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1. Full Text Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
by Bain, Calum C and Bravo-Blas, Alberto and Scott, Charlotte L and Perdiguero, Elisa Gomez and Geissmann, Frederic and Henri, Sandrine and Malissen, Bernard and Osborne, Lisa C and Artis, David and Mowat, Allan McI
Nature Immunology, ISSN 1529-2908, 08/2014, Volume 15, Issue 10, pp. 929 - 937
The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which... 
HOMEOSTASIS | DENDRITIC CELLS | MICROGLIA | INFLAMMATION | BONE-MARROW | TISSUE-RESIDENT MACROPHAGES | RECEPTOR | STEADY-STATE | IMMUNOLOGY | MYELOID CELLS | LIFE | Receptors, CCR2 - genetics | Intestinal Mucosa - metabolism | Cell Proliferation | Receptors, CCR2 - immunology | Monocytes - metabolism | Intestines - metabolism | Monocytes - immunology | Intestines - immunology | Parabiosis | Intestinal Mucosa - cytology | CD11b Antigen - genetics | Flow Cytometry | Time Factors | Intestinal Mucosa - immunology | Bone Marrow Transplantation | Gene Expression - immunology | Antigens, Differentiation - metabolism | Antigens, Ly - metabolism | Receptors, Chemokine - genetics | Macrophages - immunology | Animals, Newborn | CD11b Antigen - immunology | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Mice, Transgenic | Receptors, Chemokine - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Differentiation - immunology | Macrophages - metabolism | Models, Immunological | Receptors, CCR2 - metabolism | Animals | Antigens, Ly - immunology | Antigens, Differentiation - genetics | CD11b Antigen - metabolism | CX3C Chemokine Receptor 1 | Antigens, Differentiation - immunology | Intestines - cytology | Physiological aspects | Regulation | Immune response | Microbiota (Symbiotic organisms) | Macrophages | Properties | Index Medicus
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2. Full Text Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen
by Plantinga, Maud and Guilliams, Martin and Vanheerswynghels, Manon and Deswarte, Kim and Branco-Madeira, Filipe and Toussaint, Wendy and Vanhoutte, Leen and Neyt, Katrijn and Killeen, Nigel and Malissen, Bernard and Hammad, Hamida and Lambrecht, Bart N
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 322 - 335
Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs performs this task. By using CD64 and MAR-1... 
TH2 RESPONSES | LYMPH-NODES | BONE-MARROW | AIRWAY INFLAMMATION | MICE | CHEMOKINE RECEPTOR CCR2 | IMMUNOLOGY | INHALED ALLERGENS | VIRAL-INFECTION | URIC-ACID | T-CELLS | Inflammation - pathology | Cell Proliferation | Lymph Nodes - pathology | Dendritic Cells - immunology | Antigens, Ly - genetics | Monocytes - immunology | Th2 Cells - immunology | Adoptive Transfer | Antigens, Dermatophagoides - immunology | CD11b Antigen - genetics | Receptors, IgG - genetics | Monocytes - transplantation | Allergens - immunology | Natural Cytotoxicity Triggering Receptor 1 - genetics | Antigens, Dermatophagoides - administration & dosage | Asthma - immunology | Natural Cytotoxicity Triggering Receptor 1 - immunology | Allergens - isolation & purification | Gene Expression | Lung - pathology | CD11b Antigen - immunology | Administration, Inhalation | Mice, Transgenic | Inflammation - immunology | Lymph Nodes - immunology | Receptors, IgG - immunology | Organ Specificity | Animals | Antigens, Ly - immunology | Antigens, Dermatophagoides - isolation & purification | Mice | Asthma - pathology | Dendritic Cells - transplantation | Immunity, Cellular | Lung - immunology | Cell Movement | Pyroglyphidae - immunology | Bone marrow | Cell growth | Transgenic animals | Allergies | Chemokines | Immune system | Index Medicus
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3. Full Text The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity
by Croxford, Andrew L and Lanzinger, Margit and Hartmann, Felix J and Schreiner, Bettina and Mair, Florian and Pelczar, Pawel and Clausen, Björn E and Jung, Steffen and Greter, Melanie and Becher, Burkhard
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 502 - 514
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue... 
