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1. Full Text Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine
by Egorova, Ksenia S and Gordeev, Evgeniy G and Ananikov, Valentine P
Chemical Reviews, ISSN 0009-2665, 05/2017, Volume 117, Issue 10, pp. 7132 - 7189
Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and... 
FUNCTIONALIZED SIDE-CHAINS | WASTE-WATER TREATMENT | LIPASE-CATALYZED SYNTHESIS | LIDOCAINE TOPICAL PATCH | ELECTRIC DOUBLE-LAYER | SOLID-PHASE MICROEXTRACTION | ACID PHENETHYL ESTER | MOLECULAR-DYNAMICS SIMULATION | CHEMISTRY, MULTIDISCIPLINARY | IN-OIL MICROEMULSIONS | DIFFERENT HEAD GROUPS | Antifungal Agents - pharmacology | Biodegradation, Environmental | Solubility | Antifungal Agents - chemistry | Antineoplastic Agents - chemistry | Ionic Liquids - chemistry | Antineoplastic Agents - toxicity | Drug Delivery Systems | Ionic Liquids - pharmacology | Anti-Bacterial Agents - chemistry | Ionic Liquids - toxicity | Drug Compounding | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Anti-Bacterial Agents - toxicity | Antifungal Agents - toxicity
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2. Full Text (Eco)toxicity and biodegradability of protic ionic liquids
by Oliveira, Maria V.S and Vidal, Bruna T and Melo, Claudia M and de Miranda, Rita de C.M and Soares, Cleide M.F and Coutinho, João A.P and Ventura, Sónia P.M and Mattedi, Silvana and Lima, Álvaro S
Chemosphere, ISSN 0045-6535, 03/2016, Volume 147, pp. 460 - 466
Ionic liquids (ILs) are often claimed to be “environmentally friendly” compounds however, the knowledge of their potential toxicity towards different organisms... 
Antimicrobial activity | Toxicity evaluation | Microtox | Phytotoxicity | Biodegradability | Protic ionic liquids | PYRIDINIUM | ANION | TOXICITY | IMIDAZOLIUM | ENVIRONMENTAL SCIENCES | SOLVENTS | ANTIMICROBIAL ACTIVITIES | TERRESTRIAL ECOTOXICITY | PHASE-BEHAVIOR | ALLIUM-CEPA | SYSTEMS | Microtox (R) | Biodegradation, Environmental | Lettuce - drug effects | Quaternary Ammonium Compounds - toxicity | Escherichia coli - drug effects | Luminescence | Anti-Bacterial Agents - metabolism | Fusarium - drug effects | Antifungal Agents - chemistry | Biological Oxygen Demand Analysis | Ionic Liquids - metabolism | Lettuce - growth & development | Ionic Liquids - chemistry | Quaternary Ammonium Compounds - chemistry | Candida albicans - drug effects | Aliivibrio fischeri - drug effects | Aliivibrio fischeri - metabolism | Anti-Bacterial Agents - chemistry | Antifungal Agents - metabolism | Ionic Liquids - toxicity | Quaternary Ammonium Compounds - metabolism | Anti-Bacterial Agents - toxicity | Staphylococcus aureus - drug effects | Antifungal Agents - toxicity | Esters | Biochemical oxygen demand | Index Medicus
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3. Full Text Terrestrial pesticide exposure of amphibians: An underestimated cause of global decline?
by Brühl, Carsten A and Schmidt, Thomas and Pieper, Silvia and Alscher, Annika
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 1135
Amphibians, a class of animals in global decline, are present in agricultural landscapes characterized by agrochemical inputs. Effects of pesticides on... 
EXTINCTIONS | ACUTE TOXICITY | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | FUNGICIDE FORMULATIONS | FROGS | Rana temporaria - growth & development | Animals | Pesticides - toxicity | Mortality | Pupa - drug effects | Herbicides - toxicity | Antifungal Agents - toxicity | Insecticides - toxicity | Frogs | Toxicity | Reptiles & amphibians | Risk assessment | Pesticides
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4. Full Text Synthesis and Bioactivities of Kanamycin B‑Derived Cationic Amphiphiles
by Fosso, Marina Y and Shrestha, Sanjib K and Green, Keith D and Garneau-Tsodikova, Sylvie
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9124 - 9132
Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit enhanced antimicrobial activity. Through the attachment of hydrophobic... 
