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by Naj, Adam C and Jun, Gyungah and Beecham, Gary W and Wang, Li-San and Vardarajan, Badri Narayan and Buros, Jacqueline and Gallins, Paul J and Buxbaum, Joseph D and Jarvik, Gail P and Crane, Paul K and Larson, Eric B and Bird, Thomas D and Boeve, Bradley F and Graff-Radford, Neill R and De Jager, Philip L and Evans, Denis and Schneider, Julie A and Carrasquillo, Minerva M and Ertekin-Taner, Nilufer and Younkin, Steven G and Cruchaga, Carlos and Kauwe, John S. K and Nowotny, Petra and Kramer, Patricia and Hardy, John and Huentelman, Matthew J and Myers, Amanda J and Barmada, Michael M and Demirci, F Yesim and Baldwin, Clinton T and Green, Robert C and Rogaeva, Ekaterina and George-Hyslop, Peter St and Arnold, Steven E and Barber, Robert and Beach, Thomas and Bigio, Eileen H and Bowen, James D and Boxer, Adam and Burke, James R and Cairns, Nigel J and Carlson, Chris S and Carney, Regina M and Carroll, Steven L and Chui, Helena C and Clark, David G and Corneveaux, Jason and Cotman, Carl W and Cummings, Jeffrey L and Decarli, Charles and Dekosky, Steven T and Diaz-Arrastia, Ramon and Dick, Malcolm and Dickson, Dennis W and Ellis, William G and Faber, Kelley M and Fallon, Kenneth B and Farlow, Martin R and Ferris, Steven and Frosch, Matthew P and Galasko, Douglas R and Ganguli, Mary and Gearing, Marla and Geschwind, Daniel H and Ghetti, Bernardino and Gilbert, John R and Gilman, Sid and Giordani, Bruno and Glass, Jonathan D and Growdon, John H and Hamilton, Ronald L and Harrell, Lindy E and Head, Elizabeth and Honig, Lawrence S and Hulette, Christine M and Hyman, Bradley T and Jicha, Gregory A and Jin, Lee-Way and Johnson, Nancy and Karlawish, Jason and Karydas, Anna and Kaye, Jeffrey A and Kim, Ronald and Koo, Edward H and Kowall, Neil W and Lah, James J and Levey, Allan I and Lieberman, Andrew P and Lopez, Oscar L and MacK, Wendy J and Marson, Daniel C and Martiniuk, Frank and Mash, Deborah C and Masliah, Eliezer and McCormick, Wayne C and McCurry, Susan M and McDavid, Andrew N and McKee, Ann C and Mesulam, Marsel and Miller, Bruce L and ...
Nature Genetics, ISSN 1061-4036, 05/2011, Volume 43, Issue 5, pp. 436 - 443
Journal Article
by Hollingworth, P and Harold, D and Sims, R and Gerrish, A and Lambert, J.C and Carrasquillo, M.M and Abraham, R and Hamshere, M.L and Pahwa, J.S and Moskvina, V and Dowzell, K and Jones, N and Stretton, A and Thomas, C and Richards, A and Ivanov, D and Widdowson, C and Chapman, J and Lovestone, S and Powell, J and Proitsi, P and Lupton, M.K and Brayne, C and Rubinsztein, D.C and Gill, M and Lawlor, B and Lynch, A and Brown, K.S and Passmore, P.A and Craig, D and McGuinness, B and Todd, S and Holmes, C and Mann, D and Smith, A.D and Beaumont, H and Warden, D and Wilcock, G and Love, S and Kehoe, P.G and Hooper, N.M and Vardy, E.R.L.C and Hardy, J and Mead, S and Fox, N.C and Rossor, M and Collinge, J and Maier, W and Jessen, F and Ruther, E and Schurmann, B and Heun, R and Kolsch, H and van den Bussche, H and Heuser, I and Kornhuber, J and Wiltfang, J and Dichgans, M and Frolich, L and Hampel, H and Gallacher, J and Hull, M and Rujescu, D and Giegling, I and Goate, A.M and Kauwe, J.S.K and Cruchaga, C and Nowotny, P and Morris, J.C and Mayo, K and Sleegers, K and Bettens, K and Engelborghs, S and de Deyn, P.P and Van Broeckhoven, C and Livingston, G and Bass, N.J and Gurling, H and McQuillin, A and Gwilliam, R and Deloukas, P and Al-Chalabi, A and Shaw, C.E and Tsolaki, M and Singleton, A.B and Guerreiro, R and Muhleisen, T. W and Nothen, M. M and Moebus, S and Jockel, K.H and Klopp, N and Wichmann, H. E and Pankratz, V.S and Sando, S.B and Aasly, J.O and Barcikowska, M and Wszolek, Z.K and Dickson, D.W and Graff-Radford, N.R. and others and Alzheimer's Dis Neuroimaging and EADI1 Consortium and CHARGE Consortium and Alzheimer's Disease Neuroimaging Initiative and EADI1 consortium and CHARGE consortium and the Alzheimer's Disease Neuroimaging Initiative