EFFECTOR PHASE | COLONY-STIMULATING FACTOR | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | MACROPHAGES | IN-VIVO | LYMPH-NODES | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | T-CELLS | ENCEPHALOMYELITIS EAE | Receptors, CCR2 - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, CCR2 - immunology | Dendritic Cells - immunology | Humans | Antigens, Ly - genetics | STAT5 Transcription Factor - immunology | Autoimmunity - genetics | Monocytes - metabolism | Monocytes - immunology | Transcriptome - immunology | Interleukin-1beta - genetics | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Autoimmunity - immunology | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Antigens, Ly - metabolism | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Cytokine Receptor Common beta Subunit - metabolism | Phosphorylation - immunology | Phosphorylation - drug effects | Dendritic Cells - metabolism | Cytokine Receptor Common beta Subunit - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Interleukin-1beta - immunology | Mice, Transgenic | Inflammation - immunology | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Monocytes - drug effects | Encephalomyelitis, Autoimmune, Experimental | Receptors, CCR2 - metabolism | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Antigens, Ly - immunology | Signal Transduction - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Cytokine Receptor Common beta Subunit - genetics | Flow cytometry | Phosphorylation | Disease | Cytokines | Bone marrow | Software | Inflammation | Autoimmune diseases | Index Medicus
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4. Full Text Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
by Moro, K and Yamada, T and Tanabe, M and Takeuchi, T and Ikawa, T and Kawamoto, H and Furusawa, J and Ohtani, M and Fujii, H and Koyasu, S
NATURE, ISSN 0028-0836, 01/2010, Volume 463, Issue 7280, pp. 540 - U160
Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes... 
NATURAL-KILLER-CELLS | ROR-GAMMA-T | EXPULSION | MULTIDISCIPLINARY SCIENCES | GENERATION | DIFFERENTIATION | IL-33 | EXPRESSION | MICE LACKING | INDUCER CELLS | LYMPHOCYTES | B-Lymphocytes - cytology | Cell Proliferation | Membrane Proteins - genetics | Humans | Mice, Inbred C57BL | Antigens, Ly - genetics | Gene Expression Regulation | Adipose Tissue - cytology | Membrane Proteins - immunology | Th2 Cells - immunology | Adipose Tissue - immunology | Proto-Oncogene Proteins c-kit - immunology | Nematoda - physiology | Animals | B-Lymphocytes - immunology | Lymphocytes - immunology | Antigens, Ly - immunology | Mesentery - immunology | Antigens, Ly - metabolism | Proto-Oncogene Proteins c-kit - genetics | Mice | Nematode Infections - immunology | Cytokines - immunology | Index Medicus
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5. Full Text Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
by Schlitzer, Andreas and Sivakamasundari, V and Chen, Jinmiao and Sumatoh, Hermi Rizal Bin and Schreuder, Jaring and Lum, Josephine and Malleret, Benoit and Zhang, Sanqian and Larbi, Anis and Zolezzi, Francesca and Renia, Laurent and Poidinger, Michael and Naik, Shalin and Newell, Evan W and Robson, Paul and Ginhoux, Florent
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 718 - 728
Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8 alpha(+) (CD103(+)) cDC1 lineage, and the CD11b(+)... 
CLASSICAL DENDRITIC CELLS | HOMEOSTASIS | LYMPHOID-TISSUE | HEMATOPOIETIC STEM-CELLS | MOUSE | DYNAMICS | RECEPTOR | TRANSCRIPTION-FACTOR | IMMUNOLOGY | COMMITTED PROGENITORS | EXPRESSION | Antigens, CD - immunology | Stem Cells - immunology | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Antigens, Ly - genetics | Transcriptome - immunology | Stem Cells - metabolism | Antigens, CD - metabolism | Lectins - metabolism | Flow Cytometry | Single-Cell Analysis - methods | Bone Marrow Cells - immunology | Integrin alpha Chains - immunology | Antigens, Ly - metabolism | Cell Lineage - genetics | Dendritic Cells - metabolism | Microscopy, Electron, Scanning | CD11b Antigen - immunology | Lectins - immunology | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Mice, Transgenic | Integrin alpha Chains - metabolism | Transcriptome - genetics | Receptors, Cell Surface - immunology | CD8 Antigens - immunology | CD8 Antigens - metabolism | Animals | Antigens, Ly - immunology | Dendritic Cells - ultrastructure | Lectins - genetics | CD11b Antigen - metabolism | Bone Marrow Cells - metabolism | Cell Lineage - immunology | Cluster Analysis | Receptors, Cell Surface - genetics | Medical research | Immune response | Dendritic cells | Cell development (Biology) | Bone marrow | Medicine, Experimental | Genetic aspects | Research | Properties | Index Medicus
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6. Full Text Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus
by Shechter, Ravid and Miller, Omer and Yovel, Gili and Rosenzweig, Neta and London, Anat and Ruckh, Julia and Kim, Ki-Wook and Klein, Eugenia and Kalchenko, Vyacheslav and Bendel, Peter and Lira, Sergio A and Jung, Steffen and Schwartz, Michal
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 555 - 569
Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although... 
