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Journal of nanobiotechnology, ISSN 1477-3155, 2017, Volume 15, Issue 1, pp. 62 - 10
Background: The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development... 
Protein nanoparticles | Self-assembly | Malaria | P27 | P27A | Vaccine | Blood stage | Tex1 | CIRCUMSPOROZOITE PROTEIN | T-CELL EPITOPES | NANOSCIENCE & NANOTECHNOLOGY | ANTIGENS | HUMAN INHIBITORY ANTIBODIES | HELPER EPITOPES | RESPONSES | INVASION | PEPTIDES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | MHC CLASS-II | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Nanoparticles - chemistry | Humans | Plasmodium falciparum - immunology | Protozoan Proteins - therapeutic use | Protozoan Proteins - genetics | Malaria Vaccines - chemistry | Proliferating Cell Nuclear Antigen - genetics | Nanoparticles - therapeutic use | Plasmodium falciparum - genetics | Antigens, Protozoan - therapeutic use | Malaria Vaccines - immunology | Protein Engineering | Protein Domains | Proliferating Cell Nuclear Antigen - immunology | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Malaria Vaccines - therapeutic use | Plasmodium falciparum - chemistry | Amino Acid Sequence | Immunization | Antigens, Protozoan - chemistry | Models, Molecular | Proliferating Cell Nuclear Antigen - chemistry | Animals | Malaria, Falciparum - immunology | Mice | Mice, Inbred BALB C | Proliferating Cell Nuclear Antigen - therapeutic use | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Proteins | Prevention | Plasmodium falciparum | Immune response | Parasitic diseases | Analysis | Research | Health aspects | Public health | Coils | Animal models | Candidates | Peptides | Delivery systems | Amino acids | Vaccines | Nanoparticles | Lymphocytes | Low cost | Cross-protection | Immune system | Vector-borne diseases | Antigens | Immunoglobulins | Particulates | Epitopes | Immunogenicity | Scaffolding | Protein expression | Scaffolds
Journal Article
PloS one, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179863
Protein alpha-helical coiled coil structures are known to induce antibodies able to block critical functions in different pathogens. In a previous study, a... 
VACCINE DEVELOPMENT | ANTIBODIES | FORCE | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | ANTIGENS | NEW-GUINEAN CHILDREN | DOMAINS | EPIDEMIOLOGY | Papua New Guinea | Immunoglobulin G - blood | Humans | Peptides - genetics | Child, Preschool | Plasmodium vivax - genetics | Infant | Protozoan Proteins - genetics | Antibodies, Protozoan - blood | Malaria Vaccines - immunology | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Malaria, Vivax - prevention & control | Plasmodium vivax - chemistry | Amino Acid Sequence | Protein Conformation, alpha-Helical | Antigens, Protozoan - chemistry | Peptides - chemistry | Malaria, Vivax - parasitology | Peptides - immunology | Risk Factors | Immunity, Innate | Plasmodium vivax - immunology | Animals | Malaria, Vivax - immunology | Longitudinal Studies | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Proteins | Antigens | Immune response | Malaria | Health aspects | Immunoglobulin G | Coils | Disease | Peptides | IgG antibody | Erythrocytes | Antibodies | Infections | Biology | Vaccines | Parasites | Immunity | Tropical diseases | Population | Children | Age | Immune system | Vector-borne diseases | Pathogens | Medical research | Immunoglobulins | Markers | Equilibrium | Correlation analysis | Protein structure | Hygiene | Plasmodium vivax | Malària | Resposta immunitària | Malaria, Vivax | Malaria Vaccines | Antibodies, Protozoan | Protozoan Proteins | Antigens, Protozoan | Life Sciences | Human health and pathology | Immunology | Infectious diseases
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 6, pp. 1197 - 1209.e10
...Introduction Plasmodium falciparum (Pf) is a protozoan parasite with a complex life cycle that causes malaria, a severe and potentially fatal disease. Pf... 