Nature Genetics, ISSN 1061-4036, 2011, Volume 43, Issue 5, pp. 429 - 435
Journal Article
Journal Article
Biology of Reproduction, ISSN 0006-3363, 09/2014, Volume 91, Issue 3, pp. 78 - 78
Targeted modification of the pig genome can be challenging. Recent applications of the CRISPR/Cas9 system hold promise for improving the efficacy of genome... 
Porcine/pig | Embryo | Genetic engineering | CRISPR/Cas9 | Somatic cell nuclear transfer | Blastocyst | KNOCKOUT PIGS | embryo | CAS SYSTEM | ZINC-FINGER NUCLEASES | genetic engineering | ONE-STEP GENERATION | somatic cell nuclear transfer | porcine/pig | IN-VITRO | REPRODUCTIVE BIOLOGY | RESPIRATORY SYNDROME VIRUS | PORCINE | GENE-EXPRESSION | blastocyst | CLONING EFFICIENCY | CLONED PIGS | Embryo Culture Techniques - veterinary | Sus scrofa - physiology | Genetic Engineering - veterinary | Nuclear Transfer Techniques - veterinary | Blastocyst - physiology | Male | Green Fluorescent Proteins - genetics | Receptors, Cell Surface - antagonists & inhibitors | Antigens, CD - genetics | Antigens, CD - metabolism | Sus scrofa - genetics | Embryo Transfer - veterinary | Gene Deletion | Antigens, CD1d - genetics | Female | In Vitro Oocyte Maturation Techniques - veterinary | Transgenes | Genetic Engineering - methods | Cell Line | Green Fluorescent Proteins - metabolism | Receptors, Cell Surface - metabolism | Antigens, CD1d - chemistry | Fertilization in Vitro - veterinary | Antigens, CD1d - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Embryo, Mammalian - physiology | Animals | Oocytes - physiology | Animals, Genetically Modified - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | CRISPR-Cas Systems | Genetic Engineering - adverse effects | Animals, Genetically Modified - physiology | Mutation | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e80908 - e80908
Macrophage polarization is increasingly recognised as an important pathogenetic factor in inflammatory and neoplastic diseases. Proinflammatory M1 macrophages... 
CD163 | ACTIVATION | SCAVENGER RECEPTOR | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TUMOR-ASSOCIATED MACROPHAGES | IDENTIFICATION | HUMAN MONOCYTES | TRANSCRIPTION FACTOR | EPSTEIN-BARR-VIRUS | Immunohistochemistry | Antigens, CD - immunology | Granuloma, Foreign-Body - immunology | Infectious Mononucleosis - immunology | Humans | Granuloma, Foreign-Body - pathology | Hypersensitivity - immunology | Antigens, CD - genetics | Oxyuriasis - pathology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Proto-Oncogene Proteins c-maf - immunology | Biomarkers - metabolism | Nasal Polyps - immunology | Gene Expression | Nasal Polyps - pathology | Macrophages - classification | Macrophages - pathology | Infectious Mononucleosis - pathology | Proto-Oncogene Proteins c-maf - genetics | Immunophenotyping | STAT1 Transcription Factor - genetics | Wound Healing - immunology | Crohn Disease - immunology | Receptors, Cell Surface - immunology | Antigens, Differentiation, Myelomonocytic - genetics | STAT1 Transcription Factor - immunology | Crohn Disease - pathology | Hypersensitivity - pathology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - immunology | Oxyuriasis - immunology | Cluster Analysis | Receptors, Cell Surface - genetics | Macrophages | Analysis | Cluster analysis | Polarization | Medical research | Antigens | Transcription factors | Immunoglobulins | Wound healing | Immune response | Cloning | Labelling | Lymphocytes T | Gene expression | Infectious mononucleosis | Diseases | Studies | CD163 antigen | Pathology | Mononucleosis | Polyps | Cancer | Index Medicus
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 08/2013, Volume 1833, Issue 8, pp. 1936 - 1946
The differentiation of human peripheral blood monocytes into macrophages can be reproduced ex vivo by culturing the cells in the presence of colony-stimulating... 
