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1. Full Text Molecular basis of common variable immunodeficiency
by Neumann, C and Grimbacher, B
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, ISSN 0012-0472, 04/2007, Volume 132, Issue 16, pp. 885 - 887
recurrent infections | MEDICINE, GENERAL & INTERNAL | primary immunodeficiencies | positional cloning | common variable immunodeficiency | B cells | MUTATIONS | immunoglobulins | candidate gene sequencing | Common Variable Immunodeficiency - diagnosis | Inducible T-Cell Co-Stimulator Protein | Transmembrane Activator and CAML Interactor Protein - genetics | Diagnosis, Differential | Phenotype | Humans | Antigens, Differentiation, T-Lymphocyte - genetics | Common Variable Immunodeficiency - genetics | Genotype | Transmembrane Activator and CAML Interactor Protein - deficiency | Antigens, CD19 - genetics | Mutation
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2. Full Text The developmental pathway for CD103+ CD8+ tissue-resident memory T cells of skin
by MacKay, Laura K and Rahimpour, Azad and Ma, Joel Z and Collins, Nicholas and Stock, Angus T and Hafon, Ming-Li and Vega-Ramos, Javier and Lauzurica, Pilar and Mueller, Scott N and Stefanovic, Tijana and Tscharke, David C and Heath, William R and Inouye, Michael and Carbone, Francis R and Gebhardt, Thomas
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1294 - 1301
Tissue-resident memory T cells (TRM cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) TRM cells... 
MIGRATION | EFFECTOR | INTESTINAL EPITHELIUM | NONLYMPHOID TISSUE | RM CELLS | PERIPHERAL-TISSUES | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTE EGRESS | CD103 EXPRESSION | CUTTING EDGE | Receptors, Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - immunology | Oligonucleotide Array Sequence Analysis | Skin - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Host-Pathogen Interactions - immunology | Lectins, C-Type - metabolism | Herpesvirus 1, Human - physiology | Integrin alpha Chains - immunology | CD8-Positive T-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Transgenic | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Herpes Simplex - immunology | Mice, Knockout | Cell Differentiation - immunology | Herpes Simplex - virology | Interleukin-15 - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Antigens, CD - immunology | Lectins, C-Type - immunology | Transcriptome - immunology | Lectins, C-Type - genetics | Interleukin-15 - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | Flow Cytometry | Herpesvirus 1, Human - immunology | Receptors, Immunologic - immunology | Skin - virology | Immunologic Memory - immunology | Skin - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Integrin alpha Chains - metabolism | Transcriptome - genetics | Mice, Inbred Strains | Animals | Interleukin-15 - genetics | Receptors, Transforming Growth Factor beta - metabolism | CD8-Positive T-Lymphocytes - virology | Antigens, Differentiation, T-Lymphocyte - genetics | Protein-Serine-Threonine Kinases - immunology | Integrin alpha Chains - genetics | Receptors, Immunologic - metabolism
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3. Full Text Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells
by Skon, Cara N and Lee, June-Yong and Anderson, Kristin G and Masopust, David and Hogquist, Kristin A and Jameson, Stephen C
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1285 - 1293
Cell-mediated immunity critically depends on the localization of lymphocytes at sites of infection. While some memory T cells recirculate, a distinct lineage... 
AFFERENT LYMPHATICS | NONLYMPHOID TISSUE | RM CELLS | IN-VIVO | INFECTION | KRUPPEL-LIKE FACTOR-2 | PERIPHERAL-TISSUES | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTE EGRESS | CUTTING EDGE | Antigens, CD - immunology | Transcription, Genetic - drug effects | Lectins, C-Type - immunology | Phosphatidylinositol 3-Kinases - metabolism | Lectins, C-Type - genetics | Antigens, CD - genetics | Phosphatidylinositol 3-Kinases - immunology | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Lectins, C-Type - metabolism | Signal Transduction - immunology | Flow Cytometry | Kruppel-Like Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Receptors, Lysosphingolipid - genetics | Interleukins - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Lysosphingolipid - metabolism | Immunologic Memory - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Interleukin-33 | Mice, Inbred C57BL | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Signal Transduction - genetics | Down-Regulation - drug effects | Mice, Inbred Strains | Reverse Transcriptase Polymerase Chain Reaction | Phosphatidylinositol 3-Kinases - genetics | Receptors, Lysosphingolipid - immunology | Transforming Growth Factor beta - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Proto-Oncogene Proteins c-akt - immunology | Signal Transduction - drug effects | Down-Regulation - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Transcription, Genetic - immunology | CD8-Positive T-Lymphocytes - immunology | Kruppel-Like Transcription Factors - genetics | Kruppel-Like Transcription Factors - immunology
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4. Full Text Discovery of stimulation-responsive immune enhancers with CRISPR activation
by Simeonov, Dimitre R and Gowen, Benjamin G and Boontanrart, Mandy and Roth, Theodore L and Gagnon, John D and Mumbach, Maxwell R and Satpathy, Ansuman T and Lee, Youjin and Bray, Nicolas L and Chan, Alice Y and Lituiev, Dmytro S and Nguyen, Michelle L and Gate, Rachel E and Subramaniam, Meena and Li, Zhongmei and Woo, Jonathan M and Mitros, Therese and Ray, Graham J and Curie, Gemma L and Naddaf, Nicki and Chu, Julia S and Ma, Hong and Boyer, Eric and Van Gool, Frederic and Huang, Hailiang and Liu, Ruize and Tobin, Victoria R and Schumann, Kathrin and Daly, Mark J and Farh, Kyle K and Ansel, K. Mark and Ye, Chun J and Greenleaf, William J and Anderson, Mark S and Bluestone, Jeffrey A and Chang, Howard Y and Corn, Jacob E and Marson, Alexander
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7670, pp. 111 - 115
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional... 