circumsporozoite protein | Plasmodium falciparum | natural infection | affinity maturation | protective antibodies | malaria | memory B cells | epitope specificity | human | X-ray structures | SYSTEM | RESPONSES | IMMUNITY | TRANSMISSION | MEMORY B-CELLS | HUMAN MALARIA | STAGE | PLASMODIUM-FALCIPARUM SPOROZOITES | CIRCUMSPOROZOITE PROTEIN | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | Plasmodium berghei - immunology | Immunoglobulin Heavy Chains - biosynthesis | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | B-Lymphocytes - parasitology | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sporozoites - immunology | Epitopes - immunology | Sporozoites - chemistry | Immunity, Humoral | Female | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Protein Interaction Domains and Motifs | Immunoglobulin Heavy Chains - immunology | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Antigens, Protozoan - chemistry | Antibodies, Protozoan - immunology | Malaria - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antibodies, Protozoan - chemistry | Antibodies, Protozoan - biosynthesis | Malaria - prevention & control | Malaria, Falciparum - parasitology | Animals | B-Lymphocytes - immunology | Protein Conformation, beta-Strand | Malaria - parasitology | Malaria, Falciparum - immunology | Protein Binding | Immunologic Memory | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Viral antibodies | Wildlife conservation | Malaria | Analysis | Children's hospitals | Malaria vaccine | Antibodies | Development and progression | B cells | Health aspects | Antigenic determinants | Vector-borne diseases | Animal models | Immunological memory | Immunoglobulins | Complementarity | Molecular structure | Vaccines | Epitopes | Parasites | Aquatic insects | Immunity | Disease transmission | Lymphocytes B | Coding | Sporozoites | Monoclonal antibodies | Affinity | Immunity (humoral) | Human behavior | Complementarity-determining region 3 | Binding sites | Circumsporozoite protein
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2017, Volume 114, Issue 48, pp. E10438 - E10445
Acquired resistance against antimalarial drugs has further increased the need for an effective malaria vaccine. The current leading candidate, RTS,S, is a... 
X-ray crystallography | Antibodies | Malaria | Circumsporozoite protein | circumsporozoite protein | EFFICACY | MULTIDISCIPLINARY SCIENCES | SPOROZOITES | PHASE-3 | malaria | MOTIF | REGION | PEPTIDES | STRUCTURE VALIDATION | RTS,S/AS01 MALARIA VACCINE | SEQUENCE | antibodies | HEPARAN-SULFATE | Recombinant Proteins - therapeutic use | Epitope Mapping | Antigens, Protozoan - immunology | Malaria, Falciparum - therapy | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Plasmodium falciparum - immunology | Protozoan Proteins - therapeutic use | Malaria Vaccines - chemistry | Epitopes - immunology | Recombinant Proteins - isolation & purification | Antigens, Protozoan - therapeutic use | Malaria Vaccines - immunology | Antigens, Protozoan - isolation & purification | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Malaria Vaccines - therapeutic use | Antigens, Protozoan - chemistry | Repetitive Sequences, Amino Acid - immunology | Antibodies, Protozoan - immunology | Mice, Inbred C57BL | Recombinant Proteins - chemistry | Antibodies, Protozoan - chemistry | Animals | Recombinant Proteins - immunology | Protozoan Proteins - isolation & purification | Malaria, Falciparum - immunology | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Clinical Trials, Phase II as Topic | Proteins | Plasmodium falciparum | Analysis | Microsatellites (Genetics) | Genetic aspects | Properties | Structure | BASIC BIOLOGICAL SCIENCES | Biological Sciences | Physical Sciences | PNAS Plus
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 6, p. e0179146
Recent control scale-up has reduced malaria in many areas but new tools are needed to monitor further progress, including indicators of decreasing exposure to... 
