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Current Medicinal Chemistry, ISSN 0929-8673, 03/2016, Volume 23, Issue 8, pp. 774 - 791
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of... 
Natural drug | Polyphenol | Morin | Anti-oxidant | Anti-diabetic | Anti-inflammatory | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-oxidant | polyphenol | PSIDIUM-GUAJAVA | ANTIOXIDANT ACTIVITY RELATIONSHIPS | P-GLYCOPROTEIN | IN-VITRO | INDUCED DIABETIC-RATS | anti-inflammatory | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | flavonoid | anti-diabetic | NATURALLY-OCCURRING FLAVONOIDS | HUMAN MAST-CELLS | natural drug | QUANTITATIVE STRUCTURE | Antihypertensive Agents - pharmacology | Antioxidants - chemistry | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Antihypertensive Agents - metabolism | Neuroprotective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antineoplastic Agents - metabolism | Neuroprotective Agents - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neuroprotective Agents - chemistry | Anti-Bacterial Agents - metabolism | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Biological Products - chemistry | Animals | Flavonoids - metabolism | Biological Products - metabolism | Anti-Bacterial Agents - pharmacology | Flavonoids - chemistry
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 509 - 536
Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in mammals. Among them are the hydrophilic cardenolide ouabain and the... 
Cell proliferation | Arterial hypertension | Endogenous cardiotonic steroids | Rostafuroxin | Sodium/potassium-adenosinetriphosphatase | Cancer therapy | Ouabain | Marinobufagenin | Sodium pump | Oleandrin | Bufalin | Sodium metabolism | ouabain | PROTEIN-KINASE-C | PHYSIOLOGY | BOVINE ADRENOCORTICAL-CELLS | BUFALIN INDUCES APOPTOSIS | PLASMALEMMAL NA/K-ATPASE | cell proliferation | SIGNAL-TRANSDUCING FUNCTION | endogenous cardiotonic steroids | FACTOR-KAPPA-B | oleandrin | sodium/potassium-adenosinetriphosphatase | VASCULAR SMOOTH-MUSCLE | NA+-K+-ATPASE | CELL BIOLOGY | arterial hypertension | cancer therapy | OUABAIN-LIKE COMPOUND | sodium pump | DIGITALIS-LIKE COMPOUNDS | bufalin | rostafuroxin | sodium metabolism | marinobufagenin | Cardiac Glycosides - pharmacology | Neoplasms - metabolism | Antihypertensive Agents - pharmacology | Digoxin - metabolism | Calcium - metabolism | Humans | Myocardial Contraction - drug effects | Hypertension - drug therapy | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Antihypertensive Agents - metabolism | Ouabain - metabolism | Antineoplastic Agents - metabolism | Bufanolides - metabolism | Antineoplastic Agents - pharmacology | Blood Pressure - drug effects | Molecular Structure | Cell Death - drug effects | Sodium Chloride - metabolism | Ouabain - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Diabetes Mellitus - metabolism | Cardiovascular System - drug effects | Antihypertensive Agents - therapeutic use | Antineoplastic Agents - chemistry | Digoxin - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Neoplasms - drug therapy | Antihypertensive Agents - chemistry | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Myocytes, Cardiac - drug effects | Cardiovascular System - metabolism | Diabetes Mellitus - physiopathology | Cardiac Glycosides - chemistry | Myocytes, Cardiac - metabolism | Bufanolides - pharmacology | Cardiac Glycosides - metabolism | Cardiac Glycosides - therapeutic use | Cell Proliferation - drug effects | Neoplasms - pathology
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
Nutrients, ISSN 2072-6643, 07/2018, Volume 10, Issue 7, p. 921
Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes... 