ANTIFUNGAL CONVERSION | CHEMISTRY, MEDICINAL | TOBRAMYCIN | ANTIBACTERIAL ACTIVITY | ENZYMES | COMPLEXES | DRUG-RESISTANCE | NEOMYCIN | DERIVATIVES | AMINOGLYCOSIDE ANTIBIOTICS | STRUCTURE-BASED DESIGN | Hemolysis - drug effects | Kanamycin - toxicity | Humans | Bacteria - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Anti-Bacterial Agents - chemistry | Drug Design | Anti-Bacterial Agents - toxicity | Antifungal Agents - toxicity | Antifungal Agents - pharmacology | Cell Line | Cell Survival - drug effects | Surface-Active Agents - toxicity | Fungi - drug effects | Bacterial Infections - drug therapy | Kanamycin - analogs & derivatives | Kanamycin - pharmacology | Surface-Active Agents - pharmacology | Anti-Bacterial Agents - chemical synthesis | Drug Resistance, Microbial | Animals | Mycoses - drug therapy | Kanamycin - chemistry | Anti-Bacterial Agents - pharmacology | Mice | Surface-Active Agents - chemistry | Kanamycin - chemical synthesis | Surface-Active Agents - chemical synthesis | Index Medicus
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5. Full Text Hepatocellular toxicity of imidazole and triazole antimycotic agents
by Haegler, Patrizia and Joerin, Lorenz and Krähenbühl, Stephan and Bouitbir, Jamal
Toxicological Sciences, ISSN 1096-6080, 05/2017, Volume 157, Issue 1, pp. 183 - 195
Hepatotoxicity has been described for all antimycotic azoles currently marketed. A possible mechanism involving mitochondrial dysfunction has been postulated... 
Electron transport chain | Fluconazole | Posaconazole | Voriconazole | Apoptosis | Mitochondrial membrane potential | posaconazole | HEPARG CELLS | electron transport chain | voriconazole | RAT HEPATIC MICROSOMES | mitochondrial membrane potential | apoptosis | PRIMARY CULTURE-SYSTEM | N-DEACETYL KETOCONAZOLE | fluconazole | LIVER-INJURY | METABOLISM | ANTIFUNGAL AGENTS | HEPG2 CELLS | FLAVIN-CONTAINING MONOOXYGENASES | TOXICOLOGY | INDUCED HEPATOTOXICITY | Cell Line | DNA, Mitochondrial - drug effects | Humans | Liver - metabolism | Mice, Inbred C57BL | Male | Membrane Potential, Mitochondrial - drug effects | Mitochondria, Liver - drug effects | Animals | Triazoles - toxicity | Liver - drug effects | Adenosine Triphosphate - metabolism | Imidazoles - toxicity | Liver - cytology | Mice | Antifungal Agents - toxicity
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6. Full Text Metal based biologically active compounds: Design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes
by Chohan, Zahid H and Sumrra, Sajjad H and Youssoufi, Moulay H and Hadda, Taibi B
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 7, pp. 2739 - 2747
A new series of oxovanadium(IV) complexes have been designed and synthesized with a new class of triazole Schiff bases derived from the reaction of... 
Oxovanadium(IV) complexes | Antibacterial/antifungal/cytotoxic activity | Triazole Schiff bases | Antibacterial/antifungal/ cytotoxic activity | SALICYLALDEHYDE SEMICARBAZONE DERIVATIVES | CHEMISTRY, MEDICINAL | IN-VITRO ANTIBACTERIAL | MOIETY | CRYSTAL-STRUCTURE | SULFONAMIDES | ANTICONVULSANT EVALUATION | ANTIMICROBIAL ACTIVITIES | GROWTH | ANTIFUNGAL | VANADIUM(V) COMPLEXES | Antifungal Agents - pharmacology | Organometallic Compounds - toxicity | Fungi - drug effects | Triazoles - chemistry | Bacteria - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Magnetics | Vanadates - chemistry | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | Artemia - drug effects | Animals | Organometallic Compounds - chemical synthesis | Anti-Bacterial Agents - chemistry | Schiff Bases - chemistry | Drug Design | Organometallic Compounds - chemistry | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - toxicity | Spectrum Analysis | Antifungal Agents - toxicity | Organometallic Compounds - pharmacology | Schiff bases | Pyridine | Triazoles | Analysis | Antifungal agents | Vanadium | Antibacterial agents
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7. Repositioning the old fungicide ciclopirox for new medical uses
by Shen, Tao and Huang, Shile
Current Pharmaceutical Design, ISSN 1381-6128, 08/2016, Volume 22, Issue 28, pp. 4443 - 4450
Background: Ciclopirox (CPX) has been used as an antifungal agent in various formulations to treat superficial fungal infection for decades. Its effectiveness... 
