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PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0145833 - e0145833
Current strategies to improve the current BCG vaccine attempt to over-express genes encoding specific M. tuberculosis (Mtb) antigens and/or regulators of... 
Recombinant Fusion Proteins - immunology | Mycobacterium bovis - immunology | Avidin - immunology | Ovalbumin - immunology | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Vaccines, Synthetic - immunology | Antigens, Bacterial - genetics | Avidin - metabolism | BCG Vaccine - genetics | Biotin - metabolism | Female | Bacterial Proteins - immunology | Cell Membrane - metabolism | Macrophages - immunology | Macrophages - microbiology | Mycobacterium bovis - genetics | Ovalbumin - genetics | Cell Line | H-2 Antigens - metabolism | Mice, Inbred C57BL | Vaccines, Synthetic - genetics | Antigens, Surface - genetics | Bacterial Proteins - genetics | Animals | Mycobacterium bovis - metabolism | BCG Vaccine - immunology | Recombinant Fusion Proteins - genetics | Cell Membrane - immunology | Mice | Phagocytosis | Avidin - genetics | Mycobacterium tuberculosis - genetics | Immunogenetics | Care and treatment | Tuberculosis | Research | Mycobacterium bovis | Risk factors | Cell culture | Regulators | Media (culture) | Lymphocytes T | Infections | DNA vaccines | Vaccines | Macrophages | Drug resistance | Cell surface | Avidin | Proteins | Technology | Lymphocytes | Compartments | Bacteria | Complementation | Freeze-drying | Deoxyribonucleic acid--DNA | Recombinant | Antigen presentation | Antigens | Medical research | Ovalbumin | Immune response | Cell survival | BCG | Biotin | Gene expression | Decoration | Immune systems | Medicine | ESAT-6 antigen | Infectious diseases | Major histocompatibility complex | Immunogenicity | Influenza | Culture media | Genetic engineering | Drying | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2011, Volume 7, Issue 5, pp. e1002027 - e1002027
During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal... 
HUMAN EPITHELIAL-CELLS | FACTOR-H-BINDING | MICROBIOLOGY | SEROGROUP-B MENINGOCOCCUS | GENOME | PATHOGENIC NEISSERIAE | VACCINE CANDIDATES | VIROLOGY | OUTER-MEMBRANE PROTEIN | GENE-EXPRESSION | STAPHYLOCOCCUS-AUREUS | SERINE-PROTEASE | PARASITOLOGY | Adaptation, Physiological | Sequence Deletion | Virulence Factors - genetics | Genes, Bacterial - genetics | Humans | Neisseria meningitidis, Serogroup B - physiology | Transcriptome | Male | Neisseria meningitidis, Serogroup B - genetics | Meningococcal Infections - microbiology | Antigens, Bacterial - genetics | Bacteremia - microbiology | Bacteremia - blood | RNA, Bacterial - genetics | Adult | Female | Neisseria meningitidis, Serogroup B - pathogenicity | Bacterial Proteins - genetics | Up-Regulation - genetics | Down-Regulation - genetics | Neisseria meningitidis, Serogroup B - growth & development | Genome, Bacterial - genetics | Gene Expression Regulation, Bacterial - genetics | Host-Pathogen Interactions - genetics | Models, Biological | Meningococcal Infections - blood | Cluster Analysis | Causes of | Sepsis | Neisseria meningitidis | Genetic aspects | Research | Health aspects | Microbiology | Pathogenesis | Mortality | Genomes | Gene expression | Blood | Proteins | Studies | Evolutionary biology | Mutagenesis | DNA methylation | Meningitis | Deoxyribonucleic acid--DNA | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 04/2015, Volume 9, Issue 4, pp. e0003455 - e0003455
Emerging B. cereus strains that cause anthrax-like disease have been isolated in Cameroon (CA strain) and Cote d'Ivoire (CI strain). These strains are unusual,... 