Hypertension | Obesity | Watermelon | Liver | Cardiovascular disease | Inflammation | Adipocytes | Endothelial function | Supplements | Enterocytes | Mitochondria | Interventions | Arginine | Nitric oxide | Flow mediated dilation | Therapeutics | Aging | Insulin resistance | Muscle | Diabetes | Immune cells | DEPENDENT DIABETES-MELLITUS | therapeutics | NITRIC-OXIDE SYNTHESIS | L-ARGININE SUPPLEMENTATION | PRESERVED EJECTION FRACTION | enterocytes | HUMAN SKELETAL-MUSCLE | NUTRITION & DIETETICS | arginine | inflammation | muscle | CULTURED ENDOTHELIAL-CELLS | MUSCLE PROTEIN ANABOLISM | watermelon | adipocytes | insulin resistance | obesity | endothelial function | cardiovascular disease | nitric oxide | ORAL L-CITRULLINE | liver | SPONTANEOUSLY HYPERTENSIVE-RATS | mitochondria | immune cells | CHAIN AMINO-ACIDS | supplements | interventions | aging | hypertension | diabetes | flow mediated dilation | Vasodilator Agents - therapeutic use | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Citrulline - metabolism | Metabolic Syndrome - metabolism | Antihypertensive Agents - metabolism | Diabetic Angiopathies - physiopathology | Vasodilator Agents - metabolism | Metabolic Syndrome - physiopathology | Hypertension - prevention & control | Metabolic Syndrome - immunology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Diabetic Angiopathies - prevention & control | Dietary Supplements - adverse effects | Vascular Stiffness | Sarcopenia - metabolism | Endothelium, Vascular - immunology | Hypoglycemic Agents - therapeutic use | Diabetic Angiopathies - metabolism | Sarcopenia - immunology | Endothelium, Vascular - physiopathology | Insulin Resistance | Metabolic Syndrome - therapy | Hypertension - immunology | Citrulline - therapeutic use | Antihypertensive Agents - therapeutic use | Evidence-Based Medicine | Citrulline - adverse effects | Hypertension - physiopathology | Antihypertensive Agents - adverse effects | Hypertension - metabolism | Antioxidants - therapeutic use | Sarcopenia - physiopathology | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Endothelium, Vascular - metabolism | Models, Biological | Sarcopenia - prevention & control | Diabetic Angiopathies - immunology | Antioxidants - adverse effects | Vasodilator Agents - adverse effects | Hypoglycemic Agents - adverse effects | Health | Dietary supplements | Muscles | Amino acids | Gastrointestinal tract | Bioavailability | Citrulline | Metabolism | Nitric-oxide synthase | Substrates | Urea | L-citrulline | Synthesis | Gastrointestinal system | Blood pressure | Adults | Supplementation | Age
Journal Article
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 08/2011, Volume 91, Issue 11, pp. 1931 - 1939
Journal Article
Hypertension, ISSN 0194-911X, 07/2008, Volume 52, Issue 1, pp. 130 - 136
textabstractThe aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats. Furthermore, we... 
Aliskiren | Diabetic nephropathy | Renin inhibitor | (pro)renin receptor | TG(mRen-2)rat | RENIN/PRORENIN RECEPTOR | NONPROTEOLYTIC ACTIVATION | aliskiren | TRANSGENIC RATS | ANGIOTENSIN-II | NEPHROPATHY | MESANGIAL CELLS | PERIPHERAL VASCULAR DISEASE | renin inhibitor | HEART-RATE | PRORENIN | HYPERTENSION | diabetic nephropathy | Renin - metabolism | Antihypertensive Agents - pharmacology | Gene Expression - drug effects | Diabetic Nephropathies - etiology | Humans | Collagen Type III - metabolism | Male | Antihypertensive Agents - metabolism | Receptors, Cell Surface - antagonists & inhibitors | Albuminuria - physiopathology | Collagen Type I - genetics | Diabetic Nephropathies - physiopathology | Amides - pharmacokinetics | Albuminuria - metabolism | Blood Pressure - drug effects | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | Diabetes Mellitus, Experimental - physiopathology | Amides - pharmacology | Collagen Type IV - metabolism | Collagen Type I - metabolism | Albuminuria - etiology | Diabetic Nephropathies - metabolism | Rats | Receptors, Cell Surface - metabolism | Antihypertensive Agents - pharmacokinetics | Collagen Type III - genetics | Rats, Sprague-Dawley | Animals | Renin - antagonists & inhibitors | Transforming Growth Factor beta - genetics | Fumarates - pharmacokinetics | Fumarates - pharmacology | Collagen Type IV - genetics | Transforming Growth Factor beta - metabolism | Receptors, Cell Surface - genetics
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2016, Volume 85, pp. 182 - 201
Abstract NO has many physiological roles; in inflammation, pain, rheumatoid arthritis, immune system, gastroprotection, as antioxidant and reported to be a... 