Diabetes | HIV | Fungicide | Iron chelator | Ciclopirox | Cancer | ANTIFUNGAL AGENT | NAIL LACQUER | DEOXYHYPUSINE HYDROXYLASE | HYPUSINE MODIFICATION | SACCHAROMYCES-CEREVISIAE | iron chelator | DRUG-RESISTANCE MECHANISMS | CANDIDA-ALBICANS | PHARMACOLOGY & PHARMACY | cancer | CELL-CYCLE | fungicide | diabetes | WNT/BETA-CATENIN PATHWAY | ENDOTHELIAL GROWTH-FACTOR
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8. Full Text Synthesis, spectral characterization, in-vitro microbiological evaluation and cytotoxic activities of novel macrocyclic bis hydrazone
by Avaji, Prakash Gouda and Vinod Kumar, C.H and Patil, Sangamesh A and Shivananda, K.N and Nagaraju, C
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2009, Volume 44, Issue 9, pp. 3552 - 3559
A macrocyclic hydrazone Schiff base was synthesized by reacting 1,4-dicarbonyl phenyl dihydrazide with 2,6-diformyl-4-methyl phenol and a series of metal... 
Characterization | Synthesis | Biological | Hydrazone | Toxicity | CHEMISTRY, MEDICINAL | COPPER(II) | COBALT(II) | 1,1'-DISUBSTITUTED FERROCENES | VERSATILITY | CU(II) COMPLEXES | ZINC(II) | NICKEL(II) | LIGANDS | SCHIFF-BASES | METAL-COMPLEXES | Macrocyclic Compounds - chemistry | Bacteria - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Macrocyclic Compounds - chemical synthesis | Eggs | Schiff Bases - pharmacology | Macrocyclic Compounds - pharmacology | Microbial Sensitivity Tests | Copper - chemistry | Anti-Bacterial Agents - chemistry | Schiff Bases - chemical synthesis | Hydrazones - toxicity | Anti-Bacterial Agents - toxicity | Antifungal Agents - toxicity | Antifungal Agents - pharmacology | Fungi - drug effects | Nickel - chemistry | Schiff Bases - toxicity | Hydrazones - chemical synthesis | Hydrazones - chemistry | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Artemia - drug effects | Animals | Schiff Bases - chemistry | Anti-Bacterial Agents - pharmacology | Macrocyclic Compounds - toxicity | Toxicity Tests | Cobalt - chemistry | Electrochemical reactions | Schiff bases | Dimethylformamide | Saline waters | Microbiology | Water quality | Copper compounds | Fluorescence | Chemical properties | Soil inoculation | Cobalt | Index Medicus
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9. Full Text Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
by Özçelik, Berrin and Kartal, Murat and Orhan, Ilkay
Pharmaceutical Biology, ISSN 1388-0209, 4/2011, Volume 49, Issue 4, pp. 396 - 402
Objective: Some natural products consisting of the alkaloids yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine... 
Alkaloids | parainfluenza | phenolic acids | antimicrobial activity | antiviral activity | flavonoids | herpes simplex | ANTIBACTERIAL | PLANT SCIENCES | IN-VITRO | HEPATITIS | ISOQUINOLINE | HERPES-SIMPLEX VIRUSES | PHARMACOLOGY & PHARMACY | SILYMARIN | ANTIFUNGAL | MEDICAL LABORATORY TECHNOLOGY | EXTRACTS | TYPE-1 | MEDICINAL-PLANTS | Antiviral Agents - toxicity | Bacteria - drug effects | Cercopithecus aethiops | Biological Products - pharmacology | Cytotoxins - toxicity | Hydroxybenzoates - pharmacology | Cytotoxins - pharmacology | Cattle | Biological Products - analysis | Flavonoids - pharmacology | Anti-Bacterial Agents - toxicity | Antioxidants - analysis | Parainfluenza Virus 3, Human - drug effects | Cell Line | Alkaloids - toxicity | Antiviral Agents - pharmacology | Alkaloids - pharmacology | Fungi - drug effects | Antioxidants - pharmacology | Herpesvirus 1, Human - drug effects | Antioxidants - toxicity | Flavonoids - toxicity | Animals | Anti-Bacterial Agents - pharmacology | Biological Products - toxicity | Hydroxybenzoates - toxicity | Index Medicus
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10. Full Text Tragacanth gum biopolymer as reducing and stabilizing agent in biosonosynthesis of urchin-like ZnO nanorod arrays: A low cytotoxic photocatalyst with antibacterial and antifungal properties
by Ghayempour, Soraya and Montazer, Majid and Mahmoudi Rad, Mahnaz
Carbohydrate Polymers, ISSN 0144-8617, 01/2016, Volume 136, pp. 232 - 241
, a natural gum, has been used for centuries as emulsifier, thickener, stabilizer and binder in various fields such as food, medical and cosmetic industries.... 
