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Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 580 - 590
Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine... 
IMMUNITY | GROWTH-INHIBITION | PARASITEMIA | PROTEIN | SPECIFICITY | MEROZOITES | VACCINE | IMMUNOLOGY | BLOOD-STAGE ANTIGENS | IMMUNOGLOBULIN-G | CHILDREN | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Prospective Studies | Protozoan Proteins - antagonists & inhibitors | Humans | Merozoite Surface Protein 1 - genetics | Child, Preschool | Complement Fixation Tests | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Complement C1q - metabolism | Immunoglobulin G - biosynthesis | Malaria Vaccines - immunology | Female | Antigens, Protozoan - genetics | Merozoite Surface Protein 1 - antagonists & inhibitors | Child | Complement Pathway, Classical | Erythrocytes - immunology | Merozoites - immunology | Gene Expression | Parasitemia - immunology | Antibodies, Protozoan - biosynthesis | Host-Pathogen Interactions | Malaria, Falciparum - parasitology | Animals | Malaria Vaccines - administration & dosage | Merozoite Surface Protein 1 - immunology | Adolescent | Malaria, Falciparum - immunology | Parasitemia - prevention & control | Parasitemia - parasitology | Erythrocytes - parasitology | Protozoan Proteins - immunology | Proteins | Viral antibodies | Antibodies | Plasmodium falciparum | Malaria | Survival analysis | Parasites | Microscopy | Blood banks | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1197 - 1209.e10
Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of ( ) sporozoites, can protect from malaria in animal models... 
circumsporozoite protein | Plasmodium falciparum | natural infection | affinity maturation | protective antibodies | malaria | memory B cells | epitope specificity | human | X-ray structures | RESPONSES | IMMUNITY | MEMORY B-CELLS | NEUTRALIZING ANTIBODIES | SMALL-ANGLE SCATTERING | PLASMODIUM-FALCIPARUM SPOROZOITES | CIRCUMSPOROZOITE PROTEIN | MALARIA PARASITE | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | SALIVARY-GLANDS | Plasmodium berghei - immunology | Immunoglobulin Heavy Chains - biosynthesis | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | B-Lymphocytes - parasitology | Immunoglobulin Heavy Chains - chemistry | Crystallography, X-Ray | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Sporozoites - immunology | Epitopes - immunology | Sporozoites - chemistry | Immunity, Humoral | Female | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Protein Interaction Domains and Motifs | Immunoglobulin Heavy Chains - immunology | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Antigens, Protozoan - chemistry | Antibodies, Protozoan - immunology | Malaria - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antibodies, Protozoan - chemistry | Antibodies, Protozoan - biosynthesis | Malaria - prevention & control | Malaria, Falciparum - parasitology | Animals | B-Lymphocytes - immunology | Protein Conformation, beta-Strand | Malaria - parasitology | Malaria, Falciparum - immunology | Protein Binding | Immunologic Memory | Epitopes - chemistry | Mice | Protozoan Proteins - immunology | Viral antibodies | Wildlife conservation | Malaria | Analysis | Children's hospitals | Malaria vaccine | Antibodies | Development and progression | B cells | Health aspects | Antigenic determinants | Vector-borne diseases | Animal models | Immunological memory | Immunoglobulins | Complementarity | Molecular structure | Vaccines | Epitopes | Parasites | Aquatic insects | Immunity | Disease transmission | Lymphocytes B | Coding | Sporozoites | Monoclonal antibodies | Affinity | Immunity (humoral) | Human behavior | Complementarity-determining region 3 | Binding sites | Circumsporozoite protein | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 19913 - 19922
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 30, pp. 3726 - 3732
Journal Article
Journal of Nanobiotechnology, ISSN 1477-3155, 09/2017, Volume 15, Issue 1, pp. 62 - 62
Background: The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development... 
Protein nanoparticles | Self-assembly | Malaria | P27 | P27A | Vaccine | Blood stage | Tex1 | CIRCUMSPOROZOITE PROTEIN | T-CELL EPITOPES | NANOSCIENCE & NANOTECHNOLOGY | ANTIGENS | HUMAN INHIBITORY ANTIBODIES | HELPER EPITOPES | RESPONSES | INVASION | PEPTIDES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLASMODIUM-FALCIPARUM | MHC CLASS-II | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Nanoparticles - chemistry | Humans | Plasmodium falciparum - immunology | Protozoan Proteins - therapeutic use | Protozoan Proteins - genetics | Malaria Vaccines - chemistry | Proliferating Cell Nuclear Antigen - genetics | Nanoparticles - therapeutic use | Plasmodium falciparum - genetics | Antigens, Protozoan - therapeutic use | Malaria Vaccines - immunology | Protein Engineering | Protein Domains | Proliferating Cell Nuclear Antigen - immunology | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Malaria Vaccines - therapeutic use | Plasmodium falciparum - chemistry | Amino Acid Sequence | Immunization | Antigens, Protozoan - chemistry | Models, Molecular | Proliferating Cell Nuclear Antigen - chemistry | Animals | Malaria, Falciparum - immunology | Mice | Mice, Inbred BALB C | Proliferating Cell Nuclear Antigen - therapeutic use | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Proteins | Prevention | Plasmodium falciparum | Immune response | Parasitic diseases | Analysis | Research | Health aspects | Public health | Coils | Animal models | Candidates | Peptides | Delivery systems | Amino acids | Vaccines | Nanoparticles | Lymphocytes | Low cost | Cross-protection | Vector-borne diseases | Antigens | Immunoglobulins | Particulates | Epitopes | Immune systems | Immunogenicity | Scaffolding | Protein expression | Scaffolds | Index Medicus
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6041, pp. 463 - 467
Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the... 
