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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7693, pp. 544 - 548
Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | BLADDER-CANCER | THERAPY | LANDSCAPE | SUBTYPES | UROTHELIAL CARCINOMA | MULTIDISCIPLINARY SCIENCES | GENES | ADAPTIVE IMMUNE RESISTANCE | MPDL3280A | CD8-Positive T-Lymphocytes - cytology | Humans | Antibodies, Monoclonal - therapeutic use | Urothelium - pathology | Urologic Neoplasms - pathology | Neoplasm Metastasis | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | Immunotherapy | Antibodies - immunology | Antigens, Neoplasm - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Antigens, Neoplasm - analysis | Disease Models, Animal | Fibroblasts - metabolism | Antibodies - therapeutic use | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | B7-H1 Antigen - immunology | Urologic Neoplasms - immunology | Antibodies - pharmacology | Tumor Microenvironment - immunology | Collagen - metabolism | Phenotype | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | CD8-Positive T-Lymphocytes - drug effects | Urothelium - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Urothelium - drug effects | Transforming Growth Factor beta - metabolism | Cohort Studies | Drug Resistance, Neoplasm - drug effects | PD-1 protein | CD8 antigen | Transforming growth factor-a | Antibodies | Parenchyma | Lymphocytes T | Metastasis | Immunity | Metastases | Genotype & phenotype | Signal transduction | Lymphocytes | Cell cycle | Fibroblasts | Growth factors | Urothelial cancer | Phenotypes | Cytokines | Melanoma | Blocking | Gene expression | Patients | Generalized linear models | Signaling | Stromal cells | Medical prognosis | Collagen | PD-L1 protein | Ligands | Determinants | Infiltration | Cancer | Tumors | Apoptosis | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 12/2009, Volume 16, Issue 12, pp. 3488 - 3498
Cancer stem cells are associated with metastatic potential, treatment resistance, and poor patient prognosis. Distant recurrence remains the major cause of... 
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | PHARMACOKINETIC MODULATING CHEMOTHERAPY | PLURIPOTENT STEM-CELLS | COLON-CANCER | SURGERY | CARCINOMA CELLS | MESSENGER-RNA | ONCOLOGY | MARKER CD133 | TUMOR-REGRESSION | PREOPERATIVE CHEMORADIOTHERAPY | EXPRESSION | TOTAL MESORECTAL EXCISION | Colonic Neoplasms - radiotherapy | Neoplasm Recurrence, Local - radiotherapy | Neoplasm, Residual - metabolism | Prognosis | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Glycoproteins - metabolism | Peptides - genetics | Neoplasm Recurrence, Local - drug therapy | Male | RNA, Messenger - metabolism | Antigens, CD - genetics | Colonic Neoplasms - metabolism | Immunoenzyme Techniques | Antigens, CD - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Fluorouracil - administration & dosage | Peptides - metabolism | Uracil - administration & dosage | SOXB1 Transcription Factors - genetics | Biomarkers, Tumor - metabolism | Adult | Female | Neoplasm, Residual - radiotherapy | Retrospective Studies | Tumor Cells, Cultured | Rectal Neoplasms - drug therapy | Glycoproteins - genetics | Radiotherapy Dosage | Neoplasm Recurrence, Local - metabolism | RNA, Messenger - genetics | Survival Rate | Combined Modality Therapy | Lymphatic Metastasis | Reverse Transcriptase Polymerase Chain Reaction | AC133 Antigen | Rectal Neoplasms - radiotherapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Octamer Transcription Factor-3 - metabolism | Neoplasm, Residual - drug therapy | Tegafur - administration & dosage | Aged | Rectal Neoplasms - metabolism | Neoplasm Staging | Immunohistochemistry | Medical colleges | Care and treatment | Colon cancer | Radiation | Stem cells | Metastasis | Health aspects | Cancer | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2007, Volume 117, Issue 12, pp. 3988 - 4002
High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no data are available on the relationship between IL-6 and mammary... 