Photocatalytic activity | Antibacterial and antifungal activity | Urchin-like ZnO nanorod arrays | Tragacanth gum | Ultrasonic | POLYMER SCIENCE | ZINC-OXIDE NANOPARTICLES | CHEMISTRY, ORGANIC | LOW-TEMPERATURE | MICRO-NANOCAPSULES | FILMS | GREEN SYNTHESIS | SONOCHEMICAL SYNTHESIS | PHOTODEGRADATION | ELECTROSPRAYING METHOD | NANOCOMPOSITE | CHEMISTRY, APPLIED | LEAF EXTRACT | Nanoparticles - chemistry | Humans | Zinc Oxide - toxicity | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Photochemical Processes | Nanotubes - chemistry | Nanotubes - toxicity | Excipients - chemistry | Zinc Oxide - chemistry | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - toxicity | Catalysis | Antifungal Agents - toxicity | Reducing Agents - chemistry | Antifungal Agents - pharmacology | Ultrasonic Waves | Cell Survival - drug effects | Chemistry Techniques, Synthetic | Zinc Oxide - pharmacology | Tragacanth - chemistry | Anti-Bacterial Agents - chemical synthesis | Zinc Oxide - chemical synthesis | Fibroblasts - drug effects | Anti-Bacterial Agents - pharmacology | Fibroblasts - cytology | Nanotechnology | Zinc oxide | Polymers | Antibacterial agents | Antifungal agents | Usage | Cosmetics industry
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11. Full Text Essential Oils of Aromatic Plants with Antibacterial, Antifungal, Antiviral, and Cytotoxic Properties – an Overview
by Reichling, Jürgen and Schnitzler, Paul and Suschke, Ulrike and Saller, Reinhard
Complementary Medicine Research, ISSN 2504-2092, 04/2009, Volume 16, Issue 2, pp. 79 - 90
The abundant use of anti-infective agents resulted in the emergence of drug-resistant bacteria, fungi, and viruses. To overcome the increasing resistance of... 
Invited Review · Eingeladene Übersichtsarbeit | Medicinal plants | Antimicrobial effects | Essential oils | Cytotoxic properties | MAJOR COMPONENTS | ESCHERICHIA-COLI | HERPES-SIMPLEX-VIRUS | IN-VITRO | MELISSA-OFFICINALIS L | HUMAN SKIN CELLS | INTEGRATIVE & COMPLEMENTARY MEDICINE | STAPHYLOCOCCUS-AUREUS | TEA TREE OIL | ANTIMICROBIAL ACTIVITY | ALTERNIFOLIA ESSENTIAL OIL | Cell Survival - drug effects | Plants, Medicinal - toxicity | Antiviral Agents - therapeutic use | Antiviral Agents - toxicity | Apoptosis - drug effects | Humans | Tumor Cells, Cultured - drug effects | Treatment Outcome | Phytotherapy - trends | Antifungal Agents - therapeutic use | Antineoplastic Agents, Phytogenic - toxicity | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Oils, Volatile - therapeutic use | Phytotherapy - adverse effects | Animals | Anti-Bacterial Agents - toxicity | Oils, Volatile - toxicity | Phytotherapy - methods | Antineoplastic Agents, Phytogenic - therapeutic use | Antifungal Agents - toxicity | Index Medicus
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12. Full Text Voriconazole metabolism, toxicity, and the effect of cytochrome P450 2C19 genotype
by Zonios, Dimitrios and Yamazaki, Hiroshi and Murayama, Norie and Natarajan, Ven and Palmore, Tara and Childs, Richard and Skinner, Jeff and Bennett, John E
Journal of Infectious Diseases, ISSN 0022-1899, 06/2014, Volume 209, Issue 12, pp. 1941 - 1948
Background. Prospective evaluation of the antifungal drug, voriconazole, is needed to determine whether drug toxicity correlates with CYP2C19 genotype or serum... 