ECTO-5'-NUCLEOTIDASE CD73 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | MICROGLIA | REGENERATION | MONOCYTES | CNS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | DIVERGENT | EXPRESSION | 5'-Nucleotidase - antagonists & inhibitors | 5'-Nucleotidase - genetics | Leukocyte Common Antigens - metabolism | Meninges - immunology | Spinal Cord - metabolism | Choroid Plexus - metabolism | Choroid Plexus - immunology | Monocytes - metabolism | Green Fluorescent Proteins - genetics | Monocytes - immunology | Spinal Cord Injuries - genetics | Cell Movement - genetics | Meninges - metabolism | Cell Movement - immunology | Leukocyte Common Antigens - immunology | Flow Cytometry | 5'-Nucleotidase - immunology | Gene Expression - immunology | Antigens, Ly - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Receptors, Chemokine - genetics | Macrophages - immunology | Green Fluorescent Proteins - metabolism | Vascular Cell Adhesion Molecule-1 - immunology | Blood-Brain Barrier - immunology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Integrin alpha4beta1 - genetics | Receptors, Chemokine - immunology | Reverse Transcriptase Polymerase Chain Reaction | Adenosine Diphosphate - pharmacology | Blood-Brain Barrier - metabolism | Mice, Knockout | Integrin alpha4beta1 - immunology | Monocytes - drug effects | Spinal Cord - immunology | Microscopy, Confocal | Macrophages - metabolism | Animals | Antigens, Ly - immunology | Macrophages - drug effects | Spinal Cord Injuries - immunology | Mice | Adenosine Diphosphate - analogs & derivatives | CX3C Chemokine Receptor 1 | Spinal Cord Injuries - cerebrospinal fluid | Macrophages | Enzymes | Spinal cord injuries | Statistical analysis | Cytokines | Rodents | Recruitment | Index Medicus
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7. Full Text NK cells link obesity-induced adipose stress to inflammation and insulin resistance
by Wensveen, Felix M and Jelenčić, Vedrana and Valentić, Sonja and Šestan, Marko and Wensveen, Tamara Turk and Theurich, Sebastian and Glasner, Ariella and Mendrila, Davor and Štimac, Davor and Wunderlich, F. Thomas and Brüning, Jens C and Mandelboim, Ofer and Polić, Bojan
Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 376 - 385
An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is... 
ADAPTIVE IMMUNITY | GLOBAL TRENDS | INTERFERON-GAMMA | GLUCOSE | TISSUE | INNATE | FAT | CYTOKINE | DIFFERENTIATION | IMMUNOLOGY | T-CELLS | Inflammation - pathology | Obesity - immunology | Humans | Insulin - immunology | Antigens, Ly - genetics | Male | Killer Cells, Natural - pathology | Obesity - genetics | Natural Cytotoxicity Triggering Receptor 1 - genetics | Killer Cells, Natural - immunology | Female | Cell Differentiation | Natural Cytotoxicity Triggering Receptor 1 - immunology | Adipocytes - immunology | Macrophages - immunology | Intra-Abdominal Fat - immunology | Macrophages - pathology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Inflammation - immunology | Adipocytes - pathology | Obesity - pathology | Animals | Antigens, Ly - immunology | Interferon-gamma - immunology | Inflammation - genetics | Insulin Resistance - immunology | Mice | Intra-Abdominal Fat - pathology | Interferon-gamma - biosynthesis | Adipose tissues | Killer cells | Physiological aspects | Insulin resistance | Development and progression | Genetic aspects | Research | Risk factors | Index Medicus
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8. Full Text Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury
by Seo, Sang-Uk and Kamada, Nobuhiko and Muñoz-Planillo, Raúl and Kim, Donghyun and Kim, Yun-Gi and Koizumi, Yukiko and Hasegawa, Mizuho and Himpsl, Stephanie D and Browne, Hilary P and Lawley, Trevor D and Mobley, Harry L.T and Inohara, Naohiro and Núñez, Gabriel
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 744 - 755
The microbiota stimulates inflammation, but the signaling pathways and the members of the microbiota involved remain poorly understood. We found that the... 
