovery of Function | Laparoscopy - methods | Gastrectomy - methods | Benzimidazoles - administration & dosage | Adult | Female | Aged | Postoperative period | Patient outcomes | Antiemetics | Physiological aspects | Dosage and administration | Gastrectomy | Health aspects | Quality of life
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8. Full Text Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy
by Rapoport, Bernardo and Schwartzberg, Lee and Chasen, Martin and Powers, Dan and Arora, Sujata and Navari, Rudolph and Schnadig, Ian
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 57, pp. 23 - 30
Abstract Objective Rolapitant, a novel neurokinin-1 receptor antagonist (RA), was shown to protect against delayed chemotherapy-induced nausea and vomiting... 
Hematology, Oncology and Palliative Medicine | Multiple cycles | Rolapitant | Neurokinin-1 receptor antagonist | Antiemetic | Chemotherapy-induced nausea and vomiting | Subsequent cycles | DEXAMETHASONE | PHASE-III | APREPITANT | ORAL NK1 ANTAGONIST | CANCER | RECEPTOR ANTAGONIST | CISPLATIN-BASED CHEMOTHERAPY | PHARMACOKINETICS | ONCOLOGY | DOUBLE-BLIND | ANTIEMETICS PROVIDES PROTECTION | Granisetron - administration & dosage | Nausea - chemically induced | Humans | Middle Aged | Antiemetics - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Spiro Compounds - administration & dosage | Male | Spiro Compounds - adverse effects | Serotonin 5-HT3 Receptor Antagonists - administration & dosage | Young Adult | Clinical Trials, Phase III as Topic | Aged, 80 and over | Adult | Antiemetics - adverse effects | Female | Drug Therapy, Combination | Vomiting - prevention & control | Granisetron - adverse effects | Dexamethasone - administration & dosage | Neurokinin-1 Receptor Antagonists - adverse effects | Double-Blind Method | Administration, Oral | Ondansetron - administration & dosage | Neurokinin-1 Receptor Antagonists - administration & dosage | Treatment Outcome | Neoplasms - drug therapy | Randomized Controlled Trials as Topic | Nausea - prevention & control | Retreatment | Vomiting - chemically induced | Aged | Ondansetron - adverse effects | Clinical Trials, Phase II as Topic | Prevention | Medical colleges | Chemotherapy | Nausea | Analysis | Cancer | Index Medicus
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9. Full Text Diclofenac with or without an antiemetic for acute migraine headaches in adults
by Derry, Sheena and Derry, Sheena and Rabbie, Roy and Rabbie, Roy and Moore, R Andrew and Moore, R Andrew
The Cochrane database of systematic reviews, ISSN 1469-493X, 2013, Volume 4, Issue 9, p. CD008783
Background This review is an update of a previously published review in Issue 2, 2012 (Derry 2012a). Migraine is a common, disabling condition and a burden for... 
UNITED-STATES | POPULATION | Acute Disease | Antiemetics [administration & dosage] | Humans | CROSS-OVER | Photophobia [drug therapy; etiology] | Analgesics [administration & dosage; adverse effects] | Sumatriptan [administration & dosage] | PREVALENCE | METOCLOPRAMIDE | RANDOMIZED CLINICAL-TRIALS | 100 MG | MEDICINE, GENERAL & INTERNAL | Diclofenac [administration & dosage; adverse effects] | Nausea [drug therapy; etiology] | Migraine Disorders [complications; drug therapy] | DISEASE | DOUBLE-BLIND | Adult | Hyperacusis [drug therapy; etiology] | Drug Therapy, Combination | BURDEN | Diclofenac - adverse effects | Sumatriptan - administration & dosage | Analgesics - administration & dosage | Antiemetics - administration & dosage | Male | Migraine Disorders - drug therapy | Randomized Controlled Trials as Topic | Drug Therapy, Combination - methods | Nausea - etiology | Migraine Disorders - complications | Female | Diclofenac - administration & dosage | Nausea - drug therapy | Analgesics - adverse effects
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10. Full Text Prevention of Delayed Nausea: A University of Rochester Cancer Center Community Clinical Oncology Program Study of Patients Receiving Chemotherapy
by Joseph A. Roscoe and Charles E. Heckler and Gary R. Morrow and Supriya G. Mohile and Shaker R. Dakhil and James L. Wade and J. Philip Kuebler
Journal of Clinical Oncology, ISSN 0732-183X, 09/2012, Volume 30, Issue 27, pp. 3389 - 3395
Purpose We conducted a double-blind randomized clinical trial of the following four regimens for controlling delayed nausea (DN): group 1: palonosetron +... 
