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Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5957, pp. 1231 - 1235
Loss-of-function genetic screens in model organisms have elucidated numerous biological processes, but the diploid genome of mammalian cells has precluded... 
Haploidy | B lymphocytes | Genes | Cell lines | Medical genetics | Cell cycle | HeLa cells | Toxins | Genetic screening | Human genetics | Research Article | TARGET | PROTEIN | ADP-RIBOSYLATING TOXINS | DIPHTHAMIDE | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | INFLUENZA | RECEPTOR | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | DIPHTHERIA-TOXIN | ADP Ribose Transferases - toxicity | Histidine - analogs & derivatives | Genetic Testing | Humans | N-Acylneuraminate Cytidylyltransferase - genetics | Adenosine Diphosphate Ribose - metabolism | Bacterial Toxins - toxicity | Molecular Sequence Data | Diphtheria Toxin - toxicity | N-Acylneuraminate Cytidylyltransferase - metabolism | Exotoxins - metabolism | Antigens, Bacterial - toxicity | Monosaccharide Transport Proteins - metabolism | ADP Ribose Transferases - metabolism | Monosaccharide Transport Proteins - genetics | Virulence Factors - toxicity | Amino Acid Sequence | Histidine - biosynthesis | Influenza A Virus, H1N1 Subtype - pathogenicity | Biosynthetic Pathways | Diphtheria Toxin - metabolism | Host-Pathogen Interactions | Proteins - genetics | Bacterial Toxins - metabolism | Proteins - metabolism | Cell Line, Tumor | Exotoxins - toxicity | Virulence Factors - metabolism | Mutagenesis, Insertional | Proteins - chemistry | Antigens, Bacterial - metabolism | Peptide Elongation Factor 2 - metabolism | Research | Mutagenesis | Methods | Testing | Models | Cellular biology | Medical screening | Genomics | Influenza | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2014, Volume 279, Issue 2, pp. 220 - 229
We have previously designed and characterized versions of anthrax lethal toxin that are selectively cytotoxic in the tumor microenvironment and which display... 
Bacterial cytotoxin | Prodrug | Protease | Melanoma | Cancer | SPECIFICITY | THERAPY PRODUCES REGRESSIONS | CAPILLARY MORPHOGENESIS PROTEIN-2 | RECEPTOR | TUMOR ANGIOGENESIS | ATHYMIC NUDE-MICE | KINASE-KINASE | INHIBITION | SEQUENCE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROTECTIVE ANTIGEN | Prodrugs - administration & dosage | Injections, Intravenous | Skin Neoplasms - drug therapy | Melanoma, Experimental - drug therapy | Bacterial Toxins - toxicity | Antineoplastic Agents - administration & dosage | Antigens, Bacterial - genetics | Skin Neoplasms - blood | Prodrugs - metabolism | Antineoplastic Agents - toxicity | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Skin Neoplasms - enzymology | Time Factors | Protein Engineering | Bacterial Toxins - genetics | Female | Antineoplastic Agents - pharmacology | Antigens, Bacterial - toxicity | Skin Neoplasms - pathology | Melanoma, Experimental - enzymology | Mice, Inbred C57BL | Injections, Intraperitoneal | Melanoma, Experimental - pathology | Antigens, Bacterial - pharmacology | Antigens, Bacterial - administration & dosage | Biomarkers, Tumor - blood | Bacterial Toxins - metabolism | Maximum Tolerated Dose | Animals | Tumor Burden - drug effects | Urokinase-Type Plasminogen Activator - metabolism | Bacterial Toxins - pharmacology | Prodrugs - toxicity | Bacterial Toxins - administration & dosage | Melanoma, Experimental - blood | Mice | Matrix Metalloproteinases - metabolism | Antigens, Bacterial - metabolism | Prodrugs - pharmacology | Immunohistochemistry | Comparative analysis | Anthrax | Tumors | Index Medicus | ENGINEERS | TOXINS | MELANOMAS | MICE | TOXICITY | IN VIVO | 60 APPLIED LIFE SCIENCES | PLASMINOGEN | BLOOD | UROKINASE | prodrug | protease | melanoma | cancer | bacterial cytotoxin
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2401 - 2409
is considered one of the most successful pathogens in the history of mankind, having caused 1.7 million deaths in 2016. The amount of resistant and extensively... 
