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Nature Immunology, ISSN 1529-2908, 08/2014, Volume 15, Issue 10, pp. 929 - 937
The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which... 
HOMEOSTASIS | DENDRITIC CELLS | MICROGLIA | INFLAMMATION | BONE-MARROW | TISSUE-RESIDENT MACROPHAGES | RECEPTOR | STEADY-STATE | IMMUNOLOGY | MYELOID CELLS | LIFE | Receptors, CCR2 - genetics | Intestinal Mucosa - metabolism | Cell Proliferation | Receptors, CCR2 - immunology | Monocytes - metabolism | Intestines - metabolism | Monocytes - immunology | Intestines - immunology | Parabiosis | Intestinal Mucosa - cytology | CD11b Antigen - genetics | Flow Cytometry | Time Factors | Intestinal Mucosa - immunology | Bone Marrow Transplantation | Gene Expression - immunology | Antigens, Differentiation - metabolism | Antigens, Ly - metabolism | Receptors, Chemokine - genetics | Macrophages - immunology | Animals, Newborn | CD11b Antigen - immunology | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Mice, Transgenic | Receptors, Chemokine - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Differentiation - immunology | Macrophages - metabolism | Models, Immunological | Receptors, CCR2 - metabolism | Animals | Antigens, Ly - immunology | Antigens, Differentiation - genetics | CD11b Antigen - metabolism | CX3C Chemokine Receptor 1 | Antigens, Differentiation - immunology | Intestines - cytology | Physiological aspects | Regulation | Immune response | Microbiota (Symbiotic organisms) | Macrophages | Properties | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 718 - 728
Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8 alpha(+) (CD103(+)) cDC1 lineage, and the CD11b(+)... 
CLASSICAL DENDRITIC CELLS | HOMEOSTASIS | LYMPHOID-TISSUE | HEMATOPOIETIC STEM-CELLS | MOUSE | DYNAMICS | RECEPTOR | TRANSCRIPTION-FACTOR | IMMUNOLOGY | COMMITTED PROGENITORS | EXPRESSION | Antigens, CD - immunology | Stem Cells - immunology | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Antigens, Ly - genetics | Transcriptome - immunology | Stem Cells - metabolism | Antigens, CD - metabolism | Lectins - metabolism | Flow Cytometry | Single-Cell Analysis - methods | Bone Marrow Cells - immunology | Integrin alpha Chains - immunology | Antigens, Ly - metabolism | Cell Lineage - genetics | Dendritic Cells - metabolism | Microscopy, Electron, Scanning | CD11b Antigen - immunology | Lectins - immunology | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Mice, Transgenic | Integrin alpha Chains - metabolism | Transcriptome - genetics | Receptors, Cell Surface - immunology | CD8 Antigens - immunology | CD8 Antigens - metabolism | Animals | Antigens, Ly - immunology | Dendritic Cells - ultrastructure | Lectins - genetics | CD11b Antigen - metabolism | Bone Marrow Cells - metabolism | Cell Lineage - immunology | Cluster Analysis | Receptors, Cell Surface - genetics | Medical research | Immune response | Dendritic cells | Cell development (Biology) | Bone marrow | Medicine, Experimental | Genetic aspects | Research | Properties | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 502 - 514
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue... 
EFFECTOR PHASE | COLONY-STIMULATING FACTOR | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | MACROPHAGES | IN-VIVO | LYMPH-NODES | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | T-CELLS | ENCEPHALOMYELITIS EAE | Receptors, CCR2 - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, CCR2 - immunology | Dendritic Cells - immunology | Humans | Antigens, Ly - genetics | STAT5 Transcription Factor - immunology | Autoimmunity - genetics | Monocytes - metabolism | Monocytes - immunology | Transcriptome - immunology | Interleukin-1beta - genetics | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Autoimmunity - immunology | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Antigens, Ly - metabolism | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Cytokine Receptor Common beta Subunit - metabolism | Phosphorylation - immunology | Phosphorylation - drug effects | Dendritic Cells - metabolism | Cytokine Receptor Common beta Subunit - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Interleukin-1beta - immunology | Mice, Transgenic | Inflammation - immunology | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Monocytes - drug effects | Encephalomyelitis, Autoimmune, Experimental | Receptors, CCR2 - metabolism | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Antigens, Ly - immunology | Signal Transduction - drug effects | Inflammation - genetics | Myeloid Cells - metabolism | Cytokine Receptor Common beta Subunit - genetics | Flow cytometry | Phosphorylation | Disease | Cytokines | Bone marrow | Software | Inflammation | Autoimmune diseases | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 570 - 580
Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The... 
