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Cell Metabolism, ISSN 1550-4131, 2010, Volume 12, Issue 5, pp. 467 - 482
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 759 - 770
Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary,... 
SURFACE IGM | BCR | CHRONIC-LYMPHOCYTIC-LEUKEMIA | BRUTONS TYROSINE KINASE | HUMAN FOLLICULAR LYMPHOMA | GENE-EXPRESSION | KINASE INHIBITOR IBRUTINIB | MUTATIONS | TARGETING BTK | HEMATOLOGY | NF-KAPPA-B | Lymphoma, Follicular - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | STAT1 Transcription Factor - metabolism | Lymphoma, Follicular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Single-Cell Analysis | Immunoglobulin M - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | STAT1 Transcription Factor - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - diagnosis | Mitogen-Activated Protein Kinase 3 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - genetics | CD79 Antigens - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Lymphoma, Large B-Cell, Diffuse - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, Mantle-Cell - diagnosis | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Syk Kinase - genetics | Phospholipase C gamma - genetics | src-Family Kinases - metabolism | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Diagnosis, Differential | Phospholipase C gamma - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Lymphoma, Follicular - pathology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | CD79 Antigens - metabolism | Syk Kinase - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology | Hematology | Cancer | Lymphoid Neoplasia
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e35905 - e35905
Hematopoietic progenitor CD133(+)/c-kit(+) cells have been shown to be involved in myocardial healing following myocardial infarction (MI). Previously we... 
CD31(+) CELLS | ENDOTHELIAL PROGENITOR CELLS | ISCHEMIA/REPERFUSION INJURY | ACTIVATION | ISCHEMIC VASCULAR-DISEASE | ANGIOGENIC ACTIVITY | BONE-MARROW | BIOLOGY | RECEPTOR | TOPCARE-AMI | EXPRESSION | Up-Regulation | Capillaries - pathology | Receptors, Notch - metabolism | Cardiomegaly - pathology | Angiopoietin-1 - metabolism | Antigens, CD - metabolism | Peptides - metabolism | Serrate-Jagged Proteins | Bone Marrow - metabolism | Myocardium - metabolism | Endomyocardial Fibrosis - complications | Myocardial Infarction - physiopathology | Capillaries - metabolism | Apelin | Jagged-1 Protein | Capillaries - physiopathology | Signal Transduction | Cardiomegaly - physiopathology | Myocardial Infarction - metabolism | Receptors, CXCR4 - metabolism | Chemokine CXCL12 - metabolism | Hematopoietic Stem Cells - cytology | Endomyocardial Fibrosis - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Cardiomegaly - metabolism | Cell Movement | Actins - metabolism | Glycoproteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Myocardial Infarction - pathology | Endomyocardial Fibrosis - pathology | Membrane Proteins - metabolism | Heart Function Tests | Diabetes Mellitus, Type 2 - complications | Calcium-Binding Proteins - metabolism | Myocardium - pathology | Adipokines | AC133 Antigen | Cardiomegaly - complications | Myocardial Infarction - complications | Animals | Diabetes Mellitus, Type 2 - physiopathology | Bone Marrow - pathology | Receptor, Notch3 | Endomyocardial Fibrosis - physiopathology | Apoptosis | Advertising executives | Vascular endothelial growth factor | Adenoviruses | Heart attack | Myocardial infarction | Heart | Diabetic retinopathy | Heart attacks | Angiopoietin | Recovery of function | Smooth muscle | Cardiovascular disease | Recruitment | Angiogenesis | Toxicology | Cell growth | Ischemia | Data recovery | Rodents | Bone marrow | Repair | Heart diseases | Immunoglobulins | Diabetes mellitus | Coronary artery | Muscles | Pharmacology | c-Kit protein | Hemopoiesis | Studies | Ostomy | Coronary vessels | Fibrosis | Stem cells | Myocardium | Infarction | Diabetes | Laboratory animals | Index Medicus
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 12/2016, Volume 1863, Issue 12, pp. 3096 - 3105
Differentiation of embryonic stem (ES) cells may be regulated by mechanical strain. Herein, signaling molecules underlying mechanical stimulation of... 