Internal Medicine | Medical Education | Nitric Oxide(NO) | Antimalarial | Antihypertensive | NO-donors | Non steroidal anti-inflammatory Drugs(NSAIDs) | MEDICINE, RESEARCH & EXPERIMENTAL | III LONG-TERM | NIPRADILOL OPHTHALMIC SOLUTION | INFLAMMATORY RESPONSES | THROMBUS FORMATION | NO-DONOR | NITROXYL ANION | OPEN-ANGLE GLAUCOMA | Non steroidal anti-inflammatory Drugs (NSAIDs) | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | IN-VIVO | PHARMACOLOGY & PHARMACY | ACTIVE ULCERATIVE-COLITIS | Antimalarials - metabolism | Nitric Oxide Donors - chemistry | Anti-Infective Agents - metabolism | Humans | Nitric Oxide Donors - metabolism | Anti-Infective Agents - therapeutic use | Antimalarials - therapeutic use | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Antihypertensive Agents - metabolism | Antihypertensive Agents - therapeutic use | Antineoplastic Agents - chemistry | Antineoplastic Agents - metabolism | Antihypertensive Agents - chemistry | Animals | Anti-Infective Agents - chemistry | Antimalarials - chemistry | Platelet Aggregation Inhibitors - chemistry | Molecular Structure | Nitric Oxide Donors - therapeutic use | Platelet Aggregation Inhibitors - metabolism | Nitric Oxide - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Antioxidants | Glaucoma | Rheumatoid factor | Animal behavior | Nitric oxide | Pharmacy | Drugstores | Nitrates | Arthritis | Health aspects | Transdermal medication | Fluocinolone acetonide
Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 01/2015, Volume 282, Issue 2, pp. 297 - 317
Metabolism contributes significantly to the pharmacokinetics and pharmacodynamics of a drug. In addition, diet and genetics have a profound effect on cellular... 
inborn errors of metabolism | genome‐scale metabolic network reconstruction | constraint‐based modeling | reconstruction module | drug metabolism | genome-scale metabolic network reconstruction | constraint-based modeling | TRANSPLANT PATIENTS | GLOBAL RECONSTRUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMG-COA REDUCTASE | IN-VITRO METABOLISM | HUMAN LIVER-MICROSOMES | CLINICAL PHARMACOKINETICS | CYTOCHROME-P450 3A4 | INBORN-ERRORS | INTESTINAL-ABSORPTION | PHARMACEUTICAL DRUGS | Analgesics - therapeutic use | Inactivation, Metabolic | Humans | Immunosuppressive Agents - therapeutic use | Analgesics - metabolism | Drug-Related Side Effects and Adverse Reactions - metabolism | Analgesics - pharmacokinetics | Antihypertensive Agents - metabolism | Antihypertensive Agents - therapeutic use | Antihypertensive Agents - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Cytochrome P-450 CYP3A - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Drug Design | Immunosuppressive Agents - metabolism | Immunosuppressive Agents - adverse effects | Analgesics - adverse effects | Hypertension | Drugs | Food habits | Genomics | Cytochrome P-450 | Immunosuppressive agents | Prescribing | Metabolites | Analgesics | Analysis | Physiological aspects | Models | Statins | Metabolism | Drug therapy | Pharmacology
Journal Article