ALTERNATIVELY ACTIVATED MACROPHAGES | TYPE-2 INFLAMMATION | DENDRITIC CELLS | IMMUNE-RESPONSES | BONE-MARROW | CHEMOKINE RECEPTOR | PRODUCE INTERLEUKIN-4 | BACTERIAL-INFECTION | IL-4 PRODUCTION | IMMUNOLOGY | T-CELLS | Receptors, CCR2 - genetics | Receptors, CCR2 - immunology | Skin - metabolism | Antigens, Ly - genetics | Hypersensitivity - immunology | Monocytes - metabolism | Monocytes - immunology | Adoptive Transfer | Interleukin-4 Receptor alpha Subunit - genetics | Cell Differentiation - genetics | Inflammation - metabolism | Flow Cytometry | Hypersensitivity - metabolism | Basophils - immunology | Antigens, Ly - metabolism | Hypersensitivity - genetics | Macrophages - immunology | Skin - pathology | Skin - immunology | Interleukin-4 Receptor alpha Subunit - metabolism | Interleukin-4 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-4 Receptor alpha Subunit - immunology | Mice, Knockout | Cell Differentiation - immunology | Interleukin-4 - immunology | Macrophages - metabolism | Receptors, CCR2 - metabolism | Animals | Antigens, Ly - immunology | Inflammation - genetics | Mice | Mice, Inbred BALB C | Basophils - metabolism | Anti-inflammatory drugs | Skin | Genetic aspects | Bone marrow | Wound healing | Cytokines | Allergies | Immune system | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2012, Volume 122, Issue 9, pp. 3063 - 3087
Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | INHERITED ALS | DENDRITIC CELLS | SIGNALING PATHWAY | REGULATORY T-CELLS | CENTRAL-NERVOUS-SYSTEM | AMYOTROPHIC-LATERAL-SCLEROSIS | NF-KAPPA-B | HEXANUCLEOTIDE REPEAT | TRANSCRIPTION FACTOR | Superoxide Dismutase - genetics | Cell Proliferation | Spleen - immunology | Oligonucleotide Array Sequence Analysis | Humans | Antigens, Ly - genetics | Rats, Inbred Lew | Transcriptome | Male | MicroRNAs - metabolism | Monocytes - metabolism | Monocytes - immunology | Gene Regulatory Networks | Antigens, CD - genetics | Amyotrophic Lateral Sclerosis - drug therapy | Antigens, CD - metabolism | Microglia - immunology | RNA Interference | Spinal Cord - pathology | Inflammation Mediators - metabolism | Monocytes - pathology | Microglia - pathology | Antigens, Ly - metabolism | Female | Spleen - pathology | Amyotrophic Lateral Sclerosis - immunology | Immunomodulation | Amyotrophic Lateral Sclerosis - genetics | Mice, Inbred C57BL | Apyrase - metabolism | Rats | Mice, Transgenic | Transcription Factors - genetics | Chemotaxis | Spinal Cord - immunology | Transcription Factors - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Antigens, Ly - immunology | Metabolic Networks and Pathways | Antibodies, Monoclonal - administration & dosage | Apyrase - genetics | Mice | MicroRNAs - genetics | Macrophages, Alveolar - metabolism | Superoxide Dismutase-1 | Apoptosis | Care and treatment | Monocytes | MicroRNA | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Research | Properties | Gene expression | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 555 - 569
Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although... 
ECTO-5'-NUCLEOTIDASE CD73 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | MICROGLIA | REGENERATION | MONOCYTES | CNS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | DIVERGENT | EXPRESSION | 5'-Nucleotidase - antagonists & inhibitors | 5'-Nucleotidase - genetics | Leukocyte Common Antigens - metabolism | Meninges - immunology | Spinal Cord - metabolism | Choroid Plexus - metabolism | Choroid Plexus - immunology | Monocytes - metabolism | Green Fluorescent Proteins - genetics | Monocytes - immunology | Spinal Cord Injuries - genetics | Cell Movement - genetics | Meninges - metabolism | Cell Movement - immunology | Leukocyte Common Antigens - immunology | Flow Cytometry | 5'-Nucleotidase - immunology | Gene Expression - immunology | Antigens, Ly - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Receptors, Chemokine - genetics | Macrophages - immunology | Green Fluorescent Proteins - metabolism | Vascular Cell Adhesion Molecule-1 - immunology | Blood-Brain Barrier - immunology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Integrin alpha4beta1 - genetics | Receptors, Chemokine - immunology | Reverse Transcriptase Polymerase Chain Reaction | Adenosine Diphosphate - pharmacology | Blood-Brain Barrier - metabolism | Mice, Knockout | Integrin alpha4beta1 - immunology | Monocytes - drug effects | Spinal Cord - immunology | Microscopy, Confocal | Macrophages - metabolism | Animals | Antigens, Ly - immunology | Macrophages - drug effects | Spinal Cord Injuries - immunology | Mice | Adenosine Diphosphate - analogs & derivatives | CX3C Chemokine Receptor 1 | Spinal Cord Injuries - cerebrospinal fluid | Macrophages | Enzymes | Spinal cord injuries | Statistical analysis | Cytokines | Rodents | Recruitment | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 945 - 951
Journal Article