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Nature (London), ISSN 1476-4687, 2017, Volume 549, Issue 7670, pp. 111 - 115
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues(1-3... 
INTERLEUKIN-2 | ANTIBODIES | AUTOIMMUNE | GENE | MULTIDISCIPLINARY SCIENCES | LOCI | EXPRESSION | Antigens, CD - immunology | Antigens, CD - biosynthesis | Humans | Interleukin-2 Receptor alpha Subunit - biosynthesis | Lectins, C-Type - immunology | Autoimmunity - genetics | Lectins, C-Type - biosynthesis | Lectins, C-Type - genetics | Antigens, CD - genetics | Interleukin-2 Receptor alpha Subunit - genetics | Female | Receptors, Antigen, T-Cell - immunology | Th17 Cells - cytology | Cell Differentiation | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Cell Line | Antigens, Differentiation, T-Lymphocyte - immunology | Gene Expression Regulation - genetics | CRISPR-Cas Systems - genetics | Animals | Antigens, Differentiation, T-Lymphocyte - genetics | Th17 Cells - immunology | Enhancer Elements, Genetic - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Chromatin - genetics | Genetic research | Genetic aspects | Research | RNA processing | Immunity | Interleukin 2 receptors | CRISPR | Chromatin | Animal models | Disease | Transcription | Helper cells | Lymphocytes T | Inflammation | T cell receptors | Genetic diversity | Gene deletion | Gene expression | Gene sequencing | Studies | CD69 antigen | Immunology | Clonal deletion | Perturbation methods | Lymphocytes | Genetic engineering | Gene mapping | Immune system
Journal Article
Nature genetics, ISSN 1546-1718, 2007, Volume 39, Issue 6, pp. 721 - 723
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14062
Background: The cancer stem cell theory hypothesizes that cancers are perpetuated by cancer stem cells (CSC) or tumor initiating cells (TIC) possessing... 
COLON-CANCER | INITIATING CELLS | POPULATION | MARKER | MULTIDISCIPLINARY SCIENCES | TUMOR | HYALURONAN | CHEMORESISTANCE | FLOW-CYTOMETRY | IDENTIFICATION | LINES | Immunohistochemistry | Humans | Lung Neoplasms - metabolism | Middle Aged | Glycoproteins - metabolism | Peptides - genetics | Immunoblotting | Lung Neoplasms - pathology | Male | Transplantation, Heterologous | Gene Expression Profiling | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms, Experimental - pathology | Octamer Transcription Factor-3 - genetics | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Hyaluronan Receptors - metabolism | Neoplasms, Experimental - genetics | Neoplastic Stem Cells - pathology | Female | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Glycoproteins - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Hyaluronan Receptors - genetics | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Aged | Mice | Neoplasms, Experimental - metabolism | Squamous cell carcinoma | Lung cancer, Non-small cell | Analysis | Stem cells | Flow cytometry | Biotechnology | Laboratories | Heart surgery | Oct-4 protein | Lung cancer | Colorectal cancer | Stem cell transplantation | Proteins | Allografts | Epidermal growth factor | CD44 antigen | Xenografts | Cell cycle | CD34 antigen | Subpopulations | Cell survival | Tumor cells | Non-small cell lung carcinoma | Tumor cell lines | Cisplatin | Studies | Polymerase chain reaction | Pathology | Cytometry | Properties (attributes) | Medical prognosis | Biomarkers | In vivo methods and tests | Pluripotency | Tumors | Apoptosis | Cancer
Journal Article