MiR-142-3p | Egr2 | Molecular circuitry | Monocyte–macrophage differentiation | Chronic myelomonocytic leukemia | Monocyte-macrophage differentiation | TRANSCRIPTION FACTORS | DENDRITIC CELLS | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | CELL BIOLOGY | PATHWAY | ACUTE LYMPHOBLASTIC-LEUKEMIA | NF-KAPPA-B | MICRORNA EXPRESSION | T-CELLS | Monocytes - cytology | Early Growth Response Protein 2 - genetics | Humans | Leukemia, Myelomonocytic, Chronic - genetics | MicroRNAs - metabolism | Monocytes - metabolism | Antigens, CD - genetics | Leukemia, Myelomonocytic, Chronic - metabolism | Receptors, IgG - metabolism | Antigens, CD - metabolism | Cell Differentiation - genetics | Receptors, IgG - genetics | Early Growth Response Protein 1 - genetics | Macrophage Colony-Stimulating Factor - pharmacology | Leukemia, Myelomonocytic, Chronic - pathology | Monocytes - physiology | Repressor Proteins - metabolism | Macrophages - physiology | Receptors, Cell Surface - metabolism | Repressor Proteins - genetics | MicroRNAs - biosynthesis | Macrophages - cytology | Down-Regulation - drug effects | Antigens, Differentiation, Myelomonocytic - genetics | GPI-Linked Proteins - metabolism | Monocytes - drug effects | Up-Regulation - drug effects | Macrophages - metabolism | Cell Differentiation - drug effects | Antigens, Differentiation, Myelomonocytic - metabolism | K562 Cells | Cell Line, Tumor | Early Growth Response Protein 2 - metabolism | Macrophages - drug effects | MicroRNAs - genetics | Early Growth Response Protein 1 - metabolism | GPI-Linked Proteins - genetics | Receptors, Cell Surface - genetics | Nerve growth factor | MicroRNA | Macrophage colony stimulating factor | Macrophages | Protein binding
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2016, Volume 36, Issue 15, pp. 4182 - 4195
Stroke is a leading cause of disability and currently lacks effective therapy enabling long-term functional recovery. Ischemic brain injury causes local... 
Neuroinflammation | Stroke | Monocyte | Macrophage | Microglia | FOCAL CEREBRAL-ISCHEMIA | macrophage | RECEPTOR | MICROGLIAL CELLS | stroke | NEUROSCIENCES | IMMUNE-SYSTEM | neuroinflammation | INFLAMMATORY CELLS | STAIRCASE TEST | monocyte | CENTRAL-NERVOUS-SYSTEM | CHEMOATTRACTANT PROTEIN-1 | RAT-BRAIN | microglia | ALTERNATIVE ACTIVATION | Infarction, Middle Cerebral Artery - physiopathology | Inflammation - pathology | Recovery of Function - drug effects | Antigens, CD - biosynthesis | Male | Antibodies, Blocking - pharmacology | Antigens, CD - genetics | Lectins - biosynthesis | Stroke - physiopathology | Transforming Growth Factor beta - biosynthesis | Receptors, CCR2 - antagonists & inhibitors | Stroke - pathology | Neuronal Plasticity - physiology | Monocytes - pathology | Behavior, Animal - drug effects | Receptors, Cell Surface - biosynthesis | beta-N-Acetylhexosaminidases - genetics | Antigens, Differentiation, Myelomonocytic - biosynthesis | Macrophages - pathology | Mice, Inbred C57BL | Psychomotor Performance - drug effects | Functional Laterality | beta-N-Acetylhexosaminidases - biosynthesis | Antigens, Differentiation, Myelomonocytic - genetics | Animals | Transforming Growth Factor beta - genetics | Lectins - genetics | Mice | Chimera | Receptors, Cell Surface - genetics | Index Medicus | Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 17, pp. 7166 - 7171
HDL cholesterol (HDL-C) plasma levels are inversely related to cardiovascular disease risk. Previous studies have shown in animals and humans that HDL promotes... 