CANCER-CELLS | INITIATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | GENE SIGNATURE | CARBONIC-ANHYDRASE-IX | STEM-CELLS | STEM/PROGENITOR CELLS | SELF-RENEWAL | GROWTH-FACTOR | EXTRACELLULAR PH | IN-VITRO PROPAGATION | Carbonic Anhydrases - biosynthesis | Carcinoma, Ductal - genetics | Receptors, Notch - metabolism | Carbonic Anhydrases - genetics | Carcinoma, Ductal - pathology | Humans | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Serrate-Jagged Proteins | Female | Carcinoma, Ductal - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Carbonic Anhydrase IX | Jagged-1 Protein | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Calcium-Binding Proteins | Interleukin-6 - genetics | Neoplasm Invasiveness | Intercellular Signaling Peptides and Proteins | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Mammary Glands, Human - pathology | Up-Regulation - genetics | Autocrine Communication - genetics | Membrane Proteins | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Receptor, Notch3 | Cell Hypoxia - genetics | Breast cancer | Genetic aspects | Research | Gene expression | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3660 - 3663
in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | PATHWAY | STAT3 | NOTCH | STEM/PROGENITOR CELLS | GROWTH-FACTOR | INTERLEUKIN-6 | IDENTIFICATION | TUMORIGENESIS | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Carbonic Anhydrases - biosynthesis | Cytokine Receptor gp130 - genetics | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Janus Kinases - metabolism | RNA, Messenger - metabolism | Serrate-Jagged Proteins | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Membrane Proteins - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Mammary Glands, Human - pathology | Lung Neoplasms - therapy | Signal Transduction - genetics | Autocrine Communication - genetics | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Carcinoma - genetics | Mice | Mutation | Transcription, Genetic - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | Neoplasm Transplantation | Carbonic Anhydrases - genetics | Lung Neoplasms - pathology | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | STAT3 Transcription Factor - metabolism | Carbonic Anhydrase IX | Calcium-Binding Proteins - metabolism | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Janus Kinases - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Interleukin-6 - biosynthesis | Carcinoma - therapy | Receptor, Notch3 | Carcinoma - metabolism | Antagonists (Biochemistry) | Epithelial tumors | Dosage and administration | Diagnosis | Research | Drug therapy | Health aspects | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7302, pp. 133 - 137
The question of whether tumorigenic cancer stem cells exist in human melanomas has arisen in the last few years. Here we show that in melanomas, tumour stem... 
PROGENITORS | PROSPECTIVE IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CANCER STEM-CELLS | Bone and Bones - pathology | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Humans | Nerve Tissue Proteins - deficiency | Neural Crest - pathology | Receptors, Nerve Growth Factor - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - deficiency | Neural Crest - metabolism | Neoplasm Metastasis | Lung Neoplasms - secondary | Neoplastic Stem Cells - metabolism | Antigens, Neoplasm - metabolism | Neoplastic Stem Cells - pathology | Skin Transplantation | Antigens, Neoplasm - analysis | Skin - pathology | Melanoma - metabolism | Melanoma-Specific Antigens | Neural Crest - cytology | Melanoma - pathology | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Neoplastic Stem Cells - transplantation | Receptors, Nerve Growth Factor - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Bone Transplantation | Neoplasm Proteins - analysis | Transplantation, Heterologous - pathology | Mice | Receptors, Nerve Growth Factor - deficiency | Care and treatment | Melanoma | Stem cells | Physiological aspects | Development and progression | Nerve growth factor | Genetic aspects | Growth factor receptors | Research | Risk factors | Transplants & implants | Skin & tissue grafts | Cancer | Tumors | Human | Enrichment | Antigens | Tumours | Bones | Transplantation | Index Medicus
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 6, pp. 822 - 835
Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7635, pp. 41 - 45
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | METABOLISM | MULTIDISCIPLINARY SCIENCES | STEM-CELL | CHEMORESISTANCE | BRAIN-METASTASIS | STROMAL CELLS | TUMOR-GROWTH | CARCINOMA | PROGRESSION | Palmitic Acid - metabolism | Palmitic Acid - pharmacology | CD36 Antigens - genetics | Cell Proliferation | Mouth Neoplasms - drug therapy | Prognosis | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Diet, High-Fat - adverse effects | Male | Mouth Neoplasms - metabolism | Antibodies, Neutralizing - immunology | Mouth Neoplasms - diagnosis | CD36 Antigens - metabolism | Neoplasm Metastasis - drug therapy | Neoplastic Stem Cells - metabolism | Neoplasm Metastasis - prevention & control | Antibodies, Neutralizing - therapeutic use | Lymphatic Metastasis - pathology | Hyaluronan Receptors - metabolism | Neoplastic Stem Cells - pathology | Female | Lipid Metabolism - genetics | Disease Models, Animal | Palmitic Acid - administration & dosage | CD36 Antigens - immunology | Antibodies, Neutralizing - pharmacology | Penetrance | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | Neoplasm Metastasis - pathology | CD36 Antigens - antagonists & inhibitors | Lymphatic Metastasis - genetics | Mouth Neoplasms - pathology | Mice | Cancer cells | Genetic aspects | Metastasis | Lipid metabolism | Gene expression | Health aspects | Fatty acids | Oral cancer | Lipids | Metabolism | Cells | Tumors | Index Medicus
Journal Article
Journal Article