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Journal Article
Epilepsia, ISSN 0013-9580, 01/2013, Volume 54, Issue 1, pp. 11 - 27
Summary Several commonly prescribed antiepileptic drugs (AEDs)—including phenobarbital, phenytoin, and carbamazepine—stimulate the synthesis of a broad range... 
Enzyme‐inducing antiepileptic drug | Vascular disease | Drug metabolism | Pharmacokinetic interactions | Osteoporosis | Sexual dysfunction | Enzyme-inducing antiepileptic drug | DOSE-DEPENDENT INDUCTION | VASCULAR RISK-FACTORS | VITAMIN-D METABOLISM | NEWLY-DIAGNOSED EPILEPSY | QUALITY STANDARDS SUBCOMMITTEE | PREGNANE-X-RECEPTOR | CLINICAL NEUROLOGY | PATIENTS RECEIVING CARBAMAZEPINE | RECURRENT MALIGNANT GLIOMA | BRAIN-TUMOR CONSORTIUM | INCREASED BONE TURNOVER | Anticonvulsants - pharmacokinetics | Anti-Retroviral Agents - pharmacokinetics | Humans | Immunosuppressive Agents - pharmacokinetics | Anticonvulsants - therapeutic use | Male | Vascular Diseases - chemically induced | Pregnancy | Cytochromes - biosynthesis | Anticonvulsants - adverse effects | Drug Interactions | Enzyme Induction - drug effects | Epilepsy - drug therapy | Female | Antineoplastic Agents - pharmacokinetics | Contraceptives, Oral, Hormonal - pharmacokinetics | Antidepressive Agents - pharmacokinetics | Drugs | Antiviral agents | Enzymes | Corticosteroids | Comorbidity | Epilepsy | Anticoagulants (Medicine) | Blood circulation disorders | Phenobarbital | Physiological aspects | Hormones, Sex | Oral contraceptives | Sexual disorders | Statins | Phenytoin | Anticoagulants | Glucocorticoids | Antihypertensives | Toxicity | Withdrawal | Mortality | Antiepileptic agents | Immunosuppressive agents | Graft rejection | Sex hormones | Vascular diseases | Acquired immune deficiency syndrome | Analgesics | statins | Metabolic pathways | Cancer | Index Medicus
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | IP | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, pp. 3155 - 3160
Journal Article
Journal Article