BREAST-CANCER | ORAL NEUROKININ-1 ANTAGONIST | DEXAMETHASONE | EFFICACY | ONCOLOGY | MODERATELY EMETOGENIC CHEMOTHERAPY | DOUBLE-BLIND | APREPITANT | HIGH-DOSE CISPLATIN | PLACEBO-CONTROLLED TRIAL | ANTIEMETIC TREATMENT | Serotonin Antagonists - administration & dosage | Dexamethasone - administration & dosage | Granisetron - administration & dosage | Double-Blind Method | Drug Administration Schedule | Nausea - chemically induced | Humans | Middle Aged | Morpholines - administration & dosage | Antiemetics - administration & dosage | Male | Prochlorperazine - administration & dosage | Quinuclidines - administration & dosage | Nausea - prevention & control | Antineoplastic Agents - adverse effects | Intention to Treat Analysis | Female | Drug Therapy, Combination | Isoquinolines - administration & dosage | Neurokinin-1 Receptor Antagonists | Cmpl4 | ORIGINAL REPORTS | Cmpl3
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11. Full Text Aprepitant versus metoclopramide, both combined with dexamethasone, for the prevention of cisplatin-induced delayed emesis: A randomized, double-blind study
by Roila, Fausto and Ruggeri, B and Ballatori, E and Fatigoni, S and Caserta, C and Licitra, L and Mirabile, A and Ionta, M.T and Massidda, B and Cavanna, L and Palladino, M.A and Tocci, A and Fava, S and Colantonio, I and Angelelli, L and Ciuffreda, L and Fasola, G and Zerilli, F and Italian Grp Antiemetic Res and Italian Group for Antiemetic Research and on behalf of the Italian Group for Antiemetic Research
Annals of Oncology, ISSN 0923-7534, 06/2015, Volume 26, Issue 6, pp. 1248 - 1253
Background: A combination of aprepitant, a 5-HT3 receptor antagonist (r.a.), and dexamethasone is recommended for the prophylaxis of cisplatin-induced nausea... 
Aprepitant | Metoclopramide | Cisplatin | Delayed emesis | BREAST-CANCER | aprepitant | ANTAGONIST APREPITANT | delayed emesis | metoclopramide | CHEMOTHERAPY-INDUCED NAUSEA | EFFICACY | ONCOLOGY | PLACEBO-CONTROLLED TRIAL | HIGH-DOSE CISPLATIN | cisplatin | Nausea - chemically induced | Humans | Middle Aged | Antiemetics - administration & dosage | Dexamethasone - adverse effects | Male | Nausea - psychology | Quinuclidines - administration & dosage | Activities of Daily Living | Young Adult | Time Factors | Antineoplastic Agents - adverse effects | Adult | Antiemetics - adverse effects | Female | Vomiting - prevention & control | Morpholines - adverse effects | Dexamethasone - administration & dosage | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Morpholines - administration & dosage | Risk Factors | Metoclopramide - administration & dosage | Treatment Outcome | Nausea - prevention & control | Vomiting - chemically induced | Administration, Intravenous | Adolescent | Vomiting - psychology | Cisplatin - adverse effects | Quality of Life | Italy | Aged | Isoquinolines - administration & dosage | Drug Combinations | Index Medicus
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