toxicity | voriconazole | CYP2C19 | metabolites | INFECTIOUS DISEASES | CYP2C19 GENOTYPE | EFFICACY | SAFETY | MICROBIOLOGY | INVASIVE FUNGAL-INFECTIONS | IMMUNOLOGY | CELL TRANSPLANT RECIPIENTS | THERAPY | PHARMACOKINETICS | ANTIFUNGAL AGENT VORICONAZOLE | Cytochrome P-450 CYP2C9 | Triazoles - administration & dosage | Prospective Studies | Triazoles - blood | Pyrimidines - blood | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Dose-Response Relationship, Drug | Young Adult | Pyrimidines - toxicity | Triazoles - toxicity | Liver - drug effects | Voriconazole | Adult | Female | Antifungal Agents - toxicity | Pyrimidines - administration & dosage | Liver - metabolism | Hallucinations - chemically induced | Homozygote | Cytochrome P-450 CYP2C19 | Adolescent | Aged | Antifungal Agents - administration & dosage | Antifungal Agents - blood | Physiological aspects | Cytochrome P-450 | Research | Index Medicus | Abridged Index Medicus | Major and Brief Reports
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13. Full Text Development, characterization, and toxicity evaluation of amphotericin B–loaded gelatin nanoparticles
by Nahar, Manoj, MPharm and Mishra, Dinesh, MPharm and Dubey, Vaibhav, MPharm and Jain, Narendra Kumar, PhD
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2008, Volume 4, Issue 3, pp. 252 - 261
Abstract Our aim in the present investigation was to develop a nanoparticulate carrier of amphotericin B (AmB) for controlled delivery as well as reduced... 
Internal Medicine | Nanoparticles | Amphotericin B | Gelatin | Desolvation | Nephrotoxicity | DRUG | MEDICINE, RESEARCH & EXPERIMENTAL | METHOTREXATE | NANOSCIENCE & NANOTECHNOLOGY | 2-STEP DESOLVATION | BILAYER FRAGMENTS | RELEASE | DELIVERY-SYSTEM | IN-VITRO | CELL UPTAKE | POLYMERIC NANOPARTICLES | LYMPHOCYTES | Antifungal Agents - pharmacology | Blood Urea Nitrogen | Humans | Amphotericin B - pharmacology | Hematocrit | Male | Antifungal Agents - chemistry | Amidohydrolases - blood | Amphotericin B - toxicity | Drug Carriers | Animals | Kidney Diseases - chemically induced | Mice | Kinetics | In Vitro Techniques | Amphotericin B - chemistry | Antifungal Agents - toxicity | Hemoglobins - analysis | Hemoglobin | Urea | Antiparasitic agents | Analysis | Index Medicus
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14. Full Text Toxicity of amphotericin B deoxycholate-based induction therapy in patients with HIV-associated cryptococcal meningitis
by Bicanic, Tihana and Bottomley, Christian and Loyse, Angela and Brouwer, Annemarie E and Muzoora, Conrad and Taseera, Kabanda and Jackson, Arthur and Phulusa, Jacob and Hosseinipour, Mina C and Van Der Horst, Charles and Limmathurotsakul, Direk and White, Nicholas J and Wilson, Douglas and Wood, Robin and Meintjes, Graeme and Harrison, Thomas S and Jarvis, Joseph N
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2015, Volume 59, Issue 12, pp. 7224 - 7231
Amphotericin B deoxycholate (AmBd) is the recommended induction treatment for HIV-associated cryptococcal meningitis (CM). Its use is hampered by toxicities... 
HIGH-DOSE FLUCONAZOLE | SUPPLEMENTATION | FLUCYTOSINE | EARLY FUNGICIDAL ACTIVITY | AIDS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ANTIRETROVIRAL THERAPY | RANDOMIZED CONTROLLED-TRIAL | OUTCOMES | COMBINATION | NEPHROTOXICITY | Coinfection | Meningitis, Cryptococcal - drug therapy | Humans | Anemia - pathology | Male | Meningitis, Cryptococcal - microbiology | Amphotericin B - toxicity | Meningitis, Cryptococcal - mortality | Meningitis, Cryptococcal - pathology | HIV Infections - pathology | Amphotericin B - administration & dosage | Adult | Female | HIV Infections - mortality | Deoxycholic Acid - administration & dosage | Antifungal Agents - toxicity | Cryptococcus neoformans - growth & development | Hypokalemia - pathology | Anemia - etiology | Kidney - physiopathology | Hypokalemia - etiology | Kidney - drug effects | HIV Infections - virology | Induction Chemotherapy - methods | Deoxycholic Acid - toxicity | Hemoglobins - metabolism | Treatment Outcome | HIV - isolation & purification | Blood Cell Count | Cryptococcus neoformans - drug effects | Flucytosine - therapeutic use | Neutropenia - prevention & control | Survival Analysis | Creatinine - blood | Antifungal Agents - administration & dosage | Drug Combinations | Index Medicus | Clinical Therapeutics
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