INTERLEUKIN-2 | ANTIBODIES | AUTOIMMUNE | GENE | MULTIDISCIPLINARY SCIENCES | LOCI | EXPRESSION | Antigens, CD - immunology | Antigens, CD - biosynthesis | Humans | Interleukin-2 Receptor alpha Subunit - biosynthesis | Lectins, C-Type - immunology | Autoimmunity - genetics | Lectins, C-Type - biosynthesis | Lectins, C-Type - genetics | Antigens, CD - genetics | Interleukin-2 Receptor alpha Subunit - genetics | Female | Receptors, Antigen, T-Cell - immunology | Th17 Cells - cytology | Cell Differentiation | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Cell Line | Antigens, Differentiation, T-Lymphocyte - immunology | Gene Expression Regulation - genetics | CRISPR-Cas Systems - genetics | Animals | Antigens, Differentiation, T-Lymphocyte - genetics | Th17 Cells - immunology | Enhancer Elements, Genetic - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Chromatin - genetics | Genetic research | Genetic aspects | Research | RNA processing | Immunity | Interleukin 2 receptors | CRISPR | Chromatin | Animal models | Disease | Transcription | Helper cells | Lymphocytes T | Inflammation | T cell receptors | Genetic diversity | Gene deletion | Gene expression | Gene sequencing | Studies | CD69 antigen | Immunology | Clonal deletion | Perturbation methods | Lymphocytes | Genetic engineering | Gene mapping | Immune system
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5. Full Text Differentiation of CD8 memory T cells depends on foxo1
by Michelini, Rodrigo Hess and Doedens, Andrew L and Goldrath, Ananda W and Hedrick, Stephen M
Journal of Experimental Medicine, ISSN 0022-1007, 06/2013, Volume 210, Issue 6, pp. 1189 - 1200
The forkhead O transcription factors (FOXO) integrate a range of extracellular signals, including growth factor signaling, inflammation, oxidative stress, and... 
TRANSCRIPTION FACTORS | EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | L-SELECTIN | IN-VIVO | INFECTION | IMMUNOLOGY | BETA-CATENIN | NAIVE | EXPRESSION | CUTTING EDGE | Forkhead Transcription Factors - immunology | Lymphocytic choriomeningitis virus - immunology | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - cytology | Granzymes - metabolism | Lectins, C-Type - immunology | Cell Survival - genetics | T-Box Domain Proteins - immunology | Granzymes - genetics | Lectins, C-Type - genetics | Lymphocytic Choriomeningitis - immunology | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Lectins, C-Type - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Granzymes - immunology | T Cell Transcription Factor 1 - metabolism | Immunologic Memory - genetics | Immunologic Memory - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Hepatocyte Nuclear Factor 1-alpha | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Transgenic | Cell Survival - immunology | Forkhead Transcription Factors - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | T Cell Transcription Factor 1 - genetics | Cell Differentiation - immunology | Animals | Up-Regulation - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | T Cell Transcription Factor 1 - immunology | Forkhead Box Protein O1 | Mice | CD8-Positive T-Lymphocytes - immunology | 309
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6. Full Text Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells
by Pot, Caroline and Jin, Hulin and Awasthi, Amit and Liu, Sue Min and Lai, Chen-Yen and Madan, Rajat and Sharpe, Arlene H and Karp, Christopher L and Miaw, Shi-Chuen and Ho, I-Cheng and Kuchroo, Vijay K
The Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 2, pp. 797 - 801
IL-27 has recently been identified as a differentiation factor for the generation of IL-10-producing regulatory type 1 (Tr1) T cells. However, how IL-27... 