by Hollingworth, Paul and Harold, Denise and Sims, Rebecca and Gerrish, Amy and Lambert, Jean-Charles and Carrasquillo, Minerva M and Abraham, Richard and Hamshere, Marian L and Pahwa, Jaspreet Singh and Moskvina, Valentina and Dowzell, Kimberley and Jones, Nicola and Stretton, Alexandra and Thomas, Charlene and Richards, Alex and Ivanov, Dobril and Widdowson, Caroline and Chapman, Jade and Lovestone, Simon and Powell, John and Proitsi, Petroula and Lupton, Michelle K and Brayne, Carol and Rubinsztein, David C and Gill, Michael and Lawlor, Brian and Lynch, Aoibhinn and Brown, Kristelle S and Passmore, Peter A and Craig, David and McGuinness, Bernadette and Todd, Stephen and Holmes, Clive and Mann, David and Smith, A David and Beaumont, Helen and Warden, Donald and Wilcock, Gordon and Love, Seth and Kehoe, Patrick G and Hooper, Nigel M and Vardy, Emma R L C and Hardy, John and Mead, Simon and Fox, Nick C and Rossor, Martin and Collinge, John and Maier, Wolfgang and Jessen, Frank and Rüther, Eckart and Schürmann, Britta and Heun, Reiner and Kölsch, Heike and van den Bussche, Hendrik and Heuser, Isabella and Kornhuber, Johannes and Wiltfang, Jens and Dichgans, Martin and Frölich, Lutz and Hampel, Harald and Gallacher, John and Hüll, Michael and Rujescu, Dan and Giegling, Ina and Goate, Alison M and Kauwe, John S K and Cruchaga, Carlos and Nowotny, Petra and Morris, John C and Mayo, Kevin and Sleegers, Kristel and Bettens, Karolien and Engelborghs, Sebastiaan and De Deyn, Peter P and Van Broeckhoven, Christine and Livingston, Gill and Bass, Nicholas J and Gurling, Hugh and McQuillin, Andrew and Gwilliam, Rhian and Deloukas, Panagiotis and Al-Chalabi, Ammar and Shaw, Christopher E and Tsolaki, Magda and Singleton, Andrew B and Guerreiro, Rita and Mühleisen, Thomas W and Nöthen, Markus M and Moebus, Susanne and Jöckel, Karl-Heinz and Klopp, Norman and Wichmann, H-Erich and Pankratz, V Shane and Sando, Sigrid B and Aasly, Jan O and Barcikowska, Maria and Wszolek, Zbigniew K and Dickson, Dennis W and Graff-Radford, Neill R and Petersen, Ronald C and ... and the Alzheimer's Disease Neuroimaging Initiative and EADI1 consortium and CHARGE consortium and Alzheimer's Dis Neuroimaging and EADI1 Consortium and CHARGE Consortium and Alzheimer's Disease Neuroimaging Initiative
Nature genetics, ISSN 1546-1718, 2011, Volume 43, Issue 5, pp. 429 - 435
Journal Article
Nature immunology, ISSN 1529-2916, 2013, Volume 14, Issue 12, pp. 1285 - 1293
Cell-mediated immunity critically depends on the localization of lymphocytes at sites of infection. While some memory T cells recirculate, a distinct lineage... 
AFFERENT LYMPHATICS | NONLYMPHOID TISSUE | RM CELLS | IN-VIVO | INFECTION | KRUPPEL-LIKE FACTOR-2 | PERIPHERAL-TISSUES | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTE EGRESS | CUTTING EDGE | Antigens, CD - immunology | Transcription, Genetic - drug effects | Lectins, C-Type - immunology | Phosphatidylinositol 3-Kinases - metabolism | Lectins, C-Type - genetics | Antigens, CD - genetics | Phosphatidylinositol 3-Kinases - immunology | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Lectins, C-Type - metabolism | Signal Transduction - immunology | Flow Cytometry | Kruppel-Like Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Receptors, Lysosphingolipid - genetics | Interleukins - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Lysosphingolipid - metabolism | Immunologic Memory - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Interleukin-33 | Mice, Inbred C57BL | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Signal Transduction - genetics | Down-Regulation - drug effects | Mice, Inbred Strains | Reverse Transcriptase Polymerase Chain Reaction | Phosphatidylinositol 3-Kinases - genetics | Receptors, Lysosphingolipid - immunology | Transforming Growth Factor beta - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Proto-Oncogene Proteins c-akt - immunology | Signal Transduction - drug effects | Down-Regulation - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Transcription, Genetic - immunology | CD8-Positive T-Lymphocytes - immunology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1121 - 8
Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria... 