Thoracic aorta | Monocytes | Messenger RNA | Dendritic cells | HDL lipoproteins | Atherosclerosis | Transplantation | Macrophages | Gene expression | Cholesterols | Arginase I | Alternative activation | HEART-DISEASE | alternative activation | CORONARY ATHEROSCLEROSIS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | arginase I | DIRECTED GENE-TRANSFER | E-DEFICIENT MICE | MACROPHAGE ACTIVATION | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | TRANSGENIC MICE | Atherosclerosis - pathology | Cholesterol, HDL - metabolism | Atherosclerosis - genetics | Humans | Receptors, CCR7 - genetics | Monocytes - metabolism | Aorta - metabolism | Cholesterol, HDL - genetics | Antigens, CD - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Atherosclerosis - metabolism | Antigens, CD - metabolism | Mice, Knockout | Animals | Receptors, CCR7 - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Apolipoproteins E - genetics | Monocytes - pathology | Mice | Foam Cells - pathology | Foam Cells - metabolism | Aorta - transplantation | Disease Models, Animal | Development and progression | Genetic aspects | Inflammation | Health aspects | Cholesterol | Plasma | Transgenic animals | Rodents | Apolipoproteins | Cells | Index Medicus | CC chemokine receptors | Animal models | CCR7 protein | Transgenic mice | phenotypic plasticity | Regression analysis | Chemokine receptors | Aortic arch | Arteriosclerosis | Plasma levels | Cardiovascular diseases | Lipoproteins (high density) | Cell migration | Plaques | Biological Sciences
Journal Article
Circulation Research, ISSN 0009-7330, 01/2010, Volume 106, Issue 1, pp. 203 - 211
RATIONALE:CXCL4 is a platelet-derived chemokine that promotes macrophage differentiation from monocytes. Deletion of the PF4 gene that encodes CXCL4 reduces... 
CD163 | Atherosclerosis | CXCL4 | Macrophage | atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | PLATELET CHEMOKINES | LOW-DENSITY-LIPOPROTEIN | macrophage | CHEMOKINE PLATELET-FACTOR-4 | APOLIPOPROTEIN-E | SCAVENGER RECEPTOR | FOAM CELL-FORMATION | GENE-EXPRESSION | ATHEROSCLEROTIC LESION FORMATION | PERIPHERAL VASCULAR DISEASE | HEME OXYGENASE-1 | INTRAPLAQUE HEMORRHAGE | HEMATOLOGY | Receptors, Scavenger - biosynthesis | Antigens, CD - biosynthesis | Atherosclerosis - genetics | Humans | Monocytes - metabolism | Antigens, CD - genetics | Apolipoproteins E - metabolism | Antigens, CD - metabolism | Cell Differentiation - genetics | Heme Oxygenase-1 - genetics | Platelet Factor 4 - pharmacology | Receptors, Cell Surface - biosynthesis | Hemoglobins - pharmacology | Receptors, Scavenger - agonists | Platelet Factor 4 - genetics | Antigens, Differentiation, Myelomonocytic - biosynthesis | Heme Oxygenase-1 - biosynthesis | Gene Expression Regulation - genetics | Hemoglobins - metabolism | Receptors, Cell Surface - metabolism | Hemoglobins - genetics | Antigens, Differentiation, Myelomonocytic - genetics | Atherosclerosis - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Receptors, Scavenger - genetics | Cell Differentiation - drug effects | Antigens, Differentiation, Myelomonocytic - metabolism | Apolipoproteins E - genetics | Mice | Platelet Factor 4 - metabolism | Receptors, Cell Surface - genetics | Index Medicus
Journal Article