Reactive oxygen species | Vasculogenesis | Intracellular calcium | Embryonic stem cells | Mechanical strain | Nitric oxide | PROGENITOR CELLS | CARDIOMYOGENESIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLOW | CELL BIOLOGY | SEMAPHORIN | SHEAR-STRESS | ENDOTHELIAL-CELLS | GROWTH | BODIES | DIFFERENTIATION | Benzoxazoles - pharmacology | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Calcium - metabolism | Embryo, Mammalian | Neuropilin-1 - metabolism | Mouse Embryonic Stem Cells - cytology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Antigens, CD - genetics | Mouse Embryonic Stem Cells - drug effects | Reactive Oxygen Species - agonists | Receptors, Immunologic - antagonists & inhibitors | Antigens, CD - metabolism | Embryoid Bodies - metabolism | Embryoid Bodies - cytology | Cell Differentiation | Semaphorins - genetics | Fibroblasts - metabolism | Calcium - agonists | Signal Transduction | Semaphorins - metabolism | Ephrin-B2 - metabolism | Embryoid Bodies - drug effects | Ephrin-B2 - genetics | Biomechanical Phenomena | Myocytes, Cardiac - drug effects | Fibroblast Growth Factor 2 - genetics | Fibroblasts - drug effects | Myocytes, Cardiac - metabolism | Fibroblasts - cytology | Mice | Receptors, Immunologic - genetics | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Neuropilin-1 - genetics | Neovascularization, Physiologic - drug effects | Mouse Embryonic Stem Cells - metabolism | Neuropilin-1 - antagonists & inhibitors | Receptor, EphB4 - genetics | Ephrin-B2 - antagonists & inhibitors | Egtazic Acid - analogs & derivatives | Fibroblast Growth Factor 2 - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-sis - genetics | Myocytes, Cardiac - cytology | Proto-Oncogene Proteins c-sis - metabolism | Neovascularization, Physiologic - genetics | Gene Expression Regulation | Receptors, Cell Surface - metabolism | Nerve Tissue Proteins - genetics | Receptor, EphB4 - metabolism | Nitric Oxide - agonists | Nerve Tissue Proteins - metabolism | Triazoles - pharmacology | Animals | Egtazic Acid - pharmacology | Nitric Oxide - metabolism | Receptors, Immunologic - metabolism
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3660 - 3663
in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | PATHWAY | STAT3 | NOTCH | STEM/PROGENITOR CELLS | GROWTH-FACTOR | INTERLEUKIN-6 | IDENTIFICATION | TUMORIGENESIS | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Carbonic Anhydrases - biosynthesis | Cytokine Receptor gp130 - genetics | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Janus Kinases - metabolism | RNA, Messenger - metabolism | Serrate-Jagged Proteins | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Membrane Proteins - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Mammary Glands, Human - pathology | Lung Neoplasms - therapy | Signal Transduction - genetics | Autocrine Communication - genetics | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Carcinoma - genetics | Mice | Mutation | Transcription, Genetic - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | Neoplasm Transplantation | Carbonic Anhydrases - genetics | Lung Neoplasms - pathology | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | STAT3 Transcription Factor - metabolism | Carbonic Anhydrase IX | Calcium-Binding Proteins - metabolism | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Janus Kinases - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Interleukin-6 - biosynthesis | Carcinoma - therapy | Receptor, Notch3 | Carcinoma - metabolism | Antagonists (Biochemistry) | Epithelial tumors | Dosage and administration | Diagnosis | Research | Drug therapy | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Stem Cell Research and Therapy, ISSN 1757-6512, 04/2017, Volume 8, Issue 1, pp. 88 - 88
Background: Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from... 