SYSTEM | ENTRY | MECHANISM | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DOXORUBICIN | TUMOR | VALIDATION | MICROSCOPY | BINDING | DELIVERY | Receptors, Virus - metabolism | Humans | Arenaviruses, New World - genetics | Arenaviruses, New World - metabolism | Plasmodium vivax - genetics | Substrate Specificity | Hemochromatosis Protein - chemistry | Receptors, Virus - genetics | Protozoan Proteins - genetics | Antigens, CD - genetics | Transferrin - genetics | Apoferritins - metabolism | Antigens, CD - metabolism | Protozoan Proteins - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Viral Envelope Proteins - metabolism | Protozoan Proteins - chemistry | Antigens, CD - chemistry | Protein Interaction Domains and Motifs | Receptors, Transferrin - genetics | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Plasmodium vivax - metabolism | Viral Envelope Proteins - genetics | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Apoferritins - chemistry | Apoferritins - genetics | Hemochromatosis Protein - metabolism | Recombinant Proteins - genetics | Receptors, Transferrin - metabolism | Cryoelectron Microscopy | Receptors, Virus - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | Hemochromatosis Protein - genetics | Viral Envelope Proteins - chemistry | Transferrin - chemistry | Protein Binding | HeLa Cells | Transferrin - metabolism | Receptors, Transferrin - chemistry | Binding | Vector-borne diseases | Pathogens | Transferrin | Endocytosis | Malaria | Ferritin | Iron | Epitopes | Electron microscopy | Cellular structure | Mimicry
Journal Article
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2008, Volume 359, Issue 26, pp. 2767 - 2777
Journal Article
Blood, ISSN 1528-0020, 2017, Volume 130, Issue 2, pp. 167 - 175
Bone marrow progenitors, monocytes, and myeloid DCs contain BRAFV600E alleles in adults with LCH and ECD. Mutant allele distribution is not disease specific,... 
MANAGEMENT | DENDRITIC CELLS | NEOPLASMS | DISTINCT | MONOCYTES | SUBSETS | NOTCH | MUTATIONS | MATURATION | HEMATOLOGY | BLOOD | Antigens, CD - immunology | Dendritic Cells - immunology | Histiocytosis, Langerhans-Cell - diagnosis | Histiocytosis, Langerhans-Cell - genetics | Humans | Lectins, C-Type - immunology | Dendritic Cells - pathology | Hematopoietic Stem Cells - pathology | Erdheim-Chester Disease - immunology | Male | Receptors, Notch - genetics | Monocytes - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | Hematopoietic Stem Cells - immunology | Histiocytosis, Langerhans-Cell - pathology | Bone Marrow Cells - immunology | Monocytes - pathology | Adult | Female | Cell Differentiation | Foam Cells - pathology | Glycoproteins - genetics | Transforming Growth Factor beta - immunology | Antigens, CD1 - immunology | Diagnosis, Differential | Erdheim-Chester Disease - genetics | Gene Expression | Bone Marrow Cells - pathology | Immunophenotyping | Lipopolysaccharide Receptors - immunology | Histiocytosis, Langerhans-Cell - immunology | Erdheim-Chester Disease - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Glycoproteins - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Mannose-Binding Lectins - genetics | Mannose-Binding Lectins - immunology | Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins B-raf - immunology | Alleles | Erdheim-Chester Disease - diagnosis | Lipopolysaccharide Receptors - genetics | Foam Cells - immunology | Antigens, CD1 - genetics | Mutation | Receptors, Notch - immunology | Myeloid Neoplasia
Journal Article