EVALUATING HUMAN EXPOSURE | WESTERN KENYA | MEROZOITE SURFACE PROTEIN-1 | HOLOENDEMIC AREA | PLASMODIUM-FALCIPARUM INFECTION | CLINICAL MALARIA | MULTIDISCIPLINARY SCIENCES | GSG6-P1 SALIVARY PEPTIDE | ANOPHELES-GAMBIAE | IGG RESPONSES | ANTIBODY-RESPONSES | Salivary Glands - immunology | Antigens, Protozoan - immunology | Prevalence | Immunoglobulin G - blood | Humans | Male | Plasmodium falciparum - immunology | Young Adult | Antibodies, Protozoan - blood | Rural Health - statistics & numerical data | Health Surveys - methods | Immunoglobulin G - immunology | Malaria, Falciparum - epidemiology | Adult | Antigens, Protozoan - blood | Female | Plasmodium falciparum - physiology | Child | Senegal - epidemiology | Rural Population - statistics & numerical data | Anopheles - parasitology | Cross-Sectional Studies | Enzyme-Linked Immunosorbent Assay | Antibodies, Protozoan - immunology | Host-Parasite Interactions - immunology | Malaria, Falciparum - parasitology | Animals | Adolescent | Malaria, Falciparum - immunology | Anopheles - immunology | Health Surveys - statistics & numerical data | Cohort Studies | Control | Disease transmission | Malaria | Analysis | Risk factors | Peptides | Immunoglobulin G | Infections | Serology | Vaccines | Parasites | Blood | Proteins | Inoculation | Historical account | Villages | Children | Signatures | Indicators | Cross sections | Monitoring | Age | Vector-borne diseases | Antigens | Parasitology | Rural areas | Markers | Tools | Salivary gland | Data processing | Exposure | Conversion | Catalytic converters | Studies | Surveys | Amplification | Adults | Recording | Age groups | Malaria, Falciparum | Innate immunity | Cellular Biology | Adaptive immunology | Antigens, Protozoan | Life Sciences | Plasmodium falciparum | Immunology | Anopheles gambiae | Rural Population | Host-Parasite Interactions | Cell Behavior | Salivary Glands | Biochemistry, Molecular Biology | Antibodies, Protozoan | Rural Health | Microbiology and Parasitology | Human health and pathology | Infectious diseases | Health Surveys | Senegal | Santé publique et épidémiologie | Molecular biology
Journal Article
Malaria journal, ISSN 1475-2875, 2015, Volume 14, Issue 1, p. 278
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 30, pp. 3726 - 3732
Journal Article
Vaccine, ISSN 0264-410X, 2007, Volume 25, Issue 21, pp. 4301 - 4311
Abstract To investigate the vaccine potential of both the Toxoplasma GRA2 and GRA6 antigens, the full length recombinant proteins were produced in Escherichia... 
Allergy and Immunology | Protozoa | GRA6 | Toxoplasma gondii | Dense granule | GRA2 | Vaccination | MEDICINE, RESEARCH & EXPERIMENTAL | PARASITOPHOROUS VACUOLE | PROTEIN | ESCHERICHIA-COLI | IMMUNOLOGY | CONGENITAL TOXOPLASMOSIS | EXCRETED-SECRETED ANTIGENS | protozoa | dense granule | INTERFERON-GAMMA | GENE | GONDII | CIRCULATING ANTIGEN | DNA VACCINATION | vaccination | Toxoplasma - immunology | Antigens, Protozoan - immunology | Vaccines, Subunit - isolation & purification | Vaccines, Subunit - genetics | Humans | Lipid A - analogs & derivatives | Vaccines, Synthetic - immunology | Protozoan Proteins - genetics | Th1 Cells - immunology | Toxoplasmosis, Animal - prevention & control | Vaccines, Synthetic - isolation & purification | Antibodies, Protozoan - blood | Lipid A - immunology | Mice, Inbred CBA | Antigens, Protozoan - isolation & purification | Antigens, Protozoan - genetics | Brain - parasitology | Cytokines - immunology | Disease Models, Animal | Protozoan Vaccines - immunology | Adjuvants, Immunologic | Vaccines, Synthetic - genetics | Vaccines, Subunit - immunology | Animals | Escherichia coli - genetics | Protozoan Proteins - isolation & purification | Toxoplasmosis, Animal - immunology | Mice | Protozoan Proteins - immunology | Antigens | Analysis | Immunoglobulin G | Lipids | Health aspects | Recombinant proteins | Medical research | Parasites | Vaccines | Immune system | Toxoplasmosis, Animal | Brain | Vaccines, Subunit | Cytokines | Escherichia coli | Biochemistry, Molecular Biology | Antibodies, Protozoan | Protozoan Proteins | Lipid A | Toxoplasma | Antigens, Protozoan | Life Sciences | Th1 Cells | Protozoan Vaccines | Vaccines, Synthetic
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 360, Issue 6395, pp. 1358 - 1362
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 42, Issue 3, pp. 580 - 590
Journal Article