SEQUENCE CONSERVATION | STRAINS | GRAM-POSITIVE BACTERIA | PLASMID | GENES | GREAT APES | MICE | PROTECTIVE ANTIGEN | PLCR | PARASITOLOGY | TROPICAL MEDICINE | PXO1 | Virulence Factors - genetics | Bacillus anthracis - pathogenicity | Bacillus cereus - classification | Bacterial Capsules - metabolism | Genomics | Bacillus cereus - metabolism | Antigens, Bacterial - genetics | Anthrax - microbiology | Toxins, Biological | Bacterial Toxins - metabolism | Animals | Bacillus cereus - genetics | Virulence - genetics | Plasmids | Bacterial Capsules - genetics | Bacterial Toxins - genetics | Virulence Factors - metabolism | Mice | Bacillus anthracis - genetics | Antigens, Bacterial - metabolism | Bacillus anthracis - metabolism | Genetic aspects | Bacillus cereus | Virulence (Microbiology) | Properties | Genes | Index Medicus | Bacillus cereus/metabolism | Antigens, Bacterial/genetics | Biochemistry, Molecular Biology | Bacterial Capsules/metabolism | Bacillus cereus/classification | Virulence Factors/genetics | Virulence/genetics | Life Sciences | Bacillus cereus/genetics | Bacillus anthracis/metabolism | Bacillus anthracis/pathogenicity | Virulence Factors/metabolism | Bacterial Capsules/genetics | Anthrax/microbiology | Bacterial Toxins/genetics | Bacterial Toxins/metabolism | Molecular biology | Toxins | Genomes | Mutation | Nosocomial infections
Journal Article
Cancer Research, ISSN 0008-5472, 01/2008, Volume 68, Issue 2, pp. 379 - 387
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 36, pp. 14944 - 14949
The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer.... 
Helicobacter pylori | Epithelial cells | DNA damage | DNA | Cell nucleus | Cell lines | Bacteria | Cultured cells | Infections | Mice | Chromosome breaks | DNA damage signaling | Gastric tumorigenesis | Genomic instability | CYTOLETHAL DISTENDING TOXIN | MULTIDISCIPLINARY SCIENCES | RISK | MISMATCH REPAIR | COLONIZATION | GENETIC INSTABILITY | EPITHELIAL-CELLS | chromosome breaks | GASTRIC-CANCER | INFLAMMATION | INFECTION | MICE | genomic instability | gastric tumorigenesis | Phosphorylation | Epithelial Cells - metabolism | Humans | Stomach Neoplasms - metabolism | Helicobacter Infections - complications | Stomach Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Antigens, Bacterial - genetics | DNA Breaks, Double-Stranded | Helicobacter Infections - pathology | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Helicobacter Infections - metabolism | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Stomach Neoplasms - genetics | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Bacterial Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Genomic Islands | Epithelial Cells - pathology | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Bacterial Adhesion | Stomach Neoplasms - microbiology | Animals | Histones - genetics | Helicobacter pylori - metabolism | Epithelial Cells - microbiology | Chromosome Aberrations | Cell Line, Tumor | Bacterial Proteins - metabolism | Trans-Activators - metabolism | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Antigens, Bacterial - metabolism | Carcinogens | Cocarcinogens | Physiological aspects | Genetic aspects | Research | Health aspects | Cells | Pathogens | Gram-negative bacteria | Rodents | Index Medicus | Adhesins | Histone H2A | Mesenchyme | Gastric mucosa | Carcinogenesis | Risk factors | Mammalian cells | Metaphase | genomics | Blood groups | Chromosomes | Gastric cancer | Gel electrophoresis | virulence factors | Infection | Cytotoxins | gamma -Glutamyltransferase | Molecular modelling | Microscopy | pathogenicity islands | Ataxia telangiectasia mutated protein | Chromosome aberrations | Biological Sciences
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2014, Volume 47, Issue 1, pp. 84 - 87
A scarlet fever outbreak began in mainland China and Hong Kong in 2011 (refs. 1-6). Macrolide-and tetracycline-resistant Streptococcus pyogenes emm12 isolates... 
