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Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3660 - 3663
in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | PATHWAY | STAT3 | NOTCH | STEM/PROGENITOR CELLS | GROWTH-FACTOR | INTERLEUKIN-6 | IDENTIFICATION | TUMORIGENESIS | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Carbonic Anhydrases - biosynthesis | Cytokine Receptor gp130 - genetics | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Janus Kinases - metabolism | RNA, Messenger - metabolism | Serrate-Jagged Proteins | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Membrane Proteins - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Mammary Glands, Human - pathology | Lung Neoplasms - therapy | Signal Transduction - genetics | Autocrine Communication - genetics | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Carcinoma - genetics | Mice | Mutation | Transcription, Genetic - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | Neoplasm Transplantation | Carbonic Anhydrases - genetics | Lung Neoplasms - pathology | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | STAT3 Transcription Factor - metabolism | Carbonic Anhydrase IX | Calcium-Binding Proteins - metabolism | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Janus Kinases - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Interleukin-6 - biosynthesis | Carcinoma - therapy | Receptor, Notch3 | Carcinoma - metabolism | Antagonists (Biochemistry) | Epithelial tumors | Dosage and administration | Diagnosis | Research | Drug therapy | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2017, Volume 23, Issue 6, pp. 664 - 673
Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and treated on the basis of their site of origin. This Perspective focuses on... 
MOLECULAR CHARACTERIZATION | MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC ENDOCRINE NEOPLASMS | TRANSGENIC MOUSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIANDROGEN RESISTANCE | CONDITIONAL MOUSE MODEL | AURORA KINASE | METASTATIC PROSTATE-CANCER | T-ANTIGEN | CELL BIOLOGY | CELL LUNG-CANCER | N-MYC | Lung Neoplasms - drug therapy | Colonic Neoplasms - genetics | Carcinoma, Small Cell - genetics | Colonic Neoplasms - drug therapy | Epigenesis, Genetic | Humans | Male | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Prostatic Neoplasms - genetics | Urinary Bladder Neoplasms - genetics | Female | Cell Differentiation | Retinoblastoma Binding Proteins - genetics | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Triazoles - therapeutic use | Lung Neoplasms - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Carcinoma, Neuroendocrine - drug therapy | Carcinoma, Small Cell - drug therapy | Carcinogenesis - genetics | Head and Neck Neoplasms - drug therapy | Carcinoma, Neuroendocrine - genetics | Uterine Cervical Neoplasms - drug therapy | Urinary Bladder Neoplasms - drug therapy | Uterine Cervical Neoplasms - genetics | Disease Progression | Azepines - therapeutic use | Neuroendocrine Tumors - genetics | Proto-Oncogene Proteins c-met - genetics | Cell Lineage | Cell Plasticity - genetics | Esophageal Neoplasms - genetics | Pyrimidines - therapeutic use | Neuroendocrine Tumors - drug therapy | Head and Neck Neoplasms - genetics | Proto-Oncogene Proteins c-myc - genetics | Ubiquitin-Protein Ligases - genetics | Benzodiazepines - therapeutic use | Esophageal Neoplasms - drug therapy | Proteins | Research | Health aspects | Carcinogenesis | Gastrin | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3988 - 4002
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary... 
CANCER-CELLS | INITIATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GENE SIGNATURE | CARBONIC-ANHYDRASE-IX | STEM-CELLS | STEM/PROGENITOR CELLS | SELF-RENEWAL | GROWTH-FACTOR | EXTRACELLULAR PH | IN-VITRO PROPAGATION | Carbonic Anhydrases - biosynthesis | Carcinoma, Ductal - genetics | Receptors, Notch - metabolism | Carbonic Anhydrases - genetics | Carcinoma, Ductal - pathology | Humans | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Serrate-Jagged Proteins | Female | Carcinoma, Ductal - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Carbonic Anhydrase IX | Jagged-1 Protein | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Calcium-Binding Proteins | Interleukin-6 - genetics | Neoplasm Invasiveness | Intercellular Signaling Peptides and Proteins | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Mammary Glands, Human - pathology | Up-Regulation - genetics | Autocrine Communication - genetics | Membrane Proteins | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Receptor, Notch3 | Cell Hypoxia - genetics | Breast cancer | Genetic aspects | Research | Gene expression | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 4, pp. 1668 - 1678
Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information... 
MICRODOMAINS | METASTASIS | RAT | ONCOLOGY | COMPLEXES | CANCER-ASSOCIATED THROMBOSIS | GROWTH-FACTOR | TUMOR ANGIOGENESIS | INDUCTION | PROTEINS | ASSOCIATION | Exosomes - metabolism | Adenocarcinoma - pathology | Membrane Glycoproteins - metabolism | Lung Neoplasms - metabolism | Neoplasm Proteins - physiology | Exosomes - pathology | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Antigens, Surface - physiology | Neovascularization, Pathologic - pathology | Cell Differentiation - genetics | Membrane Glycoproteins - physiology | Adenocarcinoma - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Antigens, Neoplasm - physiology | Exosomes - physiology | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Adenocarcinoma - genetics | Cell Membrane - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Endothelial Cells - physiology | Tetraspanins | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Endothelial Cells - metabolism | RNA, Small Interfering - pharmacology | Antigens, Surface - genetics | Cells, Cultured | Rats | Signal Transduction - genetics | Membrane Glycoproteins - genetics | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neovascularization, Pathologic - genetics | Cell Proliferation - drug effects | Neovascularization, Pathologic - metabolism | Endothelial Cells - pathology | Endothelial Cells - drug effects | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5795 - 5806
The pathogenesis of hepatosplenic T-cell lymphoma (HSTL), a rare entity mostly derived from gamma delta T cells and usually with a fatal outcome, remains... 