Receptors | Obligate parasites | REPORTS | Cell membranes | Parasitism | Parasites | Parasite hosts | APICAL MEMBRANE ANTIGEN-1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | MOVING JUNCTION | TOXOPLASMA-GONDII | INHIBITORY ANTIBODY | ERYTHROCYTE | Antigens, Protozoan - immunology | Molecular Sequence Data | Toxoplasma - ultrastructure | Antigens, Protozoan - metabolism | Protozoan Proteins - metabolism | Toxoplasma - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Host-Parasite Interactions | Toxoplasma - metabolism | Antibodies, Monoclonal - immunology | Plasmodium falciparum - chemistry | Amino Acid Sequence | Peptide Fragments - metabolism | Antigens, Protozoan - chemistry | Protein Structure, Secondary | Antibodies, Protozoan - immunology | Models, Molecular | Membrane Proteins - immunology | Toxoplasma - pathogenicity | Peptide Fragments - chemistry | Membrane Proteins - chemistry | Mutagenesis | Hydrophobic and Hydrophilic Interactions | Plasmodium falciparum - pathogenicity | Protein Binding | Protein Conformation | Protozoan Proteins - immunology | Amino Acid Substitution | Physiological aspects | Cell receptors | Research | Peptides | Antigens | Pathogens | Membranes | Surface area | Necks | Assembly | Index Medicus | Medicinal Chemistry | Life Sciences | Cheminformatics | Computer Science | Bioinformatics | Chemical Sciences | Pharmaceutical sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e24413 - e24413
Background: In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2),... 
MEROZOITE SURFACE PROTEIN-2 | IMMUNOGENICITY | HUMORAL RESPONSE | CLINICAL MALARIA | MULTIDISCIPLINARY SCIENCES | ANCHORED MEMBRANE-PROTEINS | IN-VITRO GROWTH | INHIBITORY ANTIBODIES | ENDEMIC AREA | PLASMODIUM-FALCIPARUM MALARIA | PAPUA-NEW-GUINEA | Protozoan Proteins - adverse effects | Antigens, Protozoan - immunology | Dose-Response Relationship, Immunologic | Immunity, Humoral - immunology | Humans | Plasmodium falciparum - immunology | Life Cycle Stages - immunology | Malaria Vaccines - chemistry | Young Adult | Protein Isoforms - chemistry | Malaria Vaccines - adverse effects | Malaria Vaccines - immunology | Antibodies - immunology | Adult | Protozoan Proteins - chemistry | Antigens, Protozoan - adverse effects | Antigens, Protozoan - chemistry | Protein Isoforms - adverse effects | Chemistry, Pharmaceutical | Mannitol - analogs & derivatives | Immunity, Cellular - immunology | Animals | Adolescent | Mannitol - chemistry | Plasmodium falciparum - growth & development | Protein Isoforms - immunology | Oleic Acids - chemistry | Protozoan Proteins - immunology | Cohort Studies | Malaria | Malaria vaccine | Immunoglobulin G | Vaccination | Clinical trials | Product development | Vaccines | Enzyme-linked immunosorbent assay | Erythrocytes | Antibodies | Infections | Biochemistry | Parasites | Merozoite surface protein 2 | Western blotting | Proteins | Technology transfer | Children | Recombinant | Vector-borne diseases | Medical research | Antigens | Immunization | Immunoglobulins | Polypeptides | Melanoma | Microscopy | Collaboration | Isoforms | Adults | Immunofluorescence | Index Medicus
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 11/2015, Volume 212, Issue 9, pp. 1429 - 1438
Journal Article
Nature Communications, ISSN 2041-1723, 2011, Volume 2, Issue 1, pp. 601 - 601
Journal Article
Science, ISSN 0036-8075, 06/2018, Volume 360, Issue 6395, pp. 1358 - 1362
Journal Article