INFECTIONS | EVOLUTION | GROUP-A STREPTOCOCCUS | CHINA | GENETICS & HEREDITY | PYOGENES | EPIDEMICS | OUTBREAK | SPREAD | TOOL | Genetic Drift | Humans | Middle Aged | Child, Preschool | Molecular Sequence Data | Phylogeny | Antigens, Bacterial - genetics | Streptococcus pyogenes - genetics | Young Adult | Interspersed Repetitive Sequences - genetics | Disease Outbreaks | Adult | Bacterial Toxins - genetics | Streptococcus pyogenes - classification | Child | Bacterial Outer Membrane Proteins - genetics | Scarlet Fever - epidemiology | Streptococcal Infections - microbiology | Streptococcus pyogenes - drug effects | Bacterial Proteins - genetics | Streptococcal Infections - epidemiology | Mutation Rate | Streptococcus pyogenes - metabolism | Streptococcus pyogenes - virology | Prophages - genetics | Carrier Proteins - genetics | Streptococcus pyogenes - isolation & purification | DNA, Bacterial - genetics | Hong Kong - epidemiology | Adolescent | Exotoxins - genetics | Scarlet Fever - microbiology | Aged | Polymorphism, Single Nucleotide | Drug Resistance, Multiple, Bacterial - genetics | Population Surveillance | Drug resistance in microorganisms | Scarlet fever | Causes of | Streptococcus pyogenes | Genetic aspects | Research | Health aspects | Studies | Surveillance | Genes | Cloning | Phylogenetics | Population | Software | Genomes | Bacteriology | Fever | Acquisitions & mergers | Streptococcus infections | Index Medicus
Journal Article
Molecular Microbiology, ISSN 0950-382X, 07/2006, Volume 61, Issue 1, pp. 126 - 141
We have recently reported the presence of covalently linked pilus‐like structures in the human pathogen, Group B Streptococcus (GBS). The pilus operon codes... 
GRAM-POSITIVE BACTERIA | SHUTTLE VECTOR | CELL-WALL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEISSERIA-MENINGITIDIS | ENDOTHELIAL-CELLS | SURFACE-PROTEINS | GROUP-B STREPTOCOCCUS | MICROBIOLOGY | VIRULENCE | MATRIX-BINDING PROTEINS | BIOFILM FORMATION | Genomic Islands - immunology | Streptococcus agalactiae - pathogenicity | Fimbriae Proteins - metabolism | Adhesins, Bacterial - genetics | Humans | Aminoacyltransferases - genetics | Streptococcal Infections - metabolism | Streptococcus agalactiae - ultrastructure | Antigens, Bacterial - genetics | Cysteine Endopeptidases - physiology | Fimbriae, Bacterial - genetics | Microscopy, Immunoelectron | Streptococcal Infections - genetics | Streptococcus agalactiae - genetics | Adhesins, Bacterial - metabolism | Cysteine Endopeptidases - metabolism | Virulence - genetics | Female | Fimbriae Proteins - immunology | Amino Acid Sequence | Genomic Islands - genetics | Bacterial Proteins - genetics | Fimbriae, Bacterial - ultrastructure | Bacterial Proteins - physiology | Operon - genetics | Animals | Fimbriae Proteins - genetics | Cell Wall - metabolism | Cysteine Endopeptidases - genetics | Antigens, Bacterial - physiology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Mice | Aminoacyltransferases - physiology | Mutation | Adhesins, Bacterial - immunology | Amino Acid Motifs - genetics | Antigens, Bacterial - metabolism | Fimbriae, Bacterial - metabolism | Proteins | Pathogens | Microorganisms | Microbiology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/2010, Volume 327, Issue 5964, pp. 466 - 469
Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and have traditionally been thought to restrict mycobacterial growth. However,... 
Granuloma | Mycobacterium tuberculosis | Epithelial cells | Secretion | Epidermal cells | Virulence | Bacteria | Reports | Infections | Macrophages | Embryos | MYCOBACTERIUM-TUBERCULOSIS | ACTIVATION | ZEBRAFISH | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MATRIX-METALLOPROTEINASE-9 | INFECTION | RELEASE | CALMETTE-GUERIN | EXPRESSION | Granuloma - metabolism | Virulence Factors - genetics | Tuberculosis - microbiology | Mycobacterium marinum - pathogenicity | Zebrafish - embryology | Antigens, Bacterial - genetics | Mycobacterium tuberculosis - pathogenicity | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Mycobacterium Infections, Nontuberculous - microbiology | Mycobacterium marinum - metabolism | Mycobacterium marinum - growth & development | Macrophages - microbiology | Disease Models, Animal | Granuloma - microbiology | Macrophages - physiology | Recombinant Proteins - metabolism | Oligoribonucleotides, Antisense | Zebrafish Proteins - metabolism | Bacterial Proteins - genetics | Enzyme Induction | Embryo, Nonmammalian - microbiology | Animals | Epithelial Cells - enzymology | Bacterial Proteins - metabolism | Virulence Factors - metabolism | Zebrafish Proteins - genetics | Antigens, Bacterial - metabolism | Mycobacterium tuberculosis - genetics | Mycobacterium | Tuberculosis | Mycobacteria | Causes of | Genetic aspects | Health aspects | Proteins | Cellular biology | Molecular biology | Immune system | Index Medicus
Journal Article