DEXTRAN SULFATE | IMMUNE-SYSTEM | COLITIS | MACROPHAGES | MICE | INNATE LYMPHOID-CELLS | GUT MICROBIOTA | GERM-FREE | IMMUNOLOGY | PROTEUS-MIRABILIS | BOWEL-DISEASE | Receptors, CCR2 - genetics | Inflammation - pathology | Hemolysin Proteins - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Proteus Infections - genetics | Receptors, CCR2 - immunology | Hemolysin Proteins - genetics | Salmonella Infections - genetics | Antigens, Ly - genetics | Salmonella Infections - immunology | Symbiosis - immunology | Monocytes - immunology | Interleukin-1beta - genetics | Intestines - immunology | Proteus Infections - pathology | Monocytes - pathology | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Proteus mirabilis - immunology | Monocytes - microbiology | Salmonella Infections - pathology | Inflammation - microbiology | Microbiota - immunology | Macrophages - pathology | Proteus Infections - microbiology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Intestines - injuries | Interleukin-1beta - immunology | Inflammation - immunology | Proteus Infections - immunology | Inflammasomes - genetics | Mice, Knockout | Carrier Proteins - genetics | Salmonella - immunology | Animals | Intestines - microbiology | Antigens, Ly - immunology | Inflammasomes - immunology | Inflammation - genetics | Salmonella Infections - microbiology | Mice | Index Medicus
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9. Full Text Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
by Prakash Ramachandran and Antonella Pellicoro and Madeleine A. Vernon and Luke Boulter and Rebecca L. Aucott and Aysha Ali and Stephen N. Hartland and Victoria K. Snowdon and Andrea Cappon and Timothy T. Gordon-Walker and Mike J. Williams and Donald R. Dunbar and Jonathan R. Manning and Nico van Rooijen and Jonathan A. Fallowfield and Stuart J. Forbes and John P. Iredale
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2012, Volume 109, Issue 46, pp. E3186 - E3195
Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl 4 -induced model of reversible... 
Degradation | Kupffer cell | Proliferation | Collagen | Myofibroblast | Kupffer Cell | LUNG FIBROSIS | proliferation | myofibroblast | MULTIDISCIPLINARY SCIENCES | collagen | degradation | HEPATIC-FIBROSIS | RENAL FIBROSIS | IMMUNE-RESPONSES | APOPTOTIC CELLS | IN-VIVO | MONOCYTE SUBSETS | GENE-EXPRESSION | PULMONARY-FIBROSIS | T-CELLS | Liver Cirrhosis - immunology | Antigens, Ly - genetics | Matrix Metalloproteinase 9 - immunology | Matrix Metalloproteinase 12 - genetics | Insulin-Like Growth Factor I - genetics | Monocytes - immunology | MAP Kinase Signaling System - immunology | Liver Cirrhosis - chemically induced | Insulin-Like Growth Factor I - immunology | CD11b Antigen - genetics | MAP Kinase Signaling System - genetics | Matrix Metalloproteinase 9 - genetics | Monocytes - pathology | Liver Cirrhosis - genetics | Macrophages - immunology | CD11b Antigen - immunology | Macrophages - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Matrix Metalloproteinase 12 - immunology | Mice, Transgenic | Carbon Tetrachloride - toxicity | Carbon Tetrachloride Poisoning - pathology | Gene Expression Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Antigens, Ly - immunology | Carbon Tetrachloride Poisoning - immunology | Liver Cirrhosis - pathology | Carbon Tetrachloride Poisoning - genetics | Mice | Proteins | Genotype & phenotype | Signal transduction | Liver diseases | Gene expression | Rodents | Index Medicus | Biological Sciences | PNAS Plus
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10. Full Text Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4
by Egawa, Mayumi and Mukai, Kaori and Yoshikawa, Soichiro and Iki, Misako and Mukaida, Naofumi and Kawano, Yohei and Minegishi, Yoshiyuki and Karasuyama, Hajime
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 570 - 580
Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The... 
ALTERNATIVELY ACTIVATED MACROPHAGES | TYPE-2 INFLAMMATION | DENDRITIC CELLS | IMMUNE-RESPONSES | BONE-MARROW | CHEMOKINE RECEPTOR | PRODUCE INTERLEUKIN-4 | BACTERIAL-INFECTION | IL-4 PRODUCTION | IMMUNOLOGY | T-CELLS | Receptors, CCR2 - genetics | Receptors, CCR2 - immunology | Skin - metabolism | Antigens, Ly - genetics | Hypersensitivity - immunology | Monocytes - metabolism | Monocytes - immunology | Adoptive Transfer | Interleukin-4 Receptor alpha Subunit - genetics | Cell Differentiation - genetics | Inflammation - metabolism | Flow Cytometry | Hypersensitivity - metabolism | Basophils - immunology | Antigens, Ly - metabolism | Hypersensitivity - genetics | Macrophages - immunology | Skin - pathology | Skin - immunology | Interleukin-4 Receptor alpha Subunit - metabolism | Interleukin-4 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-4 Receptor alpha Subunit - immunology | Mice, Knockout | Cell Differentiation - immunology | Interleukin-4 - immunology | Macrophages - metabolism | Receptors, CCR2 - metabolism | Animals | Antigens, Ly - immunology | Inflammation - genetics | Mice | Mice, Inbred BALB C | Basophils - metabolism | Anti-inflammatory drugs | Skin | Genetic aspects | Bone marrow | Wound healing | Cytokines | Allergies | Immune system | Index Medicus
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