HABPs | Invasion assay | Vaccine | Mycobacterium tuberculosis | Rv3587c | Bioinformatics | CHEMISTRY, MEDICINAL | PROTEIN SECONDARY STRUCTURE | INFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTIMALARIAL VACCINE | SIGNAL PEPTIDES | LINES | PREDICTION | TUBERCULOSIS H37RV | INVASION | CIRCULAR-DICHROISM | ACTIVITY BINDING PEPTIDES | Peptide Fragments - toxicity | Tuberculosis Vaccines - metabolism | Bacterial Proteins - chemical synthesis | Humans | Antigens, Bacterial - immunology | Membrane Proteins - chemical synthesis | Host-Pathogen Interactions - drug effects | Vaccines, Synthetic - immunology | Membrane Proteins - toxicity | Bacterial Proteins - toxicity | Vaccines, Synthetic - metabolism | Peptide Fragments - immunology | Drug Design | Mycobacterium tuberculosis - physiology | Bacterial Proteins - immunology | Membrane Proteins - metabolism | Tuberculosis Vaccines - immunology | Antigens, Bacterial - toxicity | Vaccines, Synthetic - toxicity | Tuberculosis Vaccines - chemical synthesis | Protein Structure, Tertiary | Amino Acid Sequence | Peptide Fragments - metabolism | Tuberculosis Vaccines - toxicity | Protein Structure, Secondary | Computational Biology | Receptors, Cell Surface - metabolism | Membrane Proteins - immunology | Peptide Fragments - chemical synthesis | Cell Line, Tumor | Bacterial Proteins - metabolism | Antigens, Bacterial - metabolism | Host-Pathogen Interactions - physiology | Antigens | Tuberculosis vaccines | Tuberculosis | Peptides | Analysis | BCG | BCG vaccines | Antitubercular agents | Amino acids | Macrophages | Index Medicus
Journal Article
PLoS Biology, ISSN 1544-9173, 06/2017, Volume 15, Issue 6, pp. e2001930 - e2001930
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in... 
NKT CELLS | INVARIANT T-CELLS | GAMMA PRODUCTION | STAPHYLOCOCCAL-ENTEROTOXIN-B | ALPHA-CHAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | TOXIC-SHOCK-SYNDROME | BINDING | MR1 | MHC CLASS-II | CD1D-INDEPENDENT ACTIVATION | Superantigens - toxicity | Leukocytes, Mononuclear - metabolism | Enterotoxins - secretion | Enterotoxins - toxicity | Transplantation Chimera - immunology | Humans | Superantigens - metabolism | Mucosal-Associated Invariant T Cells - immunology | Mucosal-Associated Invariant T Cells - metabolism | Clonal Anergy - drug effects | Bone Marrow Cells - immunology | Leukocytes, Mononuclear - immunology | Bone Marrow Cells - drug effects | Female | Mucosal-Associated Invariant T Cells - cytology | Antigens, Bacterial - toxicity | Staphylococcus aureus - metabolism | Cell Line | Mucosal-Associated Invariant T Cells - drug effects | Leukocytes, Mononuclear - drug effects | Specific Pathogen-Free Organisms | Bone Marrow Cells - cytology | Streptococcus pyogenes - immunology | Cells, Cultured | Mice, Transgenic | Streptococcus pyogenes - metabolism | Immunity, Innate | Mice, SCID | Mice, Knockout | Transplantation Chimera - metabolism | Models, Immunological | Animals | Transplantation Chimera - blood | Lymphocyte Activation - drug effects | Hybridomas | Leukocytes, Mononuclear - cytology | Mice, Inbred NOD | Staphylococcus aureus - immunology | Mice | Antigens, Bacterial - metabolism | Bone Marrow Cells - metabolism | Crosses, Genetic | Klebsiella | Anergy | Mucosa | Escherichia coli | Liver | Colleges & universities | Antiinfectives and antibacterials | Invariants | Proteins | T-cell receptor | Genotype & phenotype | Signal transduction | Cell activation | Illnesses | Surgery | Bone marrow | Medical research | Cytokines | Enterotoxin B | Interleukin 12 | T cell receptors | Roles | Pools | Gene expression | Interleukin 18 | Immunosuppression | Major histocompatibility complex | Sag | Sepsis | Affinity | Animal models | Pneumonia | Interleukin | Editing | Lymphocytes T | Infections | Activation | CD223 antigen | Kinases | Immunology | Lymphocytes | Bacteria | Tumor necrosis factor-TNF | Chimeras | Bacterial infections | Transgenic mice | Inflammation | Streptococcus | Exotoxins | Cell death | Exhaustion | Writing | Interferon | Histocompatibility antigen HLA | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 05/2016, Volume 6, Issue 1, pp. 26966 - 26966
The Gram-positive bacterium Streptococcus suis serotype 2 (S. suis 2), an important zoonotic pathogen, induces strong systemic infections in humans; sepsis and... 
Virulence Factors - genetics | Humans | Bacterial Proteins - chemistry | Cell Aggregation - drug effects | Fibrinogen - chemistry | Antigens, Bacterial - genetics | Integrin alphaXbeta2 - immunology | Streptococcus suis - pathogenicity | Bacterial Proteins - toxicity | Streptococcus suis - genetics | Integrin alphaXbeta2 - genetics | Swine | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Neutrophils - microbiology | Antigens, Bacterial - toxicity | Binding Sites | Virulence Factors - toxicity | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Streptococcal Infections - microbiology | Gene Expression | Antigens, Bacterial - chemistry | Genetic Vectors - chemistry | Neutrophils - drug effects | Bacterial Proteins - genetics | Neutrophils - immunology | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Streptococcus suis - metabolism | Recombinant Proteins - genetics | Virulence Factors - chemistry | Microbial Viability | Fibrinogen - genetics | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Fibrinogen - metabolism | Protein Binding | Bacterial Proteins - metabolism | Virulence Factors - metabolism | Streptococcal Infections - immunology | Streptococcus suis - isolation & purification | Antigens, Bacterial - metabolism | Index Medicus
Journal Article