Cirrhosis | Kupffer cell | SPINK1 | Alcoholic hepatitis | HGF | Stem cell transplantation | CD68 | Macrophage | PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | COLONY-STIMULATING FACTOR | REGENERATION | MACROPHAGES | INJURY | PROLIFERATION | CELL BIOLOGY | HEPATITIS | CD34(+) | Liver - pathology | Leukocyte Common Antigens - metabolism | Humans | Middle Aged | Transcriptome | Male | Serum Amyloid A Protein - genetics | Antigens, CD - genetics | Mesenchymal Stem Cell Transplantation - adverse effects | Antigens, CD - metabolism | Mesenchymal Stromal Cells - cytology | Collagen Type I - genetics | Liver Diseases, Alcoholic - therapy | Hepatocyte Growth Factor - genetics | Adult | Female | Collagen Type I - metabolism | Serum Amyloid A Protein - metabolism | Liver - metabolism | Mesenchymal Stromal Cells - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Hepatocyte Growth Factor - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Transplantation, Autologous - adverse effects | Leukocyte Common Antigens - genetics | Aged | Trypsin Inhibitor, Kazal Pancreatic | Liver diseases | Alcohol | Inflammation | Histology | Gene expression | Macrophages | Hepatitis | Cell growth | Immunology | Granulocytes | Hepatology | Rodents | Stem cells | Gastroenterology | Bone marrow | Liver transplantation | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 945 - 951
Journal Article
Science, ISSN 0036-8075, 05/2018, Volume 360, Issue 6388, pp. 558 - 563
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 17536 - 17542
Apolipoprotein E (apoE) is a major apolipoprotein in the brain. The epsilon 4 allele of apoE is a major risk factor for Alzheimer disease, and apoE deficiency... 
CHOLESTEROL-METABOLISM | PROTEIN-KINASE-C | RECEPTOR-RELATED PROTEIN | LIPOPROTEIN RECEPTORS | LDL-RECEPTOR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | ENDOTHELIAL-CELLS | A-BETA | PLAQUE-FORMATION | Protein Kinase C - genetics | Apolipoprotein E4 - genetics | Humans | Astrocytes - pathology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Occludin | Phosphorylation - genetics | Protein Isoforms - metabolism | Pericytes - pathology | Protein Kinase C - metabolism | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Tight Junctions - metabolism | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Apolipoprotein E4 - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Pericytes - metabolism | Cells, Cultured | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Permeability | Apolipoprotein E3 - metabolism | Blood-Brain Barrier - metabolism | Gene Knock-In Techniques | Mice, Knockout | Blood-Brain Barrier - pathology | Apolipoprotein E3 - genetics | Animals | Models, Biological | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Endothelial Cells - pathology | Enzyme Activation - genetics | Tight Junctions - pathology | Astrocytes - metabolism | Protein Isoforms - genetics | Index Medicus | HDL | Neurobiology | PKC | Alzheimer Disease | Apolipoproteins | Endothelium | Tight Junction | Blood-Brain Barrier
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2929 - 2945
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 36, pp. 14944 - 14949
The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer.... 
Helicobacter pylori | Epithelial cells | DNA damage | DNA | Cell nucleus | Cell lines | Bacteria | Cultured cells | Infections | Mice | Chromosome breaks | DNA damage signaling | Gastric tumorigenesis | Genomic instability | CYTOLETHAL DISTENDING TOXIN | MULTIDISCIPLINARY SCIENCES | RISK | MISMATCH REPAIR | COLONIZATION | GENETIC INSTABILITY | EPITHELIAL-CELLS | chromosome breaks | GASTRIC-CANCER | INFLAMMATION | INFECTION | MICE | genomic instability | gastric tumorigenesis | Phosphorylation | Epithelial Cells - metabolism | Humans | Stomach Neoplasms - metabolism | Helicobacter Infections - complications | Stomach Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Antigens, Bacterial - genetics | DNA Breaks, Double-Stranded | Helicobacter Infections - pathology | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Helicobacter Infections - metabolism | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Stomach Neoplasms - genetics | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Bacterial Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Genomic Islands | Epithelial Cells - pathology | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Bacterial Adhesion | Stomach Neoplasms - microbiology | Animals | Histones - genetics | Helicobacter pylori - metabolism | Epithelial Cells - microbiology | Chromosome Aberrations | Cell Line, Tumor | Bacterial Proteins - metabolism | Trans-Activators - metabolism | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Antigens, Bacterial - metabolism | Carcinogens | Cocarcinogens | Physiological aspects | Genetic aspects | Research | Health aspects | Cells | Pathogens | Gram-negative bacteria | Rodents | Index Medicus | Adhesins | Histone H2A | Mesenchyme |