REGULATORY T-CELLS | IMMUNOLOGY | INTERLEUKIN-27 | EXPRESSION | INFLAMMATION | IL-10 | Inducible T-Cell Co-Stimulator Protein | T-Lymphocytes, Regulatory - metabolism | Proto-Oncogene Proteins c-maf - genetics | Transcriptional Activation | Proto-Oncogene Proteins c-maf - physiology | Interleukins - genetics | Animals | Interleukins - physiology | Antigens, Differentiation, T-Lymphocyte - physiology | Interleukins - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - biosynthesis | Cell Differentiation | Mice
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7. Full Text A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
by Wang, Yi-Hong and Park, Heon and Li, Zhaoxia and Zhu, Zhou and Hood, Leroy and Yang, Xuexian O and Tian, Qiang and Wang, Ying and Nurieva, Roza and Dong, Chen and Chang, Seon Hee
Nature Immunology, ISSN 1529-2908, 11/2005, Volume 6, Issue 11, pp. 1133 - 1141
Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear. Here we have evaluated in vitro and... 
IMMUNE | RESPONSES | ACTIVATION | AUTOIMMUNE INFLAMMATION | FAMILY-MEMBERS | IL-17 | RECEPTOR | IL-17-DEFICIENT MICE | IMMUNOLOGY | C-MAF | EXPRESSION | Inducible T-Cell Co-Stimulator Protein | Pneumonia - pathology | CD28 Antigens - metabolism | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | CD28 Antigens - genetics | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Pneumonia - immunology | Pneumonia - genetics | Lung - pathology | CD4-Positive T-Lymphocytes - cytology | Gene Expression Regulation | Antigens, Differentiation, T-Lymphocyte - metabolism | Interleukin-17 - genetics | Rats | Mice, Transgenic | Inflammation - immunology | Interleukin-17 - biosynthesis | Chemokines - genetics | Cell Lineage | Animals | Antigens, Differentiation, T-Lymphocyte - genetics | Inflammation - genetics | Chemokines - metabolism | Mice | Mutation
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8. Full Text Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention
by Mackay, Laura K and Braun, Asolina and Macleod, Bethany L and Collins, Nicholas and Tebartz, Christina and Bedoui, Sammy and Carbone, Francis R and Gebhardt, Thomas
Journal of Immunology, ISSN 0022-1767, 03/2015, Volume 194, Issue 5, pp. 2059 - 2063
Tissue-resident memory T cells provide local immune protection in barrier tissues, such as skin and mucosa. However, the molecular mechanisms controlling... 
IMMUNITY | MAINTENANCE | AFFERENT LYMPHATICS | VIRUS | MEMORY | RM CELLS | TISSUE | INFECTION | IMMUNOLOGY | LYMPHOCYTE EGRESS | ANTIGEN | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Coculture Techniques | Dendritic Cells - immunology | Lectins, C-Type - immunology | Dendritic Cells - pathology | Antigens, Viral - genetics | Interferon Type I - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | Receptors, Lysosphingolipid - genetics | Female | Herpesvirus 1, Human - immunology | Dendritic Cells - virology | Skin - virology | Skin - pathology | Skin - immunology | Adaptive Immunity | Antigens, Differentiation, T-Lymphocyte - immunology | Signal Transduction | Lymphocyte Activation | Mice, Inbred C57BL | Gene Expression Regulation | Immunophenotyping | Mice, Knockout | Antigens, Viral - immunology | Receptors, Lysosphingolipid - immunology | Animals | CD8-Positive T-Lymphocytes - virology | Antigens, Differentiation, T-Lymphocyte - genetics | Interferon Type I - genetics | Herpesvirus 1, Human - genetics | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology
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9. Full Text Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection
by Khan, Tahsin N and Mooster, Jana L and Kilgore, Augustus M and Osborn, Jossef F and Nolz, Jeffrey C
Journal of Experimental Medicine, ISSN 0022-1007, 05/2016, Volume 213, Issue 6, pp. 951 - 966
Tissue-resident memory (Trm) CD8(+) T cells are functionally distinct from their circulating counterparts and are potent mediators of host protection against... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | RM CELLS | IN-VIVO | VACCINATION | HSV-1 REACTIVATION | SKIN | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTE EGRESS | SENSORY NEURONS | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Antigens, Differentiation, T-Lymphocyte - immunology | Lectins, C-Type - immunology | Vaccinia - pathology | Antigens, Viral - genetics | Mice, Transgenic | Lectins, C-Type - genetics | Antigens, CD - genetics | Vaccinia virus - genetics | Vaccinia - genetics | Vaccinia virus - immunology | Antigens, Viral - immunology | Models, Immunological | Animals | Antigens, Differentiation, T-Lymphocyte - genetics | Vaccinia - immunology | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | Skin - pathology | Skin - immunology
