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Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3660 - 3663
in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | PATHWAY | STAT3 | NOTCH | STEM/PROGENITOR CELLS | GROWTH-FACTOR | INTERLEUKIN-6 | IDENTIFICATION | TUMORIGENESIS | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Carbonic Anhydrases - biosynthesis | Cytokine Receptor gp130 - genetics | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Janus Kinases - metabolism | RNA, Messenger - metabolism | Serrate-Jagged Proteins | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Membrane Proteins - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Mammary Glands, Human - pathology | Lung Neoplasms - therapy | Signal Transduction - genetics | Autocrine Communication - genetics | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Carcinoma - genetics | Mice | Mutation | Transcription, Genetic - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | Neoplasm Transplantation | Carbonic Anhydrases - genetics | Lung Neoplasms - pathology | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | STAT3 Transcription Factor - metabolism | Carbonic Anhydrase IX | Calcium-Binding Proteins - metabolism | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Janus Kinases - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Interleukin-6 - biosynthesis | Carcinoma - therapy | Receptor, Notch3 | Carcinoma - metabolism | Antagonists (Biochemistry) | Epithelial tumors | Dosage and administration | Diagnosis | Research | Drug therapy | Health aspects | Interleukin-6
Journal Article
Blood, ISSN 1528-0020, 2012, Volume 119, Issue 24, pp. 5795 - 5806
The pathogenesis of hepatosplenic T-cell lymphoma (HSTL), a rare entity mostly derived from γδ T cells and usually with a fatal outcome, remains largely... 
GAMMA-DELTA | TYROSINE KINASE | ALPHA-BETA | NON-HODGKINS-LYMPHOMA | NK-CELL | PI EXPRESSION | RECEPTOR | DRUG-RESISTANCE | HEMATOLOGY | NF-KAPPA-B | CLINICOPATHOLOGICAL ENTITY | Crystallins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Receptors, Antigen, T-Cell, gamma-delta - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Molecular Targeted Therapy | Young Adult | Base Sequence | Biomarkers, Tumor - metabolism | Adult | Female | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Genes, Neoplasm - genetics | Syk Kinase | Cell Lineage - genetics | Splenic Neoplasms - drug therapy | Liver Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Splenic Neoplasms - genetics | Liver Neoplasms - drug therapy | Lymphoma, T-Cell - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | Isochromosomes - genetics | Drug Resistance, Neoplasm - genetics | Lymphoma, T-Cell - drug therapy | Splenic Neoplasms - pathology | Chromosome Aberrations | Lymphoma, T-Cell - pathology | Aged | Biomarkers, Tumor - genetics | Cluster Analysis | Protein-Tyrosine Kinases - antagonists & inhibitors | pathology | Lymphoma, T-Cell | Genes, Neoplasm | Drug Resistance, Neoplasm | Isochromosomes | Liver Neoplasms | genetics | Crystallins | Receptors, Antigen, T-Cell, alpha-beta | drug therapy | Tumor Markers, Biological | Intracellular Signaling Peptides and Proteins | antagonists & inhibitors | Membrane Proteins | Cell Lineage | Receptors, Antigen, T-Cell, gamma-delta | metabolism | Protein-Tyrosine Kinases | Splenic Neoplasms
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 15500 - 10
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145754
... Pereira, Olga Camacho-Vanegas Affiliation: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States... 
CA-125 | MULTIDISCIPLINARY SCIENCES | EPITHELIAL OVARIAN-CANCER | Endometrial Neoplasms - mortality | Humans | Middle Aged | Ovarian Neoplasms - mortality | Genital Neoplasms, Female - drug therapy | DNA, Neoplasm - blood | Endometrial Neoplasms - genetics | Adult | Female | Neoplasm Recurrence, Local - blood | Ovarian Neoplasms - drug therapy | Genital Neoplasms, Female - genetics | CA-125 Antigen - blood | Ovarian Neoplasms - blood | Genital Neoplasms, Female - blood | Mutation - genetics | Breast Neoplasms - drug therapy | Biomarkers, Tumor - blood | Genital Neoplasms, Female - mortality | Exome - genetics | Breast Neoplasms - genetics | Breast Neoplasms - blood | Breast Neoplasms - mortality | Endometrial Neoplasms - drug therapy | Neoplasm Recurrence, Local - genetics | Aged | Biomarkers, Tumor - genetics | DNA, Neoplasm - genetics | Endometrial Neoplasms - blood | Physiological aspects | Prognosis | Biological markers | Genital cancer | Tumors | Plasma | Scanning | Ovarian carcinoma | Fallopian tube | Cancer therapies | Ovarian cancer | Gene sequencing | Computed tomography | Surgery | Quality | Imaging | Endometrium | Deoxyribonucleic acid--DNA | DNA probes | Gynecology | Breast cancer | Patients | Survival | Obstetrics | Medicine | Lead time | Chemotherapy | Surveillance | Womens health | Biomarkers | Diagnostic systems | Mutation | Reproductive system | Uterine cancer | Peritoneum | Cancer | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 6, p. e0179501
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully... 
CD2 | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | GENES | IMMUNOMODULATORY ACTION | MECHANISMS | MOLECULES | SGI-110 | Colonic Neoplasms - genetics | DNA Methylation - immunology | DNA, Neoplasm - metabolism | Humans | Antigens, Neoplasm - biosynthesis | Ovarian Neoplasms - pathology | Male | Colonic Neoplasms - metabolism | Testicular Neoplasms - pathology | Ovarian Neoplasms - genetics | Colonic Neoplasms - immunology | Female | Ovarian Neoplasms - metabolism | Caco-2 Cells | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Antigen Presentation - genetics | DNA Methylation - genetics | Testicular Neoplasms - immunology | Animals | Colonic Neoplasms - pathology | DNA, Neoplasm - immunology | Mice | DNA, Neoplasm - genetics | Ovarian Neoplasms - immunology | Colon cancer | Tumor antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Methylation | Ovarian cancer | Therapy | Biotechnology | Animal models | Ovarian carcinoma | Medical innovations | CD58 antigen | Antigen processing | Genomes | Tissues | Cancer therapies | Immunotherapy | Surgery | Cell cycle | DNA methylation | Inhibition | Colon | Drug dosages | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Antigens | Tumor cells | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Patients | Medicine | Inhibitors | Epigenetics | Solid tumors | Tumors | Cancer | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3988 - 4002
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary... 
CANCER-CELLS | INITIATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GENE SIGNATURE | CARBONIC-ANHYDRASE-IX | STEM-CELLS | STEM/PROGENITOR CELLS | SELF-RENEWAL | GROWTH-FACTOR | EXTRACELLULAR PH | IN-VITRO PROPAGATION | Carbonic Anhydrases - biosynthesis | Carcinoma, Ductal - genetics | Receptors, Notch - metabolism | Carbonic Anhydrases - genetics | Carcinoma, Ductal - pathology | Humans | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Serrate-Jagged Proteins | Female | Carcinoma, Ductal - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Carbonic Anhydrase IX | Jagged-1 Protein | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Calcium-Binding Proteins | Interleukin-6 - genetics | Neoplasm Invasiveness | Intercellular Signaling Peptides and Proteins | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Mammary Glands, Human - pathology | Up-Regulation - genetics | Autocrine Communication - genetics | Membrane Proteins | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Receptor, Notch3 | Cell Hypoxia - genetics | Breast cancer | Genetic aspects | Research | Gene expression | Health aspects | Interleukin-6
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 8840 - 8840
Tumours frequently activate genes whose expression is otherwise biased to the testis, collectively known as cancer-testis antigens (CTAs). The extent to which... 
SCAN BOX | WISP-1 | TUMOR PROGRESSION | SMURF2 | BIK | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RECEPTOR | FAMILY PROTEINS | GROWTH-FACTOR | CELL-DEATH | Neoplasm Transplantation | Prognosis | Adenocarcinoma of Lung | Lung Neoplasms - mortality | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Immunoblotting | Triple Negative Breast Neoplasms - immunology | Neoplasms - genetics | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Adenocarcinoma - genetics | Smad7 Protein - genetics | Real-Time Polymerase Chain Reaction | Wnt Signaling Pathway | Colorectal Neoplasms - mortality | Lung Neoplasms - genetics | Transforming Growth Factor beta - immunology | Antigens, Neoplasm - genetics | Cell Line | Signal Transduction | Cell Survival | Membrane Proteins - genetics | Adenocarcinoma - immunology | HCT116 Cells | Carcinogenesis - genetics | Proportional Hazards Models | Neoplasms - mortality | Triple Negative Breast Neoplasms - mortality | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Lung Neoplasms - immunology | Animals | Colorectal Neoplasms - immunology | Transforming Growth Factor beta - genetics | Triple Negative Breast Neoplasms - genetics | Neoplasms - immunology | Fluorescent Antibody Technique | Cell Line, Tumor | Mice, Inbred NOD | In Vitro Techniques | Ubiquitin-Protein Ligases - genetics | Adenocarcinoma - mortality | Index Medicus
Journal Article
BMC Cancer, ISSN 1471-2407, 12/2010, Volume 10, Issue 1, pp. 666 - 666
.... CTC detection based on the analysis of epithelial antigens might be hampered by the genetic heterogeneity of the primary tumor and loss of epithelial antigens... 
THERAPY | MESSENGER-RNA | ONCOLOGY | METASTATIC BREAST-CANCER | BONE-MARROW | MARKERS | PERIPHERAL-BLOOD | COMPARATIVE-GENOMIC-HYBRIDIZATION | CARCINOMA | Predictive Value of Tests | Cell Adhesion Molecules - genetics | Prognosis | Neoplastic Cells, Circulating - pathology | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Cyclins - genetics | Ovarian Neoplasms - pathology | Uterine Cervical Neoplasms - blood | Neoplastic Cells, Circulating - metabolism | Uterine Cervical Neoplasms - pathology | Case-Control Studies | Epithelial Cell Adhesion Molecule | Ovarian Neoplasms - genetics | Austria | Endometrial Neoplasms - genetics | Myelin and Lymphocyte-Associated Proteolipid Proteins | Adult | Female | Genital Neoplasms, Female - genetics | Antigens, Neoplasm - genetics | Proteolipids - genetics | Vesicular Transport Proteins - genetics | Ovarian Neoplasms - blood | Gene Expression Profiling - methods | Genital Neoplasms, Female - blood | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Uterine Cervical Neoplasms - genetics | Nerve Tissue Proteins - genetics | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Membrane Glycoproteins - genetics | Biomarkers, Tumor - blood | Breast Neoplasms - genetics | RNA, Messenger - blood | Breast Neoplasms - pathology | Breast Neoplasms - blood | Cell Line, Tumor | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Endometrial Neoplasms - blood | Genital Neoplasms, Female - pathology | Germany | Women | Molecular genetics | Analysis | Blood cells | Cancer cells | Physiological aspects | Genetic aspects | Research | Health aspects | Tumors
Journal Article
The American journal of surgical pathology, ISSN 0147-5185, 2017, Volume 41, Issue 3, pp. 326 - 333
Mismatch repair (MMR)-deficient endometrial carcinomas (ECs) bearing Lynch syndrome (LS)-associated germline mutations or sporadic MLH1 promoter... 
PD-L1 | mismatch repair | endometrial carcinoma | MLH1 hypermethylation | immunotherapy | Lynch syndrome | SURGERY | MICROSATELLITE INSTABILITY | INFILTRATING LYMPHOCYTES | IMMUNOSCORE | PATHOLOGY | LUNG-CANCER | PROGNOSTIC-FACTOR | IMMUNE-SYSTEM | MICROENVIRONMENT | COLORECTAL-CANCER | BLOCKADE | Immunohistochemistry | Neoplastic Syndromes, Hereditary - pathology | Prognosis | Follow-Up Studies | Endometrial Neoplasms - mortality | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Brain Neoplasms - pathology | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Neoplastic Syndromes, Hereditary - metabolism | Brain Neoplasms - metabolism | Neoplastic Syndromes, Hereditary - mortality | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | DNA Methylation | Endometrial Neoplasms - genetics | DNA Mismatch Repair | Biomarkers, Tumor - metabolism | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Promoter Regions, Genetic | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Brain Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | B7-H1 Antigen - metabolism | MutL Protein Homolog 1 - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2008, Volume 45, Issue 3, pp. 335 - 346
Journal Article