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Immunity, ISSN 1074-7613, 02/2015, Volume 42, Issue 2, pp. 252 - 264
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 2046 - 2058
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NI( cells. Here, we determined that TIGIT is upregulated... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE | LIGANDS | DNAM-1 | INHIBITORY RECEPTORS | CHRONIC VIRAL-INFECTION | NECTIN-2 CD112 | UP-REGULATION | PVR CD155 | EXPRESSION | POLIOVIRUS RECEPTOR CD155 | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Abridged Index Medicus | Oncology | Immunology | Dermatology | Therapeutics
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 09/2014, Volume 411, pp. 55 - 65
Effects of exosomes present in human plasma on immune cells have not been examined in detail. Immunological studies with plasma-derived exosomes require their... 
Exosome isolation | Immunological studies | Size-exclusion chromatography | Human plasma | Exosome characteristics | BIOCHEMICAL RESEARCH METHODS | MICROVESICLES | T-CELL | INDUCE APOPTOSIS | IMMUNOLOGY | IDENTIFICATION | SUPPRESSION | EXTRACELLULAR VESICLES | PROTEINS | CD24 | Exosomes - metabolism | Antigens, CD - immunology | Ribonucleases - chemistry | Antigens, CD - biosynthesis | Humans | Gene Expression Regulation, Neoplastic | Lectins, C-Type - immunology | Neoplasm Proteins - immunology | Male | Lectins, C-Type - biosynthesis | CD4-Positive T-Lymphocytes - pathology | Neoplasm Proteins - metabolism | Lectins, C-Type - chemistry | CD4-Positive T-Lymphocytes - immunology | Blood Buffy Coat - metabolism | Neoplasms - blood | Exosomes - immunology | Antigens, Differentiation, T-Lymphocyte - chemistry | Female | Antigens, CD - chemistry | Deoxyribonucleases - chemistry | Exosomes - ultrastructure | Microscopy, Electron, Transmission | Antigens, Differentiation, T-Lymphocyte - immunology | Blood Buffy Coat - pathology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Neoplasm Proteins - chemistry | Blood Buffy Coat - immunology | Hyaluronoglucosaminidase - chemistry | Neoplasms - immunology | Exosomes - chemistry | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Neoplasms - pathology | Index Medicus | immunological studies | size-exclusion chromatography | human plasma | exosome characteristics
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7670, pp. 111 - 115
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional... 
INTERLEUKIN-2 | ANTIBODIES | AUTOIMMUNE | GENE | MULTIDISCIPLINARY SCIENCES | LOCI | EXPRESSION | Antigens, CD - immunology | Antigens, CD - biosynthesis | Humans | Interleukin-2 Receptor alpha Subunit - biosynthesis | Lectins, C-Type - immunology | Autoimmunity - genetics | Lectins, C-Type - biosynthesis | Lectins, C-Type - genetics | Antigens, CD - genetics | Interleukin-2 Receptor alpha Subunit - genetics | Female | Receptors, Antigen, T-Cell - immunology | Th17 Cells - cytology | Cell Differentiation | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Cell Line | Antigens, Differentiation, T-Lymphocyte - immunology | Gene Expression Regulation - genetics | CRISPR-Cas Systems - genetics | Animals | Antigens, Differentiation, T-Lymphocyte - genetics | Th17 Cells - immunology | Enhancer Elements, Genetic - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Chromatin - genetics | Genetic research | Genetic aspects | Research | RNA processing | Immunity | Interleukin 2 receptors | CRISPR | Chromatin | Animal models | Disease | Transcription | Helper cells | Lymphocytes T | Inflammation | T cell receptors | Genetic diversity | Gene deletion | Gene expression | Gene sequencing | Studies | CD69 antigen | Immunology | Clonal deletion | Perturbation methods | Lymphocytes | Genetic engineering | Gene mapping | Immune system | Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2010, Volume 16, Issue 10, pp. 2861 - 2871
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2005, Volume 175, Issue 4, pp. 2340 - 2348
ICOS is a new member of the CD28 family of costimulatory molecules that is expressed on activated T cells. Its ligand B7RP-1 is constitutively expressed on B... 
GERMINAL CENTER FORMATION | CXC CHEMOKINE RECEPTOR-5 | OX40 LIGAND | IMMUNE-RESPONSES | ACTIVATION MOLECULE | INDUCIBLE COSTIMULATOR | IMMUNOLOGY | LYMPHOID FOLLICLES | EXPRESSION | MICE LACKING | CUTTING EDGE | Spleen - immunology | Mice, Inbred A | Tumor Necrosis Factor-alpha - genetics | B-Lymphocyte Subsets - cytology | CD28 Antigens - genetics | Mice, Inbred CBA | CD40 Antigens - genetics | CD28 Antigens - physiology | CD40 Antigens - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Membrane Proteins - genetics | Receptors, Cytokine - biosynthesis | Antibodies, Monoclonal - pharmacology | Antigens, Surface - biosynthesis | Spleen - cytology | Mice, Knockout | Cell Differentiation - immunology | Membrane Proteins - biosynthesis | Mice | Mice, Inbred BALB C | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | Receptors, CXCR5 | Inducible T-Cell Co-Stimulator Protein | Germinal Center - immunology | Tumor Necrosis Factors | Receptors, OX40 | Tumor Necrosis Factor-alpha - deficiency | Cell Differentiation - genetics | Membrane Proteins - deficiency | Immunization, Secondary | T-Lymphocytes, Helper-Inducer - immunology | Antigens, Differentiation, T-Lymphocyte - physiology | Receptors, Chemokine - biosynthesis | T-Lymphocytes, Helper-Inducer - cytology | B-Lymphocyte Subsets - immunology | Female | Mice, Inbred DBA | Receptors, Tumor Necrosis Factor - deficiency | Membrane Glycoproteins - immunology | Germinal Center - cytology | Receptors, Tumor Necrosis Factor - genetics | B7-1 Antigen - immunology | Mice, Inbred C57BL | Antigens, Surface - genetics | Mice, SCID | Mice, Inbred C3H | Animals | Inducible T-Cell Co-Stimulator Ligand | Spleen - metabolism | Antibodies, Monoclonal - administration & dosage | Antigens, Differentiation, T-Lymphocyte - genetics | Chemokines, CXC - metabolism | Receptors, Tumor Necrosis Factor - biosynthesis | Index Medicus | Abridged Index Medicus
Journal Article
European Journal of Immunology, ISSN 0014-2980, 04/2015, Volume 45, Issue 4, pp. 975 - 987
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2013, Volume 191, Issue 12, pp. 5973 - 5983
Invariant NKT (iNKT) cells display characteristics of both adaptive and innate lymphoid cells (ILCs). Like other ILCs, iNKT cells constitutively express ID... 
TRANSCRIPTION FACTORS | SURVIVAL | LOOP-HELIX PROTEIN | THYMOCYTE DEVELOPMENT | EFFECTOR FUNCTIONS | MEMORY | E2A | KILLER T-CELLS | LEUKEMIA ZINC-FINGER | IMMUNOLOGY | LINEAGE | Clonal Selection, Antigen-Mediated | Inhibitor of Differentiation Proteins - physiology | T-Lymphocyte Subsets - cytology | Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor | T-Box Domain Proteins - biosynthesis | Adoptive Transfer | Interleukin-4 - biosynthesis | Lymphopoiesis - physiology | Natural Killer T-Cells - metabolism | Inhibitor of Differentiation Protein 2 - genetics | Thymus Gland - growth & development | Inhibitor of Differentiation Proteins - deficiency | Kruppel-Like Transcription Factors - biosynthesis | T-Box Domain Proteins - deficiency | Cells, Cultured | Thymus Gland - cytology | Natural Killer T-Cells - cytology | Immunoglobulin Joining Region - genetics | Radiation Chimera | T-Box Domain Proteins - genetics | Promyelocytic Leukemia Zinc Finger Protein | Mice, Knockout | Inhibitor of Differentiation Protein 2 - physiology | Animals | T-Lymphocyte Subsets - metabolism | Antigens, Differentiation, T-Lymphocyte - genetics | Lymphocyte Count | Immunoglobulin Variable Region - genetics | Mice | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Kruppel-Like Transcription Factors - genetics | Interferon-gamma - biosynthesis | Index Medicus | Abridged Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2000, Volume 192, Issue 11, pp. 1545 - 1551
Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that... 
CXC chemokine receptor 5 | T helper cells | Germinal centers | T cell homing | CC chemokine receptor 7 | MIGRATION | OX40 | MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | germinal centers | IMMUNOLOGY | SECONDARY LYMPHOID ORGANS | SPLEEN | MEMORY | BLR1 | TISSUES | LYMPHOCYTES | CXCR5 protein | CCR7 protein | Index Medicus
Journal Article