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10. Full Text The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development
by Cowan, Jennifer E and Parnell, Sonia M and Nakamura, Kyoko and Caamano, Jorge H and Lane, Peter J.L and Jenkinson, Eric J and Jenkinson, William E and Anderson, Graham
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 4, pp. 675 - 681
A key role of the thymic medulla is to negatively select autoreactive CD4(+) and CD8(+) thymocytes, a process important for T cell tolerance induction.... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | PERIPHERAL LYMPHOID ORGANS | EPITHELIAL-CELLS | DENDRITIC CELLS | POSITIVELY SELECTED THYMOCYTES | SIGNALS | MICE | IMMUNOLOGY | T-CELL DEVELOPMENT | EXPRESSION | RELB | Forkhead Transcription Factors - immunology | Antigens, CD - immunology | Receptors, CCR7 - immunology | Transcription Factor RelB - immunology | Lectins, C-Type - immunology | Receptors, Antigen, T-Cell, alpha-beta - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - cytology | Cell Differentiation - physiology | Transcription Factor RelB - genetics | Antigens, Differentiation, T-Lymphocyte - immunology | Receptors, CCR - genetics | Histocompatibility Antigens Class I - immunology | Receptors, CCR7 - genetics | Thymus Gland - cytology | Histocompatibility Antigens Class I - genetics | Forkhead Transcription Factors - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | Mice, Knockout | Thymocytes - immunology | Animals | Receptors, CCR - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Thymocytes - cytology | Thymus Gland - immunology | Mice | Brief Definitive Report
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11. Full Text TIGIT and PD-1 impair tumor antigen-specific CD8 + T cells in melanoma patients
by Chauvin, Joe-Marc and Pagliano, Ornella and Fourcade, Julien and Sun, Zhaojun and Wang, Hong and Sander, Cindy and Kirkwood, John M and Chen, Tseng-Hui Timothy and Maurer, Mark and Korman, Alan J and Zarour, Hassane M
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 2046 - 2058
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NI( cells. Here, we determined that TIGIT is upregulated... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE | LIGANDS | DNAM-1 | INHIBITORY RECEPTORS | CHRONIC VIRAL-INFECTION | NECTIN-2 CD112 | UP-REGULATION | PVR CD155 | EXPRESSION | POLIOVIRUS RECEPTOR CD155 | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Oncology | Immunology | Dermatology | Therapeutics
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12. Full Text Primary B Cell Immunodeficiencies: Comparisons and Contrasts
by Conley, Mary Ellen and Dobbs, A. Kerry and Farmer, Dana M and Kilic, Sebnem and Paris, Kenneth and Grigoriadou, Sofia and Coustan-Smith, Elaine and Howard, Vanessa and Campana, Dario
Annual Review of Immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 199 - 227
Sophisticated genetic tools have made possible the identification of the genes responsible for most well-described immunodeficiencies in the past 15 years.... 
Btk | Common variable immunodeficiency | TACI | X-linked agammaglobulinemia | Hyper-IgM syndrome | DISEASE GENE SH2D1A | INDUCED CYTIDINE DEAMINASE | common variable immunodeficiency | MAJOR HISTOCOMPATIBILITY COMPLEX | IMMUNOLOGY | hyper-IgM syndrome | BRUTONS TYROSINE KINASE | ANTIBODY-DEFICIENCY SYNDROME | CLASS-SWITCH RECOMBINATION | AUTOSOMAL RECESSIVE FORM | Inducible T-Cell Co-Stimulator Protein | CD79 Antigens - immunology | Protein-Tyrosine Kinases - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Precursor Cells, B-Lymphoid - immunology | Antigens, CD19 - genetics | Protein-Tyrosine Kinases - immunology | Transmembrane Activator and CAML Interactor Protein - metabolism | Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - immunology | Immunologic Deficiency Syndromes - immunology | B-Lymphocytes - metabolism | Antigens, CD19 - immunology | Antigens, Differentiation, T-Lymphocyte - immunology |