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Advances in therapy, ISSN 0741-238X, 2/2012, Volume 29, Issue 2, pp. 163 - 177
...). The aim of these studies was to assess the potential for pharmacokinetic interaction between dapagliflozin, a sodium glucose co-transporter-2 inhibitor being developed for the treatment of T2DM... 
dapagliflozin | pharmacodynamics | Rheumatology | simvastatin | sodium glucose co-transporter-2 | Internal Medicine | Oncology | digoxin | warfarin | type 2 diabetes | Medicine & Public Health | pharmacokinetics | valsartan | Cardiology | Pharmacology/Toxicology | Endocrinology | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Hypoglycemic Agents - pharmacokinetics | Benzhydryl Compounds | Valsartan | Valine - pharmacokinetics | Humans | Middle Aged | Valine - analogs & derivatives | Male | Glucosides - pharmacokinetics | Antihypertensive Agents - pharmacokinetics | Simvastatin - pharmacokinetics | Anti-Arrhythmia Agents - pharmacokinetics | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Cross-Over Studies | Anticholesteremic Agents - pharmacokinetics | Drug Interactions | Adult | Female | Anticoagulants - pharmacokinetics | Diabetes Mellitus, Type 2 - drug therapy | Tetrazoles - pharmacokinetics | Type 2 diabetes | Warfarin | Digoxin | Simvastatin | Drug interactions | Anticoagulants (Medicine) | Glucose | Dextrose | Antilipemic agents | Cardiac glycosides | Blood circulation disorders | Cardiotonic agents | Cardiac patients | Diabetes | Heart diseases | Health technology assessment
Journal Article
American Journal of Cardiovascular Drugs, ISSN 1175-3277, 04/2010, Volume 10, Issue 2, pp. 95 - 103
Background The Polycap™ (polypill; aspirin [acetylsalicylic acid], ramipril, simvastatin, atenolol, and hydrochlorothiazide) was found to be safe and effective... 
Drug-interactions | Ramipril, pharmacokinetics | Aspirin, pharmacokinetics | Hydrochlorothiazide, pharmacokinetics | Hydrochlorothiazide/atenolol/ramipril/simvastatin/aspirin, pharmacokinetics | Salicylic-acid, pharmacokinetics | Atenolol, pharmacokinetics | Risk-factors | Hydrochlorothiazide/atenolol/ramipril/simvastatin/aspirin, drug interactions | Simvastatin, pharmacokinetics | Cardiovascular-disorders, treatment | Pharmacotherapy | Medicine & Public Health | Cardiology | Pharmacology/Toxicology | Cardiac & Cardiovascular Systems | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hydrochlorothiazide - pharmacokinetics | Simvastatin - adverse effects | Area Under Curve | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Aspirin - pharmacokinetics | Biological Availability | Male | Aspirin - administration & dosage | Ramipril - administration & dosage | Young Adult | Capsules | Drug Interactions | Aspirin - adverse effects | Atenolol - pharmacokinetics | Platelet Aggregation Inhibitors - administration & dosage | Adult | Platelet Aggregation Inhibitors - pharmacokinetics | Atenolol - administration & dosage | Ramipril - adverse effects | Tandem Mass Spectrometry - methods | Platelet Aggregation Inhibitors - adverse effects | Hydrochlorothiazide - adverse effects | Cardiovascular Diseases - etiology | Hypolipidemic Agents - adverse effects | Administration, Oral | Simvastatin - administration & dosage | Risk Factors | Ramipril - pharmacokinetics | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Simvastatin - pharmacokinetics | Antihypertensive Agents - adverse effects | Cross-Over Studies | Adolescent | Hypolipidemic Agents - administration & dosage | Atenolol - adverse effects | Chromatography, Liquid - methods | Hypolipidemic Agents - pharmacokinetics | Drug Combinations | Prevention | Complications and side effects | Drug interactions | Dosage and administration | Research | Cardiovascular diseases | Risk factors | Cardiovascular agents | Index Medicus
Journal Article
Journal Article
Clinical pharmacology and therapeutics, ISSN 0009-9236, 09/2006, Volume 80, Issue 3, pp. 235 - 245
Background The liver plays a significant role in drug metabolism; thus it would be expected that liver disease may have a detrimental effect on the activity of... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Mephenytoin - pharmacokinetics | Muscle Relaxants, Central - administration & dosage | Caffeine - administration & dosage | Chlorzoxazone - metabolism | Cytochrome P-450 Enzyme Inhibitors | Humans | Mephenytoin - metabolism | Middle Aged | Antihypertensive Agents - administration & dosage | Cytochrome P-450 Enzyme System - metabolism | Anticonvulsants - administration & dosage | Male | Antihypertensive Agents - metabolism | Mephenytoin - urine | Debrisoquin - pharmacokinetics | Caffeine - pharmacokinetics | Case-Control Studies | Chlorzoxazone - pharmacokinetics | Debrisoquin - administration & dosage | Debrisoquin - metabolism | Isoenzymes - metabolism | Adult | Chlorzoxazone - administration & dosage | Caffeine - metabolism | Severity of Illness Index | Anticonvulsants - pharmacokinetics | Phosphodiesterase Inhibitors - pharmacokinetics | Administration, Oral | Mephenytoin - analogs & derivatives | Anticonvulsants - metabolism | Antihypertensive Agents - pharmacokinetics | Muscle Relaxants, Central - metabolism | Theophylline - metabolism | Muscle Relaxants, Central - pharmacokinetics | Phosphodiesterase Inhibitors - administration & dosage | Phosphodiesterase Inhibitors - metabolism | Liver Diseases - physiopathology | Mephenytoin - administration & dosage | Liver Diseases - metabolism | Isoenzymes - antagonists & inhibitors | Physiological aspects | Medical colleges | Liver diseases | Pharmacy | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
Journal Article