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Journal Article
mBio, ISSN 2150-7511, 2017, Volume 8, Issue 4, p. e01157-17
F901318is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An understanding of the pharmacodynamics (PD) of... 
Antifungal susceptibility testing | Pharmacodynamics | Pneumonia | Antifungal agents | Antifungal resistance | Pharmacology | Drug discovery | Aspergillus fumigatus | Laboratory animals | Pharmacokinetics | Pulmonary infection | DRUG | antifungal agents | POSACONAZOLE | pharmacodynamics | MICROBIOLOGY | antifungal susceptibility testing | antifungal resistance | HEMATOGENOUS CANDIDA MENINGOENCEPHALITIS | pulmonary infection | INVASIVE PULMONARY ASPERGILLOSIS | drug discovery | pneumonia | pharmacology | AZOLE RESISTANCE | laboratory animals | pharmacokinetics | DOUBLE-BLIND | CLINICAL-IMPLICATIONS | ESOPHAGEAL CANDIDIASIS | ANTIFUNGAL THERAPY | Aspergillus fumigatus - drug effects | Triazoles - administration & dosage | Pyrroles - pharmacokinetics | Acetamides - pharmacology | Piperazines - toxicity | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Pyrimidines - toxicity | Acetamides - therapeutic use | Antifungal Agents - pharmacokinetics | Acetamides - toxicity | Triazoles - pharmacokinetics | Piperazines - pharmacokinetics | Pyrroles - therapeutic use | Antifungal Agents - toxicity | Disease Models, Animal | Neutropenia | Triazoles - therapeutic use | Antifungal Agents - pharmacology | Invasive Pulmonary Aspergillosis - drug therapy | Rabbits | Acetamides - pharmacokinetics | Drug Resistance, Multiple, Fungal | Piperazines - therapeutic use | Pneumonia - microbiology | Pyrimidines - pharmacology | Drug Discovery | Piperazines - pharmacology | Triazoles - pharmacology | Pyrroles - pharmacology | Animals | Pneumonia - drug therapy | Pyrimidines - therapeutic use | Pyrroles - toxicity | Invasive Pulmonary Aspergillosis - microbiology | Mannans - blood | Pyrimidines - pharmacokinetics | Mice
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2011, Volume 55, Issue 2, pp. 532 - 538
Journal Article
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 05/2016, Volume 16, Issue 7, pp. 555 - 578
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 12, p. e82485
MtDef4 is a 47-amino acid cysteine-rich evolutionary conserved defensin from a model legume Medicago truncatula. It is an apoplast-localized plant defense... 
TRANSLOCATION | PISUM-SATIVUM DEFENSIN-1 | NAD1 | EFFECTOR PROTEINS | MULTIDISCIPLINARY SCIENCES | FUSARIUM-OXYSPORUM | CHEMICAL-SHIFT | ANTIMICROBIAL PEPTIDES | OOMYCETE | STRESS | 3-DIMENSIONAL SOLUTION STRUCTURE | Antifungal Agents - pharmacology | Amino Acid Sequence | Defensins - metabolism | Plant Proteins - pharmacology | Amino Acids - chemistry | Models, Molecular | Molecular Sequence Data | Fusarium - drug effects | Antifungal Agents - chemistry | Defensins - chemistry | Medicago truncatula - chemistry | Medicago truncatula - metabolism | Static Electricity | Amino Acid Motifs | Sequence Alignment | Fusarium - physiology | Plant Proteins - chemistry | Defensins - pharmacology | Antifungal Agents - metabolism | Protein Binding | Protein Conformation | Phosphatidic Acids - metabolism | Plant Proteins - metabolism | Fusarium - ultrastructure | Legumes | Cysteine | Antifungal agents | Mimosaceae | Proteins | Fungi | Membrane lipids | Defense industry | Beans | Analysis | Physiological aspects | Blood lipids | Protein binding | Plasma | Membranes | Fungicides | Biosynthesis | Phospholipids | Recruitment | Antifungal activity | Evolutionary conservation | Fusarium | Chemical bonds | Plant sciences | Labeling | Phosphatidic acid | Translocation | Automation | Fusarium graminearum | Amino acid sequence | Alfalfa | Apoplast | Studies | Signaling | Acids | Internalization | Cytoplasm | Structure-function relationships
Journal Article
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2018, Volume 62, Issue 4
is a ubiquitous opportunistic pathogen. This fungus can acquire resistance to azole antifungals due to mutations in the azole target ( ). Recently, mutations... 
Antifungal resistance | Aspergillus | Azole | Antifungal agents | VORICONAZOLE | WILD-TYPE | antifunga