GAMMA-DELTA | TYROSINE KINASE | ALPHA-BETA | NON-HODGKINS-LYMPHOMA | NK-CELL | PI EXPRESSION | RECEPTOR | DRUG-RESISTANCE | HEMATOLOGY | NF-KAPPA-B | CLINICOPATHOLOGICAL ENTITY | Crystallins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Receptors, Antigen, T-Cell, gamma-delta - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Molecular Targeted Therapy | Young Adult | Base Sequence | Biomarkers, Tumor - metabolism | Adult | Female | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Genes, Neoplasm - genetics | Syk Kinase | Cell Lineage - genetics | Splenic Neoplasms - drug therapy | Liver Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Splenic Neoplasms - genetics | Liver Neoplasms - drug therapy | Lymphoma, T-Cell - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | Isochromosomes - genetics | Drug Resistance, Neoplasm - genetics | Lymphoma, T-Cell - drug therapy | Splenic Neoplasms - pathology | Chromosome Aberrations | Lymphoma, T-Cell - pathology | Aged | Biomarkers, Tumor - genetics | Cluster Analysis | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | pathology | Lymphoma, T-Cell | Genes, Neoplasm | Drug Resistance, Neoplasm | Isochromosomes | Liver Neoplasms | genetics | Crystallins | Receptors, Antigen, T-Cell, alpha-beta | drug therapy | Tumor Markers, Biological | Intracellular Signaling Peptides and Proteins | antagonists & inhibitors | Membrane Proteins | Cell Lineage | Receptors, Antigen, T-Cell, gamma-delta | metabolism | Protein-Tyrosine Kinases | Splenic Neoplasms
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3981 - 3991
Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate complete regression of metastatic melanoma have been shown to recognize mutated... 
CD4+T CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | TCR | THERAPY | RECOGNITION | ANTI-CTLA-4 | MUTATIONAL LANDSCAPE | CD4(+) | ANTIGENS | BLOCKADE | Humans | Middle Aged | Neoplasm Proteins - immunology | Molecular Sequence Data | Male | Antigen-Antibody Reactions | Epitopes - immunology | Exome | Melanoma - genetics | Peptide Fragments - immunology | Adult | Female | Receptor, ErbB-2 - immunology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Transcription Factors - immunology | Amino Acid Sequence | Antigens, Neoplasm - genetics | DNA-Binding Proteins - immunology | HLA-A2 Antigen - immunology | Antigens, Neoplasm - immunology | Interferon-gamma Release Tests | Cells, Cultured | HLA-A1 Antigen - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Epitopes - genetics | Nuclear Proteins - immunology | Melanoma - secondary | HLA-A2 Antigen - chemistry | Algorithms | Genes, erbB-2 | Melanoma - immunology | Adolescent | RNA, Neoplasm - genetics | T-Cell Antigen Receptor Specificity | T-Lymphocytes - immunology | HLA-A1 Antigen - immunology | DNA, Neoplasm - genetics | Mutation | Antigens, Neoplasm - classification | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | T cells | Lymphocytes | Identification and classification | Health aspects | Tumors | Antigens | Peptides | Cloning | Melanoma | T cell receptors | Metastasis | Cancer therapies | Patients | Studies | Immunotherapy | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0145754 - e0145754
Background High-grade serous ovarian and endometrial cancers are the most lethal female reproductive tract malignancies worldwide. In part, failure to treat... 
CA-125 | MULTIDISCIPLINARY SCIENCES | EPITHELIAL OVARIAN-CANCER | Endometrial Neoplasms - mortality | Humans | Middle Aged | Ovarian Neoplasms - mortality | Genital Neoplasms, Female - drug therapy | DNA, Neoplasm - blood | Endometrial Neoplasms - genetics | Adult | Female | Neoplasm Recurrence, Local - blood | Ovarian Neoplasms - drug therapy | Genital Neoplasms, Female - genetics | CA-125 Antigen - blood | Ovarian Neoplasms - blood | Genital Neoplasms, Female - blood | Mutation - genetics | Breast Neoplasms - drug therapy | Biomarkers, Tumor - blood | Genital Neoplasms, Female - mortality | Exome - genetics | Breast Neoplasms - genetics | Breast Neoplasms - blood | Breast Neoplasms - mortality | Endometrial Neoplasms - drug therapy | Neoplasm Recurrence, Local - genetics | Aged | Biomarkers, Tumor - genetics | DNA, Neoplasm - genetics | Endometrial Neoplasms - blood | Physiological aspects | Prognosis | Biological markers | Genital cancer | Tumors | Plasma | Scanning | Ovarian carcinoma | Medical services | Fallopian tube | Cancer therapies | Ovarian cancer | Gene sequencing | Computed tomography | Surgery | Quality | Imaging | Bioindicators | Endometrium | Deoxyribonucleic acid--DNA | DNA probes | Gynecology | Breast cancer | Patients | Survival | Obstetrics | Medicine | Lead time | Chemotherapy | Surveillance | Womens health | Biomarkers | Diagnostic systems | Mutation | Reproductive system | Uterine cancer | Peritoneum | Cancer | Index Medicus | Deoxyribonucleic acid | DNA | Computer aided tomography
Journal Article
Science, ISSN 0036-8075, 10/2015, Volume 350, Issue 6257, pp. 207 - 211
Journal Article
Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Bioindicators | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